The Trial of Chloroquine in the Treatment of Corona Virus Disease 2019 （COVID-19） and Its Research Progress in Forensic Toxicology.
Identifieur interne : 000123 ( PubMed/Checkpoint ); précédent : 000122; suivant : 000124The Trial of Chloroquine in the Treatment of Corona Virus Disease 2019 （COVID-19） and Its Research Progress in Forensic Toxicology.
Auteurs : Y J Duan [République populaire de Chine] ; Q. Liu [République populaire de Chine] ; S Q Zhao [République populaire de Chine] ; F. Huang [République populaire de Chine] ; L. Ren [République populaire de Chine] ; L. Liu [République populaire de Chine] ; Y W Zhou [République populaire de Chine]Source :
- Fa yi xue za zhi [ 1004-5619 ] ; 2020.
Abstract
Chloroquine is a long-established prescription drug that is often used clinically to treat malaria and connective tissue diseases. Since December 2019, COVID-19 （corona virus disease 2019） outbreaks caused by SARS-CoV-2 （severe acute respiratory syndrome coronavirus 2） has occurred in China and many countries around the world. Due to the lack of drugs against COVID-19, the disease spreads rapidly and the mortality rate is relatively high. Therefore, specific drugs against SARS-CoV-2 need to be quickly screened. The antimalarial drug Chloroquine phosphate which has already been approved is confirmed to have an anti-SARS-CoV-2 effect and has been included in diagnostic and therapeutic guidelines. However, awareness of the risk of chloroquine phosphate causing acute poisoning or even death should be strengthened. The dosage used according to current clinical recommended dosage and course of treatment are larger than that of previous treatment of malaria. Many provinces have required close clinical monitoring of adverse reactions. This paper reviews the pharmacological effects, poisoning and toxicological mechanisms, in vivo metabolism and distribution, and forensic issues of chloroquine drugs, in order to provide help to forensic practice and clinical work.
DOI: 10.12116/j.issn.1004-5619.2020.02.001
PubMed: 32212513
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Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhao, S Q" sort="Zhao, S Q" uniqKey="Zhao S" first="S Q" last="Zhao">S Q Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Huang, F" sort="Huang, F" uniqKey="Huang F" first="F" last="Huang">F. Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Ren, L" sort="Ren, L" uniqKey="Ren L" first="L" last="Ren">L. Ren</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Liu, L" sort="Liu, L" uniqKey="Liu L" first="L" last="Liu">L. Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhou, Y W" sort="Zhou, Y W" uniqKey="Zhou Y" first="Y W" last="Zhou">Y W Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">Fa yi xue za zhi</title><idno type="ISSN">1004-5619</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chloroquine is a long-established prescription drug that is often used clinically to treat malaria and connective tissue diseases. Since December 2019, COVID-19 （corona virus disease 2019） outbreaks caused by SARS-CoV-2 （severe acute respiratory syndrome coronavirus 2） has occurred in China and many countries around the world. Due to the lack of drugs against COVID-19, the disease spreads rapidly and the mortality rate is relatively high. Therefore, specific drugs against SARS-CoV-2 need to be quickly screened. The antimalarial drug Chloroquine phosphate which has already been approved is confirmed to have an anti-SARS-CoV-2 effect and has been included in diagnostic and therapeutic guidelines. However, awareness of the risk of chloroquine phosphate causing acute poisoning or even death should be strengthened. The dosage used according to current clinical recommended dosage and course of treatment are larger than that of previous treatment of malaria. Many provinces have required close clinical monitoring of adverse reactions. This paper reviews the pharmacological effects, poisoning and toxicological mechanisms, in vivo metabolism and distribution, and forensic issues of chloroquine drugs, in order to provide help to forensic practice and clinical work.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32212513</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1004-5619</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>Mar</Month><Day>25</Day></PubDate></JournalIssue><Title>Fa yi xue za zhi</Title><ISOAbbreviation>Fa Yi Xue Za Zhi</ISOAbbreviation></Journal><ArticleTitle>The Trial of Chloroquine in the Treatment of Corona Virus Disease 2019 （COVID-19） and Its Research Progress in Forensic Toxicology.