Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals.
Identifieur interne : 002531 ( PubMed/Checkpoint ); précédent : 002530; suivant : 002532Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals.
Auteurs : Huabiao Chen [République populaire de Chine] ; Jinlin Hou ; Xiaodong Jiang ; Shiwu Ma ; Minjie Meng ; Baomei Wang ; Minghui Zhang ; Mingxia Zhang ; Xiaoping Tang ; Fuchun Zhang ; Tao Wan ; Nan Li ; Yizhi Yu ; Hongbo Hu ; Ruifu Yang ; Wei He ; Xiaoning Wang ; Xuetao CaoSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2005.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antigènes viraux, Cytokines (métabolisme), Cytotoxicité immunologique, Femelle, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (immunologie), Humains, Lymphocytes T CD8+ (immunologie), Lymphocytes T cytotoxiques (immunologie), Mâle, Mémoire immunologique, Protéines de l'enveloppe virale (immunologie), Syndrome respiratoire aigu sévère (immunologie), Techniques in vitro, Virus du SRAS (immunologie), Épitopes, Études cas-témoins.
- MESH :
- immunologie : Glycoprotéines membranaires, Lymphocytes T CD8+, Lymphocytes T cytotoxiques, Protéines de l'enveloppe virale, Syndrome respiratoire aigu sévère, Virus du SRAS.
- métabolisme : Cytokines.
- Adolescent, Adulte, Adulte d'âge moyen, Antigènes viraux, Cytotoxicité immunologique, Femelle, Glycoprotéine de spicule des coronavirus, Humains, Mâle, Mémoire immunologique, Techniques in vitro, Épitopes, Études cas-témoins.
English descriptors
- KwdEn :
- Adolescent, Adult, Antigens, Viral, CD8-Positive T-Lymphocytes (immunology), Case-Control Studies, Cytokines (metabolism), Cytotoxicity, Immunologic, Epitopes, Female, Humans, Immunologic Memory, In Vitro Techniques, Male, Membrane Glycoproteins (immunology), Middle Aged, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Spike Glycoprotein, Coronavirus, T-Lymphocytes, Cytotoxic (immunology), Viral Envelope Proteins (immunology).
- MESH :
- chemical , immunology : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , metabolism : Cytokines.
- chemical : Antigens, Viral, Epitopes, Spike Glycoprotein, Coronavirus.
- immunology : CD8-Positive T-Lymphocytes, SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes, Cytotoxic.
- Adolescent, Adult, Case-Control Studies, Cytotoxicity, Immunologic, Female, Humans, Immunologic Memory, In Vitro Techniques, Male, Middle Aged.
Abstract
To date, the pathogenesis of severe acute respiratory syndrome (SARS) in humans is still not well understood. SARS coronavirus (SARS-CoV)-specific CTL responses, in particular their magnitude and duration of postinfection immunity, have not been extensively studied. In this study, we found that heat-inactivated SARS-CoV elicited recall CTL responses to newly identified spike protein-derived epitopes (SSp-1, S978, and S1202) in peripheral blood of all HLA-A*0201(+) recovered SARS patients over 1 year postinfection. Intriguingly, heat-inactivated SARS-CoV elicited recall-like CTL responses to SSp-1 but not to S978, S1202, or dominant epitopes from several other human viruses in 5 of 36 (13.8%) HLA-A*0201(+) healthy donors without any contact history with SARS-CoV. SSp-1-specific CTLs expanded from memory T cells of both recovered SARS patients, and the five exceptional healthy donors shared a differentiated effector CTL phenotype, CD45RA(+)CCR7(-)CD62L(-), and expressed CCR5 and CD44. However, compared with the high avidity of SSp-1-specific CTLs derived from memory T cells of recovered SARS patients, SSp-1-specific CTLs from the five exceptional healthy donors were of low avidity, as determined by their rapid tetramer dissociation kinetics and reduced cytotoxic reactivity, IFN-gamma secretion, and intracellular production of IFN-gamma, TNF-alpha, perforin, and granzyme A. These results indicate that SARS-CoV infection induces strong and long-lasting CTL-mediated immunity in surviving SARS patients, and that cross-reactive memory T cells to SARS-CoV may exist in the T cell repertoire of a small subset of healthy individuals and can be reactivated by SARS-CoV infection.
