Porcine innate and adaptative immune responses to influenza and coronavirus infections.
Identifieur interne : 002066 ( PubMed/Checkpoint ); précédent : 002065; suivant : 002067Porcine innate and adaptative immune responses to influenza and coronavirus infections.
Auteurs : Bernard Charley [France] ; Sabine Riffault ; Kristien Van ReethSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Cellules productrices d'anticorps (immunologie), Gastroentérite transmissible du porc (), Gastroentérite transmissible du porc (immunologie), Gastroentérite transmissible du porc (transmission), Humains, Immunité innée, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (médecine vétérinaire), Infections à Orthomyxoviridae (transmission), Infections à coronavirus (), Infections à coronavirus (immunologie), Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (transmission), Maladies des porcs (), Maladies des porcs (immunologie), Maladies des porcs (transmission), Production d'anticorps, Réservoirs d'agents pathogènes (médecine vétérinaire), Suidae, Vaccination (médecine vétérinaire).
- MESH :
- immunologie : Anticorps antiviraux, Cellules productrices d'anticorps, Gastroentérite transmissible du porc, Infections à Orthomyxoviridae, Infections à coronavirus, Maladies des porcs.
- médecine vétérinaire : Infections à Orthomyxoviridae, Infections à coronavirus, Réservoirs d'agents pathogènes, Vaccination.
- Animaux, Gastroentérite transmissible du porc, Humains, Immunité innée, Infections à Orthomyxoviridae, Infections à coronavirus, Maladies des porcs, Production d'anticorps, Suidae.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (immunology), Antibody Formation, Antibody-Producing Cells (immunology), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (transmission), Coronavirus Infections (veterinary), Disease Reservoirs (veterinary), Gastroenteritis, Transmissible, of Swine (immunology), Gastroenteritis, Transmissible, of Swine (prevention & control), Gastroenteritis, Transmissible, of Swine (transmission), Humans, Immunity, Innate, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (transmission), Orthomyxoviridae Infections (veterinary), Swine, Swine Diseases (immunology), Swine Diseases (prevention & control), Swine Diseases (transmission), Vaccination (veterinary).
- MESH :
- chemical , immunology : Antibodies, Viral.
- immunology : Antibody-Producing Cells, Coronavirus Infections, Gastroenteritis, Transmissible, of Swine, Orthomyxoviridae Infections, Swine Diseases.
- prevention & control : Coronavirus Infections, Gastroenteritis, Transmissible, of Swine, Orthomyxoviridae Infections, Swine Diseases.
- transmission : Coronavirus Infections, Gastroenteritis, Transmissible, of Swine, Orthomyxoviridae Infections, Swine Diseases.
- veterinary : Coronavirus Infections, Disease Reservoirs, Orthomyxoviridae Infections, Vaccination.
- Animals, Antibody Formation, Humans, Immunity, Innate, Swine.
Abstract
Both innate and adaptative immune responses contribute to the control of infectious diseases, including by limiting the spreading of zoonotic diseases from animal reservoirs to humans. Pigs represent an important animal reservoir for influenza virus infection of human populations and are also naturally infected by coronaviruses, an important group of viruses, which includes the recently emerged severe acute respiratory syndrome (SARS) virus. Studies on both innate and adaptative immune responses of pigs to influenza virus and coronaviruses contribute, therefore, to a better control of these infections in their natural hosts and will be briefly reviewed in this article. Pro-inflammatory cytokines, including type I interferon (IFN), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were found in lung secretions of influenza virus infected pigs, and correlated with the intensity of clinical signs, whereas prior vaccination against influenza strongly reduced the production of infectious virus and cytokines in the lungs upon challenge, which was associated with clinical protection. An early type I IFN production was also found in coronavirus infected pigs, including at mucosal sites. IFN induction by coronavirus is shown to involve interaction between a viral glycoprotein and a leukocyte subset, likely equivalent to plasmacytoid dendritic cells, present in the mucosae and associated lymphoid tissues. Given the IFN mediated antiviral and immunomodulatory effects, the use of IFN or IFN inducers may prove an efficient strategy for a better control of influenza virus and coronavirus infections in pigs. Because influenza and coronaviruses target mucosal surfaces, adaptative immune responses have to be characterized at mucosal sites. Thus, nasal and pulmonary antibody responses were analyzed in influenza virus infected or vaccinated pigs showing short-lived, but potentially protective local IgA and IgG antibody (Ab) responses. Interestingly, primary influenza virus infection induced long-lived increase of lung CD8(+) T cells and local lymphoproliferative responses. Pigs infected by a respiratory coronavirus (PRCV) showed virus-specific IgG Ab-secreting cells in the bronchial lymph nodes, whereas the transmissible gastroenteritis coronavirus (TGEV) induced more IgA Ab-secreting cells in gut tissues, which illustrates the importance of the route of antigen administration for inducing local immune effector mechanisms. Porcine viral infections provide, therefore, valuable models for evaluating the immune parameters that are important for controlling transmission of important viral zoonotic infections.
