Inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses.
Identifieur interne : 001857 ( PubMed/Checkpoint ); précédent : 001856; suivant : 001858Inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses.
Auteurs : James A. Wiley [États-Unis] ; Laura E. Richert ; Steve D. Swain ; Ann Harmsen ; Dale L. Barnard ; Troy D. Randall ; Mark Jutila ; Trevor Douglas ; Chris Broomell ; Mark Young ; Allen HarmsenSource :
- PloS one [ 1932-6203 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Bronches (microbiologie), Bronches (métabolisme), Bronches (virologie), Coxiella burnetii (métabolisme), Femelle, Liquide de lavage bronchoalvéolaire, Mâle, Nanoparticules (), Nanotechnologie (), Orthomyxoviridae (métabolisme), Pneumovirus (métabolisme), Poumon (immunologie), Poumon (microbiologie), Poumon (virologie), Souris, Souris de lignée BALB C, Souris de lignée C3H, Tissu lymphoïde (métabolisme), Virus du SRAS (métabolisme).
- MESH :
- immunologie : Poumon.
- microbiologie : Bronches, Poumon.
- métabolisme : Bronches, Coxiella burnetii, Orthomyxoviridae, Pneumovirus, Tissu lymphoïde, Virus du SRAS.
- virologie : Bronches, Poumon.
- Animaux, Femelle, Liquide de lavage bronchoalvéolaire, Mâle, Nanoparticules, Nanotechnologie, Souris, Souris de lignée BALB C, Souris de lignée C3H.
English descriptors
- KwdEn :
- Animals, Bronchi (metabolism), Bronchi (microbiology), Bronchi (virology), Bronchoalveolar Lavage Fluid, Coxiella burnetii (metabolism), Female, Infections (pathology), Lung (immunology), Lung (microbiology), Lung (virology), Lymphoid Tissue (metabolism), Male, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Nanoparticles (chemistry), Nanotechnology (methods), Orthomyxoviridae (metabolism), Pneumovirus (metabolism), SARS Virus (metabolism).
- MESH :
- chemistry : Nanoparticles.
- immunology : Lung.
- metabolism : Bronchi, Coxiella burnetii, Lymphoid Tissue, Orthomyxoviridae, Pneumovirus, SARS Virus.
- methods : Nanotechnology.
- microbiology : Bronchi, Lung.
- pathology : Infections.
- virology : Bronchi, Lung.
- Animals, Bronchoalveolar Lavage Fluid, Female, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C3H.
Abstract
Destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated inflammation associated with the recruitment of immune responses. The presence of antigenically disparate pulmonary viruses and the emergence of novel viruses assures the recurrence of lung damage with infection and resolution of each primary viral infection. Thus, there is a need to develop safe broad spectrum immunoprophylactic strategies capable of enhancing protective immune responses in the lung but which limits immune-mediated lung damage. The immunoprophylactic strategy described here utilizes a protein cage nanoparticle (PCN) to significantly accelerate clearance of diverse respiratory viruses after primary infection and also results in a host immune response that causes less lung damage.
DOI: 10.1371/journal.pone.0007142
PubMed: 19774076
Affiliations:
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Links to Exploration step
pubmed:19774076Le document en format XML
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The presence of antigenically disparate pulmonary viruses and the emergence of novel viruses assures the recurrence of lung damage with infection and resolution of each primary viral infection. Thus, there is a need to develop safe broad spectrum immunoprophylactic strategies capable of enhancing protective immune responses in the lung but which limits immune-mediated lung damage. The immunoprophylactic strategy described here utilizes a protein cage nanoparticle (PCN) to significantly accelerate clearance of diverse respiratory viruses after primary infection and also results in a host immune response that causes less lung damage.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19774076</PMID><DateCompleted><Year>2010</Year><Month>02</Month><Day>01</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><Issue>9</Issue><PubDate><Year>2009</Year><Month>Sep</Month><Day>23</Day></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Inducible bronchus-associated lymphoid tissue elicited by a protein cage nanoparticle enhances protection in mice against diverse respiratory viruses.</ArticleTitle><Pagination><MedlinePgn>e7142</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0007142</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Destruction of the architectural and subsequently the functional integrity of the lung following pulmonary viral infections is attributable to both the extent of pathogen replication and to the host-generated inflammation associated with the recruitment of immune responses. The presence of antigenically disparate pulmonary viruses and the emergence of novel viruses assures the recurrence of lung damage with infection and resolution of each primary viral infection. Thus, there is a need to develop safe broad spectrum immunoprophylactic strategies capable of enhancing protective immune responses in the lung but which limits immune-mediated lung damage. The immunoprophylactic strategy described here utilizes a protein cage nanoparticle (PCN) to significantly accelerate clearance of diverse respiratory viruses after primary infection and also results in a host immune response that causes less lung damage.