Inhibition of SARS coronavirus helicase by bismuth complexes.
Identifieur interne : 001D78 ( PubMed/Checkpoint ); précédent : 001D77; suivant : 001D79Inhibition of SARS coronavirus helicase by bismuth complexes.
Auteurs : Nan Yang [République populaire de Chine] ; Julian A. Tanner ; Zai Wang ; Jian-Dong Huang ; Bo-Jian Zheng ; Nianyong Zhu ; Hongzhe SunSource :
- Chemical communications (Cambridge, England) [ 1359-7345 ] ; 2007.
Descripteurs français
- KwdFr :
- Adenosine triphosphatases (antagonistes et inhibiteurs), Antienzymes (pharmacologie), Antienzymes (synthèse chimique), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Bismuth (), Chromatographie en phase liquide à haute performance, Composés organométalliques (pharmacologie), Composés organométalliques (synthèse chimique), Cristallographie aux rayons X, Diméthylsulfoxyde, Helicase (antagonistes et inhibiteurs), Modèles moléculaires, Porphyrines (pharmacologie), Porphyrines (synthèse chimique), Virus du SRAS (enzymologie), Zinc ().
- MESH :
- antagonistes et inhibiteurs : Adenosine triphosphatases, Helicase.
- enzymologie : Virus du SRAS.
- pharmacologie : Antienzymes, Antiviraux, Composés organométalliques, Porphyrines.
- synthèse chimique : Antienzymes, Antiviraux, Composés organométalliques, Porphyrines.
- Bismuth, Chromatographie en phase liquide à haute performance, Cristallographie aux rayons X, Diméthylsulfoxyde, Modèles moléculaires, Zinc.
English descriptors
- KwdEn :
- Adenosine Triphosphatases (antagonists & inhibitors), Antiviral Agents (chemical synthesis), Antiviral Agents (pharmacology), Bismuth (chemistry), Chromatography, High Pressure Liquid, Crystallography, X-Ray, DNA Helicases (antagonists & inhibitors), Dimethyl Sulfoxide, Enzyme Inhibitors (chemical synthesis), Enzyme Inhibitors (pharmacology), Models, Molecular, Organometallic Compounds (chemical synthesis), Organometallic Compounds (pharmacology), Porphyrins (chemical synthesis), Porphyrins (pharmacology), SARS Virus (enzymology), Zinc (chemistry).
- MESH :
- chemical , antagonists & inhibitors : Adenosine Triphosphatases, DNA Helicases.
- chemical , chemical synthesis : Antiviral Agents, Enzyme Inhibitors, Organometallic Compounds, Porphyrins.
- chemical , chemistry : Bismuth, Zinc.
- chemical , pharmacology : Antiviral Agents, Enzyme Inhibitors, Organometallic Compounds, Porphyrins.
- enzymology : SARS Virus.
- Chromatography, High Pressure Liquid, Crystallography, X-Ray, Dimethyl Sulfoxide, Models, Molecular.
Abstract
A series of bismuth complexes were synthesized and characterized, and most of them exhibited inhibition against the SARS coronavirus helicase ATPase and duplex-unwinding activities at micromolar concentrations.