DOI: 10.1196/annals.1373.014
PubMed: 17135502
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:17135502Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Porcine innate and adaptative immune responses to influenza and coronavirus infections.</title>
<author><name sortKey="Charley, Bernard" sort="Charley, Bernard" uniqKey="Charley B" first="Bernard" last="Charley">Bernard Charley</name>
<affiliation wicri:level="3"><nlm:affiliation>INRA, Virologie Immunologie moléculaires, 78350, Jouy-en-Josas, France. bernard.charley@jouy.inra.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA, Virologie Immunologie moléculaires, 78350, Jouy-en-Josas</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Jouy-en-Josas</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riffault, Sabine" sort="Riffault, Sabine" uniqKey="Riffault S" first="Sabine" last="Riffault">Sabine Riffault</name>
</author>
<author><name sortKey="Van Reeth, Kristien" sort="Van Reeth, Kristien" uniqKey="Van Reeth K" first="Kristien" last="Van Reeth">Kristien Van Reeth</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="RBID">pubmed:17135502</idno>
<idno type="pmid">17135502</idno>
<idno type="doi">10.1196/annals.1373.014</idno>
<idno type="wicri:Area/PubMed/Corpus">001F75</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F75</idno>
<idno type="wicri:Area/PubMed/Curation">001F75</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F75</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002066</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002066</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Porcine innate and adaptative immune responses to influenza and coronavirus infections.</title>
<author><name sortKey="Charley, Bernard" sort="Charley, Bernard" uniqKey="Charley B" first="Bernard" last="Charley">Bernard Charley</name>
<affiliation wicri:level="3"><nlm:affiliation>INRA, Virologie Immunologie moléculaires, 78350, Jouy-en-Josas, France. bernard.charley@jouy.inra.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INRA, Virologie Immunologie moléculaires, 78350, Jouy-en-Josas</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Jouy-en-Josas</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riffault, Sabine" sort="Riffault, Sabine" uniqKey="Riffault S" first="Sabine" last="Riffault">Sabine Riffault</name>
</author>
<author><name sortKey="Van Reeth, Kristien" sort="Van Reeth, Kristien" uniqKey="Van Reeth K" first="Kristien" last="Van Reeth">Kristien Van Reeth</name>
</author>
</analytic>
<series><title level="j">Annals of the New York Academy of Sciences</title>
<idno type="ISSN">0077-8923</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibody Formation</term>
<term>Antibody-Producing Cells (immunology)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (prevention & control)</term>
<term>Coronavirus Infections (transmission)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Disease Reservoirs (veterinary)</term>
<term>Gastroenteritis, Transmissible, of Swine (immunology)</term>
<term>Gastroenteritis, Transmissible, of Swine (prevention & control)</term>
<term>Gastroenteritis, Transmissible, of Swine (transmission)</term>
<term>Humans</term>
<term>Immunity, Innate</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (prevention & control)</term>
<term>Orthomyxoviridae Infections (transmission)</term>
<term>Orthomyxoviridae Infections (veterinary)</term>
<term>Swine</term>
<term>Swine Diseases (immunology)</term>
<term>Swine Diseases (prevention & control)</term>
<term>Swine Diseases (transmission)</term>
<term>Vaccination (veterinary)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Cellules productrices d'anticorps (immunologie)</term>
<term>Gastroentérite transmissible du porc ()</term>
<term>Gastroentérite transmissible du porc (immunologie)</term>
<term>Gastroentérite transmissible du porc (transmission)</term>
<term>Humains</term>
<term>Immunité innée</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Infections à Orthomyxoviridae (médecine vétérinaire)</term>
<term>Infections à Orthomyxoviridae (transmission)</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (transmission)</term>
<term>Maladies des porcs ()</term>
<term>Maladies des porcs (immunologie)</term>
<term>Maladies des porcs (transmission)</term>
<term>Production d'anticorps</term>
<term>Réservoirs d'agents pathogènes (médecine vétérinaire)</term>
<term>Suidae</term>
<term>Vaccination (médecine vétérinaire)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Cellules productrices d'anticorps</term>
<term>Gastroentérite transmissible du porc</term>
<term>Infections à Orthomyxoviridae</term>
<term>Infections à coronavirus</term>
<term>Maladies des porcs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antibody-Producing Cells</term>
<term>Coronavirus Infections</term>
<term>Gastroenteritis, Transmissible, of Swine</term>