</AbstractText><AbstractText Label="METHODOLOGY/PRINCIPAL FINDINGS" NlmCategory="RESULTS">Mice pre-treated with PCN, independent of any specific viral antigens, were protected against both sub-lethal and lethal doses of two different influenza viruses, a mouse-adapted SARS-coronavirus, or mouse pneumovirus. Treatment with PCN significantly increased survival and was marked by enhanced viral clearance, accelerated induction of viral-specific antibody production, and significant decreases in morbidity and lung damage. The enhanced protection appears to be dependent upon the prior development of inducible bronchus-associated lymphoid tissue (iBALT) in the lung in response to the PCN treatment and to be mediated through CD4+ T cell and B cell dependent mechanisms.</AbstractText><AbstractText Label="CONCLUSIONS/SIGNIFICANCE" NlmCategory="CONCLUSIONS">The immunoprophylactic strategy described utilizes an infection-independent induction of naturally occurring iBALT prior to infection by a pulmonary viral pathogen. This strategy non-specifically enhances primary immunity to respiratory viruses and is not restricted by the antigen specificities inherent in typical vaccination strategies. PCN treatment is asymptomatic in its application and importantly, ameliorates the damaging inflammation normally associated with the recruitment of immune responses into the lung.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wiley</LastName><ForeName>James A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America. jwiley@montana.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richert</LastName><ForeName>Laura E</ForeName><Initials>LE</Initials></Author><Author ValidYN="Y"><LastName>Swain</LastName><ForeName>Steve D</ForeName><Initials>SD</Initials></Author><Author ValidYN="Y"><LastName>Harmsen</LastName><ForeName>Ann</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Barnard</LastName><ForeName>Dale L</ForeName><Initials>DL</Initials></Author><Author ValidYN="Y"><LastName>Randall</LastName><ForeName>Troy D</ForeName><Initials>TD</Initials></Author><Author ValidYN="Y"><LastName>Jutila</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Douglas</LastName><ForeName>Trevor</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Broomell</LastName><ForeName>Chris</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Harmsen</LastName><ForeName>Allen</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>HHSN26620040009C/N01-AI-40009</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01AI40009</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P20-RR16455</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI083520</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI072689</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EB005364</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54-AI065357</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 EB005364</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P20-RR020185</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI072689</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 AI065357</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P20 RR016455</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL69409</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 AI083520</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL069409</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P20 RR020185</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>09</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001980" MajorTopicYN="N">Bronchi</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001992" MajorTopicYN="N">Bronchoalveolar Lavage Fluid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016997" MajorTopicYN="N">Coxiella burnetii</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007239" MajorTopicYN="N">Infections</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008221" MajorTopicYN="N">Lymphoid Tissue</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008809" MajorTopicYN="N">Mice, Inbred C3H</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053758" MajorTopicYN="N">Nanoparticles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D036103" MajorTopicYN="N">Nanotechnology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009975" MajorTopicYN="N">Orthomyxoviridae</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018111" MajorTopicYN="N">Pneumovirus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>07</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2009</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId 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Barnard</name><name sortKey="Broomell, Chris" sort="Broomell, Chris" uniqKey="Broomell C" first="Chris" last="Broomell">Chris Broomell</name><name sortKey="Douglas, Trevor" sort="Douglas, Trevor" uniqKey="Douglas T" first="Trevor" last="Douglas">Trevor Douglas</name><name sortKey="Harmsen, Allen" sort="Harmsen, Allen" uniqKey="Harmsen A" first="Allen" last="Harmsen">Allen Harmsen</name><name sortKey="Harmsen, Ann" sort="Harmsen, Ann" uniqKey="Harmsen A" first="Ann" last="Harmsen">Ann Harmsen</name><name sortKey="Jutila, Mark" sort="Jutila, Mark" uniqKey="Jutila M" first="Mark" last="Jutila">Mark Jutila</name><name sortKey="Randall, Troy D" sort="Randall, Troy D" uniqKey="Randall T" first="Troy D" last="Randall">Troy D. Randall</name><name sortKey="Richert, Laura E" sort="Richert, Laura E" uniqKey="Richert L" first="Laura E" last="Richert">Laura E. Richert</name><name sortKey="Swain, Steve D" sort="Swain, Steve D" uniqKey="Swain S" first="Steve D" last="Swain">Steve D. Swain</name><name sortKey="Young, Mark" sort="Young, Mark" uniqKey="Young M" first="Mark" last="Young">Mark Young</name></noCountry><country name="États-Unis"><region name="Montana"><name sortKey="Wiley, James A" sort="Wiley, James A" uniqKey="Wiley J" first="James A" last="Wiley">James A. Wiley</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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