Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential.
Identifieur interne : 002447 ( PubMed/Checkpoint ); précédent : 002446; suivant : 002448Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential.
Auteurs : Wei Lu [République populaire de Chine] ; Xiao-Dong Wu ; Mu De Shi ; Rui Fu Yang ; You Yu He ; Chao Bian ; Tie Liu Shi ; Sheng Yang ; Xue-Liang Zhu ; Wei-Hong Jiang ; Yi Xue Li ; Lin-Chen Yan ; Yong Yong Ji ; Ying Lin ; Guo-Mei Lin ; Lin Tian ; Jin Wang ; Hong Xia Wang ; You Hua Xie ; Gang Pei ; Jia Rui Wu ; Bing SunSource :
- FEBS letters [ 0014-5793 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- usage thérapeutique : Peptides.
- Biologie informatique, Données de séquences moléculaires, Humains, Peptides, Protéines virales, Séquence d'acides aminés, Technique de Western, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Peptides, Viral Proteins.
- chemical , therapeutic use : Peptides.
- chemistry : SARS Virus.
- Amino Acid Sequence, Blotting, Western, Computational Biology, Humans, Molecular Sequence Data.
Abstract
The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is an important viral structural protein. Based on bioinformatics analysis, 10 antigenic peptides derived from the S protein sequence were selected and synthesized. The antigenicity and immunoreactivity of all the peptides were tested in vivo and in vitro. Four peptides (P6, P8, P9 and P10) which contain B cell epitopes of the S protein were identified, and P8 peptide was confirmed in vivo to have a potential in serological diagnosis. By using a syncytia formation model, we tested the neutralization ability of all 10 peptides and their corresponding antibodies. It is interesting to find that P8 and P9 peptides inhibited syncytia formation, suggesting that the P8 and P9 spanning regions may provide a good target for anti-SARS-CoV drug design. Our data suggest that we have identified peptides derived from the S protein of SARS-CoV, which are useful for SARS treatment and diagnosis.
DOI: 10.1016/j.febslet.2005.02.070
PubMed: 15811330
Affiliations:
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200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Xiao Dong" sort="Wu, Xiao Dong" uniqKey="Wu X" first="Xiao-Dong" last="Wu">Xiao-Dong Wu</name></author><author><name sortKey="Shi, Mu De" sort="Shi, Mu De" uniqKey="Shi M" first="Mu De" last="Shi">Mu De Shi</name></author><author><name sortKey="Yang, Rui Fu" sort="Yang, Rui Fu" uniqKey="Yang R" first="Rui Fu" last="Yang">Rui Fu Yang</name></author><author><name sortKey="He, You Yu" sort="He, You Yu" uniqKey="He Y" first="You Yu" last="He">You Yu He</name></author><author><name sortKey="Bian, Chao" sort="Bian, Chao" uniqKey="Bian C" first="Chao" last="Bian">Chao Bian</name></author><author><name sortKey="Shi, Tie Liu" sort="Shi, Tie Liu" uniqKey="Shi T" first="Tie Liu" last="Shi">Tie Liu Shi</name></author><author><name sortKey="Yang, Sheng" sort="Yang, Sheng" uniqKey="Yang S" first="Sheng" last="Yang">Sheng Yang</name></author><author><name sortKey="Zhu, Xue Liang" sort="Zhu, Xue Liang" uniqKey="Zhu X" first="Xue-Liang" last="Zhu">Xue-Liang Zhu</name></author><author><name sortKey="Jiang, Wei Hong" sort="Jiang, Wei Hong" uniqKey="Jiang W" first="Wei-Hong" last="Jiang">Wei-Hong Jiang</name></author><author><name sortKey="Li, Yi Xue" sort="Li, Yi Xue" uniqKey="Li Y" first="Yi Xue" last="Li">Yi Xue Li</name></author><author><name sortKey="Yan, Lin Chen" sort="Yan, Lin Chen" uniqKey="Yan L" first="Lin-Chen" last="Yan">Lin-Chen Yan</name></author><author><name sortKey="Ji, Yong Yong" sort="Ji, Yong Yong" uniqKey="Ji Y" first="Yong Yong" last="Ji">Yong Yong Ji</name></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name></author><author><name sortKey="Lin, Guo Mei" sort="Lin, Guo Mei" uniqKey="Lin G" first="Guo-Mei" last="Lin">Guo-Mei Lin</name></author><author><name sortKey="Tian, Lin" sort="Tian, Lin" uniqKey="Tian L" first="Lin" last="Tian">Lin Tian</name></author><author><name sortKey="Wang, Jin" sort="Wang, Jin" uniqKey="Wang J" first="Jin" last="Wang">Jin