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Influenza, respiratory syncytial virus and SARS

Identifieur interne : 001865 ( Pmc/Curation ); précédent : 001864; suivant : 001866

Influenza, respiratory syncytial virus and SARS

Auteurs : Catherine Thompson ; Maria Zambon

Source :

RBID : PMC:7108372

Abstract

Acute lower respiratory tract infections (LRTIs) are a major worldwide health problem, particularly in childhood. About 30–50% of acute LRTIs are viral in origin; of these, influenza and respiratory syncytial virus are associated with the greatest disease burden in humans. Many different influenza A viruses occur naturally in animal reservoirs, and present a constant threat of zoonotic infections and global pandemics. The pandemic (H1N1) influenza virus that emerged in humans in 2009 contained a unique combination of genes originating in swine and the global human population was highly susceptible to the novel strain. The emergence of the severe acute respiratory syndrome coronavirus in 2003, and the ensuing worldwide epidemic, highlights the fact that respiratory viral infections in humans may originate in animals. Preventative measures for influenza include annual vaccination and treatment with antiviral drugs such as the neuraminidase inhibitors oseltamivir and zanamivir. Subtype-dependent resistance to antivirals can develop and should be closely monitored.


Url:
DOI: 10.1016/j.mpmed.2009.10.003
PubMed: 32288570
PubMed Central: 7108372

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PMC:7108372

Le document en format XML

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<p>Acute lower respiratory tract infections (LRTIs) are a major worldwide health problem, particularly in childhood. About 30–50% of acute LRTIs are viral in origin; of these, influenza and respiratory syncytial virus are associated with the greatest disease burden in humans. Many different influenza A viruses occur naturally in animal reservoirs, and present a constant threat of zoonotic infections and global pandemics. The pandemic (H1N1) influenza virus that emerged in humans in 2009 contained a unique combination of genes originating in swine and the global human population was highly susceptible to the novel strain. The emergence of the severe acute respiratory syndrome coronavirus in 2003, and the ensuing worldwide epidemic, highlights the fact that respiratory viral infections in humans may originate in animals. Preventative measures for influenza include annual vaccination and treatment with antiviral drugs such as the neuraminidase inhibitors oseltamivir and zanamivir. Subtype-dependent resistance to antivirals can develop and should be closely monitored.</p>
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<aff>
<bold>Catherine Thompson BSc PhD</bold>
is a Healthcare Scientist in the Respiratory Virus Reference Unit at the Health Protection Agency Centre for Infections, London, UK. Competing interests: none declared</aff>
<aff>
<bold>Maria Zambon MA PhD FRCPath</bold>
is Director of the Health Protection Agency Centre for Infections, London, UK. Competing interests: none declared</aff>
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<copyright-statement>Copyright © 2009 Published by Elsevier Ltd.</copyright-statement>
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<license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
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<abstract>
<p>Acute lower respiratory tract infections (LRTIs) are a major worldwide health problem, particularly in childhood. About 30–50% of acute LRTIs are viral in origin; of these, influenza and respiratory syncytial virus are associated with the greatest disease burden in humans. Many different influenza A viruses occur naturally in animal reservoirs, and present a constant threat of zoonotic infections and global pandemics. The pandemic (H1N1) influenza virus that emerged in humans in 2009 contained a unique combination of genes originating in swine and the global human population was highly susceptible to the novel strain. The emergence of the severe acute respiratory syndrome coronavirus in 2003, and the ensuing worldwide epidemic, highlights the fact that respiratory viral infections in humans may originate in animals. Preventative measures for influenza include annual vaccination and treatment with antiviral drugs such as the neuraminidase inhibitors oseltamivir and zanamivir. Subtype-dependent resistance to antivirals can develop and should be closely monitored.</p>
</abstract>
<kwd-group>
<title>Keywords</title>
<kwd>flu</kwd>
<kwd>H1N1</kwd>
<kwd>influenza virus</kwd>
<kwd>LRTI</kwd>
<kwd>pandemic</kwd>
<kwd>respiratory infection</kwd>
<kwd>respiratory syncytial virus</kwd>
<kwd>RSV</kwd>
<kwd>SARS coronavirus</kwd>
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