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Blood-Borne Pathogens: A Canadian Blood Services Centre for Innovation Symposium.

Identifieur interne : 000C96 ( PubMed/Checkpoint ); précédent : 000C95; suivant : 000C97

Blood-Borne Pathogens: A Canadian Blood Services Centre for Innovation Symposium.

Auteurs : Geraldine M. Walsh [Canada] ; Andrew W. Shih [Canada] ; Ziad Solh [Canada] ; Mia Golder [Canada] ; Peter Schubert [Canada] ; Margaret Fearon [Canada] ; William P. Sheffield [Canada]

Source :

Transfusion medicine reviews [ 1532-9496 ] ; 2016.

RBID : pubmed:26962008

Descripteurs français

KwdFr :
- Analyse de séquence (), Canada, Cellules cultivées, Contrôle des maladies contagieuses, Ebolavirus (génétique), Ebolavirus (isolement et purification), Fièvre hémorragique à virus Ebola (), Fièvre hémorragique à virus Ebola (sang), Fièvre hémorragique à virus Ebola (transmission), Fièvre hémorragique à virus Ebola (épidémiologie), Flambées de maladies, Gestion du risque, Humains, Inactivation virale, Maladies transmissibles émergentes (), Maladies transmissibles émergentes (transmission), Maladies transmissibles émergentes (épidémiologie), Pathogènes transmissibles par le sang (isolement et purification), Réaction transfusionnelle, Sécurité transfusionnelle (), Sécurité transfusionnelle (normes), Sécurité transfusionnelle (économie), Sélection de donneurs (), Sélection de donneurs (législation et jurisprudence), Sélection de donneurs (normes), Sélection de donneurs (organisation et administration), Techniques de culture cellulaire, Transmission de maladie infectieuse (), Érythrocytes (cytologie).
MESH :
- cytologie : Érythrocytes.
- génétique : Ebolavirus.
- isolement et purification : Ebolavirus, Pathogènes transmissibles par le sang.
- législation et jurisprudence : Sélection de donneurs.
- normes : Sécurité transfusionnelle, Sélection de donneurs.
- organisation et administration : Sélection de donneurs.
- sang : Fièvre hémorragique à virus Ebola.
- économie : Fièvre hémorragique à virus Ebola, Maladies transmissibles émergentes, Sécurité transfusionnelle.
- épidémiologie : Fièvre hémorragique à virus Ebola, Maladies transmissibles émergentes.
- Analyse de séquence, Canada, Cellules cultivées, Contrôle des maladies contagieuses, Fièvre hémorragique à virus Ebola, Flambées de maladies, Gestion du risque, Humains, Inactivation virale, Maladies transmissibles émergentes, Réaction transfusionnelle, Sécurité transfusionnelle, Sélection de donneurs, Techniques de culture cellulaire, Transmission de maladie infectieuse.

English descriptors

KwdEn :
- Blood Safety (economics), Blood Safety (methods), Blood Safety (standards), Blood-Borne Pathogens (isolation & purification), Canada, Cell Culture Techniques, Cells, Cultured, Communicable Disease Control, Communicable Diseases, Emerging (epidemiology), Communicable Diseases, Emerging (prevention & control), Communicable Diseases, Emerging (transmission), Disease Outbreaks, Disease Transmission, Infectious (prevention & control), Donor Selection (legislation & jurisprudence), Donor Selection (methods), Donor Selection (organization & administration), Donor Selection (standards), Ebolavirus (genetics), Ebolavirus (isolation & purification), Erythrocytes (cytology), Hemorrhagic Fever, Ebola (blood), Hemorrhagic Fever, Ebola (epidemiology), Hemorrhagic Fever, Ebola (prevention & control), Hemorrhagic Fever, Ebola (transmission), Humans, Risk Management, Sequence Analysis (methods), Transfusion Reaction, Virus Inactivation.
MESH :
- blood : Hemorrhagic Fever, Ebola.
- cytology : Erythrocytes.
- economics : Blood Safety.
- epidemiology : Communicable Diseases, Emerging, Hemorrhagic Fever, Ebola.
- genetics : Ebolavirus.
- isolation & purification : Blood-Borne Pathogens, Ebolavirus.
- legislation & jurisprudence : Donor Selection.
- methods : Blood Safety, Donor Selection, Sequence Analysis.
- organization & administration : Donor Selection.
- prevention & control : Communicable Diseases, Emerging, Disease Transmission, Infectious, Hemorrhagic Fever, Ebola.
- standards : Blood Safety, Donor Selection.
- transmission : Communicable Diseases, Emerging, Hemorrhagic Fever, Ebola.
- Canada, Cell Culture Techniques, Cells, Cultured, Communicable Disease Control, Disease Outbreaks, Humans, Risk Management, Transfusion Reaction, Virus Inactivation.

