Smell dysfunction: a biomarker for COVID-19.
Identifieur interne : 000183 ( PubMed/Checkpoint ); précédent : 000182; suivant : 000184Smell dysfunction: a biomarker for COVID-19.
Auteurs : Shima T. Moein [Iran] ; Seyed M R. Hashemian [Iran] ; Babak Mansourafshar [Iran] ; Ali Khorram-Tousi [Iran] ; Payam Tabarsi [Iran] ; Richard L. Doty [États-Unis]Source :
- International forum of allergy & rhinology [ 2042-6984 ] ; 2020.
Abstract
SARS-CoV-2, the virus that causes COVID-19 disease, is responsible for the largest pandemic since the 1918 H1N1 influenza outbreak. The symptoms presently recognized by the World Health Organization are cough, fever, tiredness, and difficulty breathing. Patient-reported smell and taste loss has been associated with COVID-19 infection, yet no empirical olfactory testing on a cohort of COVID-19 patients has been performed.
DOI: 10.1002/alr.22587
PubMed: 32301284
Affiliations:
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Doty</name><affiliation wicri:level="2"><nlm:affiliation>Smell & Taste Center, Department of Otorhinolaryngology-Head and Neck, Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Smell & Taste Center, Department of Otorhinolaryngology-Head and Neck, Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32301284</idno><idno type="pmid">32301284</idno><idno type="doi">10.1002/alr.22587</idno><idno type="wicri:Area/PubMed/Corpus">000062</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000062</idno><idno type="wicri:Area/PubMed/Curation">000062</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000062</idno><idno type="wicri:Area/PubMed/Checkpoint">000183</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000183</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Smell dysfunction: a biomarker for COVID-19.</title><author><name sortKey="Moein, Shima T" sort="Moein, Shima T" uniqKey="Moein S" first="Shima T" last="Moein">Shima T. Moein</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>School of Biological Sciences, Institute for Research in Fundamental Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Hashemian, Seyed M R" sort="Hashemian, Seyed M R" uniqKey="Hashemian S" first="Seyed M R" last="Hashemian">Seyed M R. Hashemian</name><affiliation wicri:level="1"><nlm:affiliation>Chronic Respiratory Diseases Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Chronic Respiratory Diseases Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Mansourafshar, Babak" sort="Mansourafshar, Babak" uniqKey="Mansourafshar B" first="Babak" last="Mansourafshar">Babak Mansourafshar</name><affiliation wicri:level="1"><nlm:affiliation>Chronic Respiratory Diseases Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Chronic Respiratory Diseases Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Khorram Tousi, Ali" sort="Khorram Tousi, Ali" uniqKey="Khorram Tousi A" first="Ali" last="Khorram-Tousi">Ali Khorram-Tousi</name><affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>School of Biological Sciences, Institute for Research in Fundamental Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Tabarsi, Payam" sort="Tabarsi, Payam" uniqKey="Tabarsi P" first="Payam" last="Tabarsi">Payam Tabarsi</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Doty, Richard L" sort="Doty, Richard L" uniqKey="Doty R" first="Richard L" last="Doty">Richard L. Doty</name><affiliation wicri:level="2"><nlm:affiliation>Smell & Taste Center, Department of Otorhinolaryngology-Head and Neck, Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Smell & Taste Center, Department of Otorhinolaryngology-Head and Neck, Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author></analytic><series><title level="j">International forum of allergy & rhinology</title><idno type="eISSN">2042-6984</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SARS-CoV-2, the virus that causes COVID-19 disease, is responsible for the largest pandemic since the 1918 H1N1 influenza outbreak. The symptoms presently recognized by the World Health Organization are cough, fever, tiredness, and difficulty breathing. Patient-reported smell and taste loss has been associated with COVID-19 infection, yet no empirical olfactory testing on a cohort of COVID-19 patients has been performed.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32301284</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2042-6984</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>17</Day></PubDate></JournalIssue><Title>International forum of allergy & rhinology</Title><ISOAbbreviation>Int Forum Allergy Rhinol</ISOAbbreviation></Journal><ArticleTitle>Smell dysfunction: a biomarker for COVID-19.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1002/alr.22587</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">SARS-CoV-2, the virus that causes COVID-19 disease, is responsible for the largest pandemic since the 1918 H1N1 influenza outbreak. The symptoms presently recognized by the World Health Organization are cough, fever, tiredness, and difficulty breathing. Patient-reported smell and taste loss has been associated with COVID-19 infection, yet no empirical olfactory testing on a cohort of COVID-19 patients has been performed.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The University of Pennsylvania Smell Identification Test (UPSIT), a well-validated 40-odorant test, was administered to 60 confirmed COVID-19 inpatients and 60 age- and sex-matched controls to assess the magnitude and frequency of their olfactory dysfunction. A mixed effects analysis of variance determined whether meaningful differences in test scores existed between the two groups and if the test scores were differentially influenced by sex.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Fifty-nine (98%) of the 60 patients exhibited some smell dysfunction [mean (95% CI) UPSIT score: 20.98 (19.47,22.48); controls: 34.10 (33.31,34.88); p<0.0001]. Thirty-five of the 60 patients (58%) were either anosmic (15/60; 25%) or severely microsmic (20/60; 33%); 16 exhibited moderate microsmia (16/60; 27%), 8 mild microsmia (8/60; 13%), and one normosmia (1/60; 2%). Deficits were evident for all 40 UPSIT odorants. No meaningful relationships between the test scores and sex, disease severity, or comorbidities were found.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Quantitative smell testing demonstrates that decreased smell function, but not always anosmia, is a major marker for SARS-CoV-2 infection and suggests the possibility that smell testing may help, in some cases, to identify COVID-19 patients in need of early treatment or quarantine. This article is protected by copyright. All rights reserved.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moein</LastName><ForeName>Shima T</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>School of Biological Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hashemian</LastName><ForeName>Seyed M R</ForeName><Initials>SMR</Initials><AffiliationInfo><Affiliation>Chronic Respiratory Diseases Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mansourafshar</LastName><ForeName>Babak</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Chronic Respiratory Diseases Research Center, National Research Institute of, Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khorram-Tousi</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Biological Sciences, Institute for Research in Fundamental Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tabarsi</LastName><ForeName>Payam</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doty</LastName><ForeName>Richard L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Smell & Taste Center, Department of Otorhinolaryngology-Head and Neck, Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int Forum Allergy Rhinol</MedlineTA><NlmUniqueID>101550261</NlmUniqueID><ISSNLinking>2042-6976</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Biomarker</Keyword><Keyword MajorTopicYN="N">Chronic Rhinosinusitis</Keyword><Keyword MajorTopicYN="N">Olfaction</Keyword><Keyword MajorTopicYN="N">Olfactory Disorders</Keyword><Keyword MajorTopicYN="N">Olfactory Test</Keyword><Keyword MajorTopicYN="N">Rhinitis</Keyword><Keyword MajorTopicYN="N">UPSIT</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>04</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32301284</ArticleId><ArticleId IdType="doi">10.1002/alr.22587</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Iran</li><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="Iran"><noRegion><name sortKey="Moein, Shima T" sort="Moein, Shima T" uniqKey="Moein S" first="Shima T" last="Moein">Shima T. Moein</name></noRegion><name sortKey="Hashemian, Seyed M R" sort="Hashemian, Seyed M R" uniqKey="Hashemian S" first="Seyed M R" last="Hashemian">Seyed M R. Hashemian</name><name sortKey="Khorram Tousi, Ali" sort="Khorram Tousi, Ali" uniqKey="Khorram Tousi A" first="Ali" last="Khorram-Tousi">Ali Khorram-Tousi</name><name sortKey="Mansourafshar, Babak" sort="Mansourafshar, Babak" uniqKey="Mansourafshar B" first="Babak" last="Mansourafshar">Babak Mansourafshar</name><name sortKey="Tabarsi, Payam" sort="Tabarsi, Payam" uniqKey="Tabarsi P" first="Payam" last="Tabarsi">Payam Tabarsi</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Doty, Richard L" sort="Doty, Richard L" uniqKey="Doty R" first="Richard L" last="Doty">Richard L. Doty</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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