Evolution of pulmonary pathology in severe acute respiratory syndrome.
Identifieur interne : 002718 ( PubMed/Checkpoint ); précédent : 002717; suivant : 002719Evolution of pulmonary pathology in severe acute respiratory syndrome.
Auteurs : Cheng Hsiang Hsiao [Taïwan] ; Mu-Zong Wu ; Chi-Long Chen ; Po-Ren Hsueh ; Shun-Wen Hsieh ; Pan-Chyr Yang ; Ih-Jen SuSource :
- Journal of the Formosan Medical Association = Taiwan yi zhi [ 0929-6646 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Poumon, Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Biopsie, Femelle, Humains, Mâle, Sujet âgé, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- pathology : Lung, Severe Acute Respiratory Syndrome.
- Adult, Aged, Biopsy, Female, Humans, Male, Middle Aged, SARS Virus.
Abstract
Severe acute respiratory syndrome (SARS) is characterized by fever with rapid progression to acute respiratory distress and it is associated with substantial morbidity and mortality. Transmission patterns suggest spread by respiratory droplet or close person-to-person contact. To elucidate the correlation of clinical presentation to the pathogenesis and course of the disease, we reviewed the pulmonary pathologic specimens of SARS patients taken at different stages of the disease.
PubMed: 15765160
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last="Hsueh">Po-Ren Hsueh</name></author><author><name sortKey="Hsieh, Shun Wen" sort="Hsieh, Shun Wen" uniqKey="Hsieh S" first="Shun-Wen" last="Hsieh">Shun-Wen Hsieh</name></author><author><name sortKey="Yang, Pan Chyr" sort="Yang, Pan Chyr" uniqKey="Yang P" first="Pan-Chyr" last="Yang">Pan-Chyr Yang</name></author><author><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15765160</idno><idno type="pmid">15765160</idno><idno type="wicri:Area/PubMed/Corpus">002844</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002844</idno><idno type="wicri:Area/PubMed/Curation">002844</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002844</idno><idno type="wicri:Area/PubMed/Checkpoint">002718</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002718</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evolution of pulmonary pathology in severe acute respiratory syndrome.</title><author><name sortKey="Hsiao, Cheng Hsiang" sort="Hsiao, Cheng Hsiang" uniqKey="Hsiao C" first="Cheng Hsiang" last="Hsiao">Cheng Hsiang Hsiao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Pathology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Mu Zong" sort="Wu, Mu Zong" uniqKey="Wu M" first="Mu-Zong" last="Wu">Mu-Zong Wu</name></author><author><name sortKey="Chen, Chi Long" sort="Chen, Chi Long" uniqKey="Chen C" first="Chi-Long" last="Chen">Chi-Long Chen</name></author><author><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name></author><author><name sortKey="Hsieh, Shun Wen" sort="Hsieh, Shun Wen" uniqKey="Hsieh S" first="Shun-Wen" last="Hsieh">Shun-Wen Hsieh</name></author><author><name sortKey="Yang, Pan Chyr" sort="Yang, Pan Chyr" uniqKey="Yang P" first="Pan-Chyr" last="Yang">Pan-Chyr Yang</name></author><author><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name></author></analytic><series><title level="j">Journal of the Formosan Medical Association = Taiwan yi zhi</title><idno type="ISSN">0929-6646</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy</term><term>Female</term><term>Humans</term><term>Lung (pathology)</term><term>Male</term><term>Middle Aged</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Biopsie</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Sujet âgé</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Biopsie</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is characterized by fever with rapid progression to acute respiratory distress and it is associated with substantial morbidity and mortality. Transmission patterns suggest spread by respiratory droplet or close person-to-person contact. To elucidate the correlation of clinical presentation to the pathogenesis and course of the disease, we reviewed the pulmonary pathologic specimens of SARS patients taken at different stages of the disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15765160</PMID><DateCompleted><Year>2005</Year><Month>06</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0929-6646</ISSN><JournalIssue CitedMedium="Print"><Volume>104</Volume><Issue>2</Issue><PubDate><Year>2005</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Journal of the Formosan Medical Association = Taiwan yi zhi</Title><ISOAbbreviation>J. Formos. Med. Assoc.</ISOAbbreviation></Journal><ArticleTitle>Evolution of pulmonary pathology in severe acute respiratory syndrome.