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.12116/j.issn.1004-5619.2020.02.001</ELocationID><Abstract><AbstractText Label="Abstract" NlmCategory="UNASSIGNED">Chloroquine is a long-established prescription drug that is often used clinically to treat malaria and connective tissue diseases. Since December 2019, COVID-19 （corona virus disease 2019） outbreaks caused by SARS-CoV-2 （severe acute respiratory syndrome coronavirus 2） has occurred in China and many countries around the world. Due to the lack of drugs against COVID-19, the disease spreads rapidly and the mortality rate is relatively high. Therefore, specific drugs against SARS-CoV-2 need to be quickly screened. The antimalarial drug Chloroquine phosphate which has already been approved is confirmed to have an anti-SARS-CoV-2 effect and has been included in diagnostic and therapeutic guidelines. However, awareness of the risk of chloroquine phosphate causing acute poisoning or even death should be strengthened. The dosage used according to current clinical recommended dosage and course of treatment are larger than that of previous treatment of malaria. Many provinces have required close clinical monitoring of adverse reactions. This paper reviews the pharmacological effects, poisoning and toxicological mechanisms, in vivo metabolism and distribution, and forensic issues of chloroquine drugs, in order to provide help to forensic practice and clinical work.</AbstractText><CopyrightInformation>Copyright© by the Editorial Department of Journal of Forensic Medicine.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Duan</LastName><ForeName>Y J</ForeName><Initials>YJ</Initials><AffiliationInfo><Affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Q</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>S Q</ForeName><Initials>SQ</Initials><AffiliationInfo><Affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Y W</ForeName><Initials>YW</Initials><AffiliationInfo><Affiliation>Department of Forensic Medicine, Tongji Medical College, Huanzhong University of Science and Technology, Wuhan 430030, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><Language>chi</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Fa Yi Xue Za Zhi</MedlineTA><NlmUniqueID>9426151</NlmUniqueID><ISSNLinking>1004-5619</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><OtherAbstract Type="Publisher" Language="chi"><AbstractText Label="题目" NlmCategory="UNASSIGNED">氯喹类药物在新型冠状病毒肺炎治疗中的试用及其法医毒理学研究进展.</AbstractText><AbstractText Label="摘要" NlmCategory="UNASSIGNED">氯喹类药物是一类历史悠久的处方药，临床常用于抗疟疾及结缔组织病的治疗。2019年12月以来，在我国各地和世界多国发生了由严重急性呼吸综合征冠状病毒2（severe acute respiratory syndrome coronavirus-2，SARS-CoV-2）引起的新型冠状病毒肺炎疫情。由于缺乏针对新型冠状病毒肺炎的药物，导致该病迅速蔓延且死亡率较高，因此亟待快速筛选抗SARS-CoV-2的特效药物，已批准使用的抗疟药磷酸氯喹被证实具有抗SARS-CoV-2的作用，并被纳入诊疗指南。但对磷酸氯喹引起急性中毒甚至死亡的风险意识也应同时加强，当前临床推荐剂量及疗程较以往治疗疟疾用药剂量偏大，多地已要求临床密切监测不良反应。本文从法医学的角度，对氯喹类药物的药理作用、中毒与毒理作用机制、体内代谢与分布及法医学鉴定要点进行综述，以期为法医学实践及临床工作提供帮助。.</AbstractText><AbstractText Label="关键词" NlmCategory="UNASSIGNED">法医病理学；法医毒理学；氯喹；新型冠状病毒肺炎；综述.</AbstractText></OtherAbstract><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">forensic pathology; forensic toxicology; chloroquine; corona virus disease 2019 （COVID-19）; review</Keyword></KeywordList><CoiStatement>The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32212513</ArticleId><ArticleId IdType="doi">10.12116/j.issn.1004-5619.2020.02.001</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Duan, Y J" sort="Duan, Y J" uniqKey="Duan Y" first="Y J" last="Duan">Y J Duan</name></region><name sortKey="Huang, F" sort="Huang, F" uniqKey="Huang F" first="F" last="Huang">F. Huang</name><name sortKey="Liu, L" sort="Liu, L" uniqKey="Liu L" first="L" last="Liu">L. Liu</name><name sortKey="Liu, Q" sort="Liu, Q" uniqKey="Liu Q" first="Q" last="Liu">Q. Liu</name><name sortKey="Ren, L" sort="Ren, L" uniqKey="Ren L" first="L" last="Ren">L. Ren</name><name sortKey="Zhao, S Q" sort="Zhao, S Q" uniqKey="Zhao S" first="S Q" last="Zhao">S Q Zhao</name><name sortKey="Zhou, Y W" sort="Zhou, Y W" uniqKey="Zhou Y" first="Y W" last="Zhou">Y W Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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