Central nervous system manifestations of COVID-19: A systematic review
Identifieur interne : 001844 ( Pmc/Curation ); précédent : 001843; suivant : 001845Central nervous system manifestations of COVID-19: A systematic review
Auteurs : Ali A. Asadi-Pooya [Iran, États-Unis] ; Leila Simani [Iran]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 2020.
Abstract
In this systematic review, we will discuss the evidence on the occurrence of central nervous system (CNS) involvement and neurological manifestations in patients with COVID-19.
MEDLINE (accessed from PubMed) and Scopus from December 01, 2019 to March 26, 2020 were systematically searched for related published articles. In both electronic databases, the following search strategy was implemented and these key words (in the title/abstract) were used: “COVID 19” OR “coronavirus” AND “brain” OR “CNS” OR “neurologic”.
Through the search strategy, we could identify two articles about neurological involvement by COVID-19. One of these publications was a narrative review and the other one was a viewpoint. However, the authors scanned the reference lists of the included studies and could identify multiple references. One study, specifically investigated the neurological manifestations of COVID-19 and could document CNS manifestations in 25% of the patients. Most of the studies investigated the manifestations of COVID-19 in general.
While neurological manifestations of COVID-19 have not been studied appropriately, it is highly likely that some of these patients, particularly those who suffer from a severe illness, have CNS involvement and neurological manifestations. Precise and targeted documentation of neurological symptoms, detailed clinical, neurological, and electrophysiological investigations of the patients, attempts to isolate SARS-CoV-2 from cerebrospinal fluid, and autopsies of the COVID-19 victims may clarify the role played by this virus in causing neurological manifestations.
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DOI: 10.1016/j.jns.2020.116832
PubMed: 32299017
PubMed Central: 7151535
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Asadi-Pooya</name><affiliation wicri:level="1"><nlm:aff id="af0005">Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0010">Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia</wicri:regionArea></affiliation></author><author><name sortKey="Simani, Leila" sort="Simani, Leila" uniqKey="Simani L" first="Leila" last="Simani">Leila Simani</name><affiliation wicri:level="1"><nlm:aff id="af0015">Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti Univsersity of Medical Sciences, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti Univsersity of Medical Sciences, Tehran</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32299017</idno><idno type="pmc">7151535</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151535</idno><idno type="RBID">PMC:7151535</idno><idno type="doi">10.1016/j.jns.2020.116832</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001844</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001844</idno><idno type="wicri:Area/Pmc/Curation">001844</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001844</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Central nervous system manifestations of COVID-19: A systematic review</title><author><name sortKey="Asadi Pooya, Ali A" sort="Asadi Pooya, Ali A" uniqKey="Asadi Pooya A" first="Ali A." last="Asadi-Pooya">Ali A. Asadi-Pooya</name><affiliation wicri:level="1"><nlm:aff id="af0005">Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0010">Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia</wicri:regionArea></affiliation></author><author><name sortKey="Simani, Leila" sort="Simani, Leila" uniqKey="Simani L" first="Leila" last="Simani">Leila Simani</name><affiliation wicri:level="1"><nlm:aff id="af0015">Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti Univsersity of Medical Sciences, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti Univsersity of Medical Sciences, Tehran</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of the Neurological Sciences</title><idno type="ISSN">0022-510X</idno><idno type="eISSN">1878-5883</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>In this systematic review, we will discuss the evidence on the occurrence of central nervous system (CNS) involvement and neurological manifestations in patients with COVID-19.</p></sec><sec><title>Methods</title><p>MEDLINE (accessed from PubMed) and Scopus from December 01, 2019 to March 26, 2020 were systematically searched for related published articles. In both electronic databases, the following search strategy was implemented and these key words (in the title/abstract) were used: “COVID 19” OR “coronavirus” AND “brain” OR “CNS” OR “neurologic”.</p></sec><sec><title>Results</title><p>Through the search strategy, we could identify two articles about neurological involvement by COVID-19. One of these publications was a narrative review and the other one was a viewpoint. However, the authors scanned the reference lists of the included studies and could identify multiple references. One study, specifically investigated the neurological manifestations of COVID-19 and could document CNS manifestations in 25% of the patients. Most of the studies investigated the manifestations of COVID-19 in general.</p></sec><sec><title>Conclusion</title><p>While neurological manifestations of COVID-19 have not been studied appropriately, it is highly likely that some of these patients, particularly those who suffer from a severe illness, have CNS involvement and neurological manifestations. Precise and targeted documentation of neurological symptoms, detailed clinical, neurological, and electrophysiological investigations of the patients, attempts to isolate SARS-CoV-2 from cerebrospinal fluid, and autopsies of the COVID-19 victims may clarify the role played by this virus in causing neurological manifestations.