Serveur d'exploration SRAS

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SARS in Singapore--predictors of disease severity.

Identifieur interne : 002021 ( PubMed/Checkpoint ); précédent : 002020; suivant : 002022

SARS in Singapore--predictors of disease severity.

Auteurs : Hoe-Nam Leong [Singapour] ; Arul Earnest ; Hong-Huay Lim ; Chee-Fang Chin ; Colin S H. Tan ; Mark E. Puhaindran ; Alex C H. Tan ; Mark I C. Chen ; Yee-Sin Leo

Source :

RBID : pubmed:16829999

Descripteurs français

English descriptors

Abstract

Severe acute respiratory syndrome (SARS) affected 8096 individuals in 29 countries, with 774 deaths. In Singapore, there were 238 cases of SARS with 33 deaths. A retrospective analysis was performed to identify predictors of poor outcome in patients with SARS locally.

PubMed: 16829999


Affiliations:


Links toward previous steps (curation, corpus...)


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pubmed:16829999

Le document en format XML

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<term>Aged, 80 and over</term>
<term>Antibodies, Viral (analysis)</term>
<term>Child</term>
<term>Child, Preschool</term>
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<term>Retrospective Studies</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
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<term>Singapore</term>
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<term>ADN viral</term>
<term>Anticorps antiviraux</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<term>SARS Virus</term>
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<term>Virus du SRAS</term>
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<term>Virus du SRAS</term>
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<term>SARS Virus</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Singapour</term>
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<term>Incidence</term>
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<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
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<term>Survival Rate</term>
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<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Indice de gravité médicale</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>RT-PCR</term>
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<term>Sujet âgé de 80 ans ou plus</term>
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<front>
<div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) affected 8096 individuals in 29 countries, with 774 deaths. In Singapore, there were 238 cases of SARS with 33 deaths. A retrospective analysis was performed to identify predictors of poor outcome in patients with SARS locally.</div>
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<Year>2006</Year>
<Month>11</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised>
<Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
</DateRevised>
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<Journal>
<ISSN IssnType="Print">0304-4602</ISSN>
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<Volume>35</Volume>
<Issue>5</Issue>
<PubDate>
<Year>2006</Year>
<Month>May</Month>
</PubDate>
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<Title>Annals of the Academy of Medicine, Singapore</Title>
<ISOAbbreviation>Ann. Acad. Med. Singap.</ISOAbbreviation>
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<ArticleTitle>SARS in Singapore--predictors of disease severity.</ArticleTitle>
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<Abstract>
<AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Severe acute respiratory syndrome (SARS) affected 8096 individuals in 29 countries, with 774 deaths. In Singapore, there were 238 cases of SARS with 33 deaths. A retrospective analysis was performed to identify predictors of poor outcome in patients with SARS locally.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Clinical, laboratory and outcome data of 234 patients admitted to Tan Tock Seng Hospital and Singapore General Hospital were collected and analysed. Only data collected at the time of admission were used in the analysis for predictors of poor outcome. Adverse events were defined as admission to the intensive care unit or death.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Clinical (temperature, FiO2) and laboratory [leukocyte, lymphocyte, neutrophil, platelet, lactate dehydrogenase (LDH), albumin] trends in groups with and without an adversarial event were presented. Fifty patients experienced an adverse event. On univariate analysis, male gender, advanced age, presence of comorbidities, neutrophilia, lymphopaenia, hyponatraemia, hypoalbuminaemia, transaminitis and elevated LDH or C-reactive protein were found to be significant predictors. On multivariate analysis, predictors of poor outcome were increased age [odds ratio (OR) 1.73 for every 10-year increase; 95% CI, 1.35 to 2.21], neutrophilia (OR 1.06 for every 1 x 10(9)/L increase; 95% CI, 1.02 to 1.11) and high LDH (OR 1.17 for every 100 U/L increase; 95% CI, 1.02 to 1.34). None of the 12 paediatric patients had an adverse event.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Advanced age, neutrophilia and high LDH predict poor outcomes in patients with SARS.</AbstractText>
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