Middle East respiratory syndrome coronavirus "MERS-CoV": current knowledge gaps.
Identifieur interne : 000D92 ( PubMed/Checkpoint ); précédent : 000D91; suivant : 000D93Middle East respiratory syndrome coronavirus "MERS-CoV": current knowledge gaps.
Auteurs : G R Banik [Australie] ; G. Khandaker [Australie] ; H. Rashid [Australie]Source :
- Paediatric respiratory reviews [ 1526-0550 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Maladies de l'appareil respiratoire (), Maladies de l'appareil respiratoire (diagnostic), Maladies de l'appareil respiratoire (virologie), Mâle, Voyage.
- MESH :
- diagnostic : Infections à coronavirus, Maladies de l'appareil respiratoire.
- virologie : Infections à coronavirus, Maladies de l'appareil respiratoire.
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Infections à coronavirus, Maladies de l'appareil respiratoire, Mâle, Voyage.
English descriptors
- KwdEn :
- Animals, Coronavirus Infections (diagnosis), Coronavirus Infections (therapy), Coronavirus Infections (virology), Female, Humans, Male, Middle East Respiratory Syndrome Coronavirus, Respiratory Tract Diseases (diagnosis), Respiratory Tract Diseases (therapy), Respiratory Tract Diseases (virology), Travel.
- MESH :
- diagnosis : Coronavirus Infections, Respiratory Tract Diseases.
- therapy : Coronavirus Infections, Respiratory Tract Diseases.
- virology : Coronavirus Infections, Respiratory Tract Diseases.
- Animals, Female, Humans, Male, Middle East Respiratory Syndrome Coronavirus, Travel.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) that causes a severe lower respiratory tract infection in humans is now considered a pandemic threat to the Gulf region. Since its discovery in 2012, MERS-CoV has reached 23 countries affecting about 1100 people, including a dozen children, and claiming over 400 lives. Compared to SARS (severe acute respiratory syndrome), MERS-CoV appears to kill more people (40% versus 10%), more quickly, and is especially more severe in those with pre-existing medical conditions. Most MERS-CoV cases (>85%) reported thus far have a history of residence in, or travel to the Middle East. The current epidemiology is characterised by slow and sustained transmission with occasional sparks. The dromedary camel is the intermediate host of MERS-CoV, but the transmission cycle is not fully understood. In this current review, we have briefly summarised the latest information on the epidemiology, clinical features, diagnosis, treatment and prevention of MERS-CoV especially highlighting the knowledge gaps in its transmission dynamics, diagnosis and preventive strategy.
DOI: 10.1016/j.prrv.2015.04.002
PubMed: 26002405
Affiliations:
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Since its discovery in 2012, MERS-CoV has reached 23 countries affecting about 1100 people, including a dozen children, and claiming over 400 lives. Compared to SARS (severe acute respiratory syndrome), MERS-CoV appears to kill more people (40% versus 10%), more quickly, and is especially more severe in those with pre-existing medical conditions. Most MERS-CoV cases (>85%) reported thus far have a history of residence in, or travel to the Middle East. The current epidemiology is characterised by slow and sustained transmission with occasional sparks. The dromedary camel is the intermediate host of MERS-CoV, but the transmission cycle is not fully understood. In this current review, we have briefly summarised the latest information on the epidemiology, clinical features, diagnosis, treatment and prevention of MERS-CoV especially highlighting the knowledge gaps in its transmission dynamics, diagnosis and preventive strategy. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26002405</PMID><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-0550</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>3</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Paediatric respiratory reviews</Title><ISOAbbreviation>Paediatr Respir Rev</ISOAbbreviation></Journal><ArticleTitle>Middle East respiratory syndrome coronavirus "MERS-CoV": current knowledge gaps.</ArticleTitle><Pagination><MedlinePgn>197-202</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.prrv.2015.04.002</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1526-0542(15)00031-7</ELocationID><Abstract><AbstractText>The Middle East respiratory syndrome coronavirus (MERS-CoV) that causes a severe lower respiratory tract infection in humans is now considered a pandemic threat to the Gulf region. Since its discovery in 2012, MERS-CoV has reached 23 countries affecting about 1100 people, including a dozen children, and claiming over 400 lives. Compared to SARS (severe acute respiratory syndrome), MERS-CoV appears to kill more people (40% versus 10%), more quickly, and is especially more severe in those with pre-existing medical conditions. Most MERS-CoV cases (>85%) reported thus far have a history of residence in, or travel to the Middle East. The current epidemiology is characterised by slow and sustained transmission with occasional sparks. The dromedary camel is the intermediate host of MERS-CoV, but the transmission cycle is not fully understood. In this current review, we have briefly summarised the latest information on the epidemiology, clinical features, diagnosis, treatment and prevention of MERS-CoV especially highlighting the knowledge gaps in its transmission dynamics, diagnosis and preventive strategy. </AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Banik</LastName><ForeName>G R</ForeName><Initials>GR</Initials><AffiliationInfo><Affiliation>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW, Australia; University of Technology Sydney, School of Medical and Molecular Biosciences, Broadway, Sydney, NSW, Australia. Electronic address: GouriRani.Banik@student.uts.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khandaker</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Centre for Perinatal Infection Research, The Children's Hospital at Westmead and The University of Sydney, Sydney, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, the University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rashid</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, the University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Paediatr Respir Rev</MedlineTA><NlmUniqueID>100898941</NlmUniqueID><ISSNLinking>1526-0542</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D065207" MajorTopicYN="Y">Middle East Respiratory Syndrome Coronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012140" MajorTopicYN="N">Respiratory Tract Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000628" 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