The aetiology, origins, and diagnosis of severe acute respiratory syndrome
Identifieur interne : 001853 ( Pmc/Curation ); précédent : 001852; suivant : 001854The aetiology, origins, and diagnosis of severe acute respiratory syndrome
Auteurs : Llm Poon [République populaire de Chine] ; Y. Guan [République populaire de Chine] ; Jm Nicholls [République populaire de Chine] ; Ky Yuen [République populaire de Chine] ; Jsm Peiris [République populaire de Chine]Source :
- The Lancet. Infectious Diseases [ 1473-3099 ] ; 2004.
Abstract
Severe acute respiratory syndrome (SARS) is a new infectious disease that first emerged in Guangdong province, China, in November, 2002. A novel coronavirus was later identified in patients with SARS. The detection of the virus in these patients, its absence in healthy controls or other patients with atypical pneumonia, and the reproduction of a similar disease in a relevant animal model fulfilled Koch's postulates for implicating this coronavirus as the causal agent of SARS. The full genome sequence was determined within weeks of the virus's identification. The rapid progress in the aetiology, the development of laboratory diagnostic tests, and the defining of routes of viral transmission were facilitated through a unique WHO-coordinated virtual network of laboratories, which shared information on a real-time basis through daily teleconferences. Subsequent studies have indicated that the SARS coronavirus is of animal origin, that its precursor is still present in animal populations within the region, and that live-animal markets in southern China may have provided the animal-human interphase that allowed this precursor virus to adapt to human-human transmission. These findings underscore the potential for the re-emergence of SARS and the need for laboratory tests for early diagnosis. However, the low viral load in the respiratory tract makes early diagnosis of SARS a diagnostic challenge, although improvements in the sensitivity of molecular diagnostic methods continue to be made.
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DOI: 10.1016/S1473-3099(04)01172-7
PubMed: 15522678
PubMed Central: 7106534
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>Severe acute respiratory syndrome (SARS) is a new infectious disease that first emerged in Guangdong province, China, in November, 2002. A novel coronavirus was later identified in patients with SARS. The detection of the virus in these patients, its absence in healthy controls or other patients with atypical pneumonia, and the reproduction of a similar disease in a relevant animal model fulfilled Koch's postulates for implicating this coronavirus as the causal agent of SARS. The full genome sequence was determined within weeks of the virus's identification. The rapid progress in the aetiology, the development of laboratory diagnostic tests, and the defining of routes of viral transmission were facilitated through a unique WHO-coordinated virtual network of laboratories, which shared information on a real-time basis through daily teleconferences. Subsequent studies have indicated that the SARS coronavirus is of animal origin, that its precursor is still present in animal populations within the region, and that live-animal markets in southern China may have provided the animal-human interphase that allowed this precursor virus to adapt to human-human transmission. These findings underscore the potential for the re-emergence of SARS and the need for laboratory tests for early diagnosis. However, the low viral load in the respiratory tract makes early diagnosis of SARS a diagnostic challenge, although improvements in the sensitivity of molecular diagnostic methods continue to be made.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fleck, F" uniqKey="Fleck F">F Fleck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caulford, P" uniqKey="Caulford P">P Caulford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Enserink, M" uniqKey="Enserink M">M Enserink</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heymann, Dl" uniqKey="Heymann D">DL Heymann</name>
</author>
<author><name sortKey="Rodier, G" uniqKey="Rodier G">G Rodier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breiman, Rf" uniqKey="Breiman R">RF Breiman</name>
</author>
<author><name sortKey="Evans, Mr" uniqKey="Evans M">MR Evans</name>
</author>
<author><name sortKey="Priser, W" uniqKey="Priser W">W Priser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name>
