SrasV1, PubMed, Checkpoint, bibRecord, 002237

Cynomolgus macaque as an animal model for severe acute respiratory syndrome.

Identifieur interne : 002237 ( PubMed/Checkpoint ); précédent : 002236; suivant : 002238

Cynomolgus macaque as an animal model for severe acute respiratory syndrome.

Auteurs : James V. Lawler [États-Unis] ; Timothy P. Endy ; Lisa E. Hensley ; Aura Garrison ; Elizabeth A. Fritz ; May Lesar ; Ralph S. Baric ; David A. Kulesh ; David A. Norwood ; Leonard P. Wasieloski ; Melanie P. Ulrich ; Tom R. Slezak ; Elizabeth Vitalis ; John W. Huggins ; Peter B. Jahrling ; Jason Paragas

Source :

PLoS medicine [ 1549-1676 ] ; 2006.

RBID : pubmed:16605302

Descripteurs français

KwdFr :
- Animaux, Enfant d'âge préscolaire, Femelle, Humains, Indice de gravité médicale, Macaca fascicularis (virologie), Modèles animaux de maladie humaine, Muqueuse (virologie), Mâle, Production d'anticorps, Réplication virale, Syndrome, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Vaccins, Virus du SRAS (pathogénicité), Virus du SRAS (physiologie).
MESH :
- immunologie : Syndrome respiratoire aigu sévère.
- pathogénicité : Virus du SRAS.
- physiologie : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- virologie : Macaca fascicularis, Muqueuse.
- Animaux, Enfant d'âge préscolaire, Femelle, Humains, Indice de gravité médicale, Modèles animaux de maladie humaine, Mâle, Production d'anticorps, Réplication virale, Syndrome, Syndrome respiratoire aigu sévère, Vaccins.

English descriptors

KwdEn :
- Animals, Antibody Formation, Child, Preschool, Disease Models, Animal, Female, Humans, Macaca fascicularis (virology), Male, Mucous Membrane (virology), SARS Virus (pathogenicity), SARS Virus (physiology), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (prevention & control), Severity of Illness Index, Syndrome, Vaccines, Virus Replication.
MESH :
- chemical : Vaccines.
- drug therapy : Severe Acute Respiratory Syndrome.
- immunology : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- physiology : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Macaca fascicularis, Mucous Membrane.
- Animals, Antibody Formation, Child, Preschool, Disease Models, Animal, Female, Humans, Male, Severity of Illness Index, Syndrome, Virus Replication.

Abstract

The emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the underlying pathogenesis of SARS-associated coronavirus (SARS-CoV) infection and to develop effective vaccines and therapeutics. We report the first findings of measurable clinical disease in nonhuman primates (NHPs) infected with SARS-CoV.

DOI: 10.1371/journal.pmed.0030149
PubMed: 16605302

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002281
to stream PubMed, to step Curation: 002281

Links to Exploration step

pubmed:16605302

Le document en format XML

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<front><div type="abstract" xml:lang="en">The emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the underlying pathogenesis of SARS-associated coronavirus (SARS-CoV) infection and to develop effective vaccines and therapeutics. We report the first findings of measurable clinical disease in nonhuman primates (NHPs) infected with SARS-CoV.</div>
</front>
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<DateCompleted><Year>2006</Year>
<Month>06</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
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<Issue>5</Issue>
<PubDate><Year>2006</Year>
<Month>May</Month>
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<Title>PLoS medicine</Title>
<ISOAbbreviation>PLoS Med.</ISOAbbreviation>
</Journal>
<ArticleTitle>Cynomolgus macaque as an animal model for severe acute respiratory syndrome.</ArticleTitle>
<Pagination><MedlinePgn>e149</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the underlying pathogenesis of SARS-associated coronavirus (SARS-CoV) infection and to develop effective vaccines and therapeutics. We report the first findings of measurable clinical disease in nonhuman primates (NHPs) infected with SARS-CoV.</AbstractText>
<AbstractText Label="METHODS AND FINDINGS" NlmCategory="RESULTS">In order to characterize clinically relevant parameters of SARS-CoV infection in NHPs, we infected cynomolgus macaques with SARS-CoV in three groups: Group I was infected in the nares and bronchus, group II in the nares and conjunctiva, and group III intravenously. Nonhuman primates in groups I and II developed mild to moderate symptomatic illness. All NHPs demonstrated evidence of viral replication and developed neutralizing antibodies. Chest radiographs from several animals in groups I and II revealed unifocal or multifocal pneumonia that peaked between days 8 and 10 postinfection. Clinical laboratory tests were not significantly changed. Overall, inoculation by a mucosal route produced more prominent disease than did intravenous inoculation. Half of the group I animals were infected with a recombinant infectious clone SARS-CoV derived from the SARS-CoV Urbani strain. This infectious clone produced disease indistinguishable from wild-type Urbani strain.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">SARS-CoV infection of cynomolgus macaques did not reproduce the severe illness seen in the majority of adult human cases of SARS; however, our results suggest similarities to the milder syndrome of SARS-CoV infection characteristically seen in young children.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lawler</LastName>
<ForeName>James V</ForeName>
<Initials>JV</Initials>
<AffiliationInfo><Affiliation>Infectious Diseases Department, National Naval Medical Center, Bethesda, Maryland, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Endy</LastName>
<ForeName>Timothy P</ForeName>
<Initials>TP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hensley</LastName>
<ForeName>Lisa E</ForeName>
<Initials>LE</Initials>
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<ForeName>Aura</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fritz</LastName>
<ForeName>Elizabeth A</ForeName>
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<Author ValidYN="Y"><LastName>Lesar</LastName>
<ForeName>May</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Baric</LastName>
<ForeName>Ralph S</ForeName>
<Initials>RS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kulesh</LastName>
<ForeName>David A</ForeName>
<Initials>DA</Initials>
</Author>
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<ForeName>David A</ForeName>
<Initials>DA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wasieloski</LastName>
<ForeName>Leonard P</ForeName>
<Initials>LP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ulrich</LastName>
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<Author ValidYN="Y"><LastName>Slezak</LastName>
<ForeName>Tom R</ForeName>
<Initials>TR</Initials>
</Author>
<Author ValidYN="Y"><LastName>Vitalis</LastName>
<ForeName>Elizabeth</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Huggins</LastName>
<ForeName>John W</ForeName>
<Initials>JW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Jahrling</LastName>
<ForeName>Peter B</ForeName>
<Initials>PB</Initials>
</Author>
<Author ValidYN="Y"><LastName>Paragas</LastName>
<ForeName>Jason</ForeName>
<Initials>J</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI059136</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>AI059136</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2006</Year>
<Month>04</Month>
<Day>18</Day>
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<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>PLoS Med. 2006 May;3(5):e194</RefSource>
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<CommentsCorrections RefType="CommentIn"><RefSource>PLoS Med. 2006 Sep;3(9):e411; author reply e415</RefSource>
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</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008252" MajorTopicYN="N">Macaca fascicularis</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009092" MajorTopicYN="N">Mucous Membrane</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
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<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
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<MeshHeading><DescriptorName UI="D013577" MajorTopicYN="N">Syndrome</DescriptorName>
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<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
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Cynomolgus macaque as an animal model for severe acute respiratory syndrome.

Cynomolgus macaque as an animal model for severe acute respiratory syndrome.

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