A novel coronavirus associated with severe acute respiratory syndrome.
Identifieur interne : 003333 ( PubMed/Checkpoint ); précédent : 003332; suivant : 003334A novel coronavirus associated with severe acute respiratory syndrome.
Auteurs : Thomas G. Ksiazek [États-Unis] ; Dean Erdman ; Cynthia S. Goldsmith ; Sherif R. Zaki ; Teresa Peret ; Shannon Emery ; Suxiang Tong ; Carlo Urbani ; James A. Comer ; Wilina Lim ; Pierre E. Rollin ; Scott F. Dowell ; Ai-Ee Ling ; Charles D. Humphrey ; Wun-Ju Shieh ; Jeannette Guarner ; Christopher D. Paddock ; Paul Rota ; Barry Fields ; Joseph Derisi ; Jyh-Yuan Yang ; Nancy Cox ; James M. Hughes ; James W. Leduc ; William J. Bellini ; Larry J. AndersonSource :
- The New England journal of medicine [ 1533-4406 ] ; 2003.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Adulte, Adulte d'âge moyen, Animaux, Femelle, Flambées de maladies, Humains, Lignée cellulaire, Liquide de lavage bronchoalvéolaire (virologie), Microscopie électronique, Mâle, Partie orale du pharynx (virologie), Phylogénie, Poumon (anatomopathologie), Poumon (virologie), Réaction de polymérisation en chaîne, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification), Virus du SRAS (ultrastructure).
- MESH :
- analyse : ARN viral.
- anatomopathologie : Poumon, Syndrome respiratoire aigu sévère.
- génétique : Virus du SRAS.
- isolement et purification : Virus du SRAS.
- virologie : Liquide de lavage bronchoalvéolaire, Partie orale du pharynx, Poumon, Syndrome respiratoire aigu sévère.
- épidémiologie : Syndrome respiratoire aigu sévère, Virus du SRAS.
- Adulte, Adulte d'âge moyen, Animaux, Femelle, Flambées de maladies, Humains, Lignée cellulaire, Microscopie électronique, Mâle, Phylogénie, Réaction de polymérisation en chaîne, Virus du SRAS.
English descriptors
- KwdEn :
- Adult, Animals, Bronchoalveolar Lavage Fluid (virology), Cell Line, Disease Outbreaks, Female, Humans, Lung (pathology), Lung (virology), Male, Microscopy, Electron, Middle Aged, Oropharynx (virology), Phylogeny, Polymerase Chain Reaction, RNA, Viral (analysis), SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), SARS Virus (ultrastructure), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , analysis : RNA, Viral.
- classification : SARS Virus.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- pathology : Lung, Severe Acute Respiratory Syndrome.
- ultrastructure : SARS Virus.
- virology : Bronchoalveolar Lavage Fluid, Lung, Oropharynx, Severe Acute Respiratory Syndrome.
- Adult, Animals, Cell Line, Disease Outbreaks, Female, Humans, Male, Microscopy, Electron, Middle Aged, Phylogeny, Polymerase Chain Reaction.
Abstract
A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak.
DOI: 10.1056/NEJMoa030781
PubMed: 12690092
Affiliations:
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pubmed:12690092Le document en format XML
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Ksiazek</name><affiliation wicri:level="1"><nlm:affiliation>Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Erdman, Dean" sort="Erdman, Dean" uniqKey="Erdman D" first="Dean" last="Erdman">Dean Erdman</name></author><author><name sortKey="Goldsmith, Cynthia S" sort="Goldsmith, Cynthia S" uniqKey="Goldsmith C" first="Cynthia S" last="Goldsmith">Cynthia S. Goldsmith</name></author><author><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R" last="Zaki">Sherif R. 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Ksiazek</name><affiliation wicri:level="1"><nlm:affiliation>Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Erdman, Dean" sort="Erdman, Dean" uniqKey="Erdman D" first="Dean" last="Erdman">Dean Erdman</name></author><author><name sortKey="Goldsmith, Cynthia S" sort="Goldsmith, Cynthia S" uniqKey="Goldsmith C" first="Cynthia S" last="Goldsmith">Cynthia S. Goldsmith</name></author><author><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R" last="Zaki">Sherif R. Zaki</name></author><author><name sortKey="Peret, Teresa" sort="Peret, Teresa" uniqKey="Peret T" first="Teresa" last="Peret">Teresa Peret</name></author><author><name sortKey="Emery, Shannon" sort="Emery, Shannon" uniqKey="Emery S" first="Shannon" last="Emery">Shannon Emery</name></author><author><name sortKey="Tong, Suxiang" sort="Tong, Suxiang" uniqKey="Tong S" first="Suxiang" last="Tong">Suxiang Tong</name></author><author><name sortKey="Urbani, Carlo" sort="Urbani, Carlo" uniqKey="Urbani C" first="Carlo" last="Urbani">Carlo Urbani</name></author><author><name sortKey="Comer, James A" sort="Comer, James A" uniqKey="Comer J" first="James A" last="Comer">James A. Comer</name></author><author><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name></author><author><name sortKey="Rollin, Pierre E" sort="Rollin, Pierre E" uniqKey="Rollin P" first="Pierre E" last="Rollin">Pierre E. Rollin</name></author><author><name sortKey="Dowell, Scott F" sort="Dowell, Scott F" uniqKey="Dowell S" first="Scott F" last="Dowell">Scott F. Dowell</name></author><author><name sortKey="Ling, Ai Ee" sort="Ling, Ai Ee" uniqKey="Ling A" first="Ai-Ee" last="Ling">Ai-Ee Ling</name></author><author><name sortKey="Humphrey, Charles D" sort="Humphrey, Charles D" uniqKey="Humphrey C" first="Charles D" last="Humphrey">Charles D. Humphrey</name></author><author><name sortKey="Shieh, Wun Ju" sort="Shieh, Wun Ju" uniqKey="Shieh W" first="Wun-Ju" last="Shieh">Wun-Ju Shieh</name></author><author><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name></author><author><name sortKey="Paddock, Christopher D" sort="Paddock, Christopher D" uniqKey="Paddock C" first="Christopher D" last="Paddock">Christopher D. Paddock</name></author><author><name sortKey="Rota, Paul" sort="Rota, Paul" uniqKey="Rota P" first="Paul" last="Rota">Paul Rota</name></author><author><name sortKey="Fields, Barry" sort="Fields, Barry" uniqKey="Fields B" first="Barry" last="Fields">Barry Fields</name></author><author><name sortKey="Derisi, Joseph" sort="Derisi, Joseph" uniqKey="Derisi J" first="Joseph" last="Derisi">Joseph Derisi</name></author><author><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name></author><author><name sortKey="Cox, Nancy" sort="Cox, Nancy" uniqKey="Cox N" first="Nancy" last="Cox">Nancy Cox</name></author><author><name sortKey="Hughes, James M" sort="Hughes, James M" uniqKey="Hughes J" first="James M" last="Hughes">James M. Hughes</name></author><author><name sortKey="Leduc, James W" sort="Leduc, James W" uniqKey="Leduc J" first="James W" last="Leduc">James W. Leduc</name></author><author><name sortKey="Bellini, William J" sort="Bellini, William J" uniqKey="Bellini W" first="William J" last="Bellini">William J. Bellini</name></author><author><name sortKey="Anderson, Larry J" sort="Anderson, Larry J" uniqKey="Anderson L" first="Larry J" last="Anderson">Larry J. Anderson</name></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Animals</term><term>Bronchoalveolar Lavage Fluid (virology)</term><term>Cell Line</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Male</term><term>Microscopy, Electron</term><term>Middle Aged</term><term>Oropharynx (virology)</term><term>Phylogeny</term><term>Polymerase Chain Reaction</term><term>RNA, Viral (analysis)</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>SARS Virus (ultrastructure)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Lignée cellulaire</term><term>Liquide de lavage bronchoalvéolaire (virologie)</term><term>Microscopie électronique</term><term>Mâle</term><term>Partie orale du pharynx (virologie)</term><term>Phylogénie</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Réaction de polymérisation en chaîne</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (isolement et purification)</term><term>Virus du SRAS (ultrastructure)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Liquide de lavage bronchoalvéolaire</term><term>Partie orale du pharynx</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bronchoalveolar Lavage Fluid</term><term>Lung</term><term>Oropharynx</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Cell Line</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Microscopy, Electron</term><term>Middle Aged</term><term>Phylogeny</term><term>Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Lignée cellulaire</term><term>Microscopie électronique</term><term>Mâle</term><term>Phylogénie</term><term>Réaction de polymérisation en chaîne</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12690092</PMID><DateCompleted><Year>2003</Year><Month>05</Month><Day>21</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1533-4406</ISSN><JournalIssue CitedMedium="Internet"><Volume>348</Volume><Issue>20</Issue><PubDate><Year>2003</Year><Month>May</Month><Day>15</Day></PubDate></JournalIssue><Title>The New England journal of medicine</Title><ISOAbbreviation>N. Engl. J. Med.</ISOAbbreviation></Journal><ArticleTitle>A novel coronavirus associated with severe acute respiratory syndrome.</ArticleTitle><Pagination><MedlinePgn>1953-66</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker from Guangdong Province, China. We conducted studies to identify the etiologic agent of this outbreak.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We received clinical specimens from patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical and histologic studies, and molecular and serologic assays, in an attempt to identify a wide range of potential pathogens.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">None of the previously described respiratory pathogens were consistently identified. However, a novel coronavirus was isolated from patients who met the case definition of SARS. Cytopathological features were noted in Vero E6 cells inoculated with a throat-swab specimen. Electron-microscopical examination revealed ultrastructural features characteristic of coronaviruses. Immunohistochemical and immunofluorescence staining revealed reactivity with group I coronavirus polyclonal antibodies. Consensus coronavirus primers designed to amplify a fragment of the polymerase gene by reverse transcription-polymerase chain reaction (RT-PCR) were used to obtain a sequence that clearly identified the isolate as a unique coronavirus only distantly related to previously sequenced coronaviruses. With specific diagnostic RT-PCR primers we identified several identical nucleotide sequences in 12 patients from several locations, a finding consistent with a point-source outbreak. Indirect fluorescence antibody tests and enzyme-linked immunosorbent assays made with the new isolate have been used to demonstrate a virus-specific serologic response. This virus may never before have circulated in the U.S. population.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A novel coronavirus is associated with this outbreak, and the evidence indicates that this virus has an etiologic role in SARS. Because of the death of Dr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus.</AbstractText><CopyrightInformation>Copyright 2003 Massachusetts Medical Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ksiazek</LastName><ForeName>Thomas G</ForeName><Initials>TG</Initials><AffiliationInfo><Affiliation>Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erdman</LastName><ForeName>Dean</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Goldsmith</LastName><ForeName>Cynthia S</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Zaki</LastName><ForeName>Sherif R</ForeName><Initials>SR</Initials></Author><Author ValidYN="Y"><LastName>Peret</LastName><ForeName>Teresa</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Emery</LastName><ForeName>Shannon</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Tong</LastName><ForeName>Suxiang</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Urbani</LastName><ForeName>Carlo</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Comer</LastName><ForeName>James A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Wilina</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Rollin</LastName><ForeName>Pierre E</ForeName><Initials>PE</Initials></Author><Author ValidYN="Y"><LastName>Dowell</LastName><ForeName>Scott F</ForeName><Initials>SF</Initials></Author><Author ValidYN="Y"><LastName>Ling</LastName><ForeName>Ai-Ee</ForeName><Initials>AE</Initials></Author><Author ValidYN="Y"><LastName>Humphrey</LastName><ForeName>Charles D</ForeName><Initials>CD</Initials></Author><Author ValidYN="Y"><LastName>Shieh</LastName><ForeName>Wun-Ju</ForeName><Initials>WJ</Initials></Author><Author ValidYN="Y"><LastName>Guarner</LastName><ForeName>Jeannette</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Paddock</LastName><ForeName>Christopher D</ForeName><Initials>CD</Initials></Author><Author