SrasV1, PubMed, Checkpoint, bibRecord, 000A98

Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.

Identifieur interne : 000A98 ( PubMed/Checkpoint ); précédent : 000A97; suivant : 000A99

Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.

Auteurs : Franziska Schandock [Allemagne] ; Camilla Frich Riber [Danemark] ; Annika Röcker [Allemagne] ; Janis A. Müller [Allemagne] ; Mirja Harms [Allemagne] ; Paulina Gajda [Danemark] ; Kaja Zuwala [Danemark] ; Anna H F. Andersen [Danemark] ; Kaja Borup L Vschall [Danemark] ; Martin Tolstrup [Danemark] ; Florian Kreppel [Allemagne] ; Jan Münch [Allemagne] ; Alexander N. Zelikin [Danemark]

Source :

Advanced healthcare materials [ 2192-2659 ] ; 2017.

RBID : pubmed:28945945

Descripteurs français

KwdFr :
- Animaux, Antiviraux (), Antiviraux (pharmacologie), Cellules HEK293, Cellules Vero, Ebolavirus (métabolisme), Humains, Maladies virales (anatomopathologie), Maladies virales (métabolisme), Maladies virales (traitement médicamenteux), Polymères (), Polymères (pharmacologie), Virus Zika (métabolisme), Virus du SRAS (métabolisme).
MESH :
- anatomopathologie : Maladies virales.
- métabolisme : Ebolavirus, Maladies virales, Virus Zika, Virus du SRAS.
- pharmacologie : Antiviraux, Polymères.
- traitement médicamenteux : Maladies virales.
- Animaux, Antiviraux, Cellules HEK293, Cellules Vero, Humains, Polymères.

English descriptors

KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Chlorocebus aethiops, Ebolavirus (metabolism), HEK293 Cells, Humans, Polymers (chemistry), Polymers (pharmacology), SARS Virus (metabolism), Vero Cells, Virus Diseases (drug therapy), Virus Diseases (metabolism), Virus Diseases (pathology), Zika Virus (metabolism).
MESH :
- chemical , chemistry : Antiviral Agents, Polymers.
- chemical , pharmacology : Antiviral Agents, Polymers.
- drug therapy : Virus Diseases.
- metabolism : Ebolavirus, SARS Virus, Virus Diseases, Zika Virus.
- pathology : Virus Diseases.
- Animals, Chlorocebus aethiops, HEK293 Cells, Humans, Vero Cells.

Abstract

Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad-spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure-activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad-spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer-based antivirals and represent promising candidates for further development as preventive microbicides.

DOI: 10.1002/adhm.201700748
PubMed: 28945945

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad-spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure-activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad-spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer-based antivirals and represent promising candidates for further development as preventive microbicides.</div>
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<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Advanced healthcare materials</Title>
<ISOAbbreviation>Adv Healthc Mater</ISOAbbreviation>
</Journal>
<ArticleTitle>Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/adhm.201700748</ELocationID>
<Abstract><AbstractText>Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad-spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure-activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad-spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer-based antivirals and represent promising candidates for further development as preventive microbicides.</AbstractText>
<CopyrightInformation>© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schandock</LastName>
<ForeName>Franziska</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Riber</LastName>
<ForeName>Camilla Frich</ForeName>
<Initials>CF</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, Aarhus University, Aarhus, 8000, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Röcker</LastName>
<ForeName>Annika</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Müller</LastName>
<ForeName>Janis A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harms</LastName>
<ForeName>Mirja</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gajda</LastName>
<ForeName>Paulina</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Aarhus University Hospital, Aarhus, 8000, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zuwala</LastName>
<ForeName>Kaja</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Aarhus University Hospital, Aarhus, 8000, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Andersen</LastName>
<ForeName>Anna H F</ForeName>
<Initials>AHF</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Aarhus University Hospital, Aarhus, 8000, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Løvschall</LastName>
<ForeName>Kaja Borup</ForeName>
<Initials>KB</Initials>
<AffiliationInfo><Affiliation>Department of Chemistry, Aarhus University, Aarhus, 8000, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tolstrup</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, Aarhus University Hospital, Aarhus, 8000, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kreppel</LastName>
<ForeName>Florian</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Münch</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institute of Molecular Virology, Ulm University Medical Center, Meyerhofstrasse 1, 89081, Ulm, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zelikin</LastName>
<ForeName>Alexander N</ForeName>
<Initials>AN</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-9864-321X</Identifier>
<AffiliationInfo><Affiliation>Department of Chemistry, Aarhus University, Aarhus, 8000, Denmark.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, 8000, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>09</Month>
<Day>25</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Adv Healthc Mater</MedlineTA>
<NlmUniqueID>101581613</NlmUniqueID>
<ISSNLinking>2192-2640</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011108">Polymers</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="Y">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029043" MajorTopicYN="N">Ebolavirus</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011108" MajorTopicYN="Y">Polymers</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000071244" MajorTopicYN="N">Zika Virus</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Zika virus</Keyword>
<Keyword MajorTopicYN="N">broad spectrum antivirals</Keyword>
<Keyword MajorTopicYN="N">microbicides</Keyword>
<Keyword MajorTopicYN="N">polyanions</Keyword>
<Keyword MajorTopicYN="N">polymers</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>06</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>08</Month>
<Day>07</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>9</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>1</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>9</Month>
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<name sortKey="L Vschall, Kaja Borup" sort="L Vschall, Kaja Borup" uniqKey="L Vschall K" first="Kaja Borup" last="L Vschall">Kaja Borup L Vschall</name>
<name sortKey="Tolstrup, Martin" sort="Tolstrup, Martin" uniqKey="Tolstrup M" first="Martin" last="Tolstrup">Martin Tolstrup</name>
<name sortKey="Zelikin, Alexander N" sort="Zelikin, Alexander N" uniqKey="Zelikin A" first="Alexander N" last="Zelikin">Alexander N. Zelikin</name>
<name sortKey="Zuwala, Kaja" sort="Zuwala, Kaja" uniqKey="Zuwala K" first="Kaja" last="Zuwala">Kaja Zuwala</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A98 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000A98 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:28945945
   |texte=   Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:28945945" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.

Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki