SrasV1, PubMed, Checkpoint, bibRecord, 002086

Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

Identifieur interne : 002086 ( PubMed/Checkpoint ); précédent : 002085; suivant : 002087

Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

Auteurs : Pi-Hui Liang [Taïwan] ; Wei-Chieh Cheng ; Yi-Ling Lee ; Han-Pang Yu ; Ying-Ta Wu ; Yi-Ling Lin ; Chi-Huey Wong

Source :

Chembiochem : a European journal of chemical biology [ 1439-4227 ] ; 2006.

RBID : pubmed:16397876

Descripteurs français

English descriptors

KwdEn :
- Animals, Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cell Line, Cell Proliferation (drug effects), Combinatorial Chemistry Techniques, Dengue Virus (drug effects), Encephalitis Virus, Japanese (drug effects), Enzyme Inhibitors (chemical synthesis), Enzyme Inhibitors (chemistry), Enzyme Inhibitors (pharmacology), Glycoside Hydrolases (antagonists & inhibitors), Heterocyclic Compounds, 1-Ring (chemical synthesis), Heterocyclic Compounds, 1-Ring (chemistry), Heterocyclic Compounds, 1-Ring (pharmacology), Humans, Imino Pyranoses (chemical synthesis), Imino Pyranoses (chemistry), Imino Pyranoses (pharmacology), Microbial Sensitivity Tests, Models, Biological, Models, Molecular, Osteoarthritis (enzymology), SARS Virus (drug effects), Structure-Activity Relationship, Substrate Specificity, beta-N-Acetylhexosaminidases (antagonists & inhibitors).
MESH :
- chemical , antagonists & inhibitors : Glycoside Hydrolases, beta-N-Acetylhexosaminidases.
- chemical , chemical synthesis : Antiviral Agents, Enzyme Inhibitors, Heterocyclic Compounds, 1-Ring, Imino Pyranoses.
- chemical , chemistry : Antiviral Agents, Enzyme Inhibitors, Heterocyclic Compounds, 1-Ring, Imino Pyranoses.
- chemical , pharmacology : Antiviral Agents, Enzyme Inhibitors, Heterocyclic Compounds, 1-Ring, Imino Pyranoses.
- drug effects : Cell Proliferation, Dengue Virus, Encephalitis Virus, Japanese, SARS Virus.
- enzymology : Osteoarthritis.
- Animals, Cell Line, Combinatorial Chemistry Techniques, Humans, Microbial Sensitivity Tests, Models, Biological, Models, Molecular, Structure-Activity Relationship, Substrate Specificity.

Abstract

A novel 5-membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein-processing alpha-glucosidase with a Ki value of 53 nM. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus, and human beta-hexosaminidase (Ki = 2.6 nM), a new target for the development of osteoarthritis therapeutics.

DOI: 10.1002/cbic.200500321
PubMed: 16397876

Affiliations:

Taïwan

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002386
to stream PubMed, to step Curation: 002386

Links to Exploration step

pubmed:16397876

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.</title>
<author><name sortKey="Liang, Pi Hui" sort="Liang, Pi Hui" uniqKey="Liang P" first="Pi-Hui" last="Liang">Pi-Hui Liang</name>
<affiliation wicri:level="1"><nlm:affiliation>The Genomics Research Center and Institute of Biomedical Sciences, Academia Sinica, No. 128, Academia Road Sec. 2, Nankang District, Taipei, 11529, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>The Genomics Research Center and Institute of Biomedical Sciences, Academia Sinica, No. 128, Academia Road Sec. 2, Nankang District, Taipei, 11529</wicri:regionArea>
<wicri:noRegion>11529</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cheng, Wei Chieh" sort="Cheng, Wei Chieh" uniqKey="Cheng W" first="Wei-Chieh" last="Cheng">Wei-Chieh Cheng</name>
</author>
<author><name sortKey="Lee, Yi Ling" sort="Lee, Yi Ling" uniqKey="Lee Y" first="Yi-Ling" last="Lee">Yi-Ling Lee</name>
</author>
<author><name sortKey="Yu, Han Pang" sort="Yu, Han Pang" uniqKey="Yu H" first="Han-Pang" last="Yu">Han-Pang Yu</name>
</author>
<author><name sortKey="Wu, Ying Ta" sort="Wu, Ying Ta" uniqKey="Wu Y" first="Ying-Ta" last="Wu">Ying-Ta Wu</name>
</author>
<author><name sortKey="Lin, Yi Ling" sort="Lin, Yi Ling" uniqKey="Lin Y" first="Yi-Ling" last="Lin">Yi-Ling Lin</name>
</author>
<author><name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="RBID">pubmed:16397876</idno>
<idno type="pmid">16397876</idno>
<idno type="doi">10.1002/cbic.200500321</idno>
<idno type="wicri:Area/PubMed/Corpus">002386</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002386</idno>
<idno type="wicri:Area/PubMed/Curation">002386</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002386</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002086</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002086</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.</title>
<author><name sortKey="Liang, Pi Hui" sort="Liang, Pi Hui" uniqKey="Liang P" first="Pi-Hui" last="Liang">Pi-Hui Liang</name>
<affiliation wicri:level="1"><nlm:affiliation>The Genomics Research Center and Institute of Biomedical Sciences, Academia Sinica, No. 128, Academia Road Sec. 2, Nankang District, Taipei, 11529, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>The Genomics Research Center and Institute of Biomedical Sciences, Academia Sinica, No. 128, Academia Road Sec. 2, Nankang District, Taipei, 11529</wicri:regionArea>
<wicri:noRegion>11529</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cheng, Wei Chieh" sort="Cheng, Wei Chieh" uniqKey="Cheng W" first="Wei-Chieh" last="Cheng">Wei-Chieh Cheng</name>
</author>
<author><name sortKey="Lee, Yi Ling" sort="Lee, Yi Ling" uniqKey="Lee Y" first="Yi-Ling" last="Lee">Yi-Ling Lee</name>
</author>
<author><name sortKey="Yu, Han Pang" sort="Yu, Han Pang" uniqKey="Yu H" first="Han-Pang" last="Yu">Han-Pang Yu</name>
</author>
<author><name sortKey="Wu, Ying Ta" sort="Wu, Ying Ta" uniqKey="Wu Y" first="Ying-Ta" last="Wu">Ying-Ta Wu</name>
</author>
<author><name sortKey="Lin, Yi Ling" sort="Lin, Yi Ling" uniqKey="Lin Y" first="Yi-Ling" last="Lin">Yi-Ling Lin</name>
</author>
<author><name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name>
</author>
</analytic>
<series><title level="j">Chembiochem : a European journal of chemical biology</title>
<idno type="ISSN">1439-4227</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antiviral Agents (chemical synthesis)</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Cell Line</term>
<term>Cell Proliferation (drug effects)</term>
<term>Combinatorial Chemistry Techniques</term>
<term>Dengue Virus (drug effects)</term>
<term>Encephalitis Virus, Japanese (drug effects)</term>
<term>Enzyme Inhibitors (chemical synthesis)</term>
<term>Enzyme Inhibitors (chemistry)</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>Glycoside Hydrolases (antagonists & inhibitors)</term>
<term>Heterocyclic Compounds, 1-Ring (chemical synthesis)</term>
<term>Heterocyclic Compounds, 1-Ring (chemistry)</term>
<term>Heterocyclic Compounds, 1-Ring (pharmacology)</term>
<term>Humans</term>
<term>Imino Pyranoses (chemical synthesis)</term>
<term>Imino Pyranoses (chemistry)</term>
<term>Imino Pyranoses (pharmacology)</term>
<term>Microbial Sensitivity Tests</term>
<term>Models, Biological</term>
<term>Models, Molecular</term>
<term>Osteoarthritis (enzymology)</term>
<term>SARS Virus (drug effects)</term>
<term>Structure-Activity Relationship</term>
<term>Substrate Specificity</term>
<term>beta-N-Acetylhexosaminidases (antagonists & inhibitors)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antienzymes ()</term>
<term>Antienzymes (pharmacologie)</term>
<term>Antienzymes (synthèse chimique)</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (synthèse chimique)</term>
<term>Arthrose (enzymologie)</term>
<term>Composés hétéromonocycliques ()</term>
<term>Composés hétéromonocycliques (pharmacologie)</term>
<term>Composés hétéromonocycliques (synthèse chimique)</term>
<term>Glycosidases (antagonistes et inhibiteurs)</term>
<term>Humains</term>
<term>Iminopyranoses ()</term>
<term>Iminopyranoses (pharmacologie)</term>
<term>Iminopyranoses (synthèse chimique)</term>
<term>Lignée cellulaire</term>
<term>Modèles biologiques</term>
<term>Modèles moléculaires</term>
<term>Prolifération cellulaire ()</term>
<term>Relation structure-activité</term>
<term>Spécificité du substrat</term>
<term>Techniques de chimie combinatoire</term>
<term>Tests de sensibilité microbienne</term>
<term>Virus de l'encéphalite japonaise (espèce) ()</term>
<term>Virus de la dengue ()</term>
<term>Virus du SRAS ()</term>
<term>beta-N-Acetylhexosaminidases (antagonistes et inhibiteurs)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Glycoside Hydrolases</term>
<term>beta-N-Acetylhexosaminidases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antiviral Agents</term>
<term>Enzyme Inhibitors</term>
<term>Heterocyclic Compounds, 1-Ring</term>
<term>Imino Pyranoses</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term>
<term>Enzyme Inhibitors</term>
<term>Heterocyclic Compounds, 1-Ring</term>
<term>Imino Pyranoses</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Enzyme Inhibitors</term>
<term>Heterocyclic Compounds, 1-Ring</term>
<term>Imino Pyranoses</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Glycosidases</term>
<term>beta-N-Acetylhexosaminidases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term>
<term>Dengue Virus</term>
<term>Encephalitis Virus, Japanese</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Arthrose</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Osteoarthritis</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antienzymes</term>
<term>Antiviraux</term>
<term>Composés hétéromonocycliques</term>
<term>Iminopyranoses</term>
</keywords>
<keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antienzymes</term>
<term>Antiviraux</term>
<term>Composés hétéromonocycliques</term>
<term>Iminopyranoses</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Combinatorial Chemistry Techniques</term>
<term>Humans</term>
<term>Microbial Sensitivity Tests</term>
<term>Models, Biological</term>
<term>Models, Molecular</term>
<term>Structure-Activity Relationship</term>
<term>Substrate Specificity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Antienzymes</term>
<term>Antiviraux</term>
<term>Composés hétéromonocycliques</term>
<term>Humains</term>
<term>Iminopyranoses</term>
<term>Lignée cellulaire</term>
<term>Modèles biologiques</term>
<term>Modèles moléculaires</term>
<term>Prolifération cellulaire</term>
<term>Relation structure-activité</term>
<term>Spécificité du substrat</term>
<term>Techniques de chimie combinatoire</term>
<term>Tests de sensibilité microbienne</term>
<term>Virus de l'encéphalite japonaise (espèce)</term>
<term>Virus de la dengue</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A novel 5-membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein-processing alpha-glucosidase with a Ki value of 53 nM. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus, and human beta-hexosaminidase (Ki = 2.6 nM), a new target for the development of osteoarthritis therapeutics.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16397876</PMID>
<DateCompleted><Year>2006</Year>
<Month>04</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1439-4227</ISSN>
<JournalIssue CitedMedium="Print"><Volume>7</Volume>
<Issue>1</Issue>
<PubDate><Year>2006</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Chembiochem : a European journal of chemical biology</Title>
<ISOAbbreviation>Chembiochem</ISOAbbreviation>
</Journal>
<ArticleTitle>Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.</ArticleTitle>
<Pagination><MedlinePgn>165-73</MedlinePgn>
</Pagination>
<Abstract><AbstractText>A novel 5-membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein-processing alpha-glucosidase with a Ki value of 53 nM. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus, and human beta-hexosaminidase (Ki = 2.6 nM), a new target for the development of osteoarthritis therapeutics.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liang</LastName>
<ForeName>Pi-Hui</ForeName>
<Initials>PH</Initials>
<AffiliationInfo><Affiliation>The Genomics Research Center and Institute of Biomedical Sciences, Academia Sinica, No. 128, Academia Road Sec. 2, Nankang District, Taipei, 11529, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cheng</LastName>
<ForeName>Wei-Chieh</ForeName>
<Initials>WC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Yi-Ling</ForeName>
<Initials>YL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Han-Pang</ForeName>
<Initials>HP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Ying-Ta</ForeName>
<Initials>YT</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Yi-Ling</ForeName>
<Initials>YL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wong</LastName>
<ForeName>Chi-Huey</ForeName>
<Initials>CH</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Chembiochem</MedlineTA>
<NlmUniqueID>100937360</NlmUniqueID>
<ISSNLinking>1439-4227</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004791">Enzyme Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006573">Heterocyclic Compounds, 1-Ring</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050112">Imino Pyranoses</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.2.1.-</RegistryNumber>
<NameOfSubstance UI="D006026">Glycoside Hydrolases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.2.1.52</RegistryNumber>
<NameOfSubstance UI="D001619">beta-N-Acetylhexosaminidases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020650" MajorTopicYN="N">Combinatorial Chemistry Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003716" MajorTopicYN="N">Dengue Virus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004664" MajorTopicYN="N">Encephalitis Virus, Japanese</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006026" MajorTopicYN="N">Glycoside Hydrolases</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006573" MajorTopicYN="N">Heterocyclic Compounds, 1-Ring</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050112" MajorTopicYN="Y">Imino Pyranoses</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010003" MajorTopicYN="N">Osteoarthritis</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013379" MajorTopicYN="N">Substrate Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001619" MajorTopicYN="N">beta-N-Acetylhexosaminidases</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year>
<Month>1</Month>
<Day>7</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2006</Year>
<Month>4</Month>
<Day>7</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2006</Year>
<Month>1</Month>
<Day>7</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">16397876</ArticleId>
<ArticleId IdType="doi">10.1002/cbic.200500321</ArticleId>
<ArticleId IdType="pmc">PMC7161998</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Methods Enzymol. 2000;327:260-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11044989</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chem Biol. 2002 Aug;9(8):891-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12204688</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2235-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8134380</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Glycobiology. 2003 Oct;13(10):93R-104R</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12851286</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Appl Toxicol. 2001 Nov-Dec;21(6):527-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11746202</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chem Biol. 2001 Jul;8(7):701-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11451670</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chem Biol. 2004 Sep;11(9):1301-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15380190</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Med Chem. 2000 Jun;7(6):663-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10702632</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Hepatology. 2001 Jun;33(6):1488-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11391538</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antivir Chem Chemother. 2002 Sep;13(5):299-304</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12630678</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2001 Oct;75(19):8987-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11533162</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Org Chem. 2004 Sep 17;69(19):6273-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15357586</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Bioorg Med Chem Lett. 2001 Feb 12;11(3):423-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11212126</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cancer Res. 1994 Mar 15;54(6):1450-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8137247</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Biol Chem. 1991 Aug 5;266(22):14504-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1650361</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Med Chem. 1999 Nov 4;42(22):4479-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10579812</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1987 Nov;84(22):8120-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2825177</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Arthritis Rheum. 2000 Jun;43(6):1307-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10857789</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10012-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15226499</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chem Biol. 2001 Nov;8(11):1061-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11731297</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Drugs. 2000 Mar;59(3):521-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10776834</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chem Rev. 2000 Dec 13;100(12):4683-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11749362</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Curr Opin Struct Biol. 1995 Oct;5(5):605-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8574695</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Med. 1998 May;4(5):610-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9585237</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Trends Pharmacol Sci. 2003 Jul;24(7):355-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12871668</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Drug Discov. 2002 Jan;1(1):65-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12119611</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11878-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10518544</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2000 Jan;74(1):564-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10590151</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 1996 Sep 1;223(1):79-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8806542</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Diabet Med. 1998 Aug;15(8):657-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9702468</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Biochem J. 2003 Sep 1;374(Pt 2):307-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12769816</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Virology. 1996 Mar 1;217(1):220-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8599206</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 2002 Apr;76(8):3596-604</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11907199</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Mol Biol. 2003 May 2;328(3):669-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12706724</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Agric Food Chem. 1999 Apr;47(4):1453-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10563998</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Virol. 1998 Dec;72(12):9729-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9811707</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Antimicrob Agents Chemother. 2004 Feb;48(2):497-504</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14742201</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 1987 Nov 5-11;330(6143):74-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2959866</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nat Rev Mol Cell Biol. 2003 Mar;4(3):181-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12612637</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><noCountry><name sortKey="Cheng, Wei Chieh" sort="Cheng, Wei Chieh" uniqKey="Cheng W" first="Wei-Chieh" last="Cheng">Wei-Chieh Cheng</name>
<name sortKey="Lee, Yi Ling" sort="Lee, Yi Ling" uniqKey="Lee Y" first="Yi-Ling" last="Lee">Yi-Ling Lee</name>
<name sortKey="Lin, Yi Ling" sort="Lin, Yi Ling" uniqKey="Lin Y" first="Yi-Ling" last="Lin">Yi-Ling Lin</name>
<name sortKey="Wong, Chi Huey" sort="Wong, Chi Huey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name>
<name sortKey="Wu, Ying Ta" sort="Wu, Ying Ta" uniqKey="Wu Y" first="Ying-Ta" last="Wu">Ying-Ta Wu</name>
<name sortKey="Yu, Han Pang" sort="Yu, Han Pang" uniqKey="Yu H" first="Han-Pang" last="Yu">Han-Pang Yu</name>
</noCountry>
<country name="Taïwan"><noRegion><name sortKey="Liang, Pi Hui" sort="Liang, Pi Hui" uniqKey="Liang P" first="Pi-Hui" last="Liang">Pi-Hui Liang</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002086 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002086 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:16397876
   |texte=   Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:16397876" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki