SrasV1, PubMed, Checkpoint, bibRecord, 000B34

Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study.

Identifieur interne : 000B34 ( PubMed/Checkpoint ); précédent : 000B33; suivant : 000B35

Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study.

Source :

European journal of medicinal chemistry [ 1768-3254 ] ; 2017.

RBID : pubmed:28624700

Descripteurs français

KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Cysteine endopeptidases (métabolisme), Disulfures (), Disulfures (pharmacologie), Disulfures (synthèse chimique), Découverte de médicament, Hydrocarbures aromatiques (), Hydrocarbures aromatiques (pharmacologie), Hydrocarbures aromatiques (synthèse chimique), Inhibiteurs de protéases (), Inhibiteurs de protéases (pharmacologie), Inhibiteurs de protéases (synthèse chimique), Protéines virales (antagonistes et inhibiteurs), Protéines virales (métabolisme), Relation dose-effet des médicaments, Relation quantitative structure-activité, Simulation de docking moléculaire, Structure moléculaire, Tests de sensibilité microbienne, Virus du SRAS (), Virus du SRAS (enzymologie).
MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Virus du SRAS.
- métabolisme : Cysteine endopeptidases, Protéines virales.
- pharmacologie : Antiviraux, Disulfures, Hydrocarbures aromatiques, Inhibiteurs de protéases.
- synthèse chimique : Antiviraux, Disulfures, Hydrocarbures aromatiques, Inhibiteurs de protéases.
- Antiviraux, Disulfures, Découverte de médicament, Hydrocarbures aromatiques, Inhibiteurs de protéases, Relation dose-effet des médicaments, Relation quantitative structure-activité, Simulation de docking moléculaire, Structure moléculaire, Tests de sensibilité microbienne, Virus du SRAS.

English descriptors

KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cysteine Endopeptidases (metabolism), Disulfides (chemical synthesis), Disulfides (chemistry), Disulfides (pharmacology), Dose-Response Relationship, Drug, Drug Discovery, Hydrocarbons, Aromatic (chemical synthesis), Hydrocarbons, Aromatic (chemistry), Hydrocarbons, Aromatic (pharmacology), Microbial Sensitivity Tests, Molecular Docking Simulation, Molecular Structure, Protease Inhibitors (chemical synthesis), Protease Inhibitors (chemistry), Protease Inhibitors (pharmacology), Quantitative Structure-Activity Relationship, SARS Virus (drug effects), SARS Virus (enzymology), Viral Proteins (antagonists & inhibitors), Viral Proteins (metabolism).
MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemical synthesis : Antiviral Agents, Disulfides, Hydrocarbons, Aromatic, Protease Inhibitors.
- chemical , chemistry : Antiviral Agents, Disulfides, Hydrocarbons, Aromatic, Protease Inhibitors.
- chemical , metabolism : Cysteine Endopeptidases, Viral Proteins.
- chemical , pharmacology : Antiviral Agents, Disulfides, Hydrocarbons, Aromatic, Protease Inhibitors.
- drug effects : SARS Virus.
- enzymology : SARS Virus.
- Dose-Response Relationship, Drug, Drug Discovery, Microbial Sensitivity Tests, Molecular Docking Simulation, Molecular Structure, Quantitative Structure-Activity Relationship.

Abstract

The worldwide outbreak of severe acute respiratory syndrome (SARS) in 2003 had caused a high rate of mortality. Main protease (M^pro) of SARS-associated coronavirus (SARS-CoV) is an important target to discover pharmaceutical compounds for the therapy of this life-threatening disease. During the course of screening new anti-SARS agents, we have identified that a series of unsymmetrical aromatic disulfides inhibited SARS-CoV M^pro significantly for the first time. Herein, 40 novel unsymmetrical aromatic disulfides were synthesized chemically and their biological activities were evaluated in vitro against SARS-CoV M^pro. These novel compounds displayed excellent IC₅₀ data in the range of 0.516-5.954 μM. Preliminary studies indicated that these disulfides are reversible and mpetitive inhibitors. A possible binding mode was generated via molecular docking simulation and a comparative field analysis (CoMFA) model was constructed to understand the structure-activity relationships. The present research therefore has provided some meaningful guidance to design and identify anti-SARS drugs with totally new chemical structures.

DOI: 10.1016/j.ejmech.2017.05.045
PubMed: 28624700

Affiliations:

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Le document en format XML

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<author><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name>
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<author><name sortKey="Wang, Zefang" sort="Wang, Zefang" uniqKey="Wang Z" first="Zefang" last="Wang">Zefang Wang</name>
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<wicri:regionArea>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457</wicri:regionArea>
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<author><name sortKey="Cai, Yan" sort="Cai, Yan" uniqKey="Cai Y" first="Yan" last="Cai">Yan Cai</name>
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<wicri:regionArea>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
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<author><name sortKey="Li, Shuang" sort="Li, Shuang" uniqKey="Li S" first="Shuang" last="Li">Shuang Li</name>
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<wicri:regionArea>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457</wicri:regionArea>
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<author><name sortKey="Fu, Sheng" sort="Fu, Sheng" uniqKey="Fu S" first="Sheng" last="Fu">Sheng Fu</name>
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<author><name sortKey="Song, Fu Hang" sort="Song, Fu Hang" uniqKey="Song F" first="Fu-Hang" last="Song">Fu-Hang Song</name>
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<wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101</wicri:regionArea>
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<author><name sortKey="Yang, Haitao" sort="Yang, Haitao" uniqKey="Yang H" first="Haitao" last="Yang">Haitao Yang</name>
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<author><name sortKey="Wang, Jian Guo" sort="Wang, Jian Guo" uniqKey="Wang J" first="Jian-Guo" last="Wang">Jian-Guo Wang</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (chemical synthesis)</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Cysteine Endopeptidases (metabolism)</term>
<term>Disulfides (chemical synthesis)</term>
<term>Disulfides (chemistry)</term>
<term>Disulfides (pharmacology)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Discovery</term>
<term>Hydrocarbons, Aromatic (chemical synthesis)</term>
<term>Hydrocarbons, Aromatic (chemistry)</term>
<term>Hydrocarbons, Aromatic (pharmacology)</term>
<term>Microbial Sensitivity Tests</term>
<term>Molecular Docking Simulation</term>
<term>Molecular Structure</term>
<term>Protease Inhibitors (chemical synthesis)</term>
<term>Protease Inhibitors (chemistry)</term>
<term>Protease Inhibitors (pharmacology)</term>
<term>Quantitative Structure-Activity Relationship</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (enzymology)</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
<term>Viral Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (synthèse chimique)</term>
<term>Cysteine endopeptidases (métabolisme)</term>
<term>Disulfures ()</term>
<term>Disulfures (pharmacologie)</term>
<term>Disulfures (synthèse chimique)</term>
<term>Découverte de médicament</term>
<term>Hydrocarbures aromatiques ()</term>
<term>Hydrocarbures aromatiques (pharmacologie)</term>
<term>Hydrocarbures aromatiques (synthèse chimique)</term>
<term>Inhibiteurs de protéases ()</term>
<term>Inhibiteurs de protéases (pharmacologie)</term>
<term>Inhibiteurs de protéases (synthèse chimique)</term>
<term>Protéines virales (antagonistes et inhibiteurs)</term>
<term>Protéines virales (métabolisme)</term>
<term>Relation dose-effet des médicaments</term>
<term>Relation quantitative structure-activité</term>
<term>Simulation de docking moléculaire</term>
<term>Structure moléculaire</term>
<term>Tests de sensibilité microbienne</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (enzymologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term>
</keywords>
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<term>Disulfides</term>
<term>Hydrocarbons, Aromatic</term>
<term>Protease Inhibitors</term>
</keywords>
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<term>Disulfides</term>
<term>Hydrocarbons, Aromatic</term>
<term>Protease Inhibitors</term>
</keywords>
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<term>Viral Proteins</term>
</keywords>
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<term>Disulfides</term>
<term>Hydrocarbons, Aromatic</term>
<term>Protease Inhibitors</term>
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<term>Disulfures</term>
<term>Hydrocarbures aromatiques</term>
<term>Inhibiteurs de protéases</term>
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<term>Inhibiteurs de protéases</term>
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<term>Microbial Sensitivity Tests</term>
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<term>Molecular Structure</term>
<term>Quantitative Structure-Activity Relationship</term>
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<term>Inhibiteurs de protéases</term>
<term>Relation dose-effet des médicaments</term>
<term>Relation quantitative structure-activité</term>
<term>Simulation de docking moléculaire</term>
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<front><div type="abstract" xml:lang="en">The worldwide outbreak of severe acute respiratory syndrome (SARS) in 2003 had caused a high rate of mortality. Main protease (M<sup>pro</sup>
) of SARS-associated coronavirus (SARS-CoV) is an important target to discover pharmaceutical compounds for the therapy of this life-threatening disease. During the course of screening new anti-SARS agents, we have identified that a series of unsymmetrical aromatic disulfides inhibited SARS-CoV M<sup>pro</sup>
 significantly for the first time. Herein, 40 novel unsymmetrical aromatic disulfides were synthesized chemically and their biological activities were evaluated in vitro against SARS-CoV M<sup>pro</sup>
. These novel compounds displayed excellent IC<sub>50</sub>
 data in the range of 0.516-5.954 μM. Preliminary studies indicated that these disulfides are reversible and mpetitive inhibitors. A possible binding mode was generated via molecular docking simulation and a comparative field analysis (CoMFA) model was constructed to understand the structure-activity relationships. The present research therefore has provided some meaningful guidance to design and identify anti-SARS drugs with totally new chemical structures.</div>