</ArticleTitle><Pagination><MedlinePgn>75-81</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">Severe acute respiratory syndrome (SARS) is characterized by fever with rapid progression to acute respiratory distress and it is associated with substantial morbidity and mortality. Transmission patterns suggest spread by respiratory droplet or close person-to-person contact. To elucidate the correlation of clinical presentation to the pathogenesis and course of the disease, we reviewed the pulmonary pathologic specimens of SARS patients taken at different stages of the disease.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Four "probable" cases of SARS were studied. SARS-associated coronavirus (SARS-CoV) infection was demonstrated using reverse transcriptase-polymerase chain reaction in all 4 patients. The pulmonary specimens were taken on day 7 after symptom onset in patient 1, day 11 in patient 2, day 17 in patient 3, and day 21 in patient 4.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The autopsy lung tissue from patient 1, who died 7 days after symptoms onset due to the complication of acute myocardial infarction, revealed mild histologic change in the lung. Only focal pulmonary edema or hemorrhage was seen. In the second patient, who died 11 days after symptom onset, severe acute alveolar damage was characterized by patchy or diffuse lung edema, hyaline membrane formation, and scarce lymphocytic infiltration. The lymphocytes were mostly CD3-positive and CD20-negative. In the third patient, biopsy specimen taken 17 days after symptom onset showed patches of organizing pneumonia with reactive fibroblastic proliferation, more abundant type II pneumocytes and clustering of CD68-positive macrophages within the alveolar spaces. Few CD68-positive syncytial multinucleated giant cells were also seen in the specimens but no viral inclusion body could be identified in these cells. The lung biopsy specimen from patient 4 taken 21 days after symptom onset showed characteristics of the fibrotic stage, with significant myofibroblastic proliferation in the alveolar space and interstitium resulting in loss of pulmonary architecture. The number of CD3-positive lymphocytes and of CD68-positive macrophages in this specimen from a patient in the fibrotic phase of diffuse alveolar damage (DAD) whose condition deteriorated was less than in the specimen from case 3 who was in the early proliferative phase of DAD and eventually recovered.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The histologic evolution of SARS coincided with the different stages of DAD: acute, proliferative organizing, and fibrotic stages. SARS cannot be differentiated from the other etiologies of DAD by morphologic examination alone. The absence of DAD does not rule out the possibility of SARS-CoV infection, particularly in the early stage of the disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hsiao</LastName><ForeName>Cheng Hsiang</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Mu-Zong</ForeName><Initials>MZ</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Chi-Long</ForeName><Initials>CL</Initials></Author><Author ValidYN="Y"><LastName>Hsueh</LastName><ForeName>Po-Ren</ForeName><Initials>PR</Initials></Author><Author ValidYN="Y"><LastName>Hsieh</LastName><ForeName>Shun-Wen</ForeName><Initials>SW</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Pan-Chyr</ForeName><Initials>PC</Initials></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Ih-Jen</ForeName><Initials>IJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Singapore</Country><MedlineTA>J Formos Med Assoc</MedlineTA><NlmUniqueID>9214933</NlmUniqueID><ISSNLinking>0929-6646</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>3</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>6</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>3</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15765160</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Chen, Chi Long" sort="Chen, Chi Long" uniqKey="Chen C" first="Chi-Long" last="Chen">Chi-Long Chen</name><name sortKey="Hsieh, Shun Wen" sort="Hsieh, Shun Wen" uniqKey="Hsieh S" first="Shun-Wen" last="Hsieh">Shun-Wen Hsieh</name><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po-Ren" last="Hsueh">Po-Ren Hsueh</name><name sortKey="Su, Ih Jen" sort="Su, Ih Jen" uniqKey="Su I" first="Ih-Jen" last="Su">Ih-Jen Su</name><name sortKey="Wu, Mu Zong" sort="Wu, Mu Zong" uniqKey="Wu M" first="Mu-Zong" last="Wu">Mu-Zong Wu</name><name sortKey="Yang, Pan Chyr" sort="Yang, Pan Chyr" uniqKey="Yang P" first="Pan-Chyr" last="Yang">Pan-Chyr Yang</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Hsiao, Cheng Hsiang" sort="Hsiao, Cheng Hsiang" uniqKey="Hsiao C" first="Cheng Hsiang" last="Hsiao">Cheng Hsiang Hsiao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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