SrasV1, Pmc, Curation, bibRecord, 001768

Broad-spectrum coronavirus antiviral drug discovery

Identifieur interne : 001768 ( Pmc/Curation ); précédent : 001767; suivant : 001769

Broad-spectrum coronavirus antiviral drug discovery

Auteurs : Allison L. Totura ; Sina Bavari

Source :

Expert Opinion on Drug Discovery [ 1746-0441 ] ; 2019.

RBID : PMC:7103675

Abstract

ABSTRACT

Introduction: The highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are lethal zoonotic viruses that have emerged into human populations these past 15 years. These coronaviruses are associated with novel respiratory syndromes that spread from person-to-person via close contact, resulting in high morbidity and mortality caused by the progression to Acute Respiratory Distress Syndrome (ARDS).

Areas covered: The risks of re-emergence of SARS-CoV from bat reservoir hosts, the persistence of MERS-CoV circulation, and the potential for future emergence of novel coronaviruses indicate antiviral drug discovery will require activity against multiple coronaviruses. In this review, approaches that antagonize viral nonstructural proteins, neutralize structural proteins, or modulate essential host elements of viral infection with varying levels of efficacy in models of highly pathogenic coronavirus disease are discussed.

Expert opinion: Treatment of SARS and MERS in outbreak settings has focused on therapeutics with general antiviral activity and good safety profiles rather than efficacy data provided by cellular, rodent, or nonhuman primate models of highly pathogenic coronavirus infection. Based on lessons learned from SARS and MERS outbreaks, lack of drugs capable of pan-coronavirus antiviral activity increases the vulnerability of public health systems to a highly pathogenic coronavirus pandemic.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103675

DOI: 10.1080/17460441.2019.1581171
PubMed: 30849247
PubMed Central: 7103675

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<author><name sortKey="Bavari, Sina" sort="Bavari, Sina" uniqKey="Bavari S" first="Sina" last="Bavari">Sina Bavari</name>
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<author><name sortKey="Bavari, Sina" sort="Bavari, Sina" uniqKey="Bavari S" first="Sina" last="Bavari">Sina Bavari</name>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p><bold>Introduction</bold>
: The highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are lethal zoonotic viruses that have emerged into human populations these past 15 years. These coronaviruses are associated with novel respiratory syndromes that spread from person-to-person via close contact, resulting in high morbidity and mortality caused by the progression to Acute Respiratory Distress Syndrome (ARDS).</p>
<p><bold>Areas covered</bold>
: The risks of re-emergence of SARS-CoV from bat reservoir hosts, the persistence of MERS-CoV circulation, and the potential for future emergence of novel coronaviruses indicate antiviral drug discovery will require activity against multiple coronaviruses. In this review, approaches that antagonize viral nonstructural proteins, neutralize structural proteins, or modulate essential host elements of viral infection with varying levels of efficacy in models of highly pathogenic coronavirus disease are discussed.</p>
<p><bold>Expert opinion</bold>
: Treatment of SARS and MERS in outbreak settings has focused on therapeutics with general antiviral activity and good safety profiles rather than efficacy data provided by cellular, rodent, or nonhuman primate models of highly pathogenic coronavirus infection. Based on lessons learned from SARS and MERS outbreaks, lack of drugs capable of pan-coronavirus antiviral activity increases the vulnerability of public health systems to a highly pathogenic coronavirus pandemic.</p>
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<biblStruct><analytic><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J Cinatl</name>
</author>
<author><name sortKey="Morgenstern, B" uniqKey="Morgenstern B">B Morgenstern</name>
</author>
<author><name sortKey="Bauer, G" uniqKey="Bauer G">G Bauer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
<author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name>
</author>
<author><name sortKey="Martina, Be" uniqKey="Martina B">BE Martina</name>
</author>
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</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Expert Opin Drug Discov</journal-id>
<journal-id journal-id-type="iso-abbrev">Expert Opin Drug Discov</journal-id>
<journal-id journal-id-type="publisher-id">IEDC</journal-id>
<journal-id journal-id-type="publisher-id">iedc20</journal-id>
<journal-title-group><journal-title>Expert Opinion on Drug Discovery</journal-title>
</journal-title-group>
<issn pub-type="ppub">1746-0441</issn>
<issn pub-type="epub">1746-045X</issn>
<publisher><publisher-name>Taylor & Francis</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">30849247</article-id>
<article-id pub-id-type="pmc">7103675</article-id>
<article-id pub-id-type="publisher-id">1581171</article-id>
<article-id pub-id-type="doi">10.1080/17460441.2019.1581171</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Broad-spectrum coronavirus antiviral drug discovery</article-title>
<alt-title alt-title-type="running-authors">A. L. TOTURA AND S. BAVARI</alt-title>
<alt-title alt-title-type="running-title">EXPERT OPINION ON DRUG DISCOVERY</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-6827-0523</contrib-id>
<name><surname>Totura</surname>
<given-names>Allison L.</given-names>
</name>
<xref ref-type="aff" rid="AFF0001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bavari</surname>
<given-names>Sina</given-names>
</name>
<xref ref-type="corresp" rid="AN0001"></xref>
<xref ref-type="aff" rid="AFF0001"></xref>
</contrib>
<aff id="AFF0001"><institution>Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases</institution>
, Fort Detrick, MD,<country>USA</country>
</aff>
</contrib-group>
<author-notes><corresp id="AN0001">CONTACT Sina Bavari <email xlink:href="sina.bavari.civ@mail.mil">sina.bavari.civ@mail.mil</email>
<institution>Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases</institution>
, Fort Detrick, MD 21702, <country>USA</country>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>08</day>
<month>3</month>
<year>2019</year>
</pub-date>
<volume>14</volume>
<issue>4</issue>
<fpage seq="9">397</fpage>
<lpage>412</lpage>
<history><date date-type="received"><day>16</day>
<month>8</month>
<year>2018</year>
</date>
<date date-type="accepted"><day>07</day>
<month>2</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 Informa UK Limited, trading as Taylor & Francis Group</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Informa UK Limited, trading as Taylor & Francis Group</copyright-holder>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="IEDC_14_1581171.pdf"></self-uri>
<abstract><title>ABSTRACT</title>
<p><bold>Introduction</bold>
: The highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are lethal zoonotic viruses that have emerged into human populations these past 15 years. These coronaviruses are associated with novel respiratory syndromes that spread from person-to-person via close contact, resulting in high morbidity and mortality caused by the progression to Acute Respiratory Distress Syndrome (ARDS).</p>
<p><bold>Areas covered</bold>
: The risks of re-emergence of SARS-CoV from bat reservoir hosts, the persistence of MERS-CoV circulation, and the potential for future emergence of novel coronaviruses indicate antiviral drug discovery will require activity against multiple coronaviruses. In this review, approaches that antagonize viral nonstructural proteins, neutralize structural proteins, or modulate essential host elements of viral infection with varying levels of efficacy in models of highly pathogenic coronavirus disease are discussed.</p>
<p><bold>Expert opinion</bold>
: Treatment of SARS and MERS in outbreak settings has focused on therapeutics with general antiviral activity and good safety profiles rather than efficacy data provided by cellular, rodent, or nonhuman primate models of highly pathogenic coronavirus infection. Based on lessons learned from SARS and MERS outbreaks, lack of drugs capable of pan-coronavirus antiviral activity increases the vulnerability of public health systems to a highly pathogenic coronavirus pandemic.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>KEYWORDS</title>
<kwd>Antiviral</kwd>
<kwd>ARDS</kwd>
<kwd>acute respiratory distress syndrome</kwd>
<kwd>bat</kwd>
<kwd>broad-spectrum</kwd>
<kwd>camel</kwd>
<kwd>civet</kwd>
<kwd>coronavirus</kwd>
<kwd>emerging virus</kwd>
<kwd>highly pathogenic virus</kwd>
<kwd>human cases</kwd>
<kwd>interferon</kwd>
<kwd>in vitro model</kwd>
<kwd>lopinavir</kwd>
<kwd>MERS</kwd>
<kwd>MERS-CoV</kwd>
<kwd>Middle East respiratory syndrome</kwd>
<kwd>pneumonia</kwd>
<kwd>primate model</kwd>
<kwd>respiratory</kwd>
<kwd>ribavirin</kwd>
<kwd>rodent model</kwd>
<kwd>SARS</kwd>
<kwd>SARS-CoV</kwd>
<kwd>severe acute respiratory syndrome</kwd>
<kwd>therapeutic</kwd>
<kwd>zoonosis</kwd>
<kwd>zoonotic</kwd>
</kwd-group>
<funding-group><award-group><funding-source><named-content content-type="funder-name">not funded</named-content>
</funding-source>
</award-group>
<funding-statement>This research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Medical Research Institute of Infectious Diseases administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and the US Army Medical Research and Materiel Command (USAMRMC).</funding-statement>
</funding-group>
<counts><fig-count count="3"></fig-count>
<table-count count="3"></table-count>
<ref-count count="127"></ref-count>
<page-count count="16"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>

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Broad-spectrum coronavirus antiviral drug discovery

Broad-spectrum coronavirus antiviral drug discovery

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