Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases.
Identifieur interne : 002970 ( PubMed/Checkpoint ); précédent : 002969; suivant : 002971Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases.
Auteurs : K F To [République populaire de Chine] ; Joanna H M. Tong ; Paul K S. Chan ; Florence W L. Au ; Stephen S C. Chim ; K C Allen Chan ; Jo L K. Cheung ; Esther Y M. Liu ; Gary M K. Tse ; Anthony W I. Lo ; Y M Dennis Lo ; H K NgSource :
- The Journal of pathology [ 0022-3417 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- isolement et purification : Virus du SRAS.
- physiologie : Virus du SRAS.
- virologie : Entérocytes, Intestin grêle, Poumon, Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Humains, Hybridation in situ, Technique FISH, Tropisme.
English descriptors
- KwdEn :
- MESH :
- isolation & purification : SARS Virus.
- physiology : SARS Virus.
- virology : Enterocytes, Intestine, Small, Lung, Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Humans, In Situ Hybridization, In Situ Hybridization, Fluorescence, Tropism, Vero Cells.
Abstract
Severe acute respiratory syndrome (SARS) is a new human infectious disease with significant morbidity and mortality. The disease has been shown to be associated with a new coronavirus (SARS-CoV). The clinical and epidemiological aspects of SARS have been described. Moreover, the viral genome of SARS-CoV has been fully sequenced. However, much of the biological behaviour of the virus is not known and data on the tissue and cellular tropism of SARS-CoV are limited. In this study, six fatal cases of SARS were investigated for the tissue and cellular tropism of SARS-CoV using an in-situ hybridization (ISH) technique. Among all the tissues studied, positive signals were seen in pneumocytes in the lungs and surface enterocytes in the small bowel. Infected pneumocytes were further confirmed by immunofluorescence-fluorescence in-situ hybridization (FISH) analysis. These results provide important information concerning the tissue tropism of SARS-CoV, which is distinct from previously identified human coronaviruses, and suggest the possible involvement of novel receptors in this infection. Whereas the lung pathology was dominated by diffuse alveolar damage, the gut was relatively intact. These findings indicated that tissue responses to SARS-CoV infection are distinct in different organs.
DOI: 10.1002/path.1510
PubMed: 14743497
Affiliations:
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pubmed:14743497Le document en format XML
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<term>In Situ Hybridization</term>
<term>In Situ Hybridization, Fluorescence</term>
<term>Intestine, Small (virology)</term>
<term>Lung (virology)</term>
<term>SARS Virus (isolation & purification)</term>
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<term>Hybridation in situ</term>
<term>Intestin grêle (virologie)</term>
<term>Poumon (virologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Technique FISH</term>
<term>Tropisme</term>
<term>Virus du SRAS (isolement et purification)</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a new human infectious disease with significant morbidity and mortality. The disease has been shown to be associated with a new coronavirus (SARS-CoV). The clinical and epidemiological aspects of SARS have been described. Moreover, the viral genome of SARS-CoV has been fully sequenced. However, much of the biological behaviour of the virus is not known and data on the tissue and cellular tropism of SARS-CoV are limited. In this study, six fatal cases of SARS were investigated for the tissue and cellular tropism of SARS-CoV using an in-situ hybridization (ISH) technique. Among all the tissues studied, positive signals were seen in pneumocytes in the lungs and surface enterocytes in the small bowel. Infected pneumocytes were further confirmed by immunofluorescence-fluorescence in-situ hybridization (FISH) analysis. These results provide important information concerning the tissue tropism of SARS-CoV, which is distinct from previously identified human coronaviruses, and suggest the possible involvement of novel receptors in this infection. Whereas the lung pathology was dominated by diffuse alveolar damage, the gut was relatively intact. These findings indicated that tissue responses to SARS-CoV infection are distinct in different organs.</div>
</front>
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<Abstract><AbstractText>Severe acute respiratory syndrome (SARS) is a new human infectious disease with significant morbidity and mortality. The disease has been shown to be associated with a new coronavirus (SARS-CoV). The clinical and epidemiological aspects of SARS have been described. Moreover, the viral genome of SARS-CoV has been fully sequenced. However, much of the biological behaviour of the virus is not known and data on the tissue and cellular tropism of SARS-CoV are limited. In this study, six fatal cases of SARS were investigated for the tissue and cellular tropism of SARS-CoV using an in-situ hybridization (ISH) technique. Among all the tissues studied, positive signals were seen in pneumocytes in the lungs and surface enterocytes in the small bowel. Infected pneumocytes were further confirmed by immunofluorescence-fluorescence in-situ hybridization (FISH) analysis. These results provide important information concerning the tissue tropism of SARS-CoV, which is distinct from previously identified human coronaviruses, and suggest the possible involvement of novel receptors in this infection. Whereas the lung pathology was dominated by diffuse alveolar damage, the gut was relatively intact. These findings indicated that tissue responses to SARS-CoV infection are distinct in different organs.</AbstractText>
<CopyrightInformation>Copyright 2004 John Wiley & Sons, Ltd.</CopyrightInformation>
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