False-negative of RT-PCR and prolonged nucleic acid conversion in COVID-19: Rather than recurrence.
Identifieur interne : 000511 ( PubMed/Checkpoint ); précédent : 000510; suivant : 000512False-negative of RT-PCR and prolonged nucleic acid conversion in COVID-19: Rather than recurrence.
Auteurs : Ai Tang Xiao ; Yi Xin Tong ; Sheng ZhangSource :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Abstract
A novel coronavirus (COVID-19) pandemic cause by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) threatens the world. We read with interest the recent report by Li et al. that included 610 patients with Coronavirus Disease 2019 (COVID-19). They reported a high false-negative rate of real-time reverse transcription polymerase chain reaction (RT-PCR) results for SARS-CoV-2 detection. In addition, recent report regarding SARS-CoV-2 "turn positive" in recovered cases with COVID-19 were published. Here, we studied the characteristics of nucleic acid conversion for SARS-CoV-2 from 70 COVID-19 patients. We found that 15 (21.4%) patients experienced a "turn positive" of nucleic acid detection by RT-PCR test for SARS-CoV-2 after two consecutive negative results, which may be related to the false negative of RT-PCR test and prolonged nucleic acid conversion This article is protected by copyright. All rights reserved.
DOI: 10.1002/jmv.25855
PubMed: 32270882
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We read with interest the recent report by Li et al. that included 610 patients with Coronavirus Disease 2019 (COVID-19). They reported a high false-negative rate of real-time reverse transcription polymerase chain reaction (RT-PCR) results for SARS-CoV-2 detection. In addition, recent report regarding SARS-CoV-2 "turn positive" in recovered cases with COVID-19 were published. Here, we studied the characteristics of nucleic acid conversion for SARS-CoV-2 from 70 COVID-19 patients. We found that 15 (21.4%) patients experienced a "turn positive" of nucleic acid detection by RT-PCR test for SARS-CoV-2 after two consecutive negative results, which may be related to the false negative of RT-PCR test and prolonged nucleic acid conversion This article is protected by copyright. All rights reserved.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32270882</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-9071</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>09</Day></PubDate></JournalIssue><Title>Journal of medical virology</Title><ISOAbbreviation>J. Med. Virol.</ISOAbbreviation></Journal><ArticleTitle>False-negative of RT-PCR and prolonged nucleic acid conversion in COVID-19: Rather than recurrence.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1002/jmv.25855</ELocationID><Abstract><AbstractText>A novel coronavirus (COVID-19) pandemic cause by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) threatens the world. We read with interest the recent report by Li et al. that included 610 patients with Coronavirus Disease 2019 (COVID-19). They reported a high false-negative rate of real-time reverse transcription polymerase chain reaction (RT-PCR) results for SARS-CoV-2 detection. In addition, recent report regarding SARS-CoV-2 "turn positive" in recovered cases with COVID-19 were published. Here, we studied the characteristics of nucleic acid conversion for SARS-CoV-2 from 70 COVID-19 patients. We found that 15 (21.4%) patients experienced a "turn positive" of nucleic acid detection by RT-PCR test for SARS-CoV-2 after two consecutive negative results, which may be related to the false negative of RT-PCR test and prolonged nucleic acid conversion This article is protected by copyright. All rights reserved.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Ai Tang</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tong</LastName><ForeName>Yi Xin</ForeName><Initials>YX</Initials><AffiliationInfo><Affiliation>Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Sheng</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-0268-8593</Identifier><AffiliationInfo><Affiliation>Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016422">Letter</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Med Virol</MedlineTA><NlmUniqueID>7705876</NlmUniqueID><ISSNLinking>0146-6615</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Coronavirus < Virus classification</Keyword><Keyword MajorTopicYN="N">SARS coronavirus < Virus classification</Keyword><Keyword MajorTopicYN="N">Shedding < Pathogenesis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32270882</ArticleId><ArticleId IdType="doi">10.1002/jmv.25855</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Tong, Yi Xin" sort="Tong, Yi Xin" uniqKey="Tong Y" first="Yi Xin" last="Tong">Yi Xin Tong</name><name sortKey="Xiao, Ai Tang" sort="Xiao, Ai Tang" uniqKey="Xiao A" first="Ai Tang" last="Xiao">Ai Tang Xiao</name><name sortKey="Zhang, Sheng" sort="Zhang, Sheng" uniqKey="Zhang S" first="Sheng" last="Zhang">Sheng Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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