SrasV1, PubMed, Checkpoint, bibRecord, 002055

Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV.

Identifieur interne : 002055 ( PubMed/Checkpoint ); précédent : 002054; suivant : 002056

Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV.

Auteurs : Ian Brierley [Royaume-Uni] ; Francisco J. Dos Ramos

Source :

Virus research [ 0168-1702 ] ; 2006.

RBID : pubmed:16310880

Descripteurs français

KwdFr :
- ARN viral (génétique), ARN viral (métabolisme), Biosynthèse des protéines, Conformation d'acide nucléique, Données de séquences moléculaires, Décalage ribosomique du cadre de lecture, Humains, Régulation de l'expression des gènes viraux, Séquence nucléotidique, Séquences régulatrices de l'acide ribonucléique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (métabolisme), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (physiologie), Virus du SRAS (génétique), Virus du SRAS (métabolisme), Virus du SRAS (physiologie).
MESH :

English descriptors

KwdEn :
- Base Sequence, Frameshifting, Ribosomal, Gene Expression Regulation, Viral, HIV-1 (genetics), HIV-1 (metabolism), HIV-1 (physiology), Humans, Molecular Sequence Data, Nucleic Acid Conformation, Protein Biosynthesis, RNA, Viral (genetics), RNA, Viral (metabolism), Regulatory Sequences, Ribonucleic Acid, SARS Virus (genetics), SARS Virus (metabolism), SARS Virus (physiology).
MESH :
- chemical , genetics : RNA, Viral.
- genetics : HIV-1, SARS Virus.
- metabolism : HIV-1, RNA, Viral, SARS Virus.
- physiology : HIV-1, SARS Virus.
- Base Sequence, Frameshifting, Ribosomal, Gene Expression Regulation, Viral, Humans, Molecular Sequence Data, Nucleic Acid Conformation, Protein Biosynthesis, Regulatory Sequences, Ribonucleic Acid.

Abstract

Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type 1 (HIV-1) and the coronavirus responsible for severe acute respiratory syndrome (SARS). The nature of the frameshift signals of HIV-1 and the SARS-CoV will be described and the impact of this knowledge on models of frameshifting will be considered. The role of frameshifting in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed.

DOI: 10.1016/j.virusres.2005.10.008
PubMed: 16310880

Affiliations:

Links toward previous steps (curation, corpus...)

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pubmed:16310880

Le document en format XML

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Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV.

Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV.

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