Recent discovery and development of inhibitors targeting coronaviruses.
Identifieur interne : 000269 ( PubMed/Checkpoint ); précédent : 000268; suivant : 000270Recent discovery and development of inhibitors targeting coronaviruses.
Auteurs : Thanigaimalai Pillaiyar [Allemagne] ; Sangeetha Meenakshisundaram [Inde] ; Manoj Manickam [Inde]Source :
- Drug discovery today [ 1878-5832 ] ; 2020.
Abstract
Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and MiddleEast respiratory syndrome (MERS) coronavirus (MERS-CoV). They cause moderate to severe respiratory and intestinal infections in humans. In this review, we focus on recent advances in the research and development of small-molecule anti-human coronavirus therapies targeting different stages of the CoV life cycle.
DOI: 10.1016/j.drudis.2020.01.015
PubMed: 32006468
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Electronic address: thanigai@uni-bonn.deand.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Meenakshisundaram, Sangeetha" sort="Meenakshisundaram, Sangeetha" uniqKey="Meenakshisundaram S" first="Sangeetha" last="Meenakshisundaram">Sangeetha Meenakshisundaram</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, Sri Krishna College of Engineering and Technology, Coimbatore, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Chemistry, Sri Krishna College of Engineering and Technology, Coimbatore, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Manickam, Manoj" sort="Manickam, Manoj" uniqKey="Manickam M" first="Manoj" last="Manickam">Manoj Manickam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, PSG Institute of Technology and Applied Research, Coimbatore, Tamil Nadu, India. Electronic address: manojm@psgitech.ac.in.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Chemistry, PSG Institute of Technology and Applied Research, Coimbatore, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Drug discovery today</title><idno type="eISSN">1878-5832</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and MiddleEast respiratory syndrome (MERS) coronavirus (MERS-CoV). They cause moderate to severe respiratory and intestinal infections in humans. In this review, we focus on recent advances in the research and development of small-molecule anti-human coronavirus therapies targeting different stages of the CoV life cycle.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32006468</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5832</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jan</Month><Day>30</Day></PubDate></JournalIssue><Title>Drug discovery today</Title><ISOAbbreviation>Drug Discov. Today</ISOAbbreviation></Journal><ArticleTitle>Recent discovery and development of inhibitors targeting coronaviruses.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S1359-6446(20)30041-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.drudis.2020.01.015</ELocationID><Abstract><AbstractText>Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and MiddleEast respiratory syndrome (MERS) coronavirus (MERS-CoV). They cause moderate to severe respiratory and intestinal infections in humans. In this review, we focus on recent advances in the research and development of small-molecule anti-human coronavirus therapies targeting different stages of the CoV life cycle.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pillaiyar</LastName><ForeName>Thanigaimalai</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany. 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