SARS in Singapore--predictors of disease severity.
Identifieur interne : 002021 ( PubMed/Checkpoint ); précédent : 002020; suivant : 002022SARS in Singapore--predictors of disease severity.
Auteurs : Hoe-Nam Leong [Singapour] ; Arul Earnest ; Hong-Huay Lim ; Chee-Fang Chin ; Colin S H. Tan ; Mark E. Puhaindran ; Alex C H. Tan ; Mark I C. Chen ; Yee-Sin LeoSource :
- Annals of the Academy of Medicine, Singapore [ 0304-4602 ] ; 2006.
Descripteurs français
- KwdFr :
- ADN viral (analyse), Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (analyse), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Incidence, Indice de gravité médicale, Mâle, Nourrisson, RT-PCR, Singapour (épidémiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Taux de survie, Technique d'immunofluorescence, Virus du SRAS (génétique), Virus du SRAS (immunologie), Études rétrospectives.
- MESH :
- analyse : ADN viral, Anticorps antiviraux.
- génétique : Virus du SRAS.
- immunologie : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- épidémiologie : Singapour, Syndrome respiratoire aigu sévère.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Incidence, Indice de gravité médicale, Mâle, Nourrisson, RT-PCR, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Technique d'immunofluorescence, Études rétrospectives.
- Wicri :
- geographic : Singapour.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Viral (analysis), Child, Child, Preschool, DNA, Viral (analysis), Female, Fluorescent Antibody Technique, Humans, Incidence, Infant, Male, Middle Aged, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology), Severity of Illness Index, Singapore (epidemiology), Survival Rate.
- MESH :
- chemical , analysis : Antibodies, Viral, DNA, Viral.
- geographic , epidemiology : Singapore.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- immunology : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Fluorescent Antibody Technique, Humans, Incidence, Infant, Male, Middle Aged, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Severity of Illness Index, Survival Rate.
Abstract
Severe acute respiratory syndrome (SARS) affected 8096 individuals in 29 countries, with 774 deaths. In Singapore, there were 238 cases of SARS with 33 deaths. A retrospective analysis was performed to identify predictors of poor outcome in patients with SARS locally.
PubMed: 16829999
Affiliations:
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pubmed:16829999Le document en format XML
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) affected 8096 individuals in 29 countries, with 774 deaths. In Singapore, there were 238 cases of SARS with 33 deaths. A retrospective analysis was performed to identify predictors of poor outcome in patients with SARS locally.</div>
</front>
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<Month>11</Month>
<Day>15</Day>
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<JournalIssue CitedMedium="Print"><Volume>35</Volume>
<Issue>5</Issue>
<PubDate><Year>2006</Year>
<Month>May</Month>
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<Title>Annals of the Academy of Medicine, Singapore</Title>
<ISOAbbreviation>Ann. Acad. Med. Singap.</ISOAbbreviation>
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<ArticleTitle>SARS in Singapore--predictors of disease severity.</ArticleTitle>
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<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Severe acute respiratory syndrome (SARS) affected 8096 individuals in 29 countries, with 774 deaths. In Singapore, there were 238 cases of SARS with 33 deaths. A retrospective analysis was performed to identify predictors of poor outcome in patients with SARS locally.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Clinical, laboratory and outcome data of 234 patients admitted to Tan Tock Seng Hospital and Singapore General Hospital were collected and analysed. Only data collected at the time of admission were used in the analysis for predictors of poor outcome. Adverse events were defined as admission to the intensive care unit or death.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Clinical (temperature, FiO2) and laboratory [leukocyte, lymphocyte, neutrophil, platelet, lactate dehydrogenase (LDH), albumin] trends in groups with and without an adversarial event were presented. Fifty patients experienced an adverse event. On univariate analysis, male gender, advanced age, presence of comorbidities, neutrophilia, lymphopaenia, hyponatraemia, hypoalbuminaemia, transaminitis and elevated LDH or C-reactive protein were found to be significant predictors. On multivariate analysis, predictors of poor outcome were increased age [odds ratio (OR) 1.73 for every 10-year increase; 95% CI, 1.35 to 2.21], neutrophilia (OR 1.06 for every 1 x 10(9)/L increase; 95% CI, 1.02 to 1.11) and high LDH (OR 1.17 for every 100 U/L increase; 95% CI, 1.02 to 1.34). None of the 12 paediatric patients had an adverse event.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Advanced age, neutrophilia and high LDH predict poor outcomes in patients with SARS.</AbstractText>
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<ForeName>Chee-Fang</ForeName>
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<Author ValidYN="Y"><LastName>Tan</LastName>
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