Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.
Identifieur interne : 000548 ( PubMed/Checkpoint ); précédent : 000547; suivant : 000549Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.
Auteurs : Hong-Long Ji [États-Unis] ; Runzhen Zhao [États-Unis] ; Sadis Matalon [États-Unis] ; Michael A. Matthay [États-Unis]Source :
- Physiological reviews [ 1522-1210 ] ; 2020.
Descripteurs français
- KwdFr :
- Comorbidité, Facteurs de risque, Fibrinolysine (métabolisme), Humains, Infections à coronavirus (mortalité), Infections à coronavirus (physiopathologie), Infections à coronavirus (sang), Infections à coronavirus (épidémiologie), Interactions hôte-pathogène (physiologie), Pandémies, Plasminogène (métabolisme), Pneumopathie virale (mortalité), Pneumopathie virale (physiopathologie), Pneumopathie virale (sang), Pneumopathie virale (épidémiologie), Susceptibilité à une maladie (sang), Syndrome de détresse respiratoire de l'adulte (physiopathologie), Syndrome de détresse respiratoire de l'adulte (sang), Syndrome de détresse respiratoire de l'adulte (virologie).
- MESH :
- mortalité : Infections à coronavirus, Pneumopathie virale.
- métabolisme : Fibrinolysine, Plasminogène.
- physiologie : Interactions hôte-pathogène.
- physiopathologie : Infections à coronavirus, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- sang : Infections à coronavirus, Pneumopathie virale, Susceptibilité à une maladie, Syndrome de détresse respiratoire de l'adulte.
- virologie : Syndrome de détresse respiratoire de l'adulte.
- épidémiologie : Infections à coronavirus, Pneumopathie virale.
- Comorbidité, Facteurs de risque, Humains, Pandémies.
English descriptors
- KwdEn :
- Betacoronavirus (metabolism), Betacoronavirus (pathogenicity), Comorbidity, Coronavirus Infections (blood), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (physiopathology), Disease Susceptibility (blood), Fibrinolysin (metabolism), Host-Pathogen Interactions (physiology), Humans, Pandemics, Plasminogen (metabolism), Pneumonia, Viral (blood), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Pneumonia, Viral (physiopathology), Respiratory Distress Syndrome, Adult (blood), Respiratory Distress Syndrome, Adult (physiopathology), Respiratory Distress Syndrome, Adult (virology), Risk Factors.
- MESH :
- chemical , metabolism : Fibrinolysin, Plasminogen.
- blood : Coronavirus Infections, Disease Susceptibility, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- metabolism : Betacoronavirus.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- physiology : Host-Pathogen Interactions.
- physiopathology : Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- virology : Respiratory Distress Syndrome, Adult.
- Comorbidity, Humans, Pandemics, Risk Factors.
Abstract
Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19.
DOI: 10.1152/physrev.00013.2020
PubMed: 32216698
Affiliations:
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Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Zhao, Runzhen" sort="Zhao, Runzhen" uniqKey="Zhao R" first="Runzhen" last="Zhao">Runzhen Zhao</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Matalon, Sadis" sort="Matalon, Sadis" uniqKey="Matalon S" first="Sadis" last="Matalon">Sadis Matalon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Matthay, Michael A" sort="Matthay, Michael A" uniqKey="Matthay M" first="Michael A" last="Matthay">Michael A. Matthay</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division 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(physiology)</term><term>Humans</term><term>Pandemics</term><term>Plasminogen (metabolism)</term><term>Pneumonia, Viral (blood)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (physiopathology)</term><term>Respiratory Distress Syndrome, Adult (blood)</term><term>Respiratory Distress Syndrome, Adult (physiopathology)</term><term>Respiratory Distress Syndrome, Adult (virology)</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Comorbidité</term><term>Facteurs de risque</term><term>Fibrinolysine (métabolisme)</term><term>Humains</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (physiopathologie)</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (épidémiologie)</term><term>Interactions hôte-pathogène (physiologie)</term><term>Pandémies</term><term>Plasminogène (métabolisme)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (physiopathologie)</term><term>Pneumopathie virale (sang)</term><term>Pneumopathie virale (épidémiologie)</term><term>Susceptibilité à une maladie (sang)</term><term>Syndrome de détresse respiratoire de l'adulte (physiopathologie)</term><term>Syndrome de détresse respiratoire de l'adulte (sang)</term><term>Syndrome de détresse respiratoire de l'adulte (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fibrinolysin</term><term>Plasminogen</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Disease Susceptibility</term><term>Pneumonia, Viral</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="metabolism" 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xml:lang="fr"><term>Comorbidité</term><term>Facteurs de risque</term><term>Humains</term><term>Pandémies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32216698</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-1210</ISSN><JournalIssue CitedMedium="Internet"><Volume>100</Volume><Issue>3</Issue><PubDate><Year>2020</Year><Month>07</Month><Day>01</Day></PubDate></JournalIssue><Title>Physiological reviews</Title><ISOAbbreviation>Physiol. Rev.</ISOAbbreviation></Journal><ArticleTitle>Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.</ArticleTitle><Pagination><MedlinePgn>1065-1075</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1152/physrev.00013.2020</ELocationID><Abstract><AbstractText>Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ji</LastName><ForeName>Hong-Long</ForeName><Initials>HL</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Runzhen</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matalon</LastName><ForeName>Sadis</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matthay</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HL087017</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R03 HL095435</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL134828</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 ES026458</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 ES027697</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Physiol Rev</MedlineTA><NlmUniqueID>0231714</NlmUniqueID><ISSNLinking>0031-9333</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9001-91-6</RegistryNumber><NameOfSubstance UI="D010958">Plasminogen</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.21.7</RegistryNumber><NameOfSubstance UI="D005341">Fibrinolysin</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004198" MajorTopicYN="N">Disease Susceptibility</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005341" MajorTopicYN="N">Fibrinolysin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010958" MajorTopicYN="N">Plasminogen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">comorbidity</Keyword><Keyword MajorTopicYN="Y">fibrinolysis</Keyword><Keyword MajorTopicYN="Y">plasmin(ogen)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32216698</ArticleId><ArticleId IdType="doi">10.1152/physrev.00013.2020</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Ji, Hong Long" sort="Ji, Hong Long" uniqKey="Ji H" first="Hong-Long" last="Ji">Hong-Long Ji</name></region><name sortKey="Matalon, Sadis" sort="Matalon, Sadis" uniqKey="Matalon S" first="Sadis" last="Matalon">Sadis Matalon</name><name sortKey="Matthay, Michael A" sort="Matthay, Michael A" uniqKey="Matthay M" first="Michael A" last="Matthay">Michael A. Matthay</name><name sortKey="Zhao, Runzhen" sort="Zhao, Runzhen" uniqKey="Zhao R" first="Runzhen" last="Zhao">Runzhen Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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