</author>
<author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name>
</author>
<author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name>
</author>
<author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name>
</author>
<author><name sortKey="Li, Ym" uniqKey="Li Y">YM Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosling, L" uniqKey="Rosling L">L Rosling</name>
</author>
<author><name sortKey="Rosling, M" uniqKey="Rosling M">M Rosling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name>
</author>
<author><name sortKey="Zeng, Gq" uniqKey="Zeng G">GQ Zeng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hong, T" uniqKey="Hong T">T Hong</name>
</author>
<author><name sortKey="Wang, Jw" uniqKey="Wang J">JW Wang</name>
</author>
<author><name sortKey="Sun, Yl" uniqKey="Sun Y">YL Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name>
</author>
<author><name sortKey="Yu, Wc" uniqKey="Yu W">WC Yu</name>
</author>
<author><name sortKey="Leung, Cw" uniqKey="Leung C">CW Leung</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
<author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Hui, D" uniqKey="Hui D">D Hui</name>
</author>
<author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Pks" uniqKey="Chan P">PKS Chan</name>
</author>
<author><name sortKey="Tam, Js" uniqKey="Tam J">JS Tam</name>
</author>
<author><name sortKey="Lam, Cw" uniqKey="Lam C">CW Lam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name>
</author>
<author><name sortKey="Low, De" uniqKey="Low D">DE Low</name>
</author>
<author><name sortKey="Henry, B" uniqKey="Henry B">B Henry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name>
</author>
<author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name>
</author>
<author><name sortKey="Goldsmith, C" uniqKey="Goldsmith C">C Goldsmith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
<author><name sortKey="Coscoy, L" uniqKey="Coscoy L">L Coscoy</name>
</author>
<author><name sortKey="Zylberg, M" uniqKey="Zylberg M">M Zylberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franks, Tj" uniqKey="Franks T">TJ Franks</name>
</author>
<author><name sortKey="Chong, Py" uniqKey="Chong P">PY Chong</name>
</author>
<author><name sortKey="Chui, P" uniqKey="Chui P">P Chui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Lee, Kc" uniqKey="Lee K">KC Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mazzulli, T" uniqKey="Mazzulli T">T Mazzulli</name>
</author>
<author><name sortKey="Farcas, Ga" uniqKey="Farcas G">GA Farcas</name>
</author>
<author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakajima, N" uniqKey="Nakajima N">N Nakajima</name>
</author>
<author><name sortKey="Asahi Ozaki, Y" uniqKey="Asahi Ozaki Y">Y Asahi-Ozaki</name>
</author>
<author><name sortKey="Nagata, N" uniqKey="Nagata N">N Nagata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chong, Py" uniqKey="Chong P">PY Chong</name>
</author>
<author><name sortKey="Chui, P" uniqKey="Chui P">P Chui</name>
</author>
<author><name sortKey="Ling, Ae" uniqKey="Ling A">AE Ling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="To, Kf" uniqKey="To K">KF To</name>
</author>
<author><name sortKey="Tong, Jh" uniqKey="Tong J">JH Tong</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name>
</author>
<author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name>
</author>
<author><name sortKey="Schutten, M" uniqKey="Schutten M">M Schutten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name>
</author>
<author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name>
</author>
<author><name sortKey="Schutten, M" uniqKey="Schutten M">M Schutten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martina, Be" uniqKey="Martina B">BE Martina</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
<author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name>
</author>
<author><name sortKey="Mcauliffe, J" uniqKey="Mcauliffe J">J McAuliffe</name>
</author>
<author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marra, Ma" uniqKey="Marra M">MA Marra</name>
</author>
<author><name sortKey="Jones, Sj" uniqKey="Jones S">SJ Jones</name>
</author>
<author><name sortKey="Astell, Cr" uniqKey="Astell C">CR Astell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name>
</author>
<author><name sortKey="Oberste, Ms" uniqKey="Oberste M">MS Oberste</name>
</author>
<author><name sortKey="Monroe, Ss" uniqKey="Monroe S">SS Monroe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lai, Mmc" uniqKey="Lai M">MMC Lai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeng, Fy" uniqKey="Zeng F">FY Zeng</name>
</author>
<author><name sortKey="Chan, Cw" uniqKey="Chan C">CW Chan</name>
</author>
<author><name sortKey="Chan, Mn" uniqKey="Chan M">MN Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name>
</author>
<author><name sortKey="Bredenbeek, Pj" uniqKey="Bredenbeek P">PJ Bredenbeek</name>
</author>
<author><name sortKey="Dobbe, Jc" uniqKey="Dobbe J">JC Dobbe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K Anand</name>
</author>
<author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name>
</author>
<author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P Wadhwani</name>
</author>
<author><name sortKey="Mesters, Jr" uniqKey="Mesters J">JR Mesters</name>
</author>
<author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R Hilgenfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wickramasinghe, C" uniqKey="Wickramasinghe C">C Wickramasinghe</name>
</author>
<author><name sortKey="Wainwright, M" uniqKey="Wainwright M">M Wainwright</name>
</author>
<author><name sortKey="Narlikar, J" uniqKey="Narlikar J">J Narlikar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name>
</author>
<author><name sortKey="He, Yq" uniqKey="He Y">YQ He</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kung, Ny" uniqKey="Kung N">NY Kung</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Perkins, Nr" uniqKey="Perkins N">NR Perkins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name>
</author>
<author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chim, Ss" uniqKey="Chim S">SS Chim</name>
</author>
<author><name sortKey="Tsui, Sk" uniqKey="Tsui S">SK Tsui</name>
</author>
<author><name sortKey="Chan, Kc" uniqKey="Chan K">KC Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ruan, Y" uniqKey="Ruan Y">Y Ruan</name>
</author>
<author><name sortKey="Wei, Cl" uniqKey="Wei C">CL Wei</name>
</author>
<author><name sortKey="Ee, La" uniqKey="Ee L">LA Ee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsui, Skw" uniqKey="Tsui S">SKW Tsui</name>
</author>
<author><name sortKey="Chim, Ssc" uniqKey="Chim S">SSC Chim</name>
</author>
<author><name sortKey="Lo, Ymd" uniqKey="Lo Y">YMD Lo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yeh, Sh" uniqKey="Yeh S">SH Yeh</name>
</author>
<author><name sortKey="Wang, Hy" uniqKey="Wang H">HY Wang</name>
</author>
<author><name sortKey="Tsai, Cy" uniqKey="Tsai C">CY Tsai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name>
</author>
<author><name sortKey="Cheng, Vcc" uniqKey="Cheng V">VCC Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Tsang, Ot" uniqKey="Tsang O">OT Tsang</name>
</author>
<author><name sortKey="Chau, Tn" uniqKey="Chau T">TN Chau</name>
</author>
<author><name sortKey="Choi, Kw" uniqKey="Choi K">KW Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, P" uniqKey="Tang P">P Tang</name>
</author>
<author><name sortKey="Louie, M" uniqKey="Louie M">M Louie</name>
</author>
<author><name sortKey="Richardson, Se" uniqKey="Richardson S">SE Richardson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Hs" uniqKey="Wu H">HS Wu</name>
</author>
<author><name sortKey="Chiu, Sc" uniqKey="Chiu S">SC Chiu</name>
</author>
<author><name sortKey="Tseng, Tc" uniqKey="Tseng T">TC Tseng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leung, Wk" uniqKey="Leung W">WK Leung</name>
</author>
<author><name sortKey="To, Kf" uniqKey="To K">KF To</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
<author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name>
</author>
<author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name>
</author>
<author><name sortKey="Cohen, T" uniqKey="Cohen T">T Cohen</name>
</author>
<author><name sortKey="Cooper, B" uniqKey="Cooper B">B Cooper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hung, Ec" uniqKey="Hung E">EC Hung</name>
</author>
<author><name sortKey="Chim, Ss" uniqKey="Chim S">SS Chim</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Wo, J" uniqKey="Wo J">J Wo</name>
</author>
<author><name sortKey="Shao, J" uniqKey="Shao J">J Shao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yam, Wc" uniqKey="Yam W">WC Yam</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Kk" uniqKey="Lau K">KK Lau</name>
</author>
<author><name sortKey="Yu, Wc" uniqKey="Yu W">WC Yu</name>
</author>
<author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name>
</author>
<author><name sortKey="Lau, St" uniqKey="Lau S">ST Lau</name>
