Inhibitory effects of anti-SARS traditional Chinese medicines on the UV irradiation of lambda-lysogen.
Identifieur interne : 002134 ( PubMed/Checkpoint ); précédent : 002133; suivant : 002135Inhibitory effects of anti-SARS traditional Chinese medicines on the UV irradiation of lambda-lysogen.
Auteurs : Yaqiong Li [République populaire de Chine] ; Jing Li ; Chengxiang FangSource :
- The American journal of Chinese medicine [ 0192-415X ] ; 2006.
Descripteurs français
- KwdFr :
- ADN bactérien (), Bactériophage lambda (effets des radiations), Bactériophage lambda (génétique), Escherichia coli (), Escherichia coli (génétique), Humains, Lysogénie (), Médicaments issus de plantes chinoises (pharmacologie), Prophages (effets des radiations), Radicaux libres, Rayons ultraviolets, Spectroscopie de résonance de spin électronique, Syndrome respiratoire aigu sévère (virologie).
- MESH :
- effets des radiations : Bactériophage lambda, Prophages.
- génétique : Bactériophage lambda, Escherichia coli.
- pharmacologie : Médicaments issus de plantes chinoises.
- virologie : Syndrome respiratoire aigu sévère.
- ADN bactérien, Escherichia coli, Humains, Lysogénie, Radicaux libres, Rayons ultraviolets, Spectroscopie de résonance de spin électronique.
English descriptors
- KwdEn :
- Bacteriophage lambda (genetics), Bacteriophage lambda (radiation effects), DNA, Bacterial (drug effects), Drugs, Chinese Herbal (pharmacology), Electron Spin Resonance Spectroscopy, Escherichia coli (drug effects), Escherichia coli (genetics), Free Radicals, Humans, Lysogeny (drug effects), Prophages (radiation effects), Severe Acute Respiratory Syndrome (virology), Ultraviolet Rays.
- MESH :
- chemical , drug effects : DNA, Bacterial.
- drug effects : Escherichia coli, Lysogeny.
- genetics : Bacteriophage lambda, Escherichia coli.
- chemical , pharmacology : Drugs, Chinese Herbal.
- radiation effects : Bacteriophage lambda, Prophages.
- virology : Severe Acute Respiratory Syndrome.
- Electron Spin Resonance Spectroscopy, Free Radicals, Humans, Ultraviolet Rays.
Abstract
By using lambda-lysogen as a model, the inhibitory effects of anti-severe acute respiratory syndrome (SARS) traditional Chinese medicines (TCMs) prescription I on the UV irradiation were investigated in this present study. It was found that the prescription I possessed obvious inhibitory effects on the UV induction of lambda-lysogen, the inhibitory rate reaching 83.87%. Among five medicinal herbs prescribed in that formula, Herba Patriniae, Radix Astragali and Radix Glycyrrhizae played important roles. When these three herbs were eliminated from the recipe separately, the inhibitory effects were prominently decreased. If only one of these five medicinal herbs was added into the medium of lambda-lysogen, the inhibitory rates ranged from 27.0% approximately 45.0%. By electron spin resonance (ESR) detection, we found that the prescription I, Herba Patriniae and other main herbs in that recipe, could quench effectively the free radicals generated in the process of lambda-lysogenic cells by UV. These results provide a novel idea for further studying the pharmacology of TCM and exploring the mechanism of SARS virus infection.
DOI: 10.1142/S0192415X06003710
PubMed: 16437747
Affiliations:
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ultraviolets</term><term>Spectroscopie de résonance de spin électronique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">By using lambda-lysogen as a model, the inhibitory effects of anti-severe acute respiratory syndrome (SARS) traditional Chinese medicines (TCMs) prescription I on the UV irradiation were investigated in this present study. It was found that the prescription I possessed obvious inhibitory effects on the UV induction of lambda-lysogen, the inhibitory rate reaching 83.87%. Among five medicinal herbs prescribed in that formula, Herba Patriniae, Radix Astragali and Radix Glycyrrhizae played important roles. When these three herbs were eliminated from the recipe separately, the inhibitory effects were prominently decreased. If only one of these five medicinal herbs was added into the medium of lambda-lysogen, the inhibitory rates ranged from 27.0% approximately 45.0%. By electron spin resonance (ESR) detection, we found that the prescription I, Herba Patriniae and other main herbs in that recipe, could quench effectively the free radicals generated in the process of lambda-lysogenic cells by UV. These results provide a novel idea for further studying the pharmacology of TCM and exploring the mechanism of SARS virus infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16437747</PMID><DateCompleted><Year>2006</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2006</Year><Month>01</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0192-415X</ISSN><JournalIssue CitedMedium="Print"><Volume>34</Volume><Issue>1</Issue><PubDate><Year>2006</Year></PubDate></JournalIssue><Title>The American journal of Chinese medicine</Title><ISOAbbreviation>Am. J. Chin. 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If only one of these five medicinal herbs was added into the medium of lambda-lysogen, the inhibitory rates ranged from 27.0% approximately 45.0%. By electron spin resonance (ESR) detection, we found that the prescription I, Herba Patriniae and other main herbs in that recipe, could quench effectively the free radicals generated in the process of lambda-lysogenic cells by UV. 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