Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19.
Identifieur interne : 000003 ( PubMed/Corpus ); précédent : 000002; suivant : 000004Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19.
Auteurs : Xiao-Shan Wei ; Xu Wang ; Yi-Ran Niu ; Lin-Lin Ye ; Wen-Bei Peng ; Zi-Hao Wang ; Wei-Bing Yang ; Bo-Han Yang ; Jian-Chu Zhang ; Wan-Li Ma ; Xiao-Rong Wang ; Qiong ZhouSource :
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [ 1542-7714 ] ; 2020.
Abstract
We compared clinical, laboratory, radiological, and outcome features of patients with SARS-CoV-2 infection (COVID-19) with pneumonia, with vs without diarrhea.
DOI: 10.1016/j.cgh.2020.04.030
PubMed: 32311512
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19.</title><author><name sortKey="Wei, Xiao Shan" sort="Wei, Xiao Shan" uniqKey="Wei X" first="Xiao-Shan" last="Wei">Xiao-Shan Wei</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xu" sort="Wang, Xu" uniqKey="Wang X" first="Xu" last="Wang">Xu Wang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Niu, Yi Ran" sort="Niu, Yi Ran" uniqKey="Niu Y" first="Yi-Ran" last="Niu">Yi-Ran Niu</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ye, Lin Lin" sort="Ye, Lin Lin" uniqKey="Ye L" first="Lin-Lin" last="Ye">Lin-Lin Ye</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Peng, Wen Bei" sort="Peng, Wen Bei" uniqKey="Peng W" first="Wen-Bei" last="Peng">Wen-Bei Peng</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Zi Hao" sort="Wang, Zi Hao" uniqKey="Wang Z" first="Zi-Hao" last="Wang">Zi-Hao Wang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Wei Bing" sort="Yang, Wei Bing" uniqKey="Yang W" first="Wei-Bing" last="Yang">Wei-Bing Yang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Bo Han" sort="Yang, Bo Han" uniqKey="Yang B" first="Bo-Han" last="Yang">Bo-Han Yang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Jian Chu" sort="Zhang, Jian Chu" uniqKey="Zhang J" first="Jian-Chu" last="Zhang">Jian-Chu Zhang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Wan Li" sort="Ma, Wan Li" uniqKey="Ma W" first="Wan-Li" last="Ma">Wan-Li Ma</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xiao Rong" sort="Wang, Xiao Rong" uniqKey="Wang X" first="Xiao-Rong" last="Wang">Xiao-Rong Wang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Qiong" sort="Zhou, Qiong" uniqKey="Zhou Q" first="Qiong" last="Zhou">Qiong Zhou</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China. Electronic address: zhouqiongtj@126.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32311512</idno><idno type="pmid">32311512</idno><idno type="doi">10.1016/j.cgh.2020.04.030</idno><idno type="wicri:Area/PubMed/Corpus">000003</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000003</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19.</title><author><name sortKey="Wei, Xiao Shan" sort="Wei, Xiao Shan" uniqKey="Wei X" first="Xiao-Shan" last="Wei">Xiao-Shan Wei</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xu" sort="Wang, Xu" uniqKey="Wang X" first="Xu" last="Wang">Xu Wang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Niu, Yi Ran" sort="Niu, Yi Ran" uniqKey="Niu Y" first="Yi-Ran" last="Niu">Yi-Ran Niu</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ye, Lin Lin" sort="Ye, Lin Lin" uniqKey="Ye L" first="Lin-Lin" last="Ye">Lin-Lin Ye</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Peng, Wen Bei" sort="Peng, Wen Bei" uniqKey="Peng W" first="Wen-Bei" last="Peng">Wen-Bei Peng</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Zi Hao" sort="Wang, Zi Hao" uniqKey="Wang Z" first="Zi-Hao" last="Wang">Zi-Hao Wang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Wei Bing" sort="Yang, Wei Bing" uniqKey="Yang W" first="Wei-Bing" last="Yang">Wei-Bing Yang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Bo Han" sort="Yang, Bo Han" uniqKey="Yang B" first="Bo-Han" last="Yang">Bo-Han Yang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Jian Chu" sort="Zhang, Jian Chu" uniqKey="Zhang J" first="Jian-Chu" last="Zhang">Jian-Chu Zhang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Wan Li" sort="Ma, Wan Li" uniqKey="Ma W" first="Wan-Li" last="Ma">Wan-Li Ma</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xiao Rong" sort="Wang, Xiao Rong" uniqKey="Wang X" first="Xiao-Rong" last="Wang">Xiao-Rong Wang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Qiong" sort="Zhou, Qiong" uniqKey="Zhou Q" first="Qiong" last="Zhou">Qiong Zhou</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China. Electronic address: zhouqiongtj@126.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</title><idno type="eISSN">1542-7714</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared clinical, laboratory, radiological, and outcome features of patients with SARS-CoV-2 infection (COVID-19) with pneumonia, with vs without diarrhea.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32311512</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1542-7714</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>17</Day></PubDate></JournalIssue><Title>Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</Title><ISOAbbreviation>Clin. Gastroenterol. Hepatol.</ISOAbbreviation></Journal><ArticleTitle>Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S1542-3565(20)30526-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cgh.2020.04.030</ELocationID><Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">We compared clinical, laboratory, radiological, and outcome features of patients with SARS-CoV-2 infection (COVID-19) with pneumonia, with vs without diarrhea.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We performed a retrospective, single-center analysis of 84 patients with SARS-CoV-2 pneumonia in Wuhan Union Hospital, China, from January 19 through February 7, 2020. Cases were confirmed by real-time reverse-transcriptase PCR of nasal and pharyngeal swab specimens for SARS-CoV-2 RNA. Blood samples were analyzed for white blood cell count, lymphocyte count, alanine aminotransferase, creatine kinase, lactate dehydrogenase, D-dimer, C-reactive protein, and in some cases, immunoglobulins, complement, lymphocyte subsets, and cytokines. Virus RNA was detected in stool samples by real-time PCR.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of the 84 patients with SARS-CoV-2 pneumonia, 26 (31%) had diarrhea. The duration of fever and dyspnea in patients with diarrhea was significantly longer than those without diarrhea (all P<.05). Stool samples from a higher proportion of patients with diarrhea tested positive for virus RNA (69%) than from patients without diarrhea (17%) (P<.001). As of February 19, a lower proportion of patients with diarrhea had a negative result from the latest throat swab for SARS-CoV-2 (77%) than patients without diarrhea (97%) (P=.010), during these patients' hospitalization. Of 76 patients with a negative result from their latest throat swab test during hospitalization, a significantly higher proportion of patients with diarrhea had a positive result from the retest for SARS-CoV-2 in stool (45%) than patients without diarrhea (20%) (P=.039).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">At a single center in Wuhan, China, 31% of patients with SARS-CoV-2 pneumonia had diarrhea. A significantly higher proportion of patients with diarrhea have virus RNA in stool than patients without diarrhea. Elimination of SARS-CoV-2 from stool takes longer than elimination from the nose and throat.</AbstractText><CopyrightInformation>Copyright © 2020 AGA Institute. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Xiao-Shan</ForeName><Initials>XS</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xu</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Niu</LastName><ForeName>Yi-Ran</ForeName><Initials>YR</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Lin-Lin</ForeName><Initials>LL</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Wen-Bei</ForeName><Initials>WB</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zi-Hao</ForeName><Initials>ZH</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Wei-Bing</ForeName><Initials>WB</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Bo-Han</ForeName><Initials>BH</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jian-Chu</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Wan-Li</ForeName><Initials>WL</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xiao-Rong</ForeName><Initials>XR</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Qiong</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China. Electronic address: zhouqiongtj@126.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Gastroenterol Hepatol</MedlineTA><NlmUniqueID>101160775</NlmUniqueID><ISSNLinking>1542-3565</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Diarrhea</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">pneumonia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>04</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32311512</ArticleId><ArticleId IdType="pii">S1542-3565(20)30526-7</ArticleId><ArticleId IdType="doi">10.1016/j.cgh.2020.04.030</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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