DOI: 10.1039/b709515e
PubMed: 17957304
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:17957304Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibition of SARS coronavirus helicase by bismuth complexes.</title>
<author><name sortKey="Yang, Nan" sort="Yang, Nan" uniqKey="Yang N" first="Nan" last="Yang">Nan Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong</wicri:regionArea>
<wicri:noRegion>Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tanner, Julian A" sort="Tanner, Julian A" uniqKey="Tanner J" first="Julian A" last="Tanner">Julian A. Tanner</name>
</author>
<author><name sortKey="Wang, Zai" sort="Wang, Zai" uniqKey="Wang Z" first="Zai" last="Wang">Zai Wang</name>
</author>
<author><name sortKey="Huang, Jian Dong" sort="Huang, Jian Dong" uniqKey="Huang J" first="Jian-Dong" last="Huang">Jian-Dong Huang</name>
</author>
<author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
</author>
<author><name sortKey="Zhu, Nianyong" sort="Zhu, Nianyong" uniqKey="Zhu N" first="Nianyong" last="Zhu">Nianyong Zhu</name>
</author>
<author><name sortKey="Sun, Hongzhe" sort="Sun, Hongzhe" uniqKey="Sun H" first="Hongzhe" last="Sun">Hongzhe Sun</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="RBID">pubmed:17957304</idno>
<idno type="pmid">17957304</idno>
<idno type="doi">10.1039/b709515e</idno>
<idno type="wicri:Area/PubMed/Corpus">001C93</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C93</idno>
<idno type="wicri:Area/PubMed/Curation">001C93</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C93</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001D78</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D78</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibition of SARS coronavirus helicase by bismuth complexes.</title>
<author><name sortKey="Yang, Nan" sort="Yang, Nan" uniqKey="Yang N" first="Nan" last="Yang">Nan Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong</wicri:regionArea>
<wicri:noRegion>Hong Kong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tanner, Julian A" sort="Tanner, Julian A" uniqKey="Tanner J" first="Julian A" last="Tanner">Julian A. Tanner</name>
</author>
<author><name sortKey="Wang, Zai" sort="Wang, Zai" uniqKey="Wang Z" first="Zai" last="Wang">Zai Wang</name>
</author>
<author><name sortKey="Huang, Jian Dong" sort="Huang, Jian Dong" uniqKey="Huang J" first="Jian-Dong" last="Huang">Jian-Dong Huang</name>
</author>
<author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
</author>
<author><name sortKey="Zhu, Nianyong" sort="Zhu, Nianyong" uniqKey="Zhu N" first="Nianyong" last="Zhu">Nianyong Zhu</name>
</author>
<author><name sortKey="Sun, Hongzhe" sort="Sun, Hongzhe" uniqKey="Sun H" first="Hongzhe" last="Sun">Hongzhe Sun</name>
</author>
</analytic>
<series><title level="j">Chemical communications (Cambridge, England)</title>
<idno type="ISSN">1359-7345</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Triphosphatases (antagonists & inhibitors)</term>
<term>Antiviral Agents (chemical synthesis)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Bismuth (chemistry)</term>
<term>Chromatography, High Pressure Liquid</term>
<term>Crystallography, X-Ray</term>
<term>DNA Helicases (antagonists & inhibitors)</term>
<term>Dimethyl Sulfoxide</term>
<term>Enzyme Inhibitors (chemical synthesis)</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>Models, Molecular</term>
<term>Organometallic Compounds (chemical synthesis)</term>
<term>Organometallic Compounds (pharmacology)</term>
<term>Porphyrins (chemical synthesis)</term>
<term>Porphyrins (pharmacology)</term>
<term>SARS Virus (enzymology)</term>
<term>Zinc (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adenosine triphosphatases (antagonistes et inhibiteurs)</term>
<term>Antienzymes (pharmacologie)</term>
<term>Antienzymes (synthèse chimique)</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (synthèse chimique)</term>
<term>Bismuth ()</term>
<term>Chromatographie en phase liquide à haute performance</term>
<term>Composés organométalliques (pharmacologie)</term>
<term>Composés organométalliques (synthèse chimique)</term>
<term>Cristallographie aux rayons X</term>
<term>Diméthylsulfoxyde</term>
<term>Helicase (antagonistes et inhibiteurs)</term>
<term>Modèles moléculaires</term>
<term>Porphyrines (pharmacologie)</term>
<term>Porphyrines (synthèse chimique)</term>
<term>Virus du SRAS (enzymologie)</term>
<term>Zinc ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Adenosine Triphosphatases</term>
<term>DNA Helicases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antiviral Agents</term>
<term>Enzyme Inhibitors</term>
<term>Organometallic Compounds</term>
<term>Porphyrins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Bismuth</term>
<term>Zinc</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Enzyme Inhibitors</term>
<term>Organometallic Compounds</term>
<term>Porphyrins</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Adenosine triphosphatases</term>
<term>Helicase</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antienzymes</term>
<term>Antiviraux</term>
<term>Composés organométalliques</term>
<term>Porphyrines</term>
</keywords>
<keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antienzymes</term>
<term>Antiviraux</term>
<term>Composés organométalliques</term>
<term>Porphyrines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Chromatography, High Pressure Liquid</term>
