Recent developments on coronavirus main protease/3C like protease inhibitors.
Identifieur interne : 001117 ( PubMed/Checkpoint ); précédent : 001116; suivant : 001118Recent developments on coronavirus main protease/3C like protease inhibitors.
Auteurs : Qi Zhao [États-Unis] ; Erin Weber ; Haitao YangSource :
- Recent patents on anti-infective drug discovery [ 2212-4071 ] ; 2013.
Descripteurs français
- KwdFr :
- Brevets comme sujet, Conception de médicament, Cristallographie aux rayons X, Cysteine endopeptidases (), Cysteine endopeptidases (métabolisme), Humains, Inhibiteurs de protéases (), Inhibiteurs de protéases (pharmacologie), Structure moléculaire, Syndrome respiratoire aigu sévère (virologie), Évaluation préclinique de médicament ().
- MESH :
- métabolisme : Cysteine endopeptidases.
- pharmacologie : Inhibiteurs de protéases.
- virologie : Syndrome respiratoire aigu sévère.
- Brevets comme sujet, Conception de médicament, Cristallographie aux rayons X, Cysteine endopeptidases, Humains, Inhibiteurs de protéases, Structure moléculaire, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Crystallography, X-Ray, Cysteine Endopeptidases (chemistry), Cysteine Endopeptidases (metabolism), Drug Design, Drug Evaluation, Preclinical (methods), Humans, Molecular Structure, Patents as Topic, Protease Inhibitors (chemistry), Protease Inhibitors (pharmacology), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , chemistry : Cysteine Endopeptidases, Protease Inhibitors.
- chemical , metabolism : Cysteine Endopeptidases.
- methods : Drug Evaluation, Preclinical.
- chemical , pharmacology : Protease Inhibitors.
- virology : Severe Acute Respiratory Syndrome.
- Crystallography, X-Ray, Drug Design, Humans, Molecular Structure, Patents as Topic.
Abstract
Coronaviruses have been thrust into the spotlight by the recurring novel human coronavirus infections following the 2003 SARS pandemic. In the years since the initial SARS outbreak, the arsenal to fight this virus family has been significantly increased by the rapid growth of coronavirus research. Among the potential viral drug targets, coronavirus 3C like proteases (3Cl) have emerged as the most popular drug target. A number of patented inhibitors with promising clinical potential have been developed via different methods of drug discovery, including virtual screening, natural product isolation and structure assisted rational drug design. This review serves as a summary of the progress in both the method of drug discovery and the related inhibitors against the coronavirus 3Cl protease.
DOI: 10.2174/1574891x113089990017
PubMed: 23879823
Affiliations:
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pubmed:23879823Le document en format XML
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<author><name sortKey="Zhao, Qi" sort="Zhao, Qi" uniqKey="Zhao Q" first="Qi" last="Zhao">Qi Zhao</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA. qi.zhao@yale.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520</wicri:regionArea>
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<author><name sortKey="Weber, Erin" sort="Weber, Erin" uniqKey="Weber E" first="Erin" last="Weber">Erin Weber</name>
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<author><name sortKey="Yang, Haitao" sort="Yang, Haitao" uniqKey="Yang H" first="Haitao" last="Yang">Haitao Yang</name>
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<term>Cysteine Endopeptidases (metabolism)</term>
<term>Drug Design</term>
<term>Drug Evaluation, Preclinical (methods)</term>
<term>Humans</term>
<term>Molecular Structure</term>
<term>Patents as Topic</term>
<term>Protease Inhibitors (chemistry)</term>
<term>Protease Inhibitors (pharmacology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
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<term>Conception de médicament</term>
<term>Cristallographie aux rayons X</term>
<term>Cysteine endopeptidases ()</term>
<term>Cysteine endopeptidases (métabolisme)</term>
<term>Humains</term>
<term>Inhibiteurs de protéases ()</term>
<term>Inhibiteurs de protéases (pharmacologie)</term>
<term>Structure moléculaire</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Évaluation préclinique de médicament ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cysteine Endopeptidases</term>
<term>Protease Inhibitors</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cysteine Endopeptidases</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cysteine endopeptidases</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Inhibiteurs de protéases</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Protease Inhibitors</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
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<term>Drug Design</term>
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<term>Molecular Structure</term>
<term>Patents as Topic</term>
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<term>Cristallographie aux rayons X</term>
<term>Cysteine endopeptidases</term>
<term>Humains</term>
<term>Inhibiteurs de protéases</term>
<term>Structure moléculaire</term>
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<front><div type="abstract" xml:lang="en">Coronaviruses have been thrust into the spotlight by the recurring novel human coronavirus infections following the 2003 SARS pandemic. In the years since the initial SARS outbreak, the arsenal to fight this virus family has been significantly increased by the rapid growth of coronavirus research. Among the potential viral drug targets, coronavirus 3C like proteases (3Cl) have emerged as the most popular drug target. A number of patented inhibitors with promising clinical potential have been developed via different methods of drug discovery, including virtual screening, natural product isolation and structure assisted rational drug design. This review serves as a summary of the progress in both the method of drug discovery and the related inhibitors against the coronavirus 3Cl protease. </div>
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<Title>Recent patents on anti-infective drug discovery</Title>
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<Abstract><AbstractText>Coronaviruses have been thrust into the spotlight by the recurring novel human coronavirus infections following the 2003 SARS pandemic. In the years since the initial SARS outbreak, the arsenal to fight this virus family has been significantly increased by the rapid growth of coronavirus research. Among the potential viral drug targets, coronavirus 3C like proteases (3Cl) have emerged as the most popular drug target. A number of patented inhibitors with promising clinical potential have been developed via different methods of drug discovery, including virtual screening, natural product isolation and structure assisted rational drug design. This review serves as a summary of the progress in both the method of drug discovery and the related inhibitors against the coronavirus 3Cl protease. </AbstractText>
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