Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141.
Identifieur interne : 002235 ( PubMed/Checkpoint ); précédent : 002234; suivant : 002236Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141.
Auteurs : Yi-Qiang Cheng [États-Unis]Source :
- Chembiochem : a European journal of chemical biology [ 1439-4227 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Antibactériens, Valinomycine.
- génétique : Streptomyces.
- métabolisme : Antiviraux, Streptomyces.
- pharmacologie : Antiviraux.
- Animaux, Cellules Vero, Données de séquences moléculaires, Famille multigénique, Gènes bactériens, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Anti-Bacterial Agents (biosynthesis), Antiviral Agents (metabolism), Antiviral Agents (pharmacology), Chlorocebus aethiops, Genes, Bacterial, Molecular Sequence Data, Multigene Family, SARS Virus (drug effects), Streptomyces (genetics), Streptomyces (metabolism), Valinomycin (biosynthesis), Vero Cells.
- MESH :
- chemical , biosynthesis : Anti-Bacterial Agents, Valinomycin.
- chemical , metabolism : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents.
- drug effects : SARS Virus.
- genetics : Streptomyces.
- metabolism : Streptomyces.
- Animals, Chlorocebus aethiops, Genes, Bacterial, Molecular Sequence Data, Multigene Family, Vero Cells.
Abstract
Valinomycin was recently reported to be the most potent agent against severe acute respiratory-syndrome coronavirus (SARS-CoV) in infected Vero E6 cells. Aimed at generating analogues by metabolic engineering, the valinomycin biosynthetic gene cluster has been cloned from Streptomyces tsusimaensis ATCC 15141. Targeted disruption of a nonribosomal peptide synthetase (NRPS) gene abolishes valinomycin production, which confirms its predicted nonribosomal-peptide origin. Sequence analysis of the NRPS system reveals four distinctive modules, two of which contain unusual domain organizations that are presumably involved in the generation of biosynthetic precursors D-alpha-hydroxyisovaleric acid and L-lactic acid. The respective adenylation domains in these two modules contain novel substrate-specificity-conferring codes that might specify for a class of hydroxyl acids for the biosynthesis of the depsipeptide natural products.
DOI: 10.1002/cbic.200500425
PubMed: 16511823
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:16511823Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141.</title><author><name sortKey="Cheng, Yi Qiang" sort="Cheng, Yi Qiang" uniqKey="Cheng Y" first="Yi-Qiang" last="Cheng">Yi-Qiang Cheng</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biological Sciences, Biotechnology Program, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA. ycheng@uwm.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Biotechnology Program, University of Wisconsin-Milwaukee, Milwaukee, WI 53211</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16511823</idno><idno type="pmid">16511823</idno><idno type="doi">10.1002/cbic.200500425</idno><idno type="wicri:Area/PubMed/Corpus">002322</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002322</idno><idno type="wicri:Area/PubMed/Curation">002322</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002322</idno><idno type="wicri:Area/PubMed/Checkpoint">002235</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002235</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141.</title><author><name sortKey="Cheng, Yi Qiang" sort="Cheng, Yi Qiang" uniqKey="Cheng Y" first="Yi-Qiang" last="Cheng">Yi-Qiang Cheng</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biological Sciences, Biotechnology Program, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA. ycheng@uwm.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, Biotechnology Program, University of Wisconsin-Milwaukee, Milwaukee, WI 53211</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author></analytic><series><title level="j">Chembiochem : a European journal of chemical biology</title><idno type="ISSN">1439-4227</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-Bacterial Agents (biosynthesis)</term><term>Antiviral Agents (metabolism)</term><term>Antiviral Agents (pharmacology)</term><term>Chlorocebus aethiops</term><term>Genes, Bacterial</term><term>Molecular Sequence Data</term><term>Multigene Family</term><term>SARS Virus (drug effects)</term><term>Streptomyces (genetics)</term><term>Streptomyces (metabolism)</term><term>Valinomycin (biosynthesis)</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antibactériens (biosynthèse)</term><term>Antiviraux (métabolisme)</term><term>Antiviraux (pharmacologie)</term><term>Cellules Vero</term><term>Données de séquences moléculaires</term><term>Famille multigénique</term><term>Gènes bactériens</term><term>Streptomyces (génétique)</term><term>Streptomyces (métabolisme)</term><term>Valinomycine (biosynthèse)</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Valinomycin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Antibactériens</term><term>Valinomycine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Streptomyces</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Streptomyces</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Streptomyces</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antiviraux</term><term>Streptomyces</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Genes, Bacterial</term><term>Molecular Sequence Data</term><term>Multigene Family</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Données de séquences moléculaires</term><term>Famille multigénique</term><term>Gènes bactériens</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Valinomycin was recently reported to be the most potent agent against severe acute respiratory-syndrome coronavirus (SARS-CoV) in infected Vero E6 cells. Aimed at generating analogues by metabolic engineering, the valinomycin biosynthetic gene cluster has been cloned from Streptomyces tsusimaensis ATCC 15141. Targeted disruption of a nonribosomal peptide synthetase (NRPS) gene abolishes valinomycin production, which confirms its predicted nonribosomal-peptide origin. Sequence analysis of the NRPS system reveals four distinctive modules, two of which contain unusual domain organizations that are presumably involved in the generation of biosynthetic precursors D-alpha-hydroxyisovaleric acid and L-lactic acid. The respective adenylation domains in these two modules contain novel substrate-specificity-conferring codes that might specify for a class of hydroxyl acids for the biosynthesis of the depsipeptide natural products.