Abstract

Testing donations for pathogens and deferring selected blood donors have reduced the risk of transmission of known pathogens by transfusion to extremely low levels in most developed countries. Protecting the blood supply from emerging infectious threats remains a serious concern in the transfusion medicine community. Transfusion services can employ indirect measures such as surveillance, hemovigilance, and donor questioning (defense), protein-, or nucleic acid based direct testing (detection), or pathogen inactivation of blood products (destruction) as strategies to mitigate the risk of transmission-transmitted infection. In the North American context, emerging threats currently include dengue, chikungunya, and hepatitis E viruses, and Babesia protozoan parasites. The 2003 SARS and 2014 Ebola outbreaks illustrate the potential of epidemics unlikely to be transmitted by blood transfusion but disruptive to blood systems. Donor-free blood products such as ex vivo generated red blood cells offer a theoretical way to avoid transmission-transmitted infection risk, although biological, engineering, and manufacturing challenges must be overcome before this approach becomes practical. Similarly, next generation sequencing of all nucleic acid in a blood sample is currently possible but impractical for generalized screening. Pathogen inactivation systems are in use in different jurisdictions around the world, and are starting to gain regulatory approval in North America. Cost concerns make it likely that pathogen inactivation will be contemplated by blood operators through the lens of health economics and risk-based decision making, rather than in zero-risk paradigms previously embraced for transfusable products. Defense of the blood supply from infectious disease risk will continue to require innovative combinations of surveillance, detection, and pathogen avoidance or inactivation.

DOI: 10.1016/j.tmrv.2016.02.003
PubMed: 26962008

Affiliations:

