Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study
Identifieur interne : 001837 ( Pmc/Curation ); précédent : 001836; suivant : 001838Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study
Auteurs : Lisi Deng [République populaire de Chine] ; Chunna Li [République populaire de Chine] ; Qi Zeng [République populaire de Chine] ; Xi Liu [République populaire de Chine] ; Xinghua Li [République populaire de Chine] ; Haitang Zhang [République populaire de Chine] ; Zhongsi Hong [République populaire de Chine] ; Jinyu Xia [République populaire de Chine]Source :
- The Journal of Infection [ 0163-4453 ] ; 2020.
Abstract
Patients were given oral arbidol and LPV/r in the combination group and oral LPV/r only in the monotherapy group for 5–21 days. Our study shows that oral arbidol and LPV/r in the combination group is associated with a significant elevated negative conversion rate of coronavirus’ test in 7-day and 14-day, compared with LPV/r only in the monotherapy group. Combination therapy is associated with a significantly improved the chest CT scans in 7-day. We suppose that reducing the viral load as soon as possible could benefit the delay of the progression of lung lesions.
Url:
DOI: 10.1016/j.jinf.2020.03.002
PubMed: 32171872
PubMed Central: 7156152
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study</title><author><name sortKey="Deng, Lisi" sort="Deng, Lisi" uniqKey="Deng L" first="Lisi" last="Deng">Lisi Deng</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Li, Chunna" sort="Li, Chunna" uniqKey="Li C" first="Chunna" last="Li">Chunna Li</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Qi" sort="Zeng, Qi" uniqKey="Zeng Q" first="Qi" last="Zeng">Qi Zeng</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Cancer Center, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Center, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Xi" sort="Liu, Xi" uniqKey="Liu X" first="Xi" last="Liu">Xi Liu</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xinghua" sort="Li, Xinghua" uniqKey="Li X" first="Xinghua" last="Li">Xinghua Li</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Haitang" sort="Zhang, Haitang" uniqKey="Zhang H" first="Haitang" last="Zhang">Haitang Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Hong, Zhongsi" sort="Hong, Zhongsi" uniqKey="Hong Z" first="Zhongsi" last="Hong">Zhongsi Hong</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country 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type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156152</idno><idno type="RBID">PMC:7156152</idno><idno type="doi">10.1016/j.jinf.2020.03.002</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001837</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001837</idno><idno type="wicri:Area/Pmc/Curation">001837</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001837</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study</title><author><name sortKey="Deng, Lisi" sort="Deng, Lisi" uniqKey="Deng L" first="Lisi" last="Deng">Lisi Deng</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Li, Chunna" sort="Li, Chunna" uniqKey="Li C" first="Chunna" last="Li">Chunna Li</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Qi" sort="Zeng, Qi" uniqKey="Zeng Q" first="Qi" last="Zeng">Qi Zeng</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Cancer Center, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cancer Center, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Xi" sort="Liu, Xi" uniqKey="Liu X" first="Xi" last="Liu">Xi Liu</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xinghua" sort="Li, Xinghua" uniqKey="Li X" first="Xinghua" last="Li">Xinghua Li</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Haitang" sort="Zhang, Haitang" uniqKey="Zhang H" first="Haitang" last="Zhang">Haitang Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Hong, Zhongsi" sort="Hong, Zhongsi" uniqKey="Hong Z" first="Zhongsi" last="Hong">Zhongsi Hong</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author><author><name sortKey="Xia, Jinyu" sort="Xia, Jinyu" uniqKey="Xia J" first="Jinyu" last="Xia">Jinyu Xia</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of Infection</title><idno type="ISSN">0163-4453</idno><idno type="eISSN">1532-2742</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0002">Patients were given oral arbidol and LPV/r in the combination group and oral LPV/r only in the monotherapy group for 5–21 days.</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0003">Our study shows that oral arbidol and LPV/r in the combination group is associated with a significant elevated negative conversion rate of coronavirus’ test in 7-day and 14-day, compared with LPV/r only in the monotherapy group.</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0004">Combination therapy is associated with a significantly improved the chest CT scans in 7-day.</p></list-item><list-item id="celistitem0004"><label>•</label><p id="para0005">We suppose that reducing the viral load as soon as possible could benefit the delay of the progression of lung lesions.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect</journal-id><journal-title-group><journal-title>The Journal of Infection</journal-title></journal-title-group><issn pub-type="ppub">0163-4453</issn><issn pub-type="epub">1532-2742</issn><publisher><publisher-name>The British Infection Association. Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32171872</article-id><article-id pub-id-type="pmc">7156152</article-id><article-id pub-id-type="publisher-id">S0163-4453(20)30113-4</article-id><article-id pub-id-type="doi">10.1016/j.jinf.2020.03.002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0001"><name><surname>Deng</surname><given-names>Lisi</given-names></name><xref rid="aff0001" ref-type="aff">a</xref><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author" id="au0002"><name><surname>Li</surname><given-names>Chunna</given-names></name><xref rid="aff0001" ref-type="aff">a</xref><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author" id="au0003"><name><surname>Zeng</surname><given-names>Qi</given-names></name><xref rid="aff0002" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au0004"><name><surname>Liu</surname><given-names>Xi</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0005"><name><surname>Li</surname><given-names>Xinghua</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0006"><name><surname>Zhang</surname><given-names>Haitang</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0007"><name><surname>Hong</surname><given-names>Zhongsi</given-names></name><email>hongzhs@mail.sysu.edu.cn</email><xref rid="aff0001" ref-type="aff">a</xref><xref rid="cor0001" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="au0008"><name><surname>Xia</surname><given-names>Jinyu</given-names></name><email>xiajinyu@mail.sysu.edu.cn</email><xref rid="aff0001" ref-type="aff">a</xref><xref rid="cor0001" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0001"><label>a</label>Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai 519000, Guangdong Province, China</aff><aff id="aff0002"><label>b</label>Cancer Center, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China</aff><author-notes><corresp id="cor0001"><label>⁎</label>Corresponding authors. <email>hongzhs@mail.sysu.edu.cn</email><email>xiajinyu@mail.sysu.edu.cn</email></corresp><fn id="fn1"><label>1</label><p id="notep0001">Equal contribution.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>11</day><month>3</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>11</day><month>3</month><year>2020</year></pub-date><history><date date-type="accepted"><day>6</day><month>3</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0001"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0002">Patients were given oral arbidol and LPV/r in the combination group and oral LPV/r only in the monotherapy group for 5–21 days.</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0003">Our study shows that oral arbidol and LPV/r in the combination group is associated with a significant elevated negative conversion rate of coronavirus’ test in 7-day and 14-day, compared with LPV/r only in the monotherapy group.</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0004">Combination therapy is associated with a significantly improved the chest CT scans in 7-day.</p></list-item><list-item id="celistitem0004"><label>•</label><p id="para0005">We suppose that reducing the viral load as soon as possible could benefit the delay of the progression of lung lesions.</p></list-item></list></p></abstract><abstract id="abs0002"><title>Summary</title><sec><title>Background</title><p>Corona Virus Disease 2019 (COVID-19) due to the 2019 novel coronavirus (SARS-CoV-2) emerged in Wuhan city and rapidly spread throughout China. We aimed to compare arbidol and lopinavir/ritonavir(LPV/r) treatment for patients with COVID-19 with LPV/r only.</p></sec><sec><title>Methods</title><p>In this retrospective cohort study, we included adults (age≥18years) with laboratory-confirmed COVID-19 without Invasive ventilation, diagnosed between Jan 17, 2020, and Feb 13, 2020. Patients, diagnosed after Jan 17, 2020, were given oral arbidol and LPV/r in the combination group and oral LPV/r only in the monotherapy group for 5–21 days. The primary endpoint was a negative conversion rate of coronavirus from the date of COVID-19 diagnosis(day7, day14), and assessed whether the pneumonia was progressing or improving by chest CT (day7).</p></sec><sec><title>Results</title><p>We analyzed 16 patients who received oral arbidol and LPV/r in the combination group and 17 who oral LPV/r only in the monotherapy group, and both initiated after diagnosis. Baseline clinical, laboratory, and chest CT characteristics were similar between groups. The SARS-CoV-2 could not be detected for 12(75%) of 16 patients’ nasopharyngeal specimens in the combination group after seven days, compared with 6 (35%) of 17 in the monotherapy group (<italic>p</italic> < 0·05). After 14 days, 15 (94%) of 16 and 9 (52·9%) of 17, respectively, SARS-CoV-2 could not be detected (<italic>p</italic> < 0·05). The chest CT scans were improving for 11(69%) of 16 patients in the combination group after seven days, compared with 5(29%) of 17 in the monotherapy group (<italic>p</italic> < 0·05).</p></sec><sec><title>Conclusion</title><p>In patients with COVID-19, the apparent favorable clinical response with arbidol and LPV/r supports further LPV/r only.</p></sec></abstract><kwd-group id="keys0001"><title>Keywords</title><kwd>Corona Virus Disease 2019</kwd><kwd>Arbidol</kwd><kwd>Lopinavir/ritonavir</kwd><kwd>Antiviral intervention</kwd><kwd>Combination therapy</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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