</author>
<author><name sortKey="Sheng, B" uniqKey="Sheng B">B Sheng</name>
</author>
<author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcintosh, K" uniqKey="Mcintosh K">K McIntosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Wong, Ok" uniqKey="Wong O">OK Wong</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Wong, Ok" uniqKey="Wong O">OK Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Lt" uniqKey="Lau L">LT Lau</name>
</author>
<author><name sortKey="Fung, Yw" uniqKey="Fung Y">YW Fung</name>
</author>
<author><name sortKey="Wong, Fp" uniqKey="Wong F">FP Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jiang, Ss" uniqKey="Jiang S">SS Jiang</name>
</author>
<author><name sortKey="Chen, Tc" uniqKey="Chen T">TC Chen</name>
</author>
<author><name sortKey="Yang, Jy" uniqKey="Yang J">JY Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, Ac" uniqKey="Yu A">AC Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Ek" uniqKey="Ng E">EK Ng</name>
</author>
<author><name sortKey="Ng, Pc" uniqKey="Ng P">PC Ng</name>
</author>
<author><name sortKey="Hon, Kl" uniqKey="Hon K">KL Hon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bressler, Am" uniqKey="Bressler A">AM Bressler</name>
</author>
<author><name sortKey="Nolte, Fs" uniqKey="Nolte F">FS Nolte</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Chiu, Ll" uniqKey="Chiu L">LL Chiu</name>
</author>
<author><name sortKey="Panning, M" uniqKey="Panning M">M Panning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Emery, Sl" uniqKey="Emery S">SL Emery</name>
</author>
<author><name sortKey="Erdman, Dd" uniqKey="Erdman D">DD Erdman</name>
</author>
<author><name sortKey="Bowen, Md" uniqKey="Bowen M">MD Bowen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
<author><name sortKey="Wong, Ok" uniqKey="Wong O">OK Wong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name>
</author>
<author><name sortKey="Wong, Bw" uniqKey="Wong B">BW Wong</name>
</author>
<author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grant, Pr" uniqKey="Grant P">PR Grant</name>
</author>
<author><name sortKey="Garson, Ja" uniqKey="Garson J">JA Garson</name>
</author>
<author><name sortKey="Tedder, Rs" uniqKey="Tedder R">RS Tedder</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
<author><name sortKey="Tam, Js" uniqKey="Tam J">JS Tam</name>
</author>
<author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Lf" uniqKey="Ng L">LF Ng</name>
</author>
<author><name sortKey="Wong, M" uniqKey="Wong M">M Wong</name>
</author>
<author><name sortKey="Koh, S" uniqKey="Koh S">S Koh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name>
</author>
<author><name sortKey="Hung, If" uniqKey="Hung I">IF Hung</name>
</author>
<author><name sortKey="Tang, Bs" uniqKey="Tang B">BS Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Hs" uniqKey="Wu H">HS Wu</name>
</author>
<author><name sortKey="Chiu, Sc" uniqKey="Chiu S">SC Chiu</name>
</author>
<author><name sortKey="Tseng, Tc" uniqKey="Tseng T">TC Tseng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, G" uniqKey="Li G">G Li</name>
</author>
<author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author><name sortKey="Xu, A" uniqKey="Xu A">A Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ho, Ty" uniqKey="Ho T">TY Ho</name>
</author>
<author><name sortKey="Wu, Sl" uniqKey="Wu S">SL Wu</name>
</author>
<author><name sortKey="Cheng, Se" uniqKey="Cheng S">SE Cheng</name>
</author>
<author><name sortKey="Wei, Yc" uniqKey="Wei Y">YC Wei</name>
</author>
<author><name sortKey="Huang, Sp" uniqKey="Huang S">SP Huang</name>
</author>
<author><name sortKey="Hsiang, Cy" uniqKey="Hsiang C">CY Hsiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Wen, J" uniqKey="Wen J">J Wen</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name>
</author>
<author><name sortKey="Yi, Y" uniqKey="Yi Y">Y Yi</name>
</author>
<author><name sortKey="Li, P" uniqKey="Li P">P Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name>
</author>
<author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
<author><name sortKey="Tsoi, Hw" uniqKey="Tsoi H">HW Tsoi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L van der Hoek</name>
</author>
<author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K Pyrc</name>
</author>
<author><name sortKey="Jebbink, Mf" uniqKey="Jebbink M">MF Jebbink</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Orellana, C" uniqKey="Orellana C">C Orellana</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Rabenau, Hf" uniqKey="Rabenau H">HF Rabenau</name>
