SrasV1, PubMed, Checkpoint, bibRecord, 001D62

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.

Identifieur interne : 001D62 ( PubMed/Checkpoint ); précédent : 001D61; suivant : 001D63

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.

Auteurs : Paul B. Mccray [États-Unis] ; Lecia Pewe ; Christine Wohlford-Lenane ; Melissa Hickey ; Lori Manzel ; Lei Shi ; Jason Netland ; Hong Peng Jia ; Carmen Halabi ; Curt D. Sigmund ; David K. Meyerholz ; Patricia Kirby ; Dwight C. Look ; Stanley Perlman

Source :

Journal of virology [ 0022-538X ] ; 2007.

RBID : pubmed:17079315

Descripteurs français

KwdFr :
- Animaux, Cellules épithéliales (anatomopathologie), Cellules épithéliales (virologie), Encéphale (anatomopathologie), Encéphale (cytologie), Encéphale (virologie), Humains, Kératine-18 (génétique), Kératine-18 (métabolisme), Modèles animaux de maladie humaine, Peptidyl-Dipeptidase A (génétique), Peptidyl-Dipeptidase A (métabolisme), Poumon (anatomopathologie), Poumon (cytologie), Poumon (virologie), Souris, Souris de lignée C57BL, Souris transgéniques, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (mortalité), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (pathogénicité).
MESH :
- anatomopathologie : Cellules épithéliales, Encéphale, Poumon, Syndrome respiratoire aigu sévère.
- cytologie : Encéphale, Poumon.
- génétique : Kératine-18, Peptidyl-Dipeptidase A.
- mortalité : Syndrome respiratoire aigu sévère.
- métabolisme : Kératine-18, Peptidyl-Dipeptidase A.
- pathogénicité : Virus du SRAS.
- virologie : Cellules épithéliales, Encéphale, Poumon, Syndrome respiratoire aigu sévère.
- Animaux, Humains, Modèles animaux de maladie humaine, Souris, Souris de lignée C57BL, Souris transgéniques.

English descriptors

KwdEn :
- Animals, Brain (cytology), Brain (pathology), Brain (virology), Disease Models, Animal, Epithelial Cells (pathology), Epithelial Cells (virology), Humans, Keratin-18 (genetics), Keratin-18 (metabolism), Lung (cytology), Lung (pathology), Lung (virology), Mice, Mice, Inbred C57BL, Mice, Transgenic, Peptidyl-Dipeptidase A (genetics), Peptidyl-Dipeptidase A (metabolism), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology).
MESH :
- chemical , genetics : Keratin-18, Peptidyl-Dipeptidase A.
- cytology : Brain, Lung.
- chemical , metabolism : Keratin-18, Peptidyl-Dipeptidase A.
- mortality : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- pathology : Brain, Epithelial Cells, Lung, Severe Acute Respiratory Syndrome.
- virology : Brain, Epithelial Cells, Lung, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic.

Abstract

The severe acute respiratory syndrome (SARS), caused by a novel coronavirus (SARS-CoV), resulted in substantial morbidity, mortality, and economic losses during the 2003 epidemic. While SARS-CoV infection has not recurred to a significant extent since 2003, it still remains a potential threat. Understanding of SARS and development of therapeutic approaches have been hampered by the absence of an animal model that mimics the human disease and is reproducible. Here we show that transgenic mice that express the SARS-CoV receptor (human angiotensin-converting enzyme 2 [hACE2]) in airway and other epithelia develop a rapidly lethal infection after intranasal inoculation with a human strain of the virus. Infection begins in airway epithelia, with subsequent alveolar involvement and extrapulmonary virus spread to the brain. Infection results in macrophage and lymphocyte infiltration in the lungs and upregulation of proinflammatory cytokines and chemokines in both the lung and the brain. This model of lethal infection with SARS-CoV should be useful for studies of pathogenesis and for the development of antiviral therapies.

DOI: 10.1128/JVI.02012-06
PubMed: 17079315

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002000
to stream PubMed, to step Curation: 002000

Links to Exploration step

pubmed:17079315

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.</title>
<author><name sortKey="Mccray, Paul B" sort="Mccray, Paul B" uniqKey="Mccray P" first="Paul B" last="Mccray">Paul B. Mccray</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. Paul-McCray@uiowa.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Iowa, Iowa City, IA 52242</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Pewe, Lecia" sort="Pewe, Lecia" uniqKey="Pewe L" first="Lecia" last="Pewe">Lecia Pewe</name>
</author>
<author><name sortKey="Wohlford Lenane, Christine" sort="Wohlford Lenane, Christine" uniqKey="Wohlford Lenane C" first="Christine" last="Wohlford-Lenane">Christine Wohlford-Lenane</name>
</author>
<author><name sortKey="Hickey, Melissa" sort="Hickey, Melissa" uniqKey="Hickey M" first="Melissa" last="Hickey">Melissa Hickey</name>
</author>
<author><name sortKey="Manzel, Lori" sort="Manzel, Lori" uniqKey="Manzel L" first="Lori" last="Manzel">Lori Manzel</name>
</author>
<author><name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name>
</author>
<author><name sortKey="Netland, Jason" sort="Netland, Jason" uniqKey="Netland J" first="Jason" last="Netland">Jason Netland</name>
</author>
<author><name sortKey="Jia, Hong Peng" sort="Jia, Hong Peng" uniqKey="Jia H" first="Hong Peng" last="Jia">Hong Peng Jia</name>
</author>
<author><name sortKey="Halabi, Carmen" sort="Halabi, Carmen" uniqKey="Halabi C" first="Carmen" last="Halabi">Carmen Halabi</name>
</author>
<author><name sortKey="Sigmund, Curt D" sort="Sigmund, Curt D" uniqKey="Sigmund C" first="Curt D" last="Sigmund">Curt D. Sigmund</name>
</author>
<author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name>
</author>
<author><name sortKey="Kirby, Patricia" sort="Kirby, Patricia" uniqKey="Kirby P" first="Patricia" last="Kirby">Patricia Kirby</name>
</author>
<author><name sortKey="Look, Dwight C" sort="Look, Dwight C" uniqKey="Look D" first="Dwight C" last="Look">Dwight C. Look</name>
</author>
<author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="RBID">pubmed:17079315</idno>
<idno type="pmid">17079315</idno>
<idno type="doi">10.1128/JVI.02012-06</idno>
<idno type="wicri:Area/PubMed/Corpus">002000</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002000</idno>
<idno type="wicri:Area/PubMed/Curation">002000</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002000</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001D62</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D62</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.</title>
<author><name sortKey="Mccray, Paul B" sort="Mccray, Paul B" uniqKey="Mccray P" first="Paul B" last="Mccray">Paul B. Mccray</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. Paul-McCray@uiowa.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, University of Iowa, Iowa City, IA 52242</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Pewe, Lecia" sort="Pewe, Lecia" uniqKey="Pewe L" first="Lecia" last="Pewe">Lecia Pewe</name>
</author>
<author><name sortKey="Wohlford Lenane, Christine" sort="Wohlford Lenane, Christine" uniqKey="Wohlford Lenane C" first="Christine" last="Wohlford-Lenane">Christine Wohlford-Lenane</name>
</author>
<author><name sortKey="Hickey, Melissa" sort="Hickey, Melissa" uniqKey="Hickey M" first="Melissa" last="Hickey">Melissa Hickey</name>
</author>
<author><name sortKey="Manzel, Lori" sort="Manzel, Lori" uniqKey="Manzel L" first="Lori" last="Manzel">Lori Manzel</name>
</author>
<author><name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name>
</author>
<author><name sortKey="Netland, Jason" sort="Netland, Jason" uniqKey="Netland J" first="Jason" last="Netland">Jason Netland</name>
</author>
<author><name sortKey="Jia, Hong Peng" sort="Jia, Hong Peng" uniqKey="Jia H" first="Hong Peng" last="Jia">Hong Peng Jia</name>
</author>
<author><name sortKey="Halabi, Carmen" sort="Halabi, Carmen" uniqKey="Halabi C" first="Carmen" last="Halabi">Carmen Halabi</name>
</author>
<author><name sortKey="Sigmund, Curt D" sort="Sigmund, Curt D" uniqKey="Sigmund C" first="Curt D" last="Sigmund">Curt D. Sigmund</name>
</author>
<author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name>
</author>
<author><name sortKey="Kirby, Patricia" sort="Kirby, Patricia" uniqKey="Kirby P" first="Patricia" last="Kirby">Patricia Kirby</name>
</author>
<author><name sortKey="Look, Dwight C" sort="Look, Dwight C" uniqKey="Look D" first="Dwight C" last="Look">Dwight C. Look</name>
</author>
<author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name>
</author>
</analytic>
<series><title level="j">Journal of virology</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Brain (cytology)</term>
<term>Brain (pathology)</term>
<term>Brain (virology)</term>
<term>Disease Models, Animal</term>
<term>Epithelial Cells (pathology)</term>
<term>Epithelial Cells (virology)</term>
<term>Humans</term>
<term>Keratin-18 (genetics)</term>
<term>Keratin-18 (metabolism)</term>
<term>Lung (cytology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
<term>Peptidyl-Dipeptidase A (genetics)</term>
<term>Peptidyl-Dipeptidase A (metabolism)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (mortality)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules épithéliales (anatomopathologie)</term>
<term>Cellules épithéliales (virologie)</term>
<term>Encéphale (anatomopathologie)</term>
<term>Encéphale (cytologie)</term>
<term>Encéphale (virologie)</term>
<term>Humains</term>
<term>Kératine-18 (génétique)</term>
<term>Kératine-18 (métabolisme)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Peptidyl-Dipeptidase A (génétique)</term>
<term>Peptidyl-Dipeptidase A (métabolisme)</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (cytologie)</term>
<term>Poumon (virologie)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris transgéniques</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (mortalité)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Keratin-18</term>
<term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Encéphale</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Encéphale</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Brain</term>
<term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Kératine-18</term>
<term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Keratin-18</term>
<term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Kératine-18</term>
<term>Peptidyl-Dipeptidase A</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Epithelial Cells</term>
<term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Encéphale</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Brain</term>
<term>Epithelial Cells</term>
<term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Transgenic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris transgéniques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The severe acute respiratory syndrome (SARS), caused by a novel coronavirus (SARS-CoV), resulted in substantial morbidity, mortality, and economic losses during the 2003 epidemic. While SARS-CoV infection has not recurred to a significant extent since 2003, it still remains a potential threat. Understanding of SARS and development of therapeutic approaches have been hampered by the absence of an animal model that mimics the human disease and is reproducible. Here we show that transgenic mice that express the SARS-CoV receptor (human angiotensin-converting enzyme 2 [hACE2]) in airway and other epithelia develop a rapidly lethal infection after intranasal inoculation with a human strain of the virus. Infection begins in airway epithelia, with subsequent alveolar involvement and extrapulmonary virus spread to the brain. Infection results in macrophage and lymphocyte infiltration in the lungs and upregulation of proinflammatory cytokines and chemokines in both the lung and the brain. This model of lethal infection with SARS-CoV should be useful for studies of pathogenesis and for the development of antiviral therapies.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17079315</PMID>
<DateCompleted><Year>2007</Year>
<Month>02</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0022-538X</ISSN>
<JournalIssue CitedMedium="Print"><Volume>81</Volume>
<Issue>2</Issue>
<PubDate><Year>2007</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Journal of virology</Title>
<ISOAbbreviation>J. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.</ArticleTitle>
<Pagination><MedlinePgn>813-21</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The severe acute respiratory syndrome (SARS), caused by a novel coronavirus (SARS-CoV), resulted in substantial morbidity, mortality, and economic losses during the 2003 epidemic. While SARS-CoV infection has not recurred to a significant extent since 2003, it still remains a potential threat. Understanding of SARS and development of therapeutic approaches have been hampered by the absence of an animal model that mimics the human disease and is reproducible. Here we show that transgenic mice that express the SARS-CoV receptor (human angiotensin-converting enzyme 2 [hACE2]) in airway and other epithelia develop a rapidly lethal infection after intranasal inoculation with a human strain of the virus. Infection begins in airway epithelia, with subsequent alveolar involvement and extrapulmonary virus spread to the brain. Infection results in macrophage and lymphocyte infiltration in the lungs and upregulation of proinflammatory cytokines and chemokines in both the lung and the brain. This model of lethal infection with SARS-CoV should be useful for studies of pathogenesis and for the development of antiviral therapies.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McCray</LastName>
<ForeName>Paul B</ForeName>
<Initials>PB</Initials>
<Suffix>Jr</Suffix>
<AffiliationInfo><Affiliation>Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. Paul-McCray@uiowa.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pewe</LastName>
<ForeName>Lecia</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wohlford-Lenane</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hickey</LastName>
<ForeName>Melissa</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Manzel</LastName>
<ForeName>Lori</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Netland</LastName>
<ForeName>Jason</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Jia</LastName>
<ForeName>Hong Peng</ForeName>
<Initials>HP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Halabi</LastName>
<ForeName>Carmen</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sigmund</LastName>
<ForeName>Curt D</ForeName>
<Initials>CD</Initials>
</Author>
<Author ValidYN="Y"><LastName>Meyerholz</LastName>
<ForeName>David K</ForeName>
<Initials>DK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kirby</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Look</LastName>
<ForeName>Dwight C</ForeName>
<Initials>DC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Perlman</LastName>
<ForeName>Stanley</ForeName>
<Initials>S</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 DK-54759</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 AI060699</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P30 DK054759</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>T32 GM007337</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P01 AI060699-02</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2006</Year>
<Month>11</Month>
<Day>01</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Virol</MedlineTA>
<NlmUniqueID>0113724</NlmUniqueID>
<ISSNLinking>0022-538X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D053538">Keratin-18</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber>
<NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="Y">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053538" MajorTopicYN="N">Keratin-18</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007703" MajorTopicYN="N">Peptidyl-Dipeptidase A</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year>
<Month>11</Month>
<Day>3</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2007</Year>
<Month>2</Month>
<Day>3</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2006</Year>
<Month>11</Month>
<Day>3</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">17079315</ArticleId>
<ArticleId IdType="pii">JVI.02012-06</ArticleId>
<ArticleId IdType="doi">10.1128/JVI.02012-06</ArticleId>
<ArticleId IdType="pmc">PMC1797474</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14695-700</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9405675</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 Oct 10;302(5643):276-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12958366</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2004 Dec 5;330(1):8-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15527829</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2004 Dec;10(12 Suppl):S88-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15577937</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2005 Feb 15;191(4):507-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15655773</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Feb;79(4):2079-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15681410</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15657466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Jun;79(12):7819-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15919935</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8275-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15919828</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Peptides. 2005 Jul;26(7):1270-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15949646</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Virol. 2005 Aug;150(8):1653-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15841337</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2005 Aug 1;202(3):415-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16043521</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Sep;79(17):11335-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16103185</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2005 Oct 15;41(8):1089-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16163626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2005 Oct 1;106(7):2366-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15860669</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14040-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16169905</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2005 Oct 28;310(5748):676-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16195424</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Dec;79(23):14614-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16282461</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2003 Nov 27;426(6965):450-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14647384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Apr;78(7):3572-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15016880</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Exp Immunol. 2004 Apr;136(1):95-103</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15030519</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pathol. 2004 Jun;203(2):622-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15141376</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pathol. 2004 Jun;203(2):631-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15141377</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 2004 Aug;72(8):4410-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15271897</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2004 Sep 15;173(6):4030-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15356152</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Oct;78(20):11429-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15452268</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2004 Oct 1;39(7):1071-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15472864</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2004 Oct 15;39(8):1247-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15486852</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biotechniques. 2004 Oct;37(4):610-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15517974</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Chem. 2005 Dec;51(12):2333-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16195357</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Dec;79(24):15511-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16306622</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2006 Mar 1;193(5):685-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16453264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Med. 2006 Feb;3(2):e27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16379499</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Microbiol. 2006 Jul;14(7):299-303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16759866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Res. 2000 Aug;48(2):184-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10926293</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1977-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12671062</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2003 May 24;361(9371):1773-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12781536</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Pathol. 2003 Aug;34(8):743-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14506633</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroscience. 1993 Dec;57(4):1007-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8309541</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Iowa</li>
</region>
<settlement><li>Iowa City</li>
</settlement>
<orgName><li>Université de l'Iowa</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Halabi, Carmen" sort="Halabi, Carmen" uniqKey="Halabi C" first="Carmen" last="Halabi">Carmen Halabi</name>
<name sortKey="Hickey, Melissa" sort="Hickey, Melissa" uniqKey="Hickey M" first="Melissa" last="Hickey">Melissa Hickey</name>
<name sortKey="Jia, Hong Peng" sort="Jia, Hong Peng" uniqKey="Jia H" first="Hong Peng" last="Jia">Hong Peng Jia</name>
<name sortKey="Kirby, Patricia" sort="Kirby, Patricia" uniqKey="Kirby P" first="Patricia" last="Kirby">Patricia Kirby</name>
<name sortKey="Look, Dwight C" sort="Look, Dwight C" uniqKey="Look D" first="Dwight C" last="Look">Dwight C. Look</name>
<name sortKey="Manzel, Lori" sort="Manzel, Lori" uniqKey="Manzel L" first="Lori" last="Manzel">Lori Manzel</name>
<name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name>
<name sortKey="Netland, Jason" sort="Netland, Jason" uniqKey="Netland J" first="Jason" last="Netland">Jason Netland</name>
<name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name>
<name sortKey="Pewe, Lecia" sort="Pewe, Lecia" uniqKey="Pewe L" first="Lecia" last="Pewe">Lecia Pewe</name>
<name sortKey="Shi, Lei" sort="Shi, Lei" uniqKey="Shi L" first="Lei" last="Shi">Lei Shi</name>
<name sortKey="Sigmund, Curt D" sort="Sigmund, Curt D" uniqKey="Sigmund C" first="Curt D" last="Sigmund">Curt D. Sigmund</name>
<name sortKey="Wohlford Lenane, Christine" sort="Wohlford Lenane, Christine" uniqKey="Wohlford Lenane C" first="Christine" last="Wohlford-Lenane">Christine Wohlford-Lenane</name>
</noCountry>
<country name="États-Unis"><region name="Iowa"><name sortKey="Mccray, Paul B" sort="Mccray, Paul B" uniqKey="Mccray P" first="Paul B" last="Mccray">Paul B. Mccray</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D62 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001D62 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:17079315
   |texte=   Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:17079315" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki