SrasV1, PubMed, Checkpoint, bibRecord, 002844

Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells.

Identifieur interne : 002844 ( PubMed/Checkpoint ); précédent : 002843; suivant : 002845

Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells.

Auteurs : Ken Y C. Chow [République populaire de Chine] ; Yin Shan Yeung ; Chung Chau Hon ; Fanya Zeng ; Ka Man Law ; Frederick C C. Leung

Source :

FEBS letters [ 0014-5793 ] ; 2005.

RBID : pubmed:16310778

Descripteurs français

English descriptors

KwdEn :
- Adenoviridae (genetics), Adenoviridae (metabolism), Animals, Apoptosis, Cell Line, Cell Survival, Chlorocebus aethiops, Genetic Vectors, Humans, Immunohistochemistry, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (genetics), Membrane Glycoproteins (metabolism), Protein Structure, Tertiary, Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Time Factors, Transduction, Genetic, Vero Cells, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (genetics), Viral Envelope Proteins (metabolism).
MESH :
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- genetics : Adenoviridae, Membrane Glycoproteins, Viral Envelope Proteins.
- metabolism : Adenoviridae, Membrane Glycoproteins, Viral Envelope Proteins.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Apoptosis, Cell Line, Cell Survival, Chlorocebus aethiops, Genetic Vectors, Humans, Immunohistochemistry, Protein Structure, Tertiary, Spike Glycoprotein, Coronavirus, Time Factors, Transduction, Genetic, Vero Cells.

Abstract

The pro-apoptotic properties of severe acute respiratory syndrome coronavirus (SARS-CoV) structural proteins were studied in vitro. By monitoring apoptosis indicators including chromatin condensation, cellular DNA fragmentation and cell membrane asymmetry, we demonstrated that the adenovirus-mediated over-expression of SARS-CoV spike (S) protein and its C-terminal domain (S2) induce apoptosis in Vero E6 cells in a time- and dosage-dependent manner, whereas the expression of its N-terminal domain (S1) and other structural proteins, including envelope (E), membrane (M) and nucleocapsid (N) protein do not. These findings suggest a possible role of S and S2 protein in SARS-CoV induced apoptosis and the molecular pathogenesis of SARS.

DOI: 10.1016/j.febslet.2005.10.065
PubMed: 16310778

Affiliations:

République populaire de Chine

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pubmed:16310778

Le document en format XML

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<front><div type="abstract" xml:lang="en">The pro-apoptotic properties of severe acute respiratory syndrome coronavirus (SARS-CoV) structural proteins were studied in vitro. By monitoring apoptosis indicators including chromatin condensation, cellular DNA fragmentation and cell membrane asymmetry, we demonstrated that the adenovirus-mediated over-expression of SARS-CoV spike (S) protein and its C-terminal domain (S2) induce apoptosis in Vero E6 cells in a time- and dosage-dependent manner, whereas the expression of its N-terminal domain (S1) and other structural proteins, including envelope (E), membrane (M) and nucleocapsid (N) protein do not. These findings suggest a possible role of S and S2 protein in SARS-CoV induced apoptosis and the molecular pathogenesis of SARS.</div>
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<Abstract><AbstractText>The pro-apoptotic properties of severe acute respiratory syndrome coronavirus (SARS-CoV) structural proteins were studied in vitro. By monitoring apoptosis indicators including chromatin condensation, cellular DNA fragmentation and cell membrane asymmetry, we demonstrated that the adenovirus-mediated over-expression of SARS-CoV spike (S) protein and its C-terminal domain (S2) induce apoptosis in Vero E6 cells in a time- and dosage-dependent manner, whereas the expression of its N-terminal domain (S1) and other structural proteins, including envelope (E), membrane (M) and nucleocapsid (N) protein do not. These findings suggest a possible role of S and S2 protein in SARS-CoV induced apoptosis and the molecular pathogenesis of SARS.</AbstractText>
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Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells.

Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells.

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