An evidence-based framework for priority clinical research questions for COVID-19.
Identifieur interne : 000319 ( PubMed/Corpus ); précédent : 000318; suivant : 000320An evidence-based framework for priority clinical research questions for COVID-19.
Auteurs : Carlyn Harris ; Gail Carson ; J Kenneth Baillie ; Peter Horby ; Harish NairSource :
- Journal of global health [ 2047-2986 ] ; 2020.
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Abstract
On 31 December, 2019, the World Health Organization China Country Office was informed of cases of pneumonia of unknown aetiology. Since then, there have been over 75 000 cases globally of the 2019 novel coronavirus (COVID-19), 2000 deaths, and over 14 000 cases recovered. Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. In 2018, we conducted a systematic review to identify priority research questions for Severe Acute Respiratory Syndrome-related coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-related coronavirus (MERS-CoV). Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak.
DOI: 10.7189/jogh.10-011001
PubMed: 32257173
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An evidence-based framework for priority clinical research questions for COVID-19.</title><author><name sortKey="Harris, Carlyn" sort="Harris, Carlyn" uniqKey="Harris C" first="Carlyn" last="Harris">Carlyn Harris</name><affiliation><nlm:affiliation>Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carson, Gail" sort="Carson, Gail" uniqKey="Carson G" first="Gail" last="Carson">Gail Carson</name><affiliation><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J Kenneth" last="Baillie">J Kenneth Baillie</name><affiliation><nlm:affiliation>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Horby, Peter" sort="Horby, Peter" uniqKey="Horby P" first="Peter" last="Horby">Peter Horby</name><affiliation><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nair, Harish" sort="Nair, Harish" uniqKey="Nair H" first="Harish" last="Nair">Harish Nair</name><affiliation><nlm:affiliation>Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32257173</idno><idno type="pmid">32257173</idno><idno type="doi">10.7189/jogh.10-011001</idno><idno type="wicri:Area/PubMed/Corpus">000319</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000319</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An evidence-based framework for priority clinical research questions for COVID-19.</title><author><name sortKey="Harris, Carlyn" sort="Harris, Carlyn" uniqKey="Harris C" first="Carlyn" last="Harris">Carlyn Harris</name><affiliation><nlm:affiliation>Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carson, Gail" sort="Carson, Gail" uniqKey="Carson G" first="Gail" last="Carson">Gail Carson</name><affiliation><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J Kenneth" last="Baillie">J Kenneth Baillie</name><affiliation><nlm:affiliation>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Horby, Peter" sort="Horby, Peter" uniqKey="Horby P" first="Peter" last="Horby">Peter Horby</name><affiliation><nlm:affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nair, Harish" sort="Nair, Harish" uniqKey="Nair H" first="Harish" last="Nair">Harish Nair</name><affiliation><nlm:affiliation>Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of global health</title><idno type="eISSN">2047-2986</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus</term><term>Coronavirus</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (virology)</term><term>Disease Outbreaks</term><term>Evidence-Based Emergency Medicine</term><term>Humans</term><term>Pandemics</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (virology)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term><term>Coronavirus</term><term>Disease Outbreaks</term><term>Evidence-Based Emergency Medicine</term><term>Humans</term><term>Pandemics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">On 31 December, 2019, the World Health Organization China Country Office was informed of cases of pneumonia of unknown aetiology. Since then, there have been over 75 000 cases globally of the 2019 novel coronavirus (COVID-19), 2000 deaths, and over 14 000 cases recovered. Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. In 2018, we conducted a systematic review to identify priority research questions for Severe Acute Respiratory Syndrome-related coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-related coronavirus (MERS-CoV). Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32257173</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>15</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2047-2986</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of global health</Title><ISOAbbreviation>J Glob Health</ISOAbbreviation></Journal><ArticleTitle>An evidence-based framework for priority clinical research questions for COVID-19.</ArticleTitle><Pagination><MedlinePgn>011001</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.7189/jogh.10-011001</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">On 31 December, 2019, the World Health Organization China Country Office was informed of cases of pneumonia of unknown aetiology. Since then, there have been over 75 000 cases globally of the 2019 novel coronavirus (COVID-19), 2000 deaths, and over 14 000 cases recovered. Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. In 2018, we conducted a systematic review to identify priority research questions for Severe Acute Respiratory Syndrome-related coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-related coronavirus (MERS-CoV). Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. Studies were grouped thematically according to clinical research questions addressed. In February 2020, available information on COVID19 was reviewed and compared to the results of the SARS-CoV and MERS-CoV systematic review.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">From the research objectives for SARS-CoV and MERS-CoV, ten themes in the literature were identified: Clinical characterisation, prognosis, diagnosis, clinical management, viral pathogenesis, epidemiological characterisation, infection prevention and control/transmission, susceptibility, psychosocial, and aetiology. For COVID19, some information on clinical presentation, diagnostic testing, and aetiology is available but many clinical research gaps have yet to be filled.</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Based on a systematic review of other severe coronaviruses, we summarise the state of clinical research for COVID-19, highlight the research gaps, and provide recommendations for the implementation of standardised protocols. Data based on internationally standardised protocols will inform clinical practice real-time.</AbstractText><CopyrightInformation>Copyright © 2020 by the Journal of Global Health. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Carlyn</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Emory University School of Medicine, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carson</LastName><ForeName>Gail</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baillie</LastName><ForeName>J Kenneth</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horby</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nair</LastName><ForeName>Harish</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D000078182">Systematic Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Scotland</Country><MedlineTA>J Glob Health</MedlineTA><NlmUniqueID>101578780</NlmUniqueID><ISSNLinking>2047-2978</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017934" MajorTopicYN="Y">Coronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055416" MajorTopicYN="Y">Evidence-Based Emergency Medicine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList><CoiStatement>Competing interests: All authors declare no competing interests. GC and PH are involved in the operation of ISARIC. KB is the ISARIC CCP Technical Lead. 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