Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2
Identifieur interne : 001796 ( Pmc/Curation ); précédent : 001795; suivant : 001797Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2
Auteurs : Guangyu Zhou [République populaire de Chine] ; Qi Zhao [République populaire de Chine]Source :
- International Journal of Biological Sciences [ 1449-2288 ] ; 2020.
Abstract
A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the SARS-CoV-2 show high homology with that of SARS-CoV. Current efforts are focusing on development of specific antiviral drugs. Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. Further, we describe the benefits, challenges and considerations of NAbs against SARS-CoV-2. Although many challenges exist, NAbs still offer a therapeutic option to control the current pandemic and the possible re-emergence of the virus in the future, and their development therefore remains a high priority.
Url:
DOI: 10.7150/ijbs.45123
PubMed: 32226289
PubMed Central: 7098029
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2</title><author><name sortKey="Zhou, Guangyu" sort="Zhou, Guangyu" uniqKey="Zhou G" first="Guangyu" last="Zhou">Guangyu Zhou</name><affiliation wicri:level="1"><nlm:aff id="A1">Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Faculty of Health Sciences, University of Macau, Taipa, Macau SPR</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Institute of Translational Medicine, University of Macau, Taipa, Macau SPR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Translational Medicine, University of Macau, Taipa, Macau SPR</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Qi" sort="Zhao, Qi" uniqKey="Zhao Q" first="Qi" last="Zhao">Qi Zhao</name><affiliation wicri:level="1"><nlm:aff id="A1">Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Faculty of Health Sciences, University of Macau, Taipa, Macau SPR</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Institute of Translational Medicine, University of Macau, Taipa, Macau SPR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Translational Medicine, University of Macau, Taipa, Macau SPR</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32226289</idno><idno type="pmc">7098029</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098029</idno><idno type="RBID">PMC:7098029</idno><idno type="doi">10.7150/ijbs.45123</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001796</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001796</idno><idno type="wicri:Area/Pmc/Curation">001796</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001796</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2</title><author><name sortKey="Zhou, Guangyu" sort="Zhou, Guangyu" uniqKey="Zhou G" first="Guangyu" last="Zhou">Guangyu Zhou</name><affiliation wicri:level="1"><nlm:aff id="A1">Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Faculty of Health Sciences, University of Macau, Taipa, Macau SPR</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Institute of Translational Medicine, University of Macau, Taipa, Macau SPR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Translational Medicine, University of Macau, Taipa, Macau SPR</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Qi" sort="Zhao, Qi" uniqKey="Zhao Q" first="Qi" last="Zhao">Qi Zhao</name><affiliation wicri:level="1"><nlm:aff id="A1">Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Faculty of Health Sciences, University of Macau, Taipa, Macau SPR</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Institute of Translational Medicine, University of Macau, Taipa, Macau SPR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Institute of Translational Medicine, University of Macau, Taipa, Macau SPR</wicri:regionArea></affiliation></author></analytic><series><title level="j">International Journal of Biological Sciences</title><idno type="eISSN">1449-2288</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the SARS-CoV-2 show high homology with that of SARS-CoV. Current efforts are focusing on development of specific antiviral drugs. Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. Further, we describe the benefits, challenges and considerations of NAbs against SARS-CoV-2. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Biol Sci</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Biol. Sci</journal-id><journal-id journal-id-type="publisher-id">ijbs</journal-id><journal-title-group><journal-title>International Journal of Biological Sciences</journal-title></journal-title-group><issn pub-type="epub">1449-2288</issn><publisher><publisher-name>Ivyspring International Publisher</publisher-name><publisher-loc>Sydney</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32226289</article-id><article-id pub-id-type="pmc">7098029</article-id><article-id pub-id-type="doi">10.7150/ijbs.45123</article-id><article-id pub-id-type="publisher-id">ijbsv16p1718</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Guangyu</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Qi</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="FNA_envelop">✉</xref></contrib></contrib-group><aff id="A1"><label>1</label>Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China.</aff><aff id="A2"><label>2</label>Institute of Translational Medicine, University of Macau, Taipa, Macau SPR, China.</aff><author-notes><corresp id="FNA_envelop">✉ Corresponding author: Qi Zhao. E-mail: <email>qizhao@um.edu.mo</email>; <email>zhaoqi@alumni.cuhk.net</email>. Tel: 853-88224824. ORCID: 0000-0002-5969-6407.</corresp><fn fn-type="COI-statement"><p>Competing Interests: The authors have declared that no competing interest exists.</p></fn></author-notes><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>15</day><month>3</month><year>2020</year></pub-date><volume>16</volume><issue>10</issue><fpage>1718</fpage><lpage>1723</lpage><history><date date-type="received"><day>20</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>1</day><month>3</month><year>2020</year></date></history><permissions><copyright-statement>© The author(s)</copyright-statement><copyright-year>2020</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>). See <ext-link ext-link-type="uri" xlink:href="http://ivyspring.com/terms">http://ivyspring.com/terms</ext-link> for full terms and conditions.</license-p></license></permissions><abstract><p>A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the SARS-CoV-2 show high homology with that of SARS-CoV. Current efforts are focusing on development of specific antiviral drugs. Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. Further, we describe the benefits, challenges and considerations of NAbs against SARS-CoV-2. Although many challenges exist, NAbs still offer a therapeutic option to control the current pandemic and the possible re-emergence of the virus in the future, and their development therefore remains a high priority.</p></abstract><kwd-group><kwd>Neutralizing antibody</kwd><kwd>SARS-CoV-2</kwd><kwd>COVID-19</kwd><kwd>severe acute respiratory syndrome</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" position="float"><label>Figure 1</label><caption><p>Schematic representation of the coronavirus and spike protein. <bold>(A)</bold> The coronavirus structure. The viral surface proteins (spike, envelope and membrane glycoproteins) are embedded in a lipid bilayer envelope. <bold>(B)</bold> Comparison of the spike (S) proteins of SARS-CoV and SARS-CoV-2. RBD, receptor-binding domain; RBM, receptor-binding motif; HR1/2, heptad repeat 1/2.</p></caption><graphic xlink:href="ijbsv16p1718g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>Schematic mechanism of the neutralizing antibodies. Competition of the neutralizing antibody with the receptor (ACE2) for binding to the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein is shown. The protruding portion (violet) of RBD is both the ACE2 receptor-binding site and the antibody epitope.