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[Study on T cell subsets and their activated molecules from the convalescent SARS patients during two follow-up surveys].

Identifieur interne : 002878 ( PubMed/Checkpoint ); précédent : 002877; suivant : 002879

[Study on T cell subsets and their activated molecules from the convalescent SARS patients during two follow-up surveys].

Auteurs : Cui Cai [République populaire de Chine] ; Xing Zeng ; Ai-Hua Ou ; Yu Huang ; Xian Zhang

Source :

RBID : pubmed:15193228

Descripteurs français

English descriptors

Abstract

To explore the changes of peripheral blood T cell subsets and their activated molecules in convalescent SARS patients.

PubMed: 15193228


Affiliations:


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pubmed:15193228

Le document en format XML

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<title xml:lang="en">[Study on T cell subsets and their activated molecules from the convalescent SARS patients during two follow-up surveys].</title>
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<name sortKey="Cai, Cui" sort="Cai, Cui" uniqKey="Cai C" first="Cui" last="Cai">Cui Cai</name>
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<nlm:affiliation>The Central Laboratory, Guangdong Provincial Hospital of TCM, Guangzhou 510120, China. X-Zeng@21cn.com</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Central Laboratory, Guangdong Provincial Hospital of TCM, Guangzhou 510120</wicri:regionArea>
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<settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
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<name sortKey="Zeng, Xing" sort="Zeng, Xing" uniqKey="Zeng X" first="Xing" last="Zeng">Xing Zeng</name>
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<name sortKey="Ou, Ai Hua" sort="Ou, Ai Hua" uniqKey="Ou A" first="Ai-Hua" last="Ou">Ai-Hua Ou</name>
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<name sortKey="Huang, Yu" sort="Huang, Yu" uniqKey="Huang Y" first="Yu" last="Huang">Yu Huang</name>
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<name sortKey="Zhang, Xian" sort="Zhang, Xian" uniqKey="Zhang X" first="Xian" last="Zhang">Xian Zhang</name>
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<term>CD3 Complex (metabolism)</term>
<term>CD4 Antigens (metabolism)</term>
<term>CD4-CD8 Ratio</term>
<term>CD8 Antigens (metabolism)</term>
<term>Convalescence</term>
<term>Flow Cytometry</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Lymphocyte Count</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>T-Lymphocyte Subsets (immunology)</term>
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<term>Convalescence</term>
<term>Cytométrie en flux</term>
<term>Humains</term>
<term>Numération des lymphocytes</term>
<term>Rapport CD4-CD8</term>
<term>Sous-populations de lymphocytes T (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Études de suivi</term>
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<term>CD4 Antigens</term>
<term>CD8 Antigens</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Sous-populations de lymphocytes T</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Severe Acute Respiratory Syndrome</term>
<term>T-Lymphocyte Subsets</term>
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<keywords scheme="MESH" xml:lang="en">
<term>CD4-CD8 Ratio</term>
<term>Convalescence</term>
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<term>Humains</term>
<term>Numération des lymphocytes</term>
<term>Rapport CD4-CD8</term>
<term>Études de suivi</term>
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<div type="abstract" xml:lang="en">To explore the changes of peripheral blood T cell subsets and their activated molecules in convalescent SARS patients.</div>
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<DateCompleted>
<Year>2004</Year>
<Month>12</Month>
<Day>14</Day>
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<DateRevised>
<Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
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<AbstractText Label="AIM" NlmCategory="OBJECTIVE">To explore the changes of peripheral blood T cell subsets and their activated molecules in convalescent SARS patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In two follow-up surveys of the SARS patients discharged from our hospital, the changes of CD3(+), CD4(+), CD8(+), CD8(+) CD28(+), CD8(+) CD28(-), CD3(+) CD25(+), CD3(+) CD69(+), CD3(+) HLA-DR(+)T cells and the ratio of CD4(+)/CD8(+) T cells in peripheral blood of SARS patients treated unitedly with Chinese and Western medicines were detected by flow cytometry.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In two follow-up surveys, the percentages of CD3(+), CD4(+), CD8(+) CD28(+) T cells and the ratio of CD4(+)/CD8(+) T cells were remarkably lower than those of normal values(P<0.05), while the percentage of CD8(+) CD28 (-) T cells was higher(P<0.01). As for the percentages of CD3(+), CD8(+), CD4(+)/CD8(+), CD3(+) CD25(+), CD3(+) CD69(+) and CD3(+) HLA-DR(+) T cells, there was marked difference between 1st and 2nd follow-up results, but for other molecules there was no notable difference.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The convalescent SARS patients' immune function gradually recovers, and the effect of SARS virus on activation of T cells gradually disappears.</AbstractText>
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