SrasV1, PubMed, Checkpoint, bibRecord, 002430

The interaction of the SARS coronavirus non-structural protein 10 with the cellular oxido-reductase system causes an extensive cytopathic effect.

Identifieur interne : 002430 ( PubMed/Checkpoint ); précédent : 002429; suivant : 002431

The interaction of the SARS coronavirus non-structural protein 10 with the cellular oxido-reductase system causes an extensive cytopathic effect.

Auteurs : Qihan Li [République populaire de Chine] ; Lichun Wang ; Chenghong Dong ; Yanchun Che ; Li Jiang ; Longding Liu ; Hongling Zhao ; Yun Liao ; Yi Sheng ; Shaozhong Dong ; Shaohui Ma

Source :

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1386-6532 ] ; 2005.

RBID : pubmed:16157265

Descripteurs français

English descriptors

KwdEn :
- Cell Line, Cytopathogenic Effect, Viral, Electron Transport Complex IV (metabolism), Humans, Membrane Potentials, Membrane Proteins (metabolism), Mitochondria (metabolism), NADH Dehydrogenase (metabolism), Nuclear Proteins, Protein Binding, SARS Virus (metabolism), SARS Virus (pathogenicity), Transcription Factors, Two-Hybrid System Techniques, Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism).
MESH :
- chemical , genetics : Viral Nonstructural Proteins.
- chemical , metabolism : Electron Transport Complex IV, Membrane Proteins, NADH Dehydrogenase, Viral Nonstructural Proteins.
- metabolism : Mitochondria, SARS Virus.
- pathogenicity : SARS Virus.
- Cell Line, Cytopathogenic Effect, Viral, Humans, Membrane Potentials, Nuclear Proteins, Protein Binding, Transcription Factors, Two-Hybrid System Techniques.

Abstract

The pathological mechanism of SARS-CoV infection was investigated. The gene for the SARS-CoV non-structural protein 10, which is located in the open reading frame of pp1a/pp1ab gene, was synthesized and used to screen for the specific cellular gene coding for the protein interacting with this nsp10 protein in a human embryo lung cDNA library using a yeast trap method. The results indicated that apart from the two subunits of cellular RNA polymerase complex, BTF3 and ATF5, this nsp10 protein was also able to interact specifically with the NADH 4L subunit and cytochrome oxidase II. Further study revealed that the activity of the NADH-cytochrome was altered and the inner mitochondrial membrane was depolarized in the transfected human embryo lung fibroblast by the nsp10 protein gene. The cytopathic effect of the Coronavirus 229E strain appeared more extensive in these cells than in the control cells.

DOI: 10.1016/j.jcv.2004.12.019
PubMed: 16157265

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002544
to stream PubMed, to step Curation: 002544

Links to Exploration step

pubmed:16157265

Le document en format XML

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<front><div type="abstract" xml:lang="en">The pathological mechanism of SARS-CoV infection was investigated. The gene for the SARS-CoV non-structural protein 10, which is located in the open reading frame of pp1a/pp1ab gene, was synthesized and used to screen for the specific cellular gene coding for the protein interacting with this nsp10 protein in a human embryo lung cDNA library using a yeast trap method. The results indicated that apart from the two subunits of cellular RNA polymerase complex, BTF3 and ATF5, this nsp10 protein was also able to interact specifically with the NADH 4L subunit and cytochrome oxidase II. Further study revealed that the activity of the NADH-cytochrome was altered and the inner mitochondrial membrane was depolarized in the transfected human embryo lung fibroblast by the nsp10 protein gene. The cytopathic effect of the Coronavirus 229E strain appeared more extensive in these cells than in the control cells.</div>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><noCountry><name sortKey="Che, Yanchun" sort="Che, Yanchun" uniqKey="Che Y" first="Yanchun" last="Che">Yanchun Che</name>
<name sortKey="Dong, Chenghong" sort="Dong, Chenghong" uniqKey="Dong C" first="Chenghong" last="Dong">Chenghong Dong</name>
<name sortKey="Dong, Shaozhong" sort="Dong, Shaozhong" uniqKey="Dong S" first="Shaozhong" last="Dong">Shaozhong Dong</name>
<name sortKey="Jiang, Li" sort="Jiang, Li" uniqKey="Jiang L" first="Li" last="Jiang">Li Jiang</name>
<name sortKey="Liao, Yun" sort="Liao, Yun" uniqKey="Liao Y" first="Yun" last="Liao">Yun Liao</name>
<name sortKey="Liu, Longding" sort="Liu, Longding" uniqKey="Liu L" first="Longding" last="Liu">Longding Liu</name>
<name sortKey="Ma, Shaohui" sort="Ma, Shaohui" uniqKey="Ma S" first="Shaohui" last="Ma">Shaohui Ma</name>
<name sortKey="Sheng, Yi" sort="Sheng, Yi" uniqKey="Sheng Y" first="Yi" last="Sheng">Yi Sheng</name>
<name sortKey="Wang, Lichun" sort="Wang, Lichun" uniqKey="Wang L" first="Lichun" last="Wang">Lichun Wang</name>
<name sortKey="Zhao, Hongling" sort="Zhao, Hongling" uniqKey="Zhao H" first="Hongling" last="Zhao">Hongling Zhao</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Li, Qihan" sort="Li, Qihan" uniqKey="Li Q" first="Qihan" last="Li">Qihan Li</name>
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The interaction of the SARS coronavirus non-structural protein 10 with the cellular oxido-reductase system causes an extensive cytopathic effect.

The interaction of the SARS coronavirus non-structural protein 10 with the cellular oxido-reductase system causes an extensive cytopathic effect.

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