</p></caption><graphic xlink:href="ijbsv16p1718g002"></graphic></fig><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Neutralizing antibodies against SARS-CoV</p></caption><table frame="hsides" rules="groups"><thead valign="top"><tr><th rowspan="1" colspan="1">Neutralizing antibody</th><th rowspan="1" colspan="1">Identification Method</th><th rowspan="1" colspan="1">Target Region</th><th rowspan="1" colspan="1">Animal model</th><th rowspan="1" colspan="1">Reference</th></tr></thead><tbody valign="top"><tr><td rowspan="1" colspan="1">80R</td><td rowspan="1" colspan="1">Phage display</td><td rowspan="1" colspan="1">S1 domain 426-492</td><td rowspan="1" colspan="1">Mouse</td><td rowspan="1" colspan="1"><xref rid="B40" ref-type="bibr">40</xref></td></tr><tr><td rowspan="1" colspan="1">CR3014</td><td rowspan="1" colspan="1">Phage display</td><td rowspan="1" colspan="1">S1 domain 318-510</td><td rowspan="1" colspan="1">Ferret</td><td rowspan="1" colspan="1"><xref rid="B41" ref-type="bibr">41</xref></td></tr><tr><td rowspan="1" colspan="1">CR3022</td><td rowspan="1" colspan="1">Phage display</td><td rowspan="1" colspan="1">S1 domain 318-510</td><td rowspan="1" colspan="1">NA</td><td rowspan="1" colspan="1"><xref rid="B42" ref-type="bibr">42</xref></td></tr><tr><td rowspan="1" colspan="1">m396</td><td rowspan="1" colspan="1">Phage display</td><td rowspan="1" colspan="1">S protein</td><td rowspan="1" colspan="1">Mouse</td><td rowspan="1" colspan="1"><xref rid="B43" ref-type="bibr">43</xref></td></tr><tr><td rowspan="1" colspan="1">B1</td><td rowspan="1" colspan="1">Phage display</td><td rowspan="1" colspan="1">S2 domain 1023-1189</td><td rowspan="1" colspan="1">NA</td><td rowspan="1" colspan="1"><xref rid="B46" ref-type="bibr">46</xref></td></tr><tr><td rowspan="1" colspan="1">Group I (S132, S228.11)</td><td rowspan="1" colspan="1">EBV transformed B cells</td><td rowspan="1" colspan="1">N-terminal RBD</td><td rowspan="1" colspan="1">NA</td><td rowspan="1" colspan="1"><xref rid="B30" ref-type="bibr">30</xref></td></tr><tr><td rowspan="1" colspan="1">Group II (S111.7, S224.17)</td><td rowspan="1" colspan="1">EBV transformed B cells</td><td rowspan="1" colspan="1">S1 domain 318-510</td><td rowspan="1" colspan="1">NA</td><td rowspan="1" colspan="1"><xref rid="B30" ref-type="bibr">30</xref></td></tr><tr><td rowspan="1" colspan="1">Group III (S3.1, S127.6, S217.4, S222.1, S237.1)</td><td rowspan="1" colspan="1">EBV transformed B cells</td><td rowspan="1" colspan="1">S1 domain 318-510</td><td rowspan="1" colspan="1">Mouse (S.1)</td><td rowspan="1" colspan="1"><xref rid="B30" ref-type="bibr">30</xref></td></tr><tr><td rowspan="1" colspan="1">Group IV (S110.4, S218.9, S223.4, S225.12, S226.10, S231.19, S232.17, S234.6)</td><td rowspan="1" colspan="1">EBV transformed B cells</td><td rowspan="1" colspan="1">S1 domain 318-510</td><td rowspan="1" colspan="1">NA</td><td rowspan="1" colspan="1"><xref rid="B30" ref-type="bibr">30</xref></td></tr><tr><td rowspan="1" colspan="1">Group V (S124.5, S219.2)</td><td rowspan="1" colspan="1">EBV transformed B cells</td><td rowspan="1" colspan="1">ND</td><td rowspan="1" colspan="1">NA</td><td rowspan="1" colspan="1"><xref rid="B30" ref-type="bibr">30</xref></td></tr><tr><td rowspan="1" colspan="1">Group VI (S109.8, S215.17, S227.14, S230.15)</td><td rowspan="1" colspan="1">EBV transformed B cells</td><td rowspan="1" colspan="1">S1 domain 318-510</td><td rowspan="1" colspan="1">Mouse</td><td rowspan="1" colspan="1"><xref rid="B30" ref-type="bibr">30</xref></td></tr><tr><td rowspan="1" colspan="1">201</td><td rowspan="1" colspan="1">HuMAb-Mouse<sup>®</sup></td><td rowspan="1" colspan="1">S1 domain 490-510</td><td rowspan="1" colspan="1">Mouse</td><td rowspan="1" colspan="1"><xref rid="B44" ref-type="bibr">44</xref>, <xref rid="B45" ref-type="bibr">45</xref></td></tr><tr><td rowspan="1" colspan="1">68</td><td rowspan="1" colspan="1">HuMAb-Mouse<sup>®</sup></td><td rowspan="1" colspan="1">S1 domain 130-150</td><td rowspan="1" colspan="1">Mouse</td><td rowspan="1" colspan="1"><xref rid="B44" ref-type="bibr">44</xref>, <xref rid="B45" ref-type="bibr">45</xref></td></tr><tr><td rowspan="1" colspan="1">1F8</td><td rowspan="1" colspan="1">XenoMouse®</td><td rowspan="1" colspan="1">S2 domain HR1</td><td rowspan="1" colspan="1">NA</td><td rowspan="1" colspan="1"><xref rid="B47" ref-type="bibr">47</xref></td></tr><tr><td rowspan="1" colspan="1">5E9</td><td rowspan="1" colspan="1">XenoMouse®</td><td rowspan="1" colspan="1">S2 domain HR2</td><td rowspan="1" colspan="1">NA</td><td rowspan="1" colspan="1"><xref rid="B47" ref-type="bibr">47</xref></td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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