Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7.
Identifieur interne : 001387 ( PubMed/Checkpoint ); précédent : 001386; suivant : 001388Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7.
Auteurs : Yaoqing Chen [République populaire de Chine] ; Luyang Cao ; Maohua Zhong ; Yan Zhang ; Chen Han ; Qiaoli Li ; Jingyi Yang ; Dihan Zhou ; Wei Shi ; Benxia He ; Fang Liu ; Jie Yu ; Ying Sun ; Yuan Cao ; Yaoming Li ; Wenxin Li ; Deying Guo ; Zhijian Cao ; Huimin YanSource :
- PloS one [ 1932-6203 ] ; 2012.
Descripteurs français
- KwdFr :
- Agents antiVIH (pharmacologie), Agents antiVIH (synthèse chimique), Agents antiVIH (toxicité), Conception de médicament, Données de séquences moléculaires, Humains, Liaison aux protéines, Lignée cellulaire, Peptides antimicrobiens cationiques (pharmacologie), Peptides antimicrobiens cationiques (synthèse chimique), Peptides antimicrobiens cationiques (toxicité), Relation dose-effet des médicaments, Structure secondaire des protéines, Séquence d'acides aminés, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), Venins de scorpion (pharmacologie), Venins de scorpion (synthèse chimique), Venins de scorpion (toxicité).
- MESH :
- pharmacologie : Agents antiVIH, Peptides antimicrobiens cationiques, Venins de scorpion.
- synthèse chimique : Agents antiVIH, Peptides antimicrobiens cationiques, Venins de scorpion.
- toxicité : Agents antiVIH, Peptides antimicrobiens cationiques, Venins de scorpion.
- Conception de médicament, Données de séquences moléculaires, Humains, Liaison aux protéines, Lignée cellulaire, Relation dose-effet des médicaments, Structure secondaire des protéines, Séquence d'acides aminés, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
English descriptors
- KwdEn :
- Amino Acid Sequence, Anti-HIV Agents (chemical synthesis), Anti-HIV Agents (pharmacology), Anti-HIV Agents (toxicity), Antimicrobial Cationic Peptides (chemical synthesis), Antimicrobial Cationic Peptides (pharmacology), Antimicrobial Cationic Peptides (toxicity), Cell Line, Dose-Response Relationship, Drug, Drug Design, HIV-1 (drug effects), Humans, Molecular Sequence Data, Protein Binding, Protein Structure, Secondary, Scorpion Venoms (chemical synthesis), Scorpion Venoms (pharmacology), Scorpion Venoms (toxicity).
- MESH :
- chemical , chemical synthesis : Anti-HIV Agents, Antimicrobial Cationic Peptides, Scorpion Venoms.
- chemical , pharmacology : Anti-HIV Agents, Antimicrobial Cationic Peptides, Scorpion Venoms.
- chemical , toxicity : Anti-HIV Agents, Antimicrobial Cationic Peptides, Scorpion Venoms.
- drug effects : HIV-1.
- Amino Acid Sequence, Cell Line, Dose-Response Relationship, Drug, Drug Design, Humans, Molecular Sequence Data, Protein Binding, Protein Structure, Secondary.
Abstract
For over 30 years, HIV/AIDS has wreaked havoc in the world. In the absence of an effective vaccine for HIV, development of new anti-HIV agents is urgently needed. We previously identified the antiviral activities of the scorpion-venom-peptide-derived mucroporin-M1 for three RNA viruses (measles viruses, SARS-CoV, and H5N1). In this investigation, a panel of scorpion venom peptides and their derivatives were designed and chosen for assessment of their anti-HIV activities. A new scorpion venom peptide derivative Kn2-7 was identified as the most potent anti-HIV-1 peptide by screening assays with an EC(50) value of 2.76 µg/ml (1.65 µM) and showed low cytotoxicity to host cells with a selective index (SI) of 13.93. Kn2-7 could inhibit all members of a standard reference panel of HIV-1 subtype B pseudotyped virus (PV) with CCR5-tropic and CXCR4-tropic NL4-3 PV strain. Furthermore, it also inhibited a CXCR4-tropic replication-competent strain of HIV-1 subtype B virus. Binding assay of Kn2-7 to HIV-1 PV by Octet Red system suggested the anti-HIV-1 activity was correlated with a direct interaction between Kn2-7 and HIV-1 envelope. These results demonstrated that peptide Kn2-7 could inhibit HIV-1 by direct interaction with viral particle and may become a promising candidate compound for further development of microbicide against HIV-1.
DOI: 10.1371/journal.pone.0034947
PubMed: 22536342
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:22536342Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7.</title>
<author><name sortKey="Chen, Yaoqing" sort="Chen, Yaoqing" uniqKey="Chen Y" first="Yaoqing" last="Chen">Yaoqing Chen</name>
<affiliation wicri:level="4"><nlm:affiliation>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
<orgName type="university">Université de Wuhan</orgName>
</affiliation>
</author>
<author><name sortKey="Cao, Luyang" sort="Cao, Luyang" uniqKey="Cao L" first="Luyang" last="Cao">Luyang Cao</name>
</author>
<author><name sortKey="Zhong, Maohua" sort="Zhong, Maohua" uniqKey="Zhong M" first="Maohua" last="Zhong">Maohua Zhong</name>
</author>
<author><name sortKey="Zhang, Yan" sort="Zhang, Yan" uniqKey="Zhang Y" first="Yan" last="Zhang">Yan Zhang</name>
</author>
<author><name sortKey="Han, Chen" sort="Han, Chen" uniqKey="Han C" first="Chen" last="Han">Chen Han</name>
</author>
<author><name sortKey="Li, Qiaoli" sort="Li, Qiaoli" uniqKey="Li Q" first="Qiaoli" last="Li">Qiaoli Li</name>
</author>
<author><name sortKey="Yang, Jingyi" sort="Yang, Jingyi" uniqKey="Yang J" first="Jingyi" last="Yang">Jingyi Yang</name>
</author>
<author><name sortKey="Zhou, Dihan" sort="Zhou, Dihan" uniqKey="Zhou D" first="Dihan" last="Zhou">Dihan Zhou</name>
</author>
<author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
</author>
<author><name sortKey="He, Benxia" sort="He, Benxia" uniqKey="He B" first="Benxia" last="He">Benxia He</name>
</author>
<author><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name>
</author>
<author><name sortKey="Yu, Jie" sort="Yu, Jie" uniqKey="Yu J" first="Jie" last="Yu">Jie Yu</name>
</author>
<author><name sortKey="Sun, Ying" sort="Sun, Ying" uniqKey="Sun Y" first="Ying" last="Sun">Ying Sun</name>
</author>
<author><name sortKey="Cao, Yuan" sort="Cao, Yuan" uniqKey="Cao Y" first="Yuan" last="Cao">Yuan Cao</name>
</author>
<author><name sortKey="Li, Yaoming" sort="Li, Yaoming" uniqKey="Li Y" first="Yaoming" last="Li">Yaoming Li</name>
</author>
<author><name sortKey="Li, Wenxin" sort="Li, Wenxin" uniqKey="Li W" first="Wenxin" last="Li">Wenxin Li</name>
</author>
<author><name sortKey="Guo, Deying" sort="Guo, Deying" uniqKey="Guo D" first="Deying" last="Guo">Deying Guo</name>
</author>
<author><name sortKey="Cao, Zhijian" sort="Cao, Zhijian" uniqKey="Cao Z" first="Zhijian" last="Cao">Zhijian Cao</name>
</author>
<author><name sortKey="Yan, Huimin" sort="Yan, Huimin" uniqKey="Yan H" first="Huimin" last="Yan">Huimin Yan</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:22536342</idno>
<idno type="pmid">22536342</idno>
<idno type="doi">10.1371/journal.pone.0034947</idno>
<idno type="wicri:Area/PubMed/Corpus">001373</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001373</idno>
<idno type="wicri:Area/PubMed/Curation">001373</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001373</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001387</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001387</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7.</title>
<author><name sortKey="Chen, Yaoqing" sort="Chen, Yaoqing" uniqKey="Chen Y" first="Yaoqing" last="Chen">Yaoqing Chen</name>
<affiliation wicri:level="4"><nlm:affiliation>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea>
<placeName><settlement type="city">Wuhan</settlement>
<region type="région">Hubei</region>
</placeName>
<orgName type="university">Université de Wuhan</orgName>
</affiliation>
</author>
<author><name sortKey="Cao, Luyang" sort="Cao, Luyang" uniqKey="Cao L" first="Luyang" last="Cao">Luyang Cao</name>
</author>
<author><name sortKey="Zhong, Maohua" sort="Zhong, Maohua" uniqKey="Zhong M" first="Maohua" last="Zhong">Maohua Zhong</name>
</author>
<author><name sortKey="Zhang, Yan" sort="Zhang, Yan" uniqKey="Zhang Y" first="Yan" last="Zhang">Yan Zhang</name>
</author>
<author><name sortKey="Han, Chen" sort="Han, Chen" uniqKey="Han C" first="Chen" last="Han">Chen Han</name>
</author>
<author><name sortKey="Li, Qiaoli" sort="Li, Qiaoli" uniqKey="Li Q" first="Qiaoli" last="Li">Qiaoli Li</name>
</author>
<author><name sortKey="Yang, Jingyi" sort="Yang, Jingyi" uniqKey="Yang J" first="Jingyi" last="Yang">Jingyi Yang</name>
</author>
<author><name sortKey="Zhou, Dihan" sort="Zhou, Dihan" uniqKey="Zhou D" first="Dihan" last="Zhou">Dihan Zhou</name>
</author>
<author><name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
</author>
<author><name sortKey="He, Benxia" sort="He, Benxia" uniqKey="He B" first="Benxia" last="He">Benxia He</name>
</author>
<author><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name>
</author>
<author><name sortKey="Yu, Jie" sort="Yu, Jie" uniqKey="Yu J" first="Jie" last="Yu">Jie Yu</name>
</author>
<author><name sortKey="Sun, Ying" sort="Sun, Ying" uniqKey="Sun Y" first="Ying" last="Sun">Ying Sun</name>
</author>