Wang</name></author><author><name sortKey="Wang, Hong Xia" sort="Wang, Hong Xia" uniqKey="Wang H" first="Hong Xia" last="Wang">Hong Xia Wang</name></author><author><name sortKey="Xie, You Hua" sort="Xie, You Hua" uniqKey="Xie Y" first="You Hua" last="Xie">You Hua Xie</name></author><author><name sortKey="Pei, Gang" sort="Pei, Gang" uniqKey="Pei G" first="Gang" last="Pei">Gang Pei</name></author><author><name sortKey="Wu, Jia Rui" sort="Wu, Jia Rui" uniqKey="Wu J" first="Jia Rui" last="Wu">Jia Rui Wu</name></author><author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name></author></analytic><series><title level="j">FEBS letters</title><idno type="ISSN">0014-5793</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Blotting, Western</term><term>Computational Biology</term><term>Humans</term><term>Molecular Sequence Data</term><term>Peptides (chemistry)</term><term>Peptides (therapeutic use)</term><term>SARS Virus (chemistry)</term><term>Viral Proteins (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Biologie informatique</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Peptides ()</term><term>Peptides (usage thérapeutique)</term><term>Protéines virales ()</term><term>Séquence d'acides aminés</term><term>Technique de Western</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptides</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Peptides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Blotting, Western</term><term>Computational Biology</term><term>Humans</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biologie informatique</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Peptides</term><term>Protéines virales</term><term>Séquence d'acides aminés</term><term>Technique de Western</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is an important viral structural protein. Based on bioinformatics analysis, 10 antigenic peptides derived from the S protein sequence were selected and synthesized. The antigenicity and immunoreactivity of all the peptides were tested in vivo and in vitro. Four peptides (P6, P8, P9 and P10) which contain B cell epitopes of the S protein were identified, and P8 peptide was confirmed in vivo to have a potential in serological diagnosis. By using a syncytia formation model, we tested the neutralization ability of all 10 peptides and their corresponding antibodies. It is interesting to find that P8 and P9 peptides inhibited syncytia formation, suggesting that the P8 and P9 spanning regions may provide a good target for anti-SARS-CoV drug design. Our data suggest that we have identified peptides derived from the S protein of SARS-CoV, which are useful for SARS treatment and diagnosis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15811330</PMID><DateCompleted><Year>2005</Year><Month>05</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0014-5793</ISSN><JournalIssue CitedMedium="Print"><Volume>579</Volume><Issue>10</Issue><PubDate><Year>2005</Year><Month>Apr</Month><Day>11</Day></PubDate></JournalIssue><Title>FEBS letters</Title><ISOAbbreviation>FEBS Lett.</ISOAbbreviation></Journal><ArticleTitle>Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential.</ArticleTitle><Pagination><MedlinePgn>2130-6</MedlinePgn></Pagination><Abstract><AbstractText>The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is an important viral structural protein. Based on bioinformatics analysis, 10 antigenic peptides derived from the S protein sequence were selected and synthesized. The antigenicity and immunoreactivity of all the peptides were tested in vivo and in vitro. Four peptides (P6, P8, P9 and P10) which contain B cell epitopes of the S protein were identified, and P8 peptide was confirmed in vivo to have a potential in serological diagnosis. By using a syncytia formation model, we tested the neutralization ability of all 10 peptides and their corresponding antibodies. It is interesting to find that P8 and P9 peptides inhibited syncytia formation, suggesting that the P8 and P9 spanning regions may provide a good target for anti-SARS-CoV drug design. Our data suggest that we have identified peptides derived from the S protein of SARS-CoV, which are useful for SARS treatment and diagnosis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xiao-Dong</ForeName><Initials>XD</Initials></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Mu De</ForeName><Initials>MD</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Rui Fu</ForeName><Initials>RF</Initials></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>You Yu</ForeName><Initials>YY</Initials></Author><Author ValidYN="Y"><LastName>Bian</LastName><ForeName>Chao</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Tie Liu</ForeName><Initials>TL</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Sheng</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Xue-Liang</ForeName><Initials>XL</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Wei-Hong</ForeName><Initials>WH</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yi Xue</ForeName><Initials>YX</Initials></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Lin-Chen</ForeName><Initials>LC</Initials></Author><Author ValidYN="Y"><LastName>Ji</LastName><ForeName>Yong Yong</ForeName><Initials>YY</Initials></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Ying</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Guo-Mei</ForeName><Initials>GM</Initials></Author><Author ValidYN="Y"><LastName>Tian</LastName><ForeName>Lin</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jin</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hong Xia</ForeName><Initials>HX</Initials></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>You Hua</ForeName><Initials>YH</Initials></Author><Author ValidYN="Y"><LastName>Pei</LastName><ForeName>Gang</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jia Rui</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Bing</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>FEBS Lett</MedlineTA><NlmUniqueID>0155157</NlmUniqueID><ISSNLinking>0014-5793</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>01</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2005</Year><Month>02</Month><Day>12</Day></PubMedPubDate><PubMedPubDate 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first="Wei-Hong" last="Jiang">Wei-Hong Jiang</name><name sortKey="Li, Yi Xue" sort="Li, Yi Xue" uniqKey="Li Y" first="Yi Xue" last="Li">Yi Xue Li</name><name sortKey="Lin, Guo Mei" sort="Lin, Guo Mei" uniqKey="Lin G" first="Guo-Mei" last="Lin">Guo-Mei Lin</name><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><name sortKey="Pei, Gang" sort="Pei, Gang" uniqKey="Pei G" first="Gang" last="Pei">Gang Pei</name><name sortKey="Shi, Mu De" sort="Shi, Mu De" uniqKey="Shi M" first="Mu De" last="Shi">Mu De Shi</name><name sortKey="Shi, Tie Liu" sort="Shi, Tie Liu" uniqKey="Shi T" first="Tie Liu" last="Shi">Tie Liu Shi</name><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><name sortKey="Tian, Lin" sort="Tian, Lin" uniqKey="Tian L" first="Lin" last="Tian">Lin Tian</name><name sortKey="Wang, Hong Xia" sort="Wang, Hong Xia" uniqKey="Wang H" first="Hong Xia" last="Wang">Hong Xia Wang</name><name sortKey="Wang, Jin" sort="Wang, Jin" uniqKey="Wang J" first="Jin" last="Wang">Jin Wang</name><name sortKey="Wu, Jia Rui" sort="Wu, Jia Rui" uniqKey="Wu J" first="Jia Rui" last="Wu">Jia Rui Wu</name><name sortKey="Wu, Xiao Dong" sort="Wu, Xiao Dong" uniqKey="Wu X" first="Xiao-Dong" last="Wu">Xiao-Dong Wu</name><name sortKey="Xie, You Hua" sort="Xie, You Hua" uniqKey="Xie Y" first="You Hua" last="Xie">You Hua Xie</name><name sortKey="Yan, Lin Chen" sort="Yan, Lin Chen" uniqKey="Yan L" first="Lin-Chen" last="Yan">Lin-Chen Yan</name><name sortKey="Yang, Rui Fu" sort="Yang, Rui Fu" uniqKey="Yang R" first="Rui Fu" last="Yang">Rui Fu Yang</name><name sortKey="Yang, Sheng" sort="Yang, Sheng" uniqKey="Yang S" first="Sheng" last="Yang">Sheng Yang</name><name sortKey="Zhu, Xue Liang" sort="Zhu, Xue Liang" uniqKey="Zhu X" first="Xue-Liang" last="Zhu">Xue-Liang Zhu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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