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16511823</PMID><DateCompleted><Year>2006</Year><Month>06</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1439-4227</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>3</Issue><PubDate><Year>2006</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Chembiochem : a European journal of chemical biology</Title><ISOAbbreviation>Chembiochem</ISOAbbreviation></Journal><ArticleTitle>Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141.</ArticleTitle><Pagination><MedlinePgn>471-7</MedlinePgn></Pagination><Abstract><AbstractText>Valinomycin was recently reported to be the most potent agent against severe acute respiratory-syndrome coronavirus (SARS-CoV) in infected Vero E6 cells. Aimed at generating analogues by metabolic engineering, the valinomycin biosynthetic gene cluster has been cloned from Streptomyces tsusimaensis ATCC 15141. Targeted disruption of a nonribosomal peptide synthetase (NRPS) gene abolishes valinomycin production, which confirms its predicted nonribosomal-peptide origin. Sequence analysis of the NRPS system reveals four distinctive modules, two of which contain unusual domain organizations that are presumably involved in the generation of biosynthetic precursors D-alpha-hydroxyisovaleric acid and L-lactic acid. The respective adenylation domains in these two modules contain novel substrate-specificity-conferring codes that might specify for a class of hydroxyl acids for the biosynthesis of the depsipeptide natural products.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Yi-Qiang</ForeName><Initials>YQ</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, Biotechnology Program, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA. ycheng@uwm.edu</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>DQ174261</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Chembiochem</MedlineTA><NlmUniqueID>100937360</NlmUniqueID><ISSNLinking>1439-4227</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>2001-95-8</RegistryNumber><NameOfSubstance UI="D014634">Valinomycin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005798" MajorTopicYN="N">Genes, Bacterial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005810" MajorTopicYN="N">Multigene Family</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013302" MajorTopicYN="N">Streptomyces</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014634" MajorTopicYN="N">Valinomycin</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>3</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>6</Month><Day>14</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>3</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16511823</ArticleId><ArticleId IdType="doi">10.1002/cbic.200500425</ArticleId><ArticleId IdType="pmc">PMC7162017</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nat Rev Microbiol. 2004 Jul;2(7):602-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15197395</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>FEBS Lett. 1974 Jun 1;42(2):127-30</Citation><ArticleIdList><ArticleId IdType="pubmed">4368457</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Bioorg Med Chem. 1999 May;7(5):895-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10400343</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nature. 2003 May 15;423(6937):240</Citation><ArticleIdList><ArticleId IdType="pubmed">12748632</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Can J Microbiol. 1957 Dec;3(7):953-65</Citation><ArticleIdList><ArticleId IdType="pubmed">13489545</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Chem Biol. 2001 Feb;8(2):207-20</Citation><ArticleIdList><ArticleId IdType="pubmed">11251294</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Science. 2004 Mar 19;303(5665):1805-10</Citation><ArticleIdList><ArticleId IdType="pubmed">15031493</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Microbiol. 2003 Dec;1(3):209-18</Citation><ArticleIdList><ArticleId IdType="pubmed">15035025</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet. 2003 Jul 26;362(9380):263-70</Citation><ArticleIdList><ArticleId IdType="pubmed">12892955</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Emerg Infect Dis. 2005 Jul;11(7):1016-20</Citation><ArticleIdList><ArticleId IdType="pubmed">16022774</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Curr Opin Chem Biol. 1999 Oct;3(5):598-606</Citation><ArticleIdList><ArticleId IdType="pubmed">10508662</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>FEMS Microbiol Lett. 2004 Jul 15;236(2):319-24</Citation><ArticleIdList><ArticleId IdType="pubmed">15251214</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Science. 1970 Feb 13;167(3920):987-8</Citation><ArticleIdList><ArticleId IdType="pubmed">5411177</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Bacteriol. 2002 Dec;184(24):7013-24</Citation><ArticleIdList><ArticleId IdType="pubmed">12446651</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Science. 2004 Mar 12;303(5664):1666-9</Citation><ArticleIdList><ArticleId IdType="pubmed">14752165</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Structure. 2002 Mar;10(3):301-10</Citation><ArticleIdList><ArticleId IdType="pubmed">12005429</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Toxicology. 2005 Aug 15;212(1):37-45</Citation><ArticleIdList><ArticleId IdType="pubmed">15876477</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Gan To Kagaku Ryoho. 1984 Dec;11(12 Pt 2):2625-32</Citation><ArticleIdList><ArticleId IdType="pubmed">6508319</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biol Chem. 2001 Mar 9;276(10):7209-17</Citation><ArticleIdList><ArticleId IdType="pubmed">11112781</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biol Chem. 1992 Jun 15;267(17):11741-4</Citation><ArticleIdList><ArticleId IdType="pubmed">1601849</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Chembiochem. 2002 Jun 3;3(6):490-504</Citation><ArticleIdList><ArticleId IdType="pubmed">12325005</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>FEBS Lett. 1977 Oct 15;82(2):337-40</Citation><ArticleIdList><ArticleId IdType="pubmed">913608</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Chembiochem. 2001 Feb 2;2(2):99-107</Citation><ArticleIdList><ArticleId IdType="pubmed">11828432</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Chem Biol. 1999 Aug;6(8):493-505</Citation><ArticleIdList><ArticleId IdType="pubmed">10421756</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biol Chem. 2000 Jun 9;275(23):17909-15</Citation><ArticleIdList><ArticleId IdType="pubmed">10751395</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10012-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15226499</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Trends Mol Med. 2003 Aug;9(8):325-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12928032</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Annu Rev Microbiol. 2004;58:453-88</Citation><ArticleIdList><ArticleId IdType="pubmed">15487945</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Annu Rev Microbiol. 1989;43:173-206</Citation><ArticleIdList><ArticleId IdType="pubmed">2679353</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Bacteriol. 1990 Jun;172(6):3108-16</Citation><ArticleIdList><ArticleId IdType="pubmed">2345137</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Annu Rev Med. 2005;56:357-81</Citation><ArticleIdList><ArticleId IdType="pubmed">15660517</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Mol Microbiol. 1993 Mar;7(6):905-14</Citation><ArticleIdList><ArticleId IdType="pubmed">8483420</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Eur J Biochem. 1995 May 15;230(1):119-26</Citation><ArticleIdList><ArticleId IdType="pubmed">7601090</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Can J Biochem. 1968 Jun;46(6):573-8</Citation><ArticleIdList><ArticleId IdType="pubmed">5660414</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Chem Biol. 2000 Mar;7(3):211-24</Citation><ArticleIdList><ArticleId IdType="pubmed">10712928</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Appl Environ Microbiol. 2005 Jan;71(1):105-13</Citation><ArticleIdList><ArticleId IdType="pubmed">15640177</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>EMBO J. 1997 Jul 16;16(14):4174-83</Citation><ArticleIdList><ArticleId IdType="pubmed">9250661</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Biotechnol. 2003 Feb;21(2):187-90</Citation><ArticleIdList><ArticleId IdType="pubmed">12536216</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Bioessays. 2000 Mar;22(3):227-34</Citation><ArticleIdList><ArticleId IdType="pubmed">10684582</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Annu Rev Biochem. 1976;45:501-30</Citation><ArticleIdList><ArticleId IdType="pubmed">786156</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Appl Microbiol. 2004;97(5):992-1000</Citation><ArticleIdList><ArticleId IdType="pubmed">15479414</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Chem Rev. 1997 Nov 10;97(7):2651-2674</Citation><ArticleIdList><ArticleId IdType="pubmed">11851476</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Theor Biol. 2005 Jan 7;232(1):71-81</Citation><ArticleIdList><ArticleId IdType="pubmed">15498594</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Yao Xue Xue Bao. 2004 Mar;39(3):236-40</Citation><ArticleIdList><ArticleId IdType="pubmed">15171664</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antivir Chem Chemother. 2005;16(1):23-31</Citation><ArticleIdList><ArticleId IdType="pubmed">15739619</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Curr Opin Chem Biol. 2005 Oct;9(5):447-58</Citation><ArticleIdList><ArticleId IdType="pubmed">16107321</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Mol Biol. 1990 Oct 5;215(3):403-10</Citation><ArticleIdList><ArticleId IdType="pubmed">2231712</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Science. 2005 Oct 28;310(5748):676-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16195424</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Appl Environ Microbiol. 1998 Dec;64(12):4767-73</Citation><ArticleIdList><ArticleId IdType="pubmed">9835560</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Gene. 1992 Jul 1;116(1):43-9</Citation><ArticleIdList><ArticleId IdType="pubmed">1628843</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Wisconsin</li></region></list><tree><country name="États-Unis"><region name="Wisconsin"><name sortKey="Cheng, Yi Qiang" sort="Cheng, Yi Qiang" uniqKey="Cheng Y" first="Yi-Qiang" last="Cheng">Yi-Qiang Cheng</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002235 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002235 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:16511823
|texte= Deciphering the biosynthetic codes for the potent anti-SARS-CoV cyclodepsipeptide valinomycin in Streptomyces tsusimaensis ATCC 15141.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:16511823" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |