The spike protein of SARS-CoV--a target for vaccine and therapeutic development.
Identifieur interne : 001757 ( PubMed/Checkpoint ); précédent : 001756; suivant : 001758The spike protein of SARS-CoV--a target for vaccine and therapeutic development.
Auteurs : Lanying Du [États-Unis] ; Yuxian He ; Yusen Zhou ; Shuwen Liu ; Bo-Jian Zheng ; Shibo JiangSource :
- Nature reviews. Microbiology [ 1740-1534 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (immunologie), Anticorps monoclonaux (usage thérapeutique), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (immunologie), Glycoprotéines membranaires (physiologie), Humains, Interférence par ARN, Peptidyl-Dipeptidase A (métabolisme), Petit ARN interférent, Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (immunologie), Protéines de l'enveloppe virale (physiologie), Pénétration virale, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (anatomopathologie), Vaccins antiviraux (immunologie), Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (physiologie).
- MESH :
- anatomopathologie : Syndrome respiratoire aigu sévère.
- génétique : Virus du SRAS.
- immunologie : Anticorps monoclonaux, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Vaccins antiviraux.
- métabolisme : Peptidyl-Dipeptidase A.
- pharmacologie : Antiviraux.
- physiologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus du SRAS.
- usage thérapeutique : Anticorps monoclonaux, Antiviraux.
- Animaux, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Humains, Interférence par ARN, Petit ARN interférent, Protéines de l'enveloppe virale, Pénétration virale, Syndrome respiratoire aigu sévère, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Monoclonal (therapeutic use), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Humans, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (immunology), Membrane Glycoproteins (physiology), Peptidyl-Dipeptidase A (metabolism), RNA Interference, RNA, Small Interfering, SARS Virus (chemistry), SARS Virus (drug effects), SARS Virus (genetics), SARS Virus (physiology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (therapy), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (immunology), Viral Envelope Proteins (physiology), Viral Vaccines (immunology), Virus Internalization.
- MESH :
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , immunology : Antibodies, Monoclonal, Membrane Glycoproteins, Viral Envelope Proteins, Viral Vaccines.
- chemical , metabolism : Peptidyl-Dipeptidase A.
- chemical , pharmacology : Antiviral Agents.
- chemical , physiology : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , therapeutic use : Antibodies, Monoclonal, Antiviral Agents.
- chemistry : SARS Virus.
- drug effects : SARS Virus.
- genetics : SARS Virus.
- pathology : Severe Acute Respiratory Syndrome.
- physiology : SARS Virus.
- prevention & control : Severe Acute Respiratory Syndrome.
- therapy : Severe Acute Respiratory Syndrome.
- Animals, Humans, RNA Interference, RNA, Small Interfering, Spike Glycoprotein, Coronavirus, Virus Internalization.
Abstract
Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. In this Review, we highlight recent advances in the development of vaccines and therapeutics based on the S protein.
DOI: 10.1038/nrmicro2090
PubMed: 19198616
Affiliations:
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Links to Exploration step
pubmed:19198616Le document en format XML
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<term>Interférence par ARN</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. In this Review, we highlight recent advances in the development of vaccines and therapeutics based on the S protein.</div>
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<name sortKey="Liu, Shuwen" sort="Liu, Shuwen" uniqKey="Liu S" first="Shuwen" last="Liu">Shuwen Liu</name>
<name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
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