Pathology and pathogenesis of severe acute respiratory syndrome.
Identifieur interne : 001D43 ( PubMed/Checkpoint ); précédent : 001D42; suivant : 001D44Pathology and pathogenesis of severe acute respiratory syndrome.
Auteurs : Jiang Gu [République populaire de Chine] ; Christine KortewegSource :
- The American journal of pathology [ 0002-9440 ] ; 2007.
Descripteurs français
- KwdFr :
- Antigène HLA-B7, Antigènes HLA-B (génétique), Antigènes HLA-DR (génétique), Chaines HLA-DRB1, Chimiokines (immunologie), Cytokines (immunologie), Humains, Immunité innée (immunologie), Modèles biologiques, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (immunologie).
- MESH :
- anatomopathologie : Syndrome respiratoire aigu sévère.
- génétique : Antigènes HLA-B, Antigènes HLA-DR, Syndrome respiratoire aigu sévère.
- immunologie : Chimiokines, Cytokines, Immunité innée, Syndrome respiratoire aigu sévère.
- Antigène HLA-B7, Chaines HLA-DRB1, Humains, Modèles biologiques.
English descriptors
- KwdEn :
- Chemokines (immunology), Cytokines (immunology), HLA-B Antigens (genetics), HLA-B7 Antigen, HLA-DR Antigens (genetics), HLA-DRB1 Chains, Humans, Immunity, Innate (immunology), Models, Biological, Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (pathology).
- MESH :
- chemical , genetics : HLA-B Antigens, HLA-DR Antigens.
- chemical , immunology : Chemokines, Cytokines.
- chemical : HLA-B7 Antigen, HLA-DRB1 Chains.
- genetics : Severe Acute Respiratory Syndrome.
- immunology : Immunity, Innate, Severe Acute Respiratory Syndrome.
- pathology : Severe Acute Respiratory Syndrome.
- Humans, Models, Biological.
Abstract
Severe acute respiratory syndrome (SARS) is an emerging infectious viral disease characterized by severe clinical manifestations of the lower respiratory tract. The pathogenesis of SARS is highly complex, with multiple factors leading to severe injury in the lungs and dissemination of the virus to several other organs. The SARS coronavirus targets the epithelial cells of the respiratory tract, resulting in diffuse alveolar damage. Several organs/cell types may be infected in the course of the illness, including mucosal cells of the intestines, tubular epithelial cells of the kidneys, neurons of the brain, and several types of immune cells, and certain organs may suffer from indirect injury. Extensive studies have provided a basic understanding of the pathogenesis of this disease. In this review we describe the most significant pathological features of SARS, explore the etiological factors causing these pathological changes, and discuss the major pathogenetic mechanisms. The latter include dysregulation of cytokines/chemokines, deficiencies in the innate immune response, direct infection of immune cells, direct viral cytopathic effects, down-regulation of lung protective angiotensin converting enzyme 2, autoimmunity, and genetic factors. It seems that both abnormal immune responses and injury to immune cells may be key factors in the pathogenesis of this new disease.
DOI: 10.2353/ajpath.2007.061088
PubMed: 17392154
Affiliations:
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qualifier="immunologie" xml:lang="fr"><term>Chimiokines</term><term>Cytokines</term><term>Immunité innée</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immunity, Innate</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Models, Biological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antigène HLA-B7</term><term>Chaines HLA-DRB1</term><term>Humains</term><term>Modèles biologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is an emerging infectious viral disease characterized by severe clinical manifestations of the lower respiratory tract. The pathogenesis of SARS is highly complex, with multiple factors leading to severe injury in the lungs and dissemination of the virus to several other organs. The SARS coronavirus targets the epithelial cells of the respiratory tract, resulting in diffuse alveolar damage. Several organs/cell types may be infected in the course of the illness, including mucosal cells of the intestines, tubular epithelial cells of the kidneys, neurons of the brain, and several types of immune cells, and certain organs may suffer from indirect injury. Extensive studies have provided a basic understanding of the pathogenesis of this disease. In this review we describe the most significant pathological features of SARS, explore the etiological factors causing these pathological changes, and discuss the major pathogenetic mechanisms. The latter include dysregulation of cytokines/chemokines, deficiencies in the innate immune response, direct infection of immune cells, direct viral cytopathic effects, down-regulation of lung protective angiotensin converting enzyme 2, autoimmunity, and genetic factors. It seems that both abnormal immune responses and injury to immune cells may be key factors in the pathogenesis of this new disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17392154</PMID><DateCompleted><Year>2007</Year><Month>05</Month><Day>04</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9440</ISSN><JournalIssue CitedMedium="Print"><Volume>170</Volume><Issue>4</Issue><PubDate><Year>2007</Year><Month>Apr</Month></PubDate></JournalIssue><Title>The American journal of pathology</Title><ISOAbbreviation>Am. J. Pathol.</ISOAbbreviation></Journal><ArticleTitle>Pathology and pathogenesis of severe acute respiratory syndrome.</ArticleTitle><Pagination><MedlinePgn>1136-47</MedlinePgn></Pagination><Abstract><AbstractText>Severe acute respiratory syndrome (SARS) is an emerging infectious viral disease characterized by severe clinical manifestations of the lower respiratory tract. The pathogenesis of SARS is highly complex, with multiple factors leading to severe injury in the lungs and dissemination of the virus to several other organs. The SARS coronavirus targets the epithelial cells of the respiratory tract, resulting in diffuse alveolar damage. Several organs/cell types may be infected in the course of the illness, including mucosal cells of the intestines, tubular epithelial cells of the kidneys, neurons of the brain, and several types of immune cells, and certain organs may suffer from indirect injury. Extensive studies have provided a basic understanding of the pathogenesis of this disease. In this review we describe the most significant pathological features of SARS, explore the etiological factors causing these pathological changes, and discuss the major pathogenetic mechanisms. The latter include dysregulation of cytokines/chemokines, deficiencies in the innate immune response, direct infection of immune cells, direct viral cytopathic effects, down-regulation of lung protective angiotensin converting enzyme 2, autoimmunity, and genetic factors. 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