Serveur d'exploration SRAS

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.

Identifieur interne : 000811 ( PubMed/Checkpoint ); précédent : 000810; suivant : 000812

A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.

Auteurs : Andrea Cortegiani [Italie] ; Giulia Ingoglia [Italie] ; Mariachiara Ippolito [Italie] ; Antonino Giarratano [Italie] ; Sharon Einav [Israël]

Source :

RBID : pubmed:32173110

Abstract

COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19.

DOI: 10.1016/j.jcrc.2020.03.005
PubMed: 32173110


Affiliations:


Links toward previous steps (curation, corpus...)


Links to Exploration step

pubmed:32173110

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.</title>
<author>
<name sortKey="Cortegiani, Andrea" sort="Cortegiani, Andrea" uniqKey="Cortegiani A" first="Andrea" last="Cortegiani">Andrea Cortegiani</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy. Electronic address: andrea.cortegiani@unipa.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo</wicri:regionArea>
<wicri:noRegion>University of Palermo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ingoglia, Giulia" sort="Ingoglia, Giulia" uniqKey="Ingoglia G" first="Giulia" last="Ingoglia">Giulia Ingoglia</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo</wicri:regionArea>
<wicri:noRegion>University of Palermo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ippolito, Mariachiara" sort="Ippolito, Mariachiara" uniqKey="Ippolito M" first="Mariachiara" last="Ippolito">Mariachiara Ippolito</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo</wicri:regionArea>
<wicri:noRegion>University of Palermo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Giarratano, Antonino" sort="Giarratano, Antonino" uniqKey="Giarratano A" first="Antonino" last="Giarratano">Antonino Giarratano</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo</wicri:regionArea>
<wicri:noRegion>University of Palermo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Einav, Sharon" sort="Einav, Sharon" uniqKey="Einav S" first="Sharon" last="Einav">Sharon Einav</name>
<affiliation wicri:level="1">
<nlm:affiliation>Intensive Care Unit of the Shaare Zedek Medical Medical Centre, Hebrew University Faculty of Medicine, Jerusalem, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Intensive Care Unit of the Shaare Zedek Medical Medical Centre, Hebrew University Faculty of Medicine, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32173110</idno>
<idno type="pmid">32173110</idno>
<idno type="doi">10.1016/j.jcrc.2020.03.005</idno>
<idno type="wicri:Area/PubMed/Corpus">000616</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000616</idno>
<idno type="wicri:Area/PubMed/Curation">000616</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000616</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000811</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000811</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.</title>
<author>
<name sortKey="Cortegiani, Andrea" sort="Cortegiani, Andrea" uniqKey="Cortegiani A" first="Andrea" last="Cortegiani">Andrea Cortegiani</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy. Electronic address: andrea.cortegiani@unipa.it.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo</wicri:regionArea>
<wicri:noRegion>University of Palermo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ingoglia, Giulia" sort="Ingoglia, Giulia" uniqKey="Ingoglia G" first="Giulia" last="Ingoglia">Giulia Ingoglia</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo</wicri:regionArea>
<wicri:noRegion>University of Palermo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ippolito, Mariachiara" sort="Ippolito, Mariachiara" uniqKey="Ippolito M" first="Mariachiara" last="Ippolito">Mariachiara Ippolito</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo</wicri:regionArea>
<wicri:noRegion>University of Palermo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Giarratano, Antonino" sort="Giarratano, Antonino" uniqKey="Giarratano A" first="Antonino" last="Giarratano">Antonino Giarratano</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo</wicri:regionArea>
<wicri:noRegion>University of Palermo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Einav, Sharon" sort="Einav, Sharon" uniqKey="Einav S" first="Sharon" last="Einav">Sharon Einav</name>
<affiliation wicri:level="1">
<nlm:affiliation>Intensive Care Unit of the Shaare Zedek Medical Medical Centre, Hebrew University Faculty of Medicine, Jerusalem, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Intensive Care Unit of the Shaare Zedek Medical Medical Centre, Hebrew University Faculty of Medicine, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Journal of critical care</title>
<idno type="eISSN">1557-8615</idno>
<imprint>
<date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="Publisher" Owner="NLM">
<PMID Version="1">32173110</PMID>
<DateRevised>
<Year>2020</Year>
<Month>03</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1557-8615</ISSN>
<JournalIssue CitedMedium="Internet">
<PubDate>
<Year>2020</Year>
<Month>Mar</Month>
<Day>10</Day>
</PubDate>
</JournalIssue>
<Title>Journal of critical care</Title>
<ISOAbbreviation>J Crit Care</ISOAbbreviation>
</Journal>
<ArticleTitle>A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">S0883-9441(20)30390-7</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcrc.2020.03.005</ELocationID>
<Abstract>
<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">PubMed, EMBASE, and three trial Registries were searched for studies on the use of chloroquine in patients with COVID-19.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. Chloroquine seems to be effective in limiting the replication of SARS-CoV-2 (virus causing COVID-19) in vitro.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. Safety data and data from high-quality clinical trials are urgently needed.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Cortegiani</LastName>
<ForeName>Andrea</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy. Electronic address: andrea.cortegiani@unipa.it.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ingoglia</LastName>
<ForeName>Giulia</ForeName>
<Initials>G</Initials>
<AffiliationInfo>
<Affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ippolito</LastName>
<ForeName>Mariachiara</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Giarratano</LastName>
<ForeName>Antonino</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Einav</LastName>
<ForeName>Sharon</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Intensive Care Unit of the Shaare Zedek Medical Medical Centre, Hebrew University Faculty of Medicine, Jerusalem, Israel.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2020</Year>
<Month>03</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>United States</Country>
<MedlineTA>J Crit Care</MedlineTA>
<NlmUniqueID>8610642</NlmUniqueID>
<ISSNLinking>0883-9441</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Chloroquine</Keyword>
<Keyword MajorTopicYN="N">Coronavirus</Keyword>
<Keyword MajorTopicYN="N">Pneumonia</Keyword>
<Keyword MajorTopicYN="N">SARS-CoV-2</Keyword>
</KeywordList>
<CoiStatement>Declaration of Competing Interest AC, GI, MI, AG, SE declare to have no competing interests.</CoiStatement>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2020</Year>
<Month>03</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2020</Year>
<Month>03</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2020</Year>
<Month>03</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2020</Year>
<Month>3</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2020</Year>
<Month>3</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2020</Year>
<Month>3</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">32173110</ArticleId>
<ArticleId IdType="pii">S0883-9441(20)30390-7</ArticleId>
<ArticleId IdType="doi">10.1016/j.jcrc.2020.03.005</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Israël</li>
<li>Italie</li>
</country>
</list>
<tree>
<country name="Italie">
<noRegion>
<name sortKey="Cortegiani, Andrea" sort="Cortegiani, Andrea" uniqKey="Cortegiani A" first="Andrea" last="Cortegiani">Andrea Cortegiani</name>
</noRegion>
<name sortKey="Giarratano, Antonino" sort="Giarratano, Antonino" uniqKey="Giarratano A" first="Antonino" last="Giarratano">Antonino Giarratano</name>
<name sortKey="Ingoglia, Giulia" sort="Ingoglia, Giulia" uniqKey="Ingoglia G" first="Giulia" last="Ingoglia">Giulia Ingoglia</name>
<name sortKey="Ippolito, Mariachiara" sort="Ippolito, Mariachiara" uniqKey="Ippolito M" first="Mariachiara" last="Ippolito">Mariachiara Ippolito</name>
</country>
<country name="Israël">
<noRegion>
<name sortKey="Einav, Sharon" sort="Einav, Sharon" uniqKey="Einav S" first="Sharon" last="Einav">Sharon Einav</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000811 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000811 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:32173110
   |texte=   A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:32173110" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1 

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021