SrasV1, PubMed, Checkpoint, bibRecord, 002755

Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice.

Identifieur interne : 002755 ( PubMed/Checkpoint ); précédent : 002754; suivant : 002756

Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice.

Auteurs : Thomas C. Greenough [États-Unis] ; Gregory J. Babcock ; Anjeanette Roberts ; Hector J. Hernandez ; William D. Thomas ; Jennifer A. Coccia ; Robert F. Graziano ; Mohan Srinivasan ; Israel Lowy ; Robert W. Finberg ; Kanta Subbarao ; Leatrice Vogel ; Mohan Somasundaran ; Katherine Luzuriaga ; John L. Sullivan ; Donna M. Ambrosino

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2005.

RBID : pubmed:15655773

Descripteurs français

English descriptors

KwdEn :
- Animals, Antibodies, Monoclonal (therapeutic use), Antibodies, Viral (therapeutic use), Cells, Cultured, Disease Models, Animal, Epitope Mapping, Epitopes (immunology), Female, Immunization, Passive, Lung (virology), Membrane Glycoproteins (immunology), Mice, Mice, Inbred BALB C, Mice, Transgenic, Neutralization Tests, Protein Binding, SARS Virus (immunology), Severe Acute Respiratory Syndrome (prevention & control), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (immunology).
MESH :
- chemical , immunology : Epitopes, Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , therapeutic use : Antibodies, Monoclonal, Antibodies, Viral.
- immunology : SARS Virus.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Lung.
- Animals, Cells, Cultured, Disease Models, Animal, Epitope Mapping, Female, Immunization, Passive, Mice, Mice, Inbred BALB C, Mice, Transgenic, Neutralization Tests, Protein Binding, Spike Glycoprotein, Coronavirus.

Abstract

Severe acute respiratory syndrome (SARS) remains a significant public health concern after the epidemic in 2003. Human monoclonal antibodies (MAbs) that neutralize SARS-associated coronavirus (SARS-CoV) could provide protection for exposed individuals.

DOI: 10.1086/427242
PubMed: 15655773

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002933
to stream PubMed, to step Curation: 002933

Links to Exploration step

pubmed:15655773

Le document en format XML

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<term>Disease Models, Animal</term>
<term>Epitope Mapping</term>
<term>Epitopes (immunology)</term>
<term>Female</term>
<term>Immunization, Passive</term>
<term>Lung (virology)</term>
<term>Membrane Glycoproteins (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Transgenic</term>
<term>Neutralization Tests</term>
<term>Protein Binding</term>
<term>SARS Virus (immunology)</term>
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<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (immunology)</term>
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<term>Anticorps antiviraux (usage thérapeutique)</term>
<term>Anticorps monoclonaux (usage thérapeutique)</term>
<term>Cartographie épitopique</term>
<term>Cellules cultivées</term>
<term>Femelle</term>
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<term>Liaison aux protéines</term>
<term>Modèles animaux de maladie humaine</term>
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<term>Souris de lignée BALB C</term>
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<term>Viral Envelope Proteins</term>
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<term>Virus du SRAS</term>
<term>Épitopes</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) remains a significant public health concern after the epidemic in 2003. Human monoclonal antibodies (MAbs) that neutralize SARS-associated coronavirus (SARS-CoV) could provide protection for exposed individuals.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15655773</PMID>
<DateCompleted><Year>2005</Year>
<Month>03</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0022-1899</ISSN>
<JournalIssue CitedMedium="Print"><Volume>191</Volume>
<Issue>4</Issue>
<PubDate><Year>2005</Year>
<Month>Feb</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice.</ArticleTitle>
<Pagination><MedlinePgn>507-14</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Severe acute respiratory syndrome (SARS) remains a significant public health concern after the epidemic in 2003. Human monoclonal antibodies (MAbs) that neutralize SARS-associated coronavirus (SARS-CoV) could provide protection for exposed individuals.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Transgenic mice with human immunoglobulin genes were immunized with the recombinant major surface (S) glycoprotein ectodomain of SARS-CoV. Epitopes of 2 neutralizing MAbs derived from these mice were mapped and evaluated in a murine model of SARS-CoV infection.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Both MAbs bound to S glycoprotein expressed on transfected cells but differed in their ability to block binding of S glycoprotein to Vero E6 cells. Immunoprecipitation analysis revealed 2 antibody-binding epitopes: one MAb (201) bound within the receptor-binding domain at aa 490-510, and the other MAb (68) bound externally to the domain at aa 130-150. Mice that received 40 mg/kg of either MAb prior to challenge with SARS-CoV were completely protected from virus replication in the lungs, and doses as low as 1.6 mg/kg offered significant protection.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Two neutralizing epitopes were defined for MAbs to SARS-CoV S glycoprotein. Antibodies to both epitopes protected mice against SARS-CoV challenge. Clinical trials are planned to test MAb 201, a fully human MAb specific for the epitope within the receptor-binding region.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Greenough</LastName>
<ForeName>Thomas C</ForeName>
<Initials>TC</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 02130, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Babcock</LastName>
<ForeName>Gregory J</ForeName>
<Initials>GJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Roberts</LastName>
<ForeName>Anjeanette</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hernandez</LastName>
<ForeName>Hector J</ForeName>
<Initials>HJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Thomas</LastName>
<ForeName>William D</ForeName>
<Initials>WD</Initials>
<Suffix>Jr</Suffix>
</Author>
<Author ValidYN="Y"><LastName>Coccia</LastName>
<ForeName>Jennifer A</ForeName>
<Initials>JA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Graziano</LastName>
<ForeName>Robert F</ForeName>
<Initials>RF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Srinivasan</LastName>
<ForeName>Mohan</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lowy</LastName>
<ForeName>Israel</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Finberg</LastName>
<ForeName>Robert W</ForeName>
<Initials>RW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Subbarao</LastName>
<ForeName>Kanta</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Vogel</LastName>
<ForeName>Leatrice</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Somasundaran</LastName>
<ForeName>Mohan</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Luzuriaga</LastName>
<ForeName>Katherine</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sullivan</LastName>
<ForeName>John L</ForeName>
<Initials>JL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ambrosino</LastName>
<ForeName>Donna M</ForeName>
<Initials>DM</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>N01-AI65315</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P30-AI042845</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
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<Month>01</Month>
<Day>14</Day>
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<MedlineTA>J Infect Dis</MedlineTA>
<NlmUniqueID>0413675</NlmUniqueID>
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Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice.

Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice.

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