</author>
<author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J Cinatl</name>
</author>
<author><name sortKey="Morgenstern, B" uniqKey="Morgenstern B">B Morgenstern</name>
</author>
<author><name sortKey="Bauer, G" uniqKey="Bauer G">G Bauer</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name>
</author>
<author><name sortKey="Doerr, Hw" uniqKey="Doerr H">HW Doerr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Normile, D" uniqKey="Normile D">D Normile</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Lancet Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Lancet Infect Dis</journal-id>
<journal-title-group><journal-title>The Lancet. Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">1473-3099</issn>
<issn pub-type="epub">1474-4457</issn>
<publisher><publisher-name>Elsevier Ltd.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">15522678</article-id>
<article-id pub-id-type="pmc">7106534</article-id>
<article-id pub-id-type="publisher-id">S1473-3099(04)01172-7</article-id>
<article-id pub-id-type="doi">10.1016/S1473-3099(04)01172-7</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The aetiology, origins, and diagnosis of severe acute respiratory syndrome</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Poon</surname>
<given-names>LLM</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guan</surname>
<given-names>Y</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nicholls</surname>
<given-names>JM</given-names>
</name>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yuen</surname>
<given-names>KY</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peiris</surname>
<given-names>JSM</given-names>
</name>
<degrees>Dr</degrees>
<email>malik@hkucc.hku.hk</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="cor1" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>a</label>
Department of Microbiology, University of Hong Kong, Hong Kong SAR, China</aff>
<aff id="aff2"><label>b</label>
Department of Pathology, University of Hong Kong, Hong Kong SAR, China</aff>
<author-notes><corresp id="cor1"><label>*</label>
Dr J S M Peiris, Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China. Fax +852 2855 1241 <email>malik@hkucc.hku.hk</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>30</day>
<month>10</month>
<year>2004</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>11</month>
<year>2004</year>
</pub-date>
<pub-date pub-type="epub"><day>30</day>
<month>10</month>
<year>2004</year>
</pub-date>
<volume>4</volume>
<issue>11</issue>
<fpage>663</fpage>
<lpage>671</lpage>
<permissions><copyright-statement>Copyright © 2004 Elsevier Ltd. All rights reserved.</copyright-statement>
<copyright-year>2004</copyright-year>
<copyright-holder>Elsevier Ltd</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract><title>Summary</title>
<p>Severe acute respiratory syndrome (SARS) is a new infectious disease that first emerged in Guangdong province, China, in November, 2002. A novel coronavirus was later identified in patients with SARS. The detection of the virus in these patients, its absence in healthy controls or other patients with atypical pneumonia, and the reproduction of a similar disease in a relevant animal model fulfilled Koch's postulates for implicating this coronavirus as the causal agent of SARS. The full genome sequence was determined within weeks of the virus's identification. The rapid progress in the aetiology, the development of laboratory diagnostic tests, and the defining of routes of viral transmission were facilitated through a unique WHO-coordinated virtual network of laboratories, which shared information on a real-time basis through daily teleconferences. Subsequent studies have indicated that the SARS coronavirus is of animal origin, that its precursor is still present in animal populations within the region, and that live-animal markets in southern China may have provided the animal-human interphase that allowed this precursor virus to adapt to human-human transmission. These findings underscore the potential for the re-emergence of SARS and the need for laboratory tests for early diagnosis. However, the low viral load in the respiratory tract makes early diagnosis of SARS a diagnostic challenge, although improvements in the sensitivity of molecular diagnostic methods continue to be made.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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