The 3D structure analysis of SARS-CoV S1 protein reveals a link to influenza virus neuraminidase and implications for drug and antibody discovery.
Identifieur interne : 002994 ( PubMed/Checkpoint ); précédent : 002993; suivant : 002995The 3D structure analysis of SARS-CoV S1 protein reveals a link to influenza virus neuraminidase and implications for drug and antibody discovery.
Auteurs : Xue Wu Zhang [République populaire de Chine] ; Yee Leng Yap [République populaire de Chine]Source :
- Theochem [ 0166-1280 ] ; 2004.
Abstract
The spike protein of SARS-associated coronavirus (SARS-CoV) is an important target for anti-SARS drug discovery. Its S1 domain is responsible for receptor binding and SARS-CoV entry into cells. In this study, we constructed a rational 3D model for S1 domain of SARS-CoV spike protein by fold recognition and molecular modeling techniques. We found that there is a structure similarity between S1 protein and influenza virus neuraminidase. Our analyses suggest that the existing anti-influenza virus inhibitors and anti-neuraminidase antibody could be used as a starting point for designing anti-SARS drugs, vaccines and antibodies. Interestingly, our prediction for antibody is consistent with a recently experimental discovery of anti-SARS antibody.
DOI: 10.1016/j.theochem.2004.04.065
PubMed: 32287547
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Man Building, 8 Sassoon Road, Pokfulam, HongKong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong University-Pasteur Research Centre, Dexter H.C. Man Building, 8 Sassoon Road, Pokfulam, HongKong</wicri:regionArea><wicri:noRegion>HongKong</wicri:noRegion></affiliation></author><author><name sortKey="Yap, Yee Leng" sort="Yap, Yee Leng" uniqKey="Yap Y" first="Yee Leng" last="Yap">Yee Leng Yap</name><affiliation wicri:level="1"><nlm:affiliation>Hong Kong University-Pasteur Research Centre, Dexter H.C. Man Building, 8 Sassoon Road, Pokfulam, HongKong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong University-Pasteur Research Centre, Dexter H.C. Man Building, 8 Sassoon Road, Pokfulam, HongKong</wicri:regionArea><wicri:noRegion>HongKong</wicri:noRegion></affiliation></author></analytic><series><title level="j">Theochem</title><idno type="ISSN">0166-1280</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The spike protein of SARS-associated coronavirus (SARS-CoV) is an important target for anti-SARS drug discovery. Its S1 domain is responsible for receptor binding and SARS-CoV entry into cells. In this study, we constructed a rational 3D model for S1 domain of SARS-CoV spike protein by fold recognition and molecular modeling techniques. We found that there is a structure similarity between S1 protein and influenza virus neuraminidase. Our analyses suggest that the existing anti-influenza virus inhibitors and anti-neuraminidase antibody could be used as a starting point for designing anti-SARS drugs, vaccines and antibodies. Interestingly, our prediction for antibody is consistent with a recently experimental discovery of anti-SARS antibody.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32287547</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0166-1280</ISSN><JournalIssue CitedMedium="Print"><Volume>681</Volume><Issue>1</Issue><PubDate><Year>2004</Year><Month>Jul</Month><Day>26</Day></PubDate></JournalIssue><Title>Theochem</Title><ISOAbbreviation>Theochem</ISOAbbreviation></Journal><ArticleTitle>The 3D structure analysis of SARS-CoV S1 protein reveals a link to influenza virus neuraminidase and implications for drug and antibody discovery.</ArticleTitle><Pagination><MedlinePgn>137-141</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.theochem.2004.04.065</ELocationID><Abstract><AbstractText>The spike protein of SARS-associated coronavirus (SARS-CoV) is an important target for anti-SARS drug discovery. Its S1 domain is responsible for receptor binding and SARS-CoV entry into cells. In this study, we constructed a rational 3D model for S1 domain of SARS-CoV spike protein by fold recognition and molecular modeling techniques. We found that there is a structure similarity between S1 protein and influenza virus neuraminidase. Our analyses suggest that the existing anti-influenza virus inhibitors and anti-neuraminidase antibody could be used as a starting point for designing anti-SARS drugs, vaccines and antibodies. Interestingly, our prediction for antibody is consistent with a recently experimental discovery of anti-SARS antibody.</AbstractText><CopyrightInformation>Copyright © 2004 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xue Wu</ForeName><Initials>XW</Initials><AffiliationInfo><Affiliation>Hong Kong University-Pasteur Research Centre, Dexter H.C. Man Building, 8 Sassoon Road, Pokfulam, HongKong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yap</LastName><ForeName>Yee Leng</ForeName><Initials>YL</Initials><AffiliationInfo><Affiliation>Hong Kong University-Pasteur Research Centre, Dexter H.C. 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