<term>Crystallography, X-Ray</term>
<term>Dimethyl Sulfoxide</term>
<term>Models, Molecular</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Bismuth</term>
<term>Chromatographie en phase liquide à haute performance</term>
<term>Cristallographie aux rayons X</term>
<term>Diméthylsulfoxyde</term>
<term>Modèles moléculaires</term>
<term>Zinc</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A series of bismuth complexes were synthesized and characterized, and most of them exhibited inhibition against the SARS coronavirus helicase ATPase and duplex-unwinding activities at micromolar concentrations.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17957304</PMID>
<DateCompleted><Year>2008</Year>
<Month>01</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1359-7345</ISSN>
<JournalIssue CitedMedium="Print"><Issue>42</Issue>
<PubDate><Year>2007</Year>
<Month>Nov</Month>
<Day>14</Day>
</PubDate>
</JournalIssue>
<Title>Chemical communications (Cambridge, England)</Title>
<ISOAbbreviation>Chem. Commun. (Camb.)</ISOAbbreviation>
</Journal>
<ArticleTitle>Inhibition of SARS coronavirus helicase by bismuth complexes.</ArticleTitle>
<Pagination><MedlinePgn>4413-5</MedlinePgn>
</Pagination>
<Abstract><AbstractText>A series of bismuth complexes were synthesized and characterized, and most of them exhibited inhibition against the SARS coronavirus helicase ATPase and duplex-unwinding activities at micromolar concentrations.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Nan</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tanner</LastName>
<ForeName>Julian A</ForeName>
<Initials>JA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Zai</ForeName>
<Initials>Z</Initials>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Jian-Dong</ForeName>
<Initials>JD</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Bo-Jian</ForeName>
<Initials>BJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Nianyong</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Hongzhe</ForeName>
<Initials>H</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2007</Year>
<Month>08</Month>
<Day>16</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Chem Commun (Camb)</MedlineTA>
<NlmUniqueID>9610838</NlmUniqueID>
<ISSNLinking>1359-7345</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004791">Enzyme Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009942">Organometallic Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011166">Porphyrins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber>
<NameOfSubstance UI="D000251">Adenosine Triphosphatases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.4.-</RegistryNumber>
<NameOfSubstance UI="D004265">DNA Helicases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>J41CSQ7QDS</RegistryNumber>
<NameOfSubstance UI="D015032">Zinc</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>U015TT5I8H</RegistryNumber>
<NameOfSubstance UI="D001729">Bismuth</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>YOW8V9698H</RegistryNumber>
<NameOfSubstance UI="D004121">Dimethyl Sulfoxide</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000251" MajorTopicYN="N">Adenosine Triphosphatases</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001729" MajorTopicYN="N">Bismuth</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018360" MajorTopicYN="N">Crystallography, X-Ray</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004265" MajorTopicYN="N">DNA Helicases</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004121" MajorTopicYN="N">Dimethyl Sulfoxide</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009942" MajorTopicYN="N">Organometallic Compounds</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011166" MajorTopicYN="N">Porphyrins</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015032" MajorTopicYN="N">Zinc</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year>
<Month>10</Month>
<Day>25</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2008</Year>
<Month>1</Month>
<Day>24</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2007</Year>
<Month>10</Month>
<Day>25</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">17957304</ArticleId>
<ArticleId IdType="doi">10.1039/b709515e</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><noCountry><name sortKey="Huang, Jian Dong" sort="Huang, Jian Dong" uniqKey="Huang J" first="Jian-Dong" last="Huang">Jian-Dong Huang</name>
<name sortKey="Sun, Hongzhe" sort="Sun, Hongzhe" uniqKey="Sun H" first="Hongzhe" last="Sun">Hongzhe Sun</name>
<name sortKey="Tanner, Julian A" sort="Tanner, Julian A" uniqKey="Tanner J" first="Julian A" last="Tanner">Julian A. Tanner</name>
<name sortKey="Wang, Zai" sort="Wang, Zai" uniqKey="Wang Z" first="Zai" last="Wang">Zai Wang</name>
<name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
<name sortKey="Zhu, Nianyong" sort="Zhu, Nianyong" uniqKey="Zhu N" first="Nianyong" last="Zhu">Nianyong Zhu</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Yang, Nan" sort="Yang, Nan" uniqKey="Yang N" first="Nan" last="Yang">Nan Yang</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D78 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001D78 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:17957304 |texte= Inhibition of SARS coronavirus helicase by bismuth complexes. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:17957304" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |