SrasV1, PubMed, Checkpoint, bibRecord, 001848

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.

Identifieur interne : 001848 ( PubMed/Checkpoint ); précédent : 001847; suivant : 001849

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.

Auteurs : Chaewoon Lee [Corée du Sud] ; Jin Moo Lee ; Na-Ra Lee ; Dong-Eun Kim ; Yong-Joo Jeong ; Youhoon Chong

Source :

Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2009.

RBID : pubmed:19625187

Descripteurs français

KwdFr :
- 4H-1-Benzopyran-4-ones (), 4H-1-Benzopyran-4-ones (pharmacologie), 4H-1-Benzopyran-4-ones (synthèse chimique), Antienzymes (), Antienzymes (pharmacologie), Antienzymes (synthèse chimique), Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Catéchols (), Helicase (antagonistes et inhibiteurs), Helicase (métabolisme), Relation structure-activité, Virus du SRAS (enzymologie).
MESH :
- antagonistes et inhibiteurs : Helicase.
- enzymologie : Virus du SRAS.
- métabolisme : Helicase.
- pharmacologie : 4H-1-Benzopyran-4-ones, Antienzymes, Antiviraux.
- synthèse chimique : 4H-1-Benzopyran-4-ones, Antienzymes, Antiviraux.
- 4H-1-Benzopyran-4-ones, Antienzymes, Antiviraux, Catéchols, Relation structure-activité.

English descriptors

KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Catechols (chemistry), Chromones (chemical synthesis), Chromones (chemistry), Chromones (pharmacology), DNA Helicases (antagonists & inhibitors), DNA Helicases (metabolism), Enzyme Inhibitors (chemical synthesis), Enzyme Inhibitors (chemistry), Enzyme Inhibitors (pharmacology), SARS Virus (enzymology), Structure-Activity Relationship.
MESH :
- chemical , antagonists & inhibitors : DNA Helicases.
- chemical , chemical synthesis : Antiviral Agents, Chromones, Enzyme Inhibitors.
- chemical , chemistry : Antiviral Agents, Catechols, Chromones, Enzyme Inhibitors.
- chemical , metabolism : DNA Helicases.
- chemical , pharmacology : Antiviral Agents, Chromones, Enzyme Inhibitors.
- enzymology : SARS Virus.
- Structure-Activity Relationship.

Abstract

Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.

DOI: 10.1016/j.bmcl.2009.07.009
PubMed: 19625187

Affiliations:

Links toward previous steps (curation, corpus...)

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Links to Exploration step

pubmed:19625187

Le document en format XML

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<term>Antiviral Agents (chemistry)</term>
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<term>Catechols (chemistry)</term>
<term>Chromones (chemical synthesis)</term>
<term>Chromones (chemistry)</term>
<term>Chromones (pharmacology)</term>
<term>DNA Helicases (antagonists & inhibitors)</term>
<term>DNA Helicases (metabolism)</term>
<term>Enzyme Inhibitors (chemical synthesis)</term>
<term>Enzyme Inhibitors (chemistry)</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>SARS Virus (enzymology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>4H-1-Benzopyran-4-ones ()</term>
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<term>4H-1-Benzopyran-4-ones (synthèse chimique)</term>
<term>Antienzymes ()</term>
<term>Antienzymes (pharmacologie)</term>
<term>Antienzymes (synthèse chimique)</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (synthèse chimique)</term>
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<term>Helicase (antagonistes et inhibiteurs)</term>
<term>Helicase (métabolisme)</term>
<term>Relation structure-activité</term>
<term>Virus du SRAS (enzymologie)</term>
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<front><div type="abstract" xml:lang="en">Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct pharmacophore featuring an arylmethyl group attached to a diketoacid. In order to search for the pharmacophore space around the diketoacid core, three classes of dihydroxychromone derivatives were prepared. Based on SAR study, an extended feature of the pharmacophore model of SARS-CoV NTPase/helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit.</div>
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Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.

Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.

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