</front>
</TEI>
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<DateCompleted><Year>2017</Year>
<Month>09</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1768-3254</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>137</Volume>
<PubDate><Year>2017</Year>
<Month>Sep</Month>
<Day>08</Day>
</PubDate>
</JournalIssue>
<Title>European journal of medicinal chemistry</Title>
<ISOAbbreviation>Eur J Med Chem</ISOAbbreviation>
</Journal>
<ArticleTitle>Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study.</ArticleTitle>
<Pagination><MedlinePgn>450-461</MedlinePgn>
</Pagination>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejmech.2017.05.045</ELocationID>
<Abstract><AbstractText>The worldwide outbreak of severe acute respiratory syndrome (SARS) in 2003 had caused a high rate of mortality. Main protease (M<sup>pro</sup>
) of SARS-associated coronavirus (SARS-CoV) is an important target to discover pharmaceutical compounds for the therapy of this life-threatening disease. During the course of screening new anti-SARS agents, we have identified that a series of unsymmetrical aromatic disulfides inhibited SARS-CoV M<sup>pro</sup>
 significantly for the first time. Herein, 40 novel unsymmetrical aromatic disulfides were synthesized chemically and their biological activities were evaluated in vitro against SARS-CoV M<sup>pro</sup>
. These novel compounds displayed excellent IC<sub>50</sub>
 data in the range of 0.516-5.954 μM. Preliminary studies indicated that these disulfides are reversible and mpetitive inhibitors. A possible binding mode was generated via molecular docking simulation and a comparative field analysis (CoMFA) model was constructed to understand the structure-activity relationships. The present research therefore has provided some meaningful guidance to design and identify anti-SARS drugs with totally new chemical structures.</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier Masson SAS. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>State-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bao</LastName>
<ForeName>Bo-Bo</ForeName>
<Initials>BB</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Guo-Qing</ForeName>
<Initials>GQ</Initials>
<AffiliationInfo><Affiliation>State-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Cheng</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China. Electronic address: chengchen@tju.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xu-Meng</ForeName>
<Initials>XM</Initials>
<AffiliationInfo><Affiliation>State-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>State-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Zefang</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cai</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Shuang</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fu</LastName>
<ForeName>Sheng</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Fu-Hang</ForeName>
<Initials>FH</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Haitao</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jian-Guo</ForeName>
<Initials>JG</Initials>
<AffiliationInfo><Affiliation>State-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China. Electronic address: nkwjg@nankai.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>06</Month>
<Day>09</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>France</Country>
<MedlineTA>Eur J Med Chem</MedlineTA>
<NlmUniqueID>0420510</NlmUniqueID>
<ISSNLinking>0223-5234</ISSNLinking>
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<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
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<NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance>
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<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
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<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D062105" MajorTopicYN="Y">Molecular Docking Simulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011480" MajorTopicYN="N">Protease Inhibitors</DescriptorName>
<QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021281" MajorTopicYN="Y">Quantitative Structure-Activity Relationship</DescriptorName>
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<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aromatic disulfide</Keyword>
<Keyword MajorTopicYN="N">In vitro activity</Keyword>
<Keyword MajorTopicYN="N">Molecular docking</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV M(pro)</Keyword>
</KeywordList>
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<Day>27</Day>
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<Month>05</Month>
<Day>17</Day>
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<name sortKey="Cai, Yan" sort="Cai, Yan" uniqKey="Cai Y" first="Yan" last="Cai">Yan Cai</name>
<name sortKey="Chen, Cheng" sort="Chen, Cheng" uniqKey="Chen C" first="Cheng" last="Chen">Cheng Chen</name>
<name sortKey="Fu, Sheng" sort="Fu, Sheng" uniqKey="Fu S" first="Sheng" last="Fu">Sheng Fu</name>
<name sortKey="Li, Shuang" sort="Li, Shuang" uniqKey="Li S" first="Shuang" last="Li">Shuang Li</name>
<name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name>
<name sortKey="Song, Fu Hang" sort="Song, Fu Hang" uniqKey="Song F" first="Fu-Hang" last="Song">Fu-Hang Song</name>
<name sortKey="Song, Guo Qing" sort="Song, Guo Qing" uniqKey="Song G" first="Guo-Qing" last="Song">Guo-Qing Song</name>
<name sortKey="Wang, Jian Guo" sort="Wang, Jian Guo" uniqKey="Wang J" first="Jian-Guo" last="Wang">Jian-Guo Wang</name>
<name sortKey="Wang, Zefang" sort="Wang, Zefang" uniqKey="Wang Z" first="Zefang" last="Wang">Zefang Wang</name>
<name sortKey="Yang, Haitao" sort="Yang, Haitao" uniqKey="Yang H" first="Haitao" last="Yang">Haitao Yang</name>
<name sortKey="Zhang, Xu Meng" sort="Zhang, Xu Meng" uniqKey="Zhang X" first="Xu-Meng" last="Zhang">Xu-Meng Zhang</name>
</country>
</tree>
</affiliations>
</record>

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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B34 | SxmlIndent | more

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:28624700
   |texte=   Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:28624700" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

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Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study.

Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study.

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