<author><name sortKey="Cao, Yuan" sort="Cao, Yuan" uniqKey="Cao Y" first="Yuan" last="Cao">Yuan Cao</name>
</author>
<author><name sortKey="Li, Yaoming" sort="Li, Yaoming" uniqKey="Li Y" first="Yaoming" last="Li">Yaoming Li</name>
</author>
<author><name sortKey="Li, Wenxin" sort="Li, Wenxin" uniqKey="Li W" first="Wenxin" last="Li">Wenxin Li</name>
</author>
<author><name sortKey="Guo, Deying" sort="Guo, Deying" uniqKey="Guo D" first="Deying" last="Guo">Deying Guo</name>
</author>
<author><name sortKey="Cao, Zhijian" sort="Cao, Zhijian" uniqKey="Cao Z" first="Zhijian" last="Cao">Zhijian Cao</name>
</author>
<author><name sortKey="Yan, Huimin" sort="Yan, Huimin" uniqKey="Yan H" first="Huimin" last="Yan">Huimin Yan</name>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Anti-HIV Agents (chemical synthesis)</term>
<term>Anti-HIV Agents (pharmacology)</term>
<term>Anti-HIV Agents (toxicity)</term>
<term>Antimicrobial Cationic Peptides (chemical synthesis)</term>
<term>Antimicrobial Cationic Peptides (pharmacology)</term>
<term>Antimicrobial Cationic Peptides (toxicity)</term>
<term>Cell Line</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Design</term>
<term>HIV-1 (drug effects)</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Protein Binding</term>
<term>Protein Structure, Secondary</term>
<term>Scorpion Venoms (chemical synthesis)</term>
<term>Scorpion Venoms (pharmacology)</term>
<term>Scorpion Venoms (toxicity)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agents antiVIH (pharmacologie)</term>
<term>Agents antiVIH (synthèse chimique)</term>
<term>Agents antiVIH (toxicité)</term>
<term>Conception de médicament</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Peptides antimicrobiens cationiques (pharmacologie)</term>
<term>Peptides antimicrobiens cationiques (synthèse chimique)</term>
<term>Peptides antimicrobiens cationiques (toxicité)</term>
<term>Relation dose-effet des médicaments</term>
<term>Structure secondaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term>
<term>Venins de scorpion (pharmacologie)</term>
<term>Venins de scorpion (synthèse chimique)</term>
<term>Venins de scorpion (toxicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Antimicrobial Cationic Peptides</term>
<term>Scorpion Venoms</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Antimicrobial Cationic Peptides</term>
<term>Scorpion Venoms</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Anti-HIV Agents</term>
<term>Antimicrobial Cationic Peptides</term>
<term>Scorpion Venoms</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agents antiVIH</term>
<term>Peptides antimicrobiens cationiques</term>
<term>Venins de scorpion</term>
</keywords>
<keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Agents antiVIH</term>
<term>Peptides antimicrobiens cationiques</term>
<term>Venins de scorpion</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Agents antiVIH</term>
<term>Peptides antimicrobiens cationiques</term>
<term>Venins de scorpion</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Cell Line</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Design</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Protein Binding</term>
<term>Protein Structure, Secondary</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Conception de médicament</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Relation dose-effet des médicaments</term>
<term>Structure secondaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">For over 30 years, HIV/AIDS has wreaked havoc in the world. In the absence of an effective vaccine for HIV, development of new anti-HIV agents is urgently needed. We previously identified the antiviral activities of the scorpion-venom-peptide-derived mucroporin-M1 for three RNA viruses (measles viruses, SARS-CoV, and H5N1). In this investigation, a panel of scorpion venom peptides and their derivatives were designed and chosen for assessment of their anti-HIV activities. A new scorpion venom peptide derivative Kn2-7 was identified as the most potent anti-HIV-1 peptide by screening assays with an EC(50) value of 2.76 µg/ml (1.65 µM) and showed low cytotoxicity to host cells with a selective index (SI) of 13.93. Kn2-7 could inhibit all members of a standard reference panel of HIV-1 subtype B pseudotyped virus (PV) with CCR5-tropic and CXCR4-tropic NL4-3 PV strain. Furthermore, it also inhibited a CXCR4-tropic replication-competent strain of HIV-1 subtype B virus. Binding assay of Kn2-7 to HIV-1 PV by Octet Red system suggested the anti-HIV-1 activity was correlated with a direct interaction between Kn2-7 and HIV-1 envelope. These results demonstrated that peptide Kn2-7 could inhibit HIV-1 by direct interaction with viral particle and may become a promising candidate compound for further development of microbicide against HIV-1.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22536342</PMID>
<DateCompleted><Year>2012</Year>
<Month>08</Month>
<Day>31</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<Issue>4</Issue>
<PubDate><Year>2012</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7.</ArticleTitle>
<Pagination><MedlinePgn>e34947</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0034947</ELocationID>
<Abstract><AbstractText>For over 30 years, HIV/AIDS has wreaked havoc in the world. In the absence of an effective vaccine for HIV, development of new anti-HIV agents is urgently needed. We previously identified the antiviral activities of the scorpion-venom-peptide-derived mucroporin-M1 for three RNA viruses (measles viruses, SARS-CoV, and H5N1). In this investigation, a panel of scorpion venom peptides and their derivatives were designed and chosen for assessment of their anti-HIV activities. A new scorpion venom peptide derivative Kn2-7 was identified as the most potent anti-HIV-1 peptide by screening assays with an EC(50) value of 2.76 µg/ml (1.65 µM) and showed low cytotoxicity to host cells with a selective index (SI) of 13.93. Kn2-7 could inhibit all members of a standard reference panel of HIV-1 subtype B pseudotyped virus (PV) with CCR5-tropic and CXCR4-tropic NL4-3 PV strain. Furthermore, it also inhibited a CXCR4-tropic replication-competent strain of HIV-1 subtype B virus. Binding assay of Kn2-7 to HIV-1 PV by Octet Red system suggested the anti-HIV-1 activity was correlated with a direct interaction between Kn2-7 and HIV-1 envelope. These results demonstrated that peptide Kn2-7 could inhibit HIV-1 by direct interaction with viral particle and may become a promising candidate compound for further development of microbicide against HIV-1.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yaoqing</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Luyang</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhong</LastName>
<ForeName>Maohua</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Chen</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Qiaoli</ForeName>
<Initials>Q</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Jingyi</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Dihan</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Benxia</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Fang</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Jie</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Ying</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Yuan</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yaoming</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Wenxin</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Deying</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Zhijian</ForeName>
<Initials>Z</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Huimin</ForeName>
<Initials>H</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>04</Month>
<Day>19</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D023181">Antimicrobial Cationic Peptides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C574603">Kn2-7 peptide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012604">Scorpion Venoms</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV Agents</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D023181" MajorTopicYN="N">Antimicrobial Cationic Peptides</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015195" MajorTopicYN="N">Drug Design</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017433" MajorTopicYN="N">Protein Structure, Secondary</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012604" MajorTopicYN="N">Scorpion Venoms</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year>
<Month>12</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2012</Year>
<Month>03</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2012</Year>
<Month>4</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2012</Year>
<Month>4</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2012</Year>
<Month>9</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">22536342</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pone.0034947</ArticleId>
<ArticleId IdType="pii">PONE-D-11-25439</ArticleId>
<ArticleId IdType="pmc">PMC3334916</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Anal Biochem. 2008 Jun 15;377(2):209-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18405656</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Toxicon. 2006 Mar;47(3):348-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16387337</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 May;74(10):4868-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10775626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2010 Oct 16;376(9749):1329-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20851460</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2003 Mar 20;422(6929):307-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12646921</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2007 May 1;23(9):1148-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17341497</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Biotechnol. 1998 Feb;16(2):82-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9487736</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1998 Apr;72(4):2855-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9525605</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Protoc Immunol. 2005 Jan;Chapter 12:Unit 12.11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18432938</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Genomics. 2009;10:290</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19570192</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Nov;79(22):14318-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16254366</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Protein Expr Purif. 2008 Aug;60(2):147-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18538581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 1993 Jul 20;232(2):584-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8345525</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1986 Aug;59(2):284-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3016298</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6096719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Q Rev Biophys. 1977 Feb;10(1):1-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">327501</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2001 Aug 31;286(4):820-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11520071</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biopolymers. 1998;47(6):451-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10333737</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Biochem. 2000 Aug;267(16):5023-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10931184</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1996 Jun 28;85(7):1149-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8674120</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2002 Jan 24;415(6870):389-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11807545</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1996 Jun 20;381(6584):661-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8649511</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rev Med Virol. 2011 Mar;21(2):110-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21412935</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Microbiol Rev. 2006 Jul;19(3):491-511</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16847082</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2008 Nov;52(11):3967-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18779362</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Peptides. 2004 Feb;25(2):143-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15062994</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Biochem. 2002 Oct;269(19):4799-810</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12354111</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>AIDS Res Hum Retroviruses. 2008 Jul;24(7):925-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18627218</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Reprod. 1996 Jan;54(1):173-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8838015</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2009 Aug;53(8):3472-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19451300</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Peptides. 2011 Jan;32(1):11-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20950663</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2000 Feb;173:5-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10719663</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2007 Jan;73(1):60-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16949681</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Antimicrob Agents. 2004 Apr;23(4):382-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15081088</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2011 Jun;90(3):195-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21459115</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011;6(9):e24296</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21935396</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Leukoc Biol. 1995 Aug;58(2):128-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7643008</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2000 Apr 14;471(2-3):165-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10767415</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochimie. 2000 Sep-Oct;82(9-10):861-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11086216</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Peptides. 2011 Jul;32(7):1518-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21620914</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2004 Jan 1;32(Database issue):D590-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14681488</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2010 Jun;86(3):306-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20347875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1996 Aug 9;86(3):367-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8756719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1991 Nov;65(11):5765-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1920615</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2007 Jun 20;363(1):79-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17306322</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Commun. 1991 Jul;3(7):207-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1867954</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1996 May 10;272(5263):872-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8629022</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Dec 3;361(23):2209-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19843557</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2008 Nov 29;372(9653):1881-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19012954</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Expert Opin Emerg Drugs. 2007 Mar;12(1):23-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17355212</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mem Inst Oswaldo Cruz. 2007 Jun;102(4):469-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17612767</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2006 Jun 1;176(11):6900-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16709850</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Infect Dis. 2002 Nov 21;2:27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12445331</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 2007 Sep;75(3):227-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17459492</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Z Med J. 1977 Oct 12;86(597):327-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">272537</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Aug;79(16):10108-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16051804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Microbiol. 2005 Mar;3(3):238-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15703760</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antimicrob Agents Chemother. 2002 Jun;46(6):1896-905</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12019106</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Hubei</li>
</region>
<settlement><li>Wuhan</li>
</settlement>
<orgName><li>Université de Wuhan</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Cao, Luyang" sort="Cao, Luyang" uniqKey="Cao L" first="Luyang" last="Cao">Luyang Cao</name>
<name sortKey="Cao, Yuan" sort="Cao, Yuan" uniqKey="Cao Y" first="Yuan" last="Cao">Yuan Cao</name>
<name sortKey="Cao, Zhijian" sort="Cao, Zhijian" uniqKey="Cao Z" first="Zhijian" last="Cao">Zhijian Cao</name>
<name sortKey="Guo, Deying" sort="Guo, Deying" uniqKey="Guo D" first="Deying" last="Guo">Deying Guo</name>
<name sortKey="Han, Chen" sort="Han, Chen" uniqKey="Han C" first="Chen" last="Han">Chen Han</name>
<name sortKey="He, Benxia" sort="He, Benxia" uniqKey="He B" first="Benxia" last="He">Benxia He</name>
<name sortKey="Li, Qiaoli" sort="Li, Qiaoli" uniqKey="Li Q" first="Qiaoli" last="Li">Qiaoli Li</name>
<name sortKey="Li, Wenxin" sort="Li, Wenxin" uniqKey="Li W" first="Wenxin" last="Li">Wenxin Li</name>
<name sortKey="Li, Yaoming" sort="Li, Yaoming" uniqKey="Li Y" first="Yaoming" last="Li">Yaoming Li</name>
<name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name>
<name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
<name sortKey="Sun, Ying" sort="Sun, Ying" uniqKey="Sun Y" first="Ying" last="Sun">Ying Sun</name>
<name sortKey="Yan, Huimin" sort="Yan, Huimin" uniqKey="Yan H" first="Huimin" last="Yan">Huimin Yan</name>
<name sortKey="Yang, Jingyi" sort="Yang, Jingyi" uniqKey="Yang J" first="Jingyi" last="Yang">Jingyi Yang</name>
<name sortKey="Yu, Jie" sort="Yu, Jie" uniqKey="Yu J" first="Jie" last="Yu">Jie Yu</name>
<name sortKey="Zhang, Yan" sort="Zhang, Yan" uniqKey="Zhang Y" first="Yan" last="Zhang">Yan Zhang</name>
<name sortKey="Zhong, Maohua" sort="Zhong, Maohua" uniqKey="Zhong M" first="Maohua" last="Zhong">Maohua Zhong</name>
<name sortKey="Zhou, Dihan" sort="Zhou, Dihan" uniqKey="Zhou D" first="Dihan" last="Zhou">Dihan Zhou</name>
</noCountry>
<country name="République populaire de Chine"><region name="Hubei"><name sortKey="Chen, Yaoqing" sort="Chen, Yaoqing" uniqKey="Chen Y" first="Yaoqing" last="Chen">Yaoqing Chen</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001387 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001387 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:22536342 |texte= Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:22536342" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |