Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice.
Identifieur interne : 001769 ( PubMed/Checkpoint ); précédent : 001768; suivant : 001770Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice.
Auteurs : Satoshi Ohno [Japon] ; Shunsuke Kohyama ; Maiko Taneichi ; Osamu Moriya ; Hidenori Hayashi ; Hiroshi Oda ; Masahito Mori ; Akiharu Kobayashi ; Toshitaka Akatsuka ; Tetsuya Uchida ; Masanori MatsuiSource :
- Vaccine [ 1873-2518 ] ; 2009.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (), Adjuvants immunologiques (pharmacologie), Animaux, Antigène HLA-A2, Antigènes HLA-A (génétique), Antigènes HLA-A (immunologie), Déterminants antigéniques des lymphocytes T (immunologie), Déterminants antigéniques des lymphocytes T (métabolisme), Humains, Liaison aux protéines, Lignée cellulaire, Liposomes (métabolisme), Liposomes (pharmacologie), Lymphocytes T cytotoxiques (immunologie), Souris, Souris transgéniques, Syndrome respiratoire aigu sévère (immunologie), Vaccins antiviraux (immunologie), Virus de la vaccine (génétique), Virus du SRAS (immunologie).
- MESH :
- génétique : Antigènes HLA-A, Virus de la vaccine.
- immunologie : Antigènes HLA-A, Déterminants antigéniques des lymphocytes T, Lymphocytes T cytotoxiques, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virus du SRAS.
- métabolisme : Déterminants antigéniques des lymphocytes T, Liposomes.
- pharmacologie : Adjuvants immunologiques, Liposomes.
- Adjuvants immunologiques, Animaux, Antigène HLA-A2, Humains, Liaison aux protéines, Lignée cellulaire, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (chemistry), Adjuvants, Immunologic (pharmacology), Animals, Cell Line, Chlorocebus aethiops, Epitopes, T-Lymphocyte (immunology), Epitopes, T-Lymphocyte (metabolism), HLA-A Antigens (genetics), HLA-A Antigens (immunology), HLA-A2 Antigen, Humans, Liposomes (metabolism), Liposomes (pharmacology), Mice, Mice, Transgenic, Protein Binding, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), T-Lymphocytes, Cytotoxic (immunology), Vaccinia virus (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , chemistry : Adjuvants, Immunologic.
- chemical , genetics : HLA-A Antigens.
- chemical , immunology : Epitopes, T-Lymphocyte, HLA-A Antigens, Viral Vaccines.
- chemical , metabolism : Epitopes, T-Lymphocyte, Liposomes.
- chemical , pharmacology : Adjuvants, Immunologic, Liposomes.
- genetics : Vaccinia virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes, Cytotoxic.
- Animals, Cell Line, Chlorocebus aethiops, HLA-A2 Antigen, Humans, Mice, Mice, Transgenic, Protein Binding.
Abstract
We investigated whether the surface-linked liposomal peptide was applicable to a vaccine based on cytotoxic T lymphocytes (CTLs) against severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). We first identified four HLA-A*0201-restricted CTL epitopes derived from SARS-CoV using HLA-A*0201 transgenic mice and recombinant adenovirus expressing predicted epitopes. These peptides were coupled to the surface of liposomes, and inoculated into mice. Two of the liposomal peptides were effective for peptide-specific CTL induction, and one of them was efficient for the clearance of vaccinia virus expressing epitopes of SARS-CoV, suggesting that the surface-linked liposomal peptide might offer an effective CTL-based vaccine against SARS.
DOI: 10.1016/j.vaccine.2009.04.001
PubMed: 19490987
Affiliations:
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pubmed:19490987Le document en format XML
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last="Taneichi">Maiko Taneichi</name></author><author><name sortKey="Moriya, Osamu" sort="Moriya, Osamu" uniqKey="Moriya O" first="Osamu" last="Moriya">Osamu Moriya</name></author><author><name sortKey="Hayashi, Hidenori" sort="Hayashi, Hidenori" uniqKey="Hayashi H" first="Hidenori" last="Hayashi">Hidenori Hayashi</name></author><author><name sortKey="Oda, Hiroshi" sort="Oda, Hiroshi" uniqKey="Oda H" first="Hiroshi" last="Oda">Hiroshi Oda</name></author><author><name sortKey="Mori, Masahito" sort="Mori, Masahito" uniqKey="Mori M" first="Masahito" last="Mori">Masahito Mori</name></author><author><name sortKey="Kobayashi, Akiharu" sort="Kobayashi, Akiharu" uniqKey="Kobayashi A" first="Akiharu" last="Kobayashi">Akiharu Kobayashi</name></author><author><name sortKey="Akatsuka, Toshitaka" sort="Akatsuka, Toshitaka" uniqKey="Akatsuka T" first="Toshitaka" last="Akatsuka">Toshitaka Akatsuka</name></author><author><name sortKey="Uchida, Tetsuya" sort="Uchida, Tetsuya" uniqKey="Uchida T" first="Tetsuya" last="Uchida">Tetsuya Uchida</name></author><author><name sortKey="Matsui, Masanori" sort="Matsui, Masanori" uniqKey="Matsui M" first="Masanori" last="Matsui">Masanori Matsui</name></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic (chemistry)</term><term>Adjuvants, Immunologic (pharmacology)</term><term>Animals</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Epitopes, T-Lymphocyte (metabolism)</term><term>HLA-A Antigens (genetics)</term><term>HLA-A Antigens (immunology)</term><term>HLA-A2 Antigen</term><term>Humans</term><term>Liposomes (metabolism)</term><term>Liposomes (pharmacology)</term><term>Mice</term><term>Mice, Transgenic</term><term>Protein Binding</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Vaccinia virus (genetics)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques ()</term><term>Adjuvants immunologiques (pharmacologie)</term><term>Animaux</term><term>Antigène HLA-A2</term><term>Antigènes HLA-A (génétique)</term><term>Antigènes HLA-A (immunologie)</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Déterminants antigéniques des lymphocytes T (métabolisme)</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Liposomes (métabolisme)</term><term>Liposomes (pharmacologie)</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Souris</term><term>Souris transgéniques</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Vaccins antiviraux (immunologie)</term><term>Virus de la vaccine (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Adjuvants, Immunologic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-A Antigens</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>HLA-A Antigens</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>Liposomes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Liposomes</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Vaccinia virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA-A</term><term>Virus de la vaccine</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes HLA-A</term><term>Déterminants antigéniques des lymphocytes T</term><term>Lymphocytes T cytotoxiques</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Déterminants antigéniques des lymphocytes T</term><term>Liposomes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Liposomes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>HLA-A2 Antigen</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term><term>Protein Binding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Animaux</term><term>Antigène HLA-A2</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Souris</term><term>Souris transgéniques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated whether the surface-linked liposomal peptide was applicable to a vaccine based on cytotoxic T lymphocytes (CTLs) against severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). We first identified four HLA-A*0201-restricted CTL epitopes derived from SARS-CoV using HLA-A*0201 transgenic mice and recombinant adenovirus expressing predicted epitopes. These peptides were coupled to the surface of liposomes, and inoculated into mice. Two of the liposomal peptides were effective for peptide-specific CTL induction, and one of them was efficient for the clearance of vaccinia virus expressing epitopes of SARS-CoV, suggesting that the surface-linked liposomal peptide might offer an effective CTL-based vaccine against SARS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19490987</PMID><DateCompleted><Year>2009</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>29</Issue><PubDate><Year>2009</Year><Month>Jun</Month><Day>12</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice.</ArticleTitle><Pagination><MedlinePgn>3912-20</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2009.04.001</ELocationID><Abstract><AbstractText>We investigated whether the surface-linked liposomal peptide was applicable to a vaccine based on cytotoxic T lymphocytes (CTLs) against severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). We first identified four HLA-A*0201-restricted CTL epitopes derived from SARS-CoV using HLA-A*0201 transgenic mice and recombinant adenovirus expressing predicted epitopes. These peptides were coupled to the surface of liposomes, and inoculated into mice. Two of the liposomal peptides were effective for peptide-specific CTL induction, and one of them was efficient for the clearance of vaccinia virus expressing epitopes of SARS-CoV, suggesting that the surface-linked liposomal peptide might offer an effective CTL-based vaccine against SARS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ohno</LastName><ForeName>Satoshi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Saitama 350-0495, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kohyama</LastName><ForeName>Shunsuke</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Taneichi</LastName><ForeName>Maiko</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Moriya</LastName><ForeName>Osamu</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Hayashi</LastName><ForeName>Hidenori</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Oda</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Mori</LastName><ForeName>Masahito</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kobayashi</LastName><ForeName>Akiharu</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Akatsuka</LastName><ForeName>Toshitaka</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Uchida</LastName><ForeName>Tetsuya</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Matsui</LastName><ForeName>Masanori</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>04</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000276">Adjuvants, Immunologic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018984">Epitopes, T-Lymphocyte</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015234">HLA-A Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C435939">HLA-A*02:01 antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015789">HLA-A2 Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008081">Liposomes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014765">Viral Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000276" MajorTopicYN="N">Adjuvants, Immunologic</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018984" MajorTopicYN="N">Epitopes, T-Lymphocyte</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015234" MajorTopicYN="N">HLA-A Antigens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015789" MajorTopicYN="N">HLA-A2 Antigen</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008081" MajorTopicYN="N">Liposomes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013602" MajorTopicYN="N">T-Lymphocytes, Cytotoxic</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014616" MajorTopicYN="N">Vaccinia virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014765" MajorTopicYN="N">Viral Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2008</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2009</Year><Month>03</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2009</Year><Month>04</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>6</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>6</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>9</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19490987</ArticleId><ArticleId IdType="pii">S0264-410X(09)00531-3</ArticleId><ArticleId 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sort="Taneichi, Maiko" uniqKey="Taneichi M" first="Maiko" last="Taneichi">Maiko Taneichi</name><name sortKey="Uchida, Tetsuya" sort="Uchida, Tetsuya" uniqKey="Uchida T" first="Tetsuya" last="Uchida">Tetsuya Uchida</name></noCountry><country name="Japon"><noRegion><name sortKey="Ohno, Satoshi" sort="Ohno, Satoshi" uniqKey="Ohno S" first="Satoshi" last="Ohno">Satoshi Ohno</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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