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Le document en format XML

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<term>Blood Safety (methods)</term>
<term>Blood Safety (standards)</term>
<term>Blood-Borne Pathogens (isolation & purification)</term>
<term>Canada</term>
<term>Cell Culture Techniques</term>
<term>Cells, Cultured</term>
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<term>Donor Selection (methods)</term>
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<term>Ebolavirus (isolation & purification)</term>
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<term>Donor Selection</term>
<term>Sequence Analysis</term>
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<term>Hemorrhagic Fever, Ebola</term>
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<term>Donor Selection</term>
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<term>Maladies transmissibles émergentes</term>
<term>Sécurité transfusionnelle</term>
</keywords>
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<term>Cellules cultivées</term>
<term>Contrôle des maladies contagieuses</term>
<term>Fièvre hémorragique à virus Ebola</term>
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<term>Inactivation virale</term>
<term>Maladies transmissibles émergentes</term>
<term>Réaction transfusionnelle</term>
<term>Sécurité transfusionnelle</term>
<term>Sélection de donneurs</term>
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<front><div type="abstract" xml:lang="en">Testing donations for pathogens and deferring selected blood donors have reduced the risk of transmission of known pathogens by transfusion to extremely low levels in most developed countries. Protecting the blood supply from emerging infectious threats remains a serious concern in the transfusion medicine community. Transfusion services can employ indirect measures such as surveillance, hemovigilance, and donor questioning (defense), protein-, or nucleic acid based direct testing (detection), or pathogen inactivation of blood products (destruction) as strategies to mitigate the risk of transmission-transmitted infection. In the North American context, emerging threats currently include dengue, chikungunya, and hepatitis E viruses, and Babesia protozoan parasites. The 2003 SARS and 2014 Ebola outbreaks illustrate the potential of epidemics unlikely to be transmitted by blood transfusion but disruptive to blood systems. Donor-free blood products such as ex vivo generated red blood cells offer a theoretical way to avoid transmission-transmitted infection risk, although biological, engineering, and manufacturing challenges must be overcome before this approach becomes practical. Similarly, next generation sequencing of all nucleic acid in a blood sample is currently possible but impractical for generalized screening. Pathogen inactivation systems are in use in different jurisdictions around the world, and are starting to gain regulatory approval in North America. Cost concerns make it likely that pathogen inactivation will be contemplated by blood operators through the lens of health economics and risk-based decision making, rather than in zero-risk paradigms previously embraced for transfusable products. Defense of the blood supply from infectious disease risk will continue to require innovative combinations of surveillance, detection, and pathogen avoidance or inactivation. </div>
</front>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.tmrv.2016.02.003</ELocationID>
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<Abstract><AbstractText>Testing donations for pathogens and deferring selected blood donors have reduced the risk of transmission of known pathogens by transfusion to extremely low levels in most developed countries. Protecting the blood supply from emerging infectious threats remains a serious concern in the transfusion medicine community. Transfusion services can employ indirect measures such as surveillance, hemovigilance, and donor questioning (defense), protein-, or nucleic acid based direct testing (detection), or pathogen inactivation of blood products (destruction) as strategies to mitigate the risk of transmission-transmitted infection. In the North American context, emerging threats currently include dengue, chikungunya, and hepatitis E viruses, and Babesia protozoan parasites. The 2003 SARS and 2014 Ebola outbreaks illustrate the potential of epidemics unlikely to be transmitted by blood transfusion but disruptive to blood systems. Donor-free blood products such as ex vivo generated red blood cells offer a theoretical way to avoid transmission-transmitted infection risk, although biological, engineering, and manufacturing challenges must be overcome before this approach becomes practical. Similarly, next generation sequencing of all nucleic acid in a blood sample is currently possible but impractical for generalized screening. Pathogen inactivation systems are in use in different jurisdictions around the world, and are starting to gain regulatory approval in North America. Cost concerns make it likely that pathogen inactivation will be contemplated by blood operators through the lens of health economics and risk-based decision making, rather than in zero-risk paradigms previously embraced for transfusable products. Defense of the blood supply from infectious disease risk will continue to require innovative combinations of surveillance, detection, and pathogen avoidance or inactivation. </AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Walsh</LastName>
<ForeName>Geraldine M</ForeName>
<Initials>GM</Initials>
<AffiliationInfo><Affiliation>Centre for Innovation, Canadian Blood Services, Hamilton, Ottawa, and Vancouver, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shih</LastName>
<ForeName>Andrew W</ForeName>
<Initials>AW</Initials>
<AffiliationInfo><Affiliation>Medical Services and Innovation, Canadian Blood Services, McMaster University, Hamilton, Canada; Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solh</LastName>
<ForeName>Ziad</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Medical Services and Innovation, Canadian Blood Services, McMaster University, Hamilton, Canada; Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Golder</LastName>
<ForeName>Mia</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre for Innovation, Canadian Blood Services, Hamilton, Ottawa, and Vancouver, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schubert</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre for Innovation, Canadian Blood Services, Hamilton, Ottawa, and Vancouver, Canada; Centre for Blood Research, University of British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fearon</LastName>
<ForeName>Margaret</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Medical Services and Innovation, Canadian Blood Services, McMaster University, Hamilton, Canada; Pathology and Laboratory Medicine, University of Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sheffield</LastName>
<ForeName>William P</ForeName>
<Initials>WP</Initials>
<AffiliationInfo><Affiliation>Centre for Innovation, Canadian Blood Services, Hamilton, Ottawa, and Vancouver, Canada; Pathology and Molecular Medicine, McMaster University, Hamilton, Canada. Electronic address: sheffiel@mcmaster.ca.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016423">Congress</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>02</Month>
<Day>23</Day>
</ArticleDate>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Transfus Med Rev</MedlineTA>
<NlmUniqueID>8709027</NlmUniqueID>
<ISSNLinking>0887-7963</ISSNLinking>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D058731" MajorTopicYN="Y">Blood Safety</DescriptorName>
<QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
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<MeshHeading><DescriptorName UI="D017848" MajorTopicYN="Y">Blood-Borne Pathogens</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N">Canada</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018929" MajorTopicYN="N">Cell Culture Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003140" MajorTopicYN="N">Communicable Disease Control</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021821" MajorTopicYN="N">Communicable Diseases, Emerging</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
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<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
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<MeshHeading><DescriptorName UI="D018562" MajorTopicYN="N">Disease Transmission, Infectious</DescriptorName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
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<MeshHeading><DescriptorName UI="D046148" MajorTopicYN="N">Donor Selection</DescriptorName>
<QualifierName UI="Q000331" MajorTopicYN="N">legislation & jurisprudence</QualifierName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
<QualifierName UI="Q000458" MajorTopicYN="N">organization & administration</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
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<MeshHeading><DescriptorName UI="D029043" MajorTopicYN="N">Ebolavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004912" MajorTopicYN="N">Erythrocytes</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019142" MajorTopicYN="N">Hemorrhagic Fever, Ebola</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012308" MajorTopicYN="N">Risk Management</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017421" MajorTopicYN="N">Sequence Analysis</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
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<MeshHeading><DescriptorName UI="D065227" MajorTopicYN="N">Transfusion Reaction</DescriptorName>
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<MeshHeading><DescriptorName UI="D038301" MajorTopicYN="N">Virus Inactivation</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Blood-borne pathogens</Keyword>
<Keyword MajorTopicYN="N">Health economics</Keyword>
<Keyword MajorTopicYN="N">Next generation sequencing</Keyword>
<Keyword MajorTopicYN="N">Pathogen inactivation</Keyword>
<Keyword MajorTopicYN="N">Transfusion</Keyword>
<Keyword MajorTopicYN="N">Transfusion-transmitted infection</Keyword>
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<Day>18</Day>
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Blood-Borne Pathogens: A Canadian Blood Services Centre for Innovation Symposium.

Blood-Borne Pathogens: A Canadian Blood Services Centre for Innovation Symposium.

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