DOI: 10.4049/jimmunol.175.1.591
PubMed: 15972696
Affiliations:
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pubmed:15972696Le document en format XML
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China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Immunology, Second Military Medical University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Hou, Jinlin" sort="Hou, Jinlin" uniqKey="Hou J" first="Jinlin" last="Hou">Jinlin Hou</name></author><author><name sortKey="Jiang, Xiaodong" sort="Jiang, Xiaodong" uniqKey="Jiang X" first="Xiaodong" last="Jiang">Xiaodong Jiang</name></author><author><name sortKey="Ma, Shiwu" sort="Ma, Shiwu" uniqKey="Ma S" first="Shiwu" last="Ma">Shiwu Ma</name></author><author><name sortKey="Meng, Minjie" sort="Meng, Minjie" uniqKey="Meng M" first="Minjie" last="Meng">Minjie Meng</name></author><author><name sortKey="Wang, Baomei" sort="Wang, Baomei" uniqKey="Wang B" first="Baomei" last="Wang">Baomei Wang</name></author><author><name sortKey="Zhang, Minghui" sort="Zhang, Minghui" uniqKey="Zhang M" first="Minghui" 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Memory</term><term>In Vitro Techniques</term><term>Male</term><term>Membrane Glycoproteins (immunology)</term><term>Middle Aged</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Spike Glycoprotein, Coronavirus</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Viral Envelope Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes viraux</term><term>Cytokines (métabolisme)</term><term>Cytotoxicité immunologique</term><term>Femelle</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (immunologie)</term><term>Humains</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Mâle</term><term>Mémoire immunologique</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>Syndrome respiratoire aigu sévère 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xml:lang="en">To date, the pathogenesis of severe acute respiratory syndrome (SARS) in humans is still not well understood. SARS coronavirus (SARS-CoV)-specific CTL responses, in particular their magnitude and duration of postinfection immunity, have not been extensively studied. In this study, we found that heat-inactivated SARS-CoV elicited recall CTL responses to newly identified spike protein-derived epitopes (SSp-1, S978, and S1202) in peripheral blood of all HLA-A*0201(+) recovered SARS patients over 1 year postinfection. Intriguingly, heat-inactivated SARS-CoV elicited recall-like CTL responses to SSp-1 but not to S978, S1202, or dominant epitopes from several other human viruses in 5 of 36 (13.8%) HLA-A*0201(+) healthy donors without any contact history with SARS-CoV. SSp-1-specific CTLs expanded from memory T cells of both recovered SARS patients, and the five exceptional healthy donors shared a differentiated effector CTL phenotype, CD45RA(+)CCR7(-)CD62L(-), and expressed CCR5 and CD44. However, compared with the high avidity of SSp-1-specific CTLs derived from memory T cells of recovered SARS patients, SSp-1-specific CTLs from the five exceptional healthy donors were of low avidity, as determined by their rapid tetramer dissociation kinetics and reduced cytotoxic reactivity, IFN-gamma secretion, and intracellular production of IFN-gamma, TNF-alpha, perforin, and granzyme A. These results indicate that SARS-CoV infection induces strong and long-lasting CTL-mediated immunity in surviving SARS patients, and that cross-reactive memory T cells to SARS-CoV may exist in the T cell repertoire of a small subset of healthy individuals and can be reactivated by SARS-CoV infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15972696</PMID><DateCompleted><Year>2005</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-1767</ISSN><JournalIssue CitedMedium="Print"><Volume>175</Volume><Issue>1</Issue><PubDate><Year>2005</Year><Month>Jul</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of immunology (Baltimore, Md. : 1950)</Title><ISOAbbreviation>J. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals.</ArticleTitle><Pagination><MedlinePgn>591-8</MedlinePgn></Pagination><Abstract><AbstractText>To date, the pathogenesis of severe acute respiratory syndrome (SARS) in humans is still not well understood. SARS coronavirus (SARS-CoV)-specific CTL responses, in particular their magnitude and duration of postinfection immunity, have not been extensively studied. In this study, we found that heat-inactivated SARS-CoV elicited recall CTL responses to newly identified spike protein-derived epitopes (SSp-1, S978, and S1202) in peripheral blood of all HLA-A*0201(+) recovered SARS patients over 1 year postinfection. Intriguingly, heat-inactivated SARS-CoV elicited recall-like CTL responses to SSp-1 but not to S978, S1202, or dominant epitopes from several other human viruses in 5 of 36 (13.8%) HLA-A*0201(+) healthy donors without any contact history with SARS-CoV. SSp-1-specific CTLs expanded from memory T cells of both recovered SARS patients, and the five exceptional healthy donors shared a differentiated effector CTL phenotype, CD45RA(+)CCR7(-)CD62L(-), and expressed CCR5 and CD44. However, compared with the high avidity of SSp-1-specific CTLs derived from memory T cells of recovered SARS patients, SSp-1-specific CTLs from the five exceptional healthy donors were of low avidity, as determined by their rapid tetramer dissociation kinetics and reduced cytotoxic reactivity, IFN-gamma secretion, and intracellular production of IFN-gamma, TNF-alpha, perforin, and granzyme A. These results indicate that SARS-CoV infection induces strong and long-lasting CTL-mediated immunity in surviving SARS patients, and that cross-reactive memory T cells to SARS-CoV may exist in the T cell repertoire of a small subset of healthy individuals and can be reactivated by SARS-CoV infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Huabiao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Immunology, Second Military Medical University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Jinlin</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Xiaodong</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Shiwu</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Meng</LastName><ForeName>Minjie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Baomei</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Minghui</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Mingxia</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Xiaoping</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Fuchun</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Wan</LastName><ForeName>Tao</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Nan</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Yizhi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Hongbo</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Ruifu</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xiaoning</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Xuetao</ForeName><Initials>X</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Immunol</MedlineTA><NlmUniqueID>2985117R</NlmUniqueID><ISSNLinking>0022-1767</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000939">Epitopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C578557">spike glycoprotein, SARS-CoV</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003602" MajorTopicYN="N">Cytotoxicity, Immunologic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000939" MajorTopicYN="N">Epitopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007156" MajorTopicYN="Y">Immunologic Memory</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013602" MajorTopicYN="N">T-Lymphocytes, Cytotoxic</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>6</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>9</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>6</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15972696</ArticleId><ArticleId IdType="pii">175/1/591</ArticleId><ArticleId IdType="doi">10.4049/jimmunol.175.1.591</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Cao, Xuetao" sort="Cao, Xuetao" uniqKey="Cao X" first="Xuetao" last="Cao">Xuetao Cao</name><name sortKey="He, Wei" sort="He, Wei" uniqKey="He W" first="Wei" last="He">Wei He</name><name sortKey="Hou, Jinlin" sort="Hou, Jinlin" uniqKey="Hou J" first="Jinlin" last="Hou">Jinlin Hou</name><name sortKey="Hu, Hongbo" sort="Hu, Hongbo" uniqKey="Hu H" first="Hongbo" last="Hu">Hongbo Hu</name><name sortKey="Jiang, Xiaodong" sort="Jiang, Xiaodong" uniqKey="Jiang X" first="Xiaodong" last="Jiang">Xiaodong Jiang</name><name sortKey="Li, Nan" sort="Li, Nan" uniqKey="Li N" first="Nan" last="Li">Nan Li</name><name sortKey="Ma, Shiwu" sort="Ma, Shiwu" uniqKey="Ma S" first="Shiwu" last="Ma">Shiwu Ma</name><name sortKey="Meng, Minjie" sort="Meng, Minjie" uniqKey="Meng M" first="Minjie" last="Meng">Minjie Meng</name><name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name><name sortKey="Wan, Tao" sort="Wan, Tao" uniqKey="Wan T" first="Tao" last="Wan">Tao Wan</name><name sortKey="Wang, Baomei" sort="Wang, Baomei" uniqKey="Wang B" first="Baomei" last="Wang">Baomei Wang</name><name sortKey="Wang, Xiaoning" sort="Wang, Xiaoning" uniqKey="Wang X" first="Xiaoning" last="Wang">Xiaoning Wang</name><name sortKey="Yang, Ruifu" sort="Yang, Ruifu" uniqKey="Yang R" first="Ruifu" last="Yang">Ruifu Yang</name><name sortKey="Yu, Yizhi" sort="Yu, Yizhi" uniqKey="Yu Y" first="Yizhi" last="Yu">Yizhi Yu</name><name sortKey="Zhang, Fuchun" sort="Zhang, Fuchun" uniqKey="Zhang F" first="Fuchun" last="Zhang">Fuchun Zhang</name><name sortKey="Zhang, Minghui" sort="Zhang, Minghui" uniqKey="Zhang M" first="Minghui" last="Zhang">Minghui Zhang</name><name sortKey="Zhang, Mingxia" sort="Zhang, Mingxia" uniqKey="Zhang M" first="Mingxia" last="Zhang">Mingxia Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Huabiao" sort="Chen, Huabiao" uniqKey="Chen H" first="Huabiao" last="Chen">Huabiao Chen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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