<term>Orthomyxoviridae Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
<term>Infections à coronavirus</term>
<term>Réservoirs d'agents pathogènes</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term>
<term>Gastroenteritis, Transmissible, of Swine</term>
<term>Orthomyxoviridae Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term>
<term>Gastroenteritis, Transmissible, of Swine</term>
<term>Orthomyxoviridae Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
<term>Disease Reservoirs</term>
<term>Orthomyxoviridae Infections</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Antibody Formation</term>
<term>Humans</term>
<term>Immunity, Innate</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Gastroentérite transmissible du porc</term>
<term>Humains</term>
<term>Immunité innée</term>
<term>Infections à Orthomyxoviridae</term>
<term>Infections à coronavirus</term>
<term>Maladies des porcs</term>
<term>Production d'anticorps</term>
<term>Suidae</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Both innate and adaptative immune responses contribute to the control of infectious diseases, including by limiting the spreading of zoonotic diseases from animal reservoirs to humans. Pigs represent an important animal reservoir for influenza virus infection of human populations and are also naturally infected by coronaviruses, an important group of viruses, which includes the recently emerged severe acute respiratory syndrome (SARS) virus. Studies on both innate and adaptative immune responses of pigs to influenza virus and coronaviruses contribute, therefore, to a better control of these infections in their natural hosts and will be briefly reviewed in this article. Pro-inflammatory cytokines, including type I interferon (IFN), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were found in lung secretions of influenza virus infected pigs, and correlated with the intensity of clinical signs, whereas prior vaccination against influenza strongly reduced the production of infectious virus and cytokines in the lungs upon challenge, which was associated with clinical protection. An early type I IFN production was also found in coronavirus infected pigs, including at mucosal sites. IFN induction by coronavirus is shown to involve interaction between a viral glycoprotein and a leukocyte subset, likely equivalent to plasmacytoid dendritic cells, present in the mucosae and associated lymphoid tissues. Given the IFN mediated antiviral and immunomodulatory effects, the use of IFN or IFN inducers may prove an efficient strategy for a better control of influenza virus and coronavirus infections in pigs. Because influenza and coronaviruses target mucosal surfaces, adaptative immune responses have to be characterized at mucosal sites. Thus, nasal and pulmonary antibody responses were analyzed in influenza virus infected or vaccinated pigs showing short-lived, but potentially protective local IgA and IgG antibody (Ab) responses. Interestingly, primary influenza virus infection induced long-lived increase of lung CD8(+) T cells and local lymphoproliferative responses. Pigs infected by a respiratory coronavirus (PRCV) showed virus-specific IgG Ab-secreting cells in the bronchial lymph nodes, whereas the transmissible gastroenteritis coronavirus (TGEV) induced more IgA Ab-secreting cells in gut tissues, which illustrates the importance of the route of antigen administration for inducing local immune effector mechanisms. Porcine viral infections provide, therefore, valuable models for evaluating the immune parameters that are important for controlling transmission of important viral zoonotic infections.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17135502</PMID>
<DateCompleted><Year>2007</Year>
<Month>04</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2008</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0077-8923</ISSN>
<JournalIssue CitedMedium="Print"><Volume>1081</Volume>
<PubDate><Year>2006</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Annals of the New York Academy of Sciences</Title>
<ISOAbbreviation>Ann. N. Y. Acad. Sci.</ISOAbbreviation>
</Journal>
<ArticleTitle>Porcine innate and adaptative immune responses to influenza and coronavirus infections.</ArticleTitle>