ValidYN="Y"><LastName>Rota</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Fields</LastName><ForeName>Barry</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>DeRisi</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Jyh-Yuan</ForeName><Initials>JY</Initials></Author><Author ValidYN="Y"><LastName>Cox</LastName><ForeName>Nancy</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Hughes</LastName><ForeName>James M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>LeDuc</LastName><ForeName>James W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Bellini</LastName><ForeName>William J</ForeName><Initials>WJ</Initials></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Larry J</ForeName><Initials>LJ</Initials></Author><Author ValidYN="Y"><CollectiveName>SARS Working Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2003</Year><Month>04</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>N Engl J Med</MedlineTA><NlmUniqueID>0255562</NlmUniqueID><ISSNLinking>0028-4793</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2003 May 15;348(20):1948-51</RefSource><PMID Version="1">12748314</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2003 Aug 14;349(7):709</RefSource><PMID Version="1">12917313</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001992" MajorTopicYN="N">Bronchoalveolar Lavage Fluid</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008854" MajorTopicYN="N">Microscopy, Electron</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009960" MajorTopicYN="N">Oropharynx</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>4</Month><Day>12</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>5</Month><Day>22</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>4</Month><Day>12</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId><ArticleId IdType="doi">10.1056/NEJMoa030781</ArticleId><ArticleId IdType="pii">NEJMoa030781</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Anderson, Larry J" sort="Anderson, Larry J" uniqKey="Anderson L" first="Larry J" last="Anderson">Larry J. Anderson</name><name sortKey="Bellini, William J" sort="Bellini, William J" uniqKey="Bellini W" first="William J" last="Bellini">William J. Bellini</name><name sortKey="Comer, James A" sort="Comer, James A" uniqKey="Comer J" first="James A" last="Comer">James A. Comer</name><name sortKey="Cox, Nancy" sort="Cox, Nancy" uniqKey="Cox N" first="Nancy" last="Cox">Nancy Cox</name><name sortKey="Derisi, Joseph" sort="Derisi, Joseph" uniqKey="Derisi J" first="Joseph" last="Derisi">Joseph Derisi</name><name sortKey="Dowell, Scott F" sort="Dowell, Scott F" uniqKey="Dowell S" first="Scott F" last="Dowell">Scott F. Dowell</name><name sortKey="Emery, Shannon" sort="Emery, Shannon" uniqKey="Emery S" first="Shannon" last="Emery">Shannon Emery</name><name sortKey="Erdman, Dean" sort="Erdman, Dean" uniqKey="Erdman D" first="Dean" last="Erdman">Dean Erdman</name><name sortKey="Fields, Barry" sort="Fields, Barry" uniqKey="Fields B" first="Barry" last="Fields">Barry Fields</name><name sortKey="Goldsmith, Cynthia S" sort="Goldsmith, Cynthia S" uniqKey="Goldsmith C" first="Cynthia S" last="Goldsmith">Cynthia S. Goldsmith</name><name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name><name sortKey="Hughes, James M" sort="Hughes, James M" uniqKey="Hughes J" first="James M" last="Hughes">James M. Hughes</name><name sortKey="Humphrey, Charles D" sort="Humphrey, Charles D" uniqKey="Humphrey C" first="Charles D" last="Humphrey">Charles D. Humphrey</name><name sortKey="Leduc, James W" sort="Leduc, James W" uniqKey="Leduc J" first="James W" last="Leduc">James W. Leduc</name><name sortKey="Lim, Wilina" sort="Lim, Wilina" uniqKey="Lim W" first="Wilina" last="Lim">Wilina Lim</name><name sortKey="Ling, Ai Ee" sort="Ling, Ai Ee" uniqKey="Ling A" first="Ai-Ee" last="Ling">Ai-Ee Ling</name><name sortKey="Paddock, Christopher D" sort="Paddock, Christopher D" uniqKey="Paddock C" first="Christopher D" last="Paddock">Christopher D. Paddock</name><name sortKey="Peret, Teresa" sort="Peret, Teresa" uniqKey="Peret T" first="Teresa" last="Peret">Teresa Peret</name><name sortKey="Rollin, Pierre E" sort="Rollin, Pierre E" uniqKey="Rollin P" first="Pierre E" last="Rollin">Pierre E. Rollin</name><name sortKey="Rota, Paul" sort="Rota, Paul" uniqKey="Rota P" first="Paul" last="Rota">Paul Rota</name><name sortKey="Shieh, Wun Ju" sort="Shieh, Wun Ju" uniqKey="Shieh W" first="Wun-Ju" last="Shieh">Wun-Ju Shieh</name><name sortKey="Tong, Suxiang" sort="Tong, Suxiang" uniqKey="Tong S" first="Suxiang" last="Tong">Suxiang Tong</name><name sortKey="Urbani, Carlo" sort="Urbani, Carlo" uniqKey="Urbani C" first="Carlo" last="Urbani">Carlo Urbani</name><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name><name sortKey="Zaki, Sherif R" sort="Zaki, Sherif R" uniqKey="Zaki S" first="Sherif R" last="Zaki">Sherif R. Zaki</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G" last="Ksiazek">Thomas G. Ksiazek</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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