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rothan, H A" uniqKey="Rothan H">H.A. Rothan</name></author><author><name sortKey="Byrareddy, S N" uniqKey="Byrareddy S">S.N. 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Armstrong</name></author><author><name sortKey="On Behalf Of The Guideline Development Dissemination And Implementation Subcommittee Of The American Academy Of Neurology" uniqKey="On Behalf Of The Guideline Development Dissemination And Implementation Subcommittee Of The American Academy Of Neurology">on behalf of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y C" uniqKey="Li Y">Y.C. Li</name></author><author><name sortKey="Bai, W Z" uniqKey="Bai W">W.Z. Bai</name></author><author><name sortKey="Hashikawa, T" uniqKey="Hashikawa T">T. Hashikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baig, A M" uniqKey="Baig A">A.M. Baig</name></author><author><name sortKey="Khaleeq, A" uniqKey="Khaleeq A">A. Khaleeq</name></author><author><name sortKey="Ali, U" uniqKey="Ali U">U. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol Sci</journal-id><journal-id journal-id-type="iso-abbrev">J. Neurol. Sci</journal-id><journal-title-group><journal-title>Journal of the Neurological Sciences</journal-title></journal-title-group><issn pub-type="ppub">0022-510X</issn><issn pub-type="epub">1878-5883</issn><publisher><publisher-name>Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32299017</article-id><article-id pub-id-type="pmc">7151535</article-id><article-id pub-id-type="publisher-id">S0022-510X(20)30168-4</article-id><article-id pub-id-type="doi">10.1016/j.jns.2020.116832</article-id><article-id pub-id-type="publisher-id">116832</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Central nervous system manifestations of COVID-19: A systematic review</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0005"><name><surname>Asadi-Pooya</surname><given-names>Ali A.</given-names></name><email>aliasadipooya@yahoo.com</email><xref rid="af0005" ref-type="aff">a</xref><xref rid="af0010" ref-type="aff">b</xref><xref rid="cr0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="au0010"><name><surname>Simani</surname><given-names>Leila</given-names></name><xref rid="af0015" ref-type="aff">c</xref></contrib></contrib-group><aff id="af0005"><label>a</label>Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran</aff><aff id="af0010"><label>b</label>Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA</aff><aff id="af0015"><label>c</label>Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti Univsersity of Medical Sciences, Tehran, Iran</aff><author-notes><corresp id="cr0005"><label>⁎</label>Corresponding author at: Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. <email>aliasadipooya@yahoo.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>11</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>15</day><month>6</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>11</day><month>4</month><year>2020</year></pub-date><volume>413</volume><fpage>116832</fpage><lpage>116832</lpage><history><date date-type="received"><day>7</day><month>4</month><year>2020</year></date><date date-type="accepted"><day>8</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Elsevier B.V.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ab0005"><sec><title>Objective</title><p>In this systematic review, we will discuss the evidence on the occurrence of central nervous system (CNS) involvement and neurological manifestations in patients with COVID-19.</p></sec><sec><title>Methods</title><p>MEDLINE (accessed from PubMed) and Scopus from December 01, 2019 to March 26, 2020 were systematically searched for related published articles. In both electronic databases, the following search strategy was implemented and these key words (in the title/abstract) were used: “COVID 19” OR “coronavirus” AND “brain” OR “CNS” OR “neurologic”.</p></sec><sec><title>Results</title><p>Through the search strategy, we could identify two articles about neurological involvement by COVID-19. One of these publications was a narrative review and the other one was a viewpoint. However, the authors scanned the reference lists of the included studies and could identify multiple references. One study, specifically investigated the neurological manifestations of COVID-19 and could document CNS manifestations in 25% of the patients. Most of the studies investigated the manifestations of COVID-19 in general.</p></sec><sec><title>Conclusion</title><p>While neurological manifestations of COVID-19 have not been studied appropriately, it is highly likely that some of these patients, particularly those who suffer from a severe illness, have CNS involvement and neurological manifestations. Precise and targeted documentation of neurological symptoms, detailed clinical, neurological, and electrophysiological investigations of the patients, attempts to isolate SARS-CoV-2 from cerebrospinal fluid, and autopsies of the COVID-19 victims may clarify the role played by this virus in causing neurological manifestations.</p></sec></abstract><abstract abstract-type="author-highlights" id="ab0010"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="li0005"><label>•</label><p id="p0005">Some patients with COVID-19 may show nonspecific neurological symptoms, such as confusion and headache.</p></list-item><list-item id="li0010"><label>•</label><p id="p0010">A few patients with COVID-19 showed more specific neurological manifestations, such as seizure or cerebrovascular problems.</p></list-item><list-item id="li0015"><label>•</label><p id="p0015">Neuroinvasion of SARS-CoV2 may partially explain why some patients develop respiratory failure.</p></list-item></list></p></abstract><kwd-group id="ks0005"><title>Keywords</title><kwd>CNS</kwd><kwd>Coronavirus</kwd><kwd>COVID-19</kwd><kwd>Neurological</kwd><kwd>Seizure</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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