Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics.
Identifieur interne : 002136 ( PubMed/Checkpoint ); précédent : 002135; suivant : 002137Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics.
Auteurs : Jan Balzarini [Belgique] ; Els Keyaerts ; Leen Vijgen ; Herman Egberink ; Erik De Clercq ; Marc Van Ranst ; Svetlana S. Printsevskaya ; Eugenia N. Olsufyeva ; Svetlana E. Solovieva ; Maria N. PreobrazhenskayaSource :
- Antiviral research [ 0166-3542 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Antibactériens (), Antibactériens (pharmacologie), Antibactériens (synthèse chimique), Coronavirus félin (), Coronavirus félin (physiologie), Effet cytopathogène viral (), Glycopeptides (), Glycopeptides (pharmacologie), Glycopeptides (synthèse chimique), Humains, Inactivation virale, Lignée cellulaire, Réplication virale (), Téicoplanine (), Téicoplanine (pharmacologie), Vancomycine (), Vancomycine (pharmacologie), Vancomycine (synthèse chimique), Virus du SRAS (), Virus du SRAS (physiologie).
- MESH :
- pharmacologie : Antibactériens, Glycopeptides, Téicoplanine, Vancomycine.
- physiologie : Coronavirus félin, Virus du SRAS.
- synthèse chimique : Antibactériens, Glycopeptides, Vancomycine.
- Animaux, Antibactériens, Coronavirus félin, Effet cytopathogène viral, Glycopeptides, Humains, Inactivation virale, Lignée cellulaire, Réplication virale, Téicoplanine, Vancomycine, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Anti-Bacterial Agents (chemical synthesis), Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Cell Line, Coronavirus, Feline (drug effects), Coronavirus, Feline (physiology), Cytopathogenic Effect, Viral (drug effects), Glycopeptides (chemical synthesis), Glycopeptides (chemistry), Glycopeptides (pharmacology), Humans, SARS Virus (drug effects), SARS Virus (physiology), Teicoplanin (chemistry), Teicoplanin (pharmacology), Vancomycin (chemical synthesis), Vancomycin (chemistry), Vancomycin (pharmacology), Virus Inactivation, Virus Replication (drug effects).
- MESH :
- chemical , chemical synthesis : Anti-Bacterial Agents, Glycopeptides, Vancomycin.
- chemical , chemistry : Anti-Bacterial Agents, Glycopeptides, Teicoplanin, Vancomycin.
- chemical , pharmacology : Anti-Bacterial Agents, Glycopeptides, Teicoplanin, Vancomycin.
- drug effects : Coronavirus, Feline, Cytopathogenic Effect, Viral, SARS Virus, Virus Replication.
- physiology : Coronavirus, Feline, SARS Virus.
- Animals, Cell Line, Humans, Virus Inactivation.
Abstract
Various semisynthetic derivatives of glycopeptide antibiotics including vancomycin, eremomycin, teicoplanin, ristocetin A and DA-40926 have been evaluated for their inhibitory activity against feline infectious peritonitis virus (FIPV) and human (SARS-CoV, Frankfurt-1 strain) coronavirus in cell culture in comparison with their activity against human immunodeficiency virus (HIV). Several glycopeptide derivatives modified with hydrophobic substituents showed selective antiviral activity. For the most active compounds, the 50% effective concentrations (EC(50)) were in the lower micromolar range. In general, removal of the carbohydrate parts of the molecules did not affect the antiviral activity of the compounds. Some compounds showed inhibitory activity against both, whereas other compounds proved inhibitory to either, FIPV or SARS-CoV. There was no close correlation between the EC(50) values of the glycopeptide derivatives for FIPV or SARS-CoV.
DOI: 10.1016/j.antiviral.2006.03.005
PubMed: 16675038
Affiliations:
Links toward previous steps (curation, corpus...)
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pubmed:16675038Le document en format XML
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<term>Cytopathogenic Effect, Viral</term>
<term>SARS Virus</term>
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<front><div type="abstract" xml:lang="en">Various semisynthetic derivatives of glycopeptide antibiotics including vancomycin, eremomycin, teicoplanin, ristocetin A and DA-40926 have been evaluated for their inhibitory activity against feline infectious peritonitis virus (FIPV) and human (SARS-CoV, Frankfurt-1 strain) coronavirus in cell culture in comparison with their activity against human immunodeficiency virus (HIV). Several glycopeptide derivatives modified with hydrophobic substituents showed selective antiviral activity. For the most active compounds, the 50% effective concentrations (EC(50)) were in the lower micromolar range. In general, removal of the carbohydrate parts of the molecules did not affect the antiviral activity of the compounds. Some compounds showed inhibitory activity against both, whereas other compounds proved inhibitory to either, FIPV or SARS-CoV. There was no close correlation between the EC(50) values of the glycopeptide derivatives for FIPV or SARS-CoV.</div>
</front>
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<ArticleTitle>Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics.</ArticleTitle>
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<Abstract><AbstractText>Various semisynthetic derivatives of glycopeptide antibiotics including vancomycin, eremomycin, teicoplanin, ristocetin A and DA-40926 have been evaluated for their inhibitory activity against feline infectious peritonitis virus (FIPV) and human (SARS-CoV, Frankfurt-1 strain) coronavirus in cell culture in comparison with their activity against human immunodeficiency virus (HIV). Several glycopeptide derivatives modified with hydrophobic substituents showed selective antiviral activity. For the most active compounds, the 50% effective concentrations (EC(50)) were in the lower micromolar range. In general, removal of the carbohydrate parts of the molecules did not affect the antiviral activity of the compounds. Some compounds showed inhibitory activity against both, whereas other compounds proved inhibitory to either, FIPV or SARS-CoV. There was no close correlation between the EC(50) values of the glycopeptide derivatives for FIPV or SARS-CoV.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Balzarini</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. jan.balzarini@rega.kuleuven.be</Affiliation>
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<Author ValidYN="Y"><LastName>Preobrazhenskaya</LastName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D038301" MajorTopicYN="N">Virus Inactivation</DescriptorName>
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<affiliations><list><country><li>Belgique</li>
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