Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019.
Identifieur interne : 000331 ( PubMed/Corpus ); précédent : 000330; suivant : 000332Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019.
Auteurs : Yujiao Jin ; Miaochan Wang ; Zhongbao Zuo ; Chaoming Fan ; Fei Ye ; Zhaobin Cai ; Ying Wang ; Huaizhong Cui ; Kenu Pan ; Aifang XuSource :
- International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [ 1878-3511 ] ; 2020.
Abstract
To investigate the diagnostic value of serological testing and dynamic variance of serum antibody in coronavirus disease 2019 (COVID-19).
DOI: 10.1016/j.ijid.2020.03.065
PubMed: 32251798
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019.</title><author><name sortKey="Jin, Yujiao" sort="Jin, Yujiao" uniqKey="Jin Y" first="Yujiao" last="Jin">Yujiao Jin</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Miaochan" sort="Wang, Miaochan" uniqKey="Wang M" first="Miaochan" last="Wang">Miaochan Wang</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zuo, Zhongbao" sort="Zuo, Zhongbao" uniqKey="Zuo Z" first="Zhongbao" last="Zuo">Zhongbao Zuo</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Chaoming" sort="Fan, Chaoming" uniqKey="Fan C" first="Chaoming" last="Fan">Chaoming Fan</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ye, Fei" sort="Ye, Fei" uniqKey="Ye F" first="Fei" last="Ye">Fei Ye</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cai, Zhaobin" sort="Cai, Zhaobin" uniqKey="Cai Z" first="Zhaobin" last="Cai">Zhaobin Cai</name><affiliation><nlm:affiliation>Department of Cardiovascular Medicine, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Ying" sort="Wang, Ying" uniqKey="Wang Y" first="Ying" last="Wang">Ying Wang</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cui, Huaizhong" sort="Cui, Huaizhong" uniqKey="Cui H" first="Huaizhong" last="Cui">Huaizhong Cui</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pan, Kenu" sort="Pan, Kenu" uniqKey="Pan K" first="Kenu" last="Pan">Kenu Pan</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Aifang" sort="Xu, Aifang" uniqKey="Xu A" first="Aifang" last="Xu">Aifang Xu</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China. Electronic address: xuaifangxxh@163.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32251798</idno><idno type="pmid">32251798</idno><idno type="doi">10.1016/j.ijid.2020.03.065</idno><idno type="wicri:Area/PubMed/Corpus">000331</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000331</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019.</title><author><name sortKey="Jin, Yujiao" sort="Jin, Yujiao" uniqKey="Jin Y" first="Yujiao" last="Jin">Yujiao Jin</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Miaochan" sort="Wang, Miaochan" uniqKey="Wang M" first="Miaochan" last="Wang">Miaochan Wang</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zuo, Zhongbao" sort="Zuo, Zhongbao" uniqKey="Zuo Z" first="Zhongbao" last="Zuo">Zhongbao Zuo</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Chaoming" sort="Fan, Chaoming" uniqKey="Fan C" first="Chaoming" last="Fan">Chaoming Fan</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ye, Fei" sort="Ye, Fei" uniqKey="Ye F" first="Fei" last="Ye">Fei Ye</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cai, Zhaobin" sort="Cai, Zhaobin" uniqKey="Cai Z" first="Zhaobin" last="Cai">Zhaobin Cai</name><affiliation><nlm:affiliation>Department of Cardiovascular Medicine, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Ying" sort="Wang, Ying" uniqKey="Wang Y" first="Ying" last="Wang">Ying Wang</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cui, Huaizhong" sort="Cui, Huaizhong" uniqKey="Cui H" first="Huaizhong" last="Cui">Huaizhong Cui</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pan, Kenu" sort="Pan, Kenu" uniqKey="Pan K" first="Kenu" last="Pan">Kenu Pan</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Aifang" sort="Xu, Aifang" uniqKey="Xu A" first="Aifang" last="Xu">Aifang Xu</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China. Electronic address: xuaifangxxh@163.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</title><idno type="eISSN">1878-3511</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the diagnostic value of serological testing and dynamic variance of serum antibody in coronavirus disease 2019 (COVID-19).</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32251798</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-3511</ISSN><JournalIssue CitedMedium="Internet"><Volume>94</Volume><PubDate><Year>2020</Year><Month>Apr</Month><Day>03</Day></PubDate></JournalIssue><Title>International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</Title><ISOAbbreviation>Int. J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019.</ArticleTitle><Pagination><MedlinePgn>49-52</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1201-9712(20)30198-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijid.2020.03.065</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the diagnostic value of serological testing and dynamic variance of serum antibody in coronavirus disease 2019 (COVID-19).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This study retrospectively included 43 patients with a laboratory-confirmed infection and 33 patients with a suspected infection, in whom the disease was eventually excluded. The IgM/IgG titer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was measured by chemiluminescence immunoassay analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared to molecular detection, the sensitivities of serum IgM and IgG antibodies to diagnose COVID-19 were 48.1% and 88.9%, and the specificities were 100% and 90.9%, respectively.In the COVID-19 group, the IgM-positive rate increased slightly at first and then decreased over time; in contrast, the IgG-positive rate increased to 100% and was higher than IgM at all times. The IgM-positive rate and titer were not significantly different before and after conversion to virus-negative. The IgG-positive rate was up to 90% and not significantly different before and after conversion to virus-negative. However, the median IgG titer after conversion to virus-negative was double that before, and the difference was significant.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Viral serological testing is an effective means of diagnosis for SARS-CoV-2 infection. The positive rate and titer variance of IgG are higher than those of IgM in COVID-19.</AbstractText><CopyrightInformation>Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Yujiao</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Miaochan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zuo</LastName><ForeName>Zhongbao</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Chaoming</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Fei</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Zhaobin</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Medicine, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cui</LastName><ForeName>Huaizhong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pan</LastName><ForeName>Kenu</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Aifang</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Xixi Hospital of Hangzhou, Hangzhou 310023, Zhejiang, China. Electronic address: xuaifangxxh@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>Int J Infect Dis</MedlineTA><NlmUniqueID>9610933</NlmUniqueID><ISSNLinking>1201-9712</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Diagnosis</Keyword><Keyword MajorTopicYN="N">Immunoglobulin G</Keyword><Keyword MajorTopicYN="N">Immunoglobulin M</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Serological test</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>03</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32251798</ArticleId><ArticleId IdType="pii">S1201-9712(20)30198-3</ArticleId><ArticleId IdType="doi">10.1016/j.ijid.2020.03.065</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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