<Pagination><MedlinePgn>130-6</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Both innate and adaptative immune responses contribute to the control of infectious diseases, including by limiting the spreading of zoonotic diseases from animal reservoirs to humans. Pigs represent an important animal reservoir for influenza virus infection of human populations and are also naturally infected by coronaviruses, an important group of viruses, which includes the recently emerged severe acute respiratory syndrome (SARS) virus. Studies on both innate and adaptative immune responses of pigs to influenza virus and coronaviruses contribute, therefore, to a better control of these infections in their natural hosts and will be briefly reviewed in this article. Pro-inflammatory cytokines, including type I interferon (IFN), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were found in lung secretions of influenza virus infected pigs, and correlated with the intensity of clinical signs, whereas prior vaccination against influenza strongly reduced the production of infectious virus and cytokines in the lungs upon challenge, which was associated with clinical protection. An early type I IFN production was also found in coronavirus infected pigs, including at mucosal sites. IFN induction by coronavirus is shown to involve interaction between a viral glycoprotein and a leukocyte subset, likely equivalent to plasmacytoid dendritic cells, present in the mucosae and associated lymphoid tissues. Given the IFN mediated antiviral and immunomodulatory effects, the use of IFN or IFN inducers may prove an efficient strategy for a better control of influenza virus and coronavirus infections in pigs. Because influenza and coronaviruses target mucosal surfaces, adaptative immune responses have to be characterized at mucosal sites. Thus, nasal and pulmonary antibody responses were analyzed in influenza virus infected or vaccinated pigs showing short-lived, but potentially protective local IgA and IgG antibody (Ab) responses. Interestingly, primary influenza virus infection induced long-lived increase of lung CD8(+) T cells and local lymphoproliferative responses. Pigs infected by a respiratory coronavirus (PRCV) showed virus-specific IgG Ab-secreting cells in the bronchial lymph nodes, whereas the transmissible gastroenteritis coronavirus (TGEV) induced more IgA Ab-secreting cells in gut tissues, which illustrates the importance of the route of antigen administration for inducing local immune effector mechanisms. Porcine viral infections provide, therefore, valuable models for evaluating the immune parameters that are important for controlling transmission of important viral zoonotic infections.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Charley</LastName>
<ForeName>Bernard</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>INRA, Virologie Immunologie moléculaires, 78350, Jouy-en-Josas, France. bernard.charley@jouy.inra.fr</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Riffault</LastName>
<ForeName>Sabine</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Van Reeth</LastName>
<ForeName>Kristien</ForeName>
<Initials>K</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Ann N Y Acad Sci</MedlineTA>
<NlmUniqueID>7506858</NlmUniqueID>
<ISSNLinking>0077-8923</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000917" MajorTopicYN="N">Antibody Formation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000921" MajorTopicYN="N">Antibody-Producing Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
<QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004197" MajorTopicYN="N">Disease Reservoirs</DescriptorName>
<QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005761" MajorTopicYN="N">Gastroenteritis, Transmissible, of Swine</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
<QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013553" MajorTopicYN="N">Swine Diseases</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName>
<QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName>
</MeshHeading>
</MeshHeadingList>
<NumberOfReferences>36</NumberOfReferences>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year>
<Month>12</Month>
<Day>1</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2007</Year>
<Month>4</Month>
<Day>21</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2006</Year>
<Month>12</Month>
<Day>1</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">17135502</ArticleId>
<ArticleId IdType="pii">1081/1/130</ArticleId>
<ArticleId IdType="doi">10.1196/annals.1373.014</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Jouy-en-Josas</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Riffault, Sabine" sort="Riffault, Sabine" uniqKey="Riffault S" first="Sabine" last="Riffault">Sabine Riffault</name>
<name sortKey="Van Reeth, Kristien" sort="Van Reeth, Kristien" uniqKey="Van Reeth K" first="Kristien" last="Van Reeth">Kristien Van Reeth</name>
</noCountry>
<country name="France"><region name="Île-de-France"><name sortKey="Charley, Bernard" sort="Charley, Bernard" uniqKey="Charley B" first="Bernard" last="Charley">Bernard Charley</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002066 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002066 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:17135502 |texte= Porcine innate and adaptative immune responses to influenza and coronavirus infections. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:17135502" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |