Pathophysiological Characteristics and Therapeutic Approaches for Pulmonary Injury and Cardiovascular Complications of Coronavirus Disease 2019
Identifieur interne : 001713 ( Pmc/Curation ); précédent : 001712; suivant : 001714Pathophysiological Characteristics and Therapeutic Approaches for Pulmonary Injury and Cardiovascular Complications of Coronavirus Disease 2019
Auteurs : Yong-Jian Geng [États-Unis] ; Zhi-Yao Wei [République populaire de Chine] ; Hai-Yan Qian [République populaire de Chine] ; Ji Huang [République populaire de Chine] ; Robert Lodato [États-Unis] ; Richard J. Castriotta [États-Unis]Source :
- Cardiovascular Pathology [ 1054-8807 ] ; 2020.
Abstract
The pandemic of coronavirus disease 2019 (COVID-19) has emerged as a major health crisis, with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) having infected over a million people around the world within a few months of its identification as a human pathogen. Initially, SARS-CoV-2 infects cells in the respiratory system and causes inflammation and cell death. Subsequently, the virus spreads out and damages other vital organs and tissues, triggering a complicated spectrum of pathophysiological changes and symptoms, including cardiovascular complications. Acting as the receptor for SARS-CoV entering mammalian cells, angiotensin converting enzyme-2 (ACE2) plays a pivotal role in the regulation of cardiovascular cell function. Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment. This review provides a summary of the rapidly appearing laboratory and clinical evidence for the pathophysiology and therapeutic approaches to COVID-19 pulmonary and cardiovascular complications.
Url:
DOI: 10.1016/j.carpath.2020.107228
PubMed: NONE
PubMed Central: 7162778
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathophysiological Characteristics and Therapeutic Approaches for Pulmonary Injury and Cardiovascular Complications of Coronavirus Disease 2019</title><author><name sortKey="Geng, Yong Jian" sort="Geng, Yong Jian" uniqKey="Geng Y" first="Yong-Jian" last="Geng">Yong-Jian Geng</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Wei, Zhi Yao" sort="Wei, Zhi Yao" uniqKey="Wei Z" first="Zhi-Yao" last="Wei">Zhi-Yao Wei</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Center for Coronary Heart Disease, Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Coronary Heart Disease, Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Qian, Hai Yan" sort="Qian, Hai Yan" uniqKey="Qian H" first="Hai-Yan" last="Qian">Hai-Yan Qian</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Center for Coronary Heart Disease, Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Coronary Heart Disease, Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Ji" sort="Huang, Ji" uniqKey="Huang J" first="Ji" last="Huang">Ji Huang</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Lodato, Robert" sort="Lodato, Robert" uniqKey="Lodato R" first="Robert" last="Lodato">Robert Lodato</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Castriotta, Richard J" sort="Castriotta, Richard J" uniqKey="Castriotta R" first="Richard J." last="Castriotta">Richard J. Castriotta</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0004">Division of Pulmonary, Critical and Sleep Medicine, University of South California Keck School of Medicine, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Critical and Sleep Medicine, University of South California Keck School of Medicine, Los Angeles, California</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7162778</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162778</idno><idno type="RBID">PMC:7162778</idno><idno type="doi">10.1016/j.carpath.2020.107228</idno><idno type="pmid">NONE</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001713</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001713</idno><idno type="wicri:Area/Pmc/Curation">001713</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001713</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pathophysiological Characteristics and Therapeutic Approaches for Pulmonary Injury and Cardiovascular Complications of Coronavirus Disease 2019</title><author><name sortKey="Geng, Yong Jian" sort="Geng, Yong Jian" uniqKey="Geng Y" first="Yong-Jian" last="Geng">Yong-Jian Geng</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Wei, Zhi Yao" sort="Wei, Zhi Yao" uniqKey="Wei Z" first="Zhi-Yao" last="Wei">Zhi-Yao Wei</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Center for Coronary Heart Disease, Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Coronary Heart Disease, Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Qian, Hai Yan" sort="Qian, Hai Yan" uniqKey="Qian H" first="Hai-Yan" last="Qian">Hai-Yan Qian</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Center for Coronary Heart Disease, Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Coronary Heart Disease, Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Ji" sort="Huang, Ji" uniqKey="Huang J" first="Ji" last="Huang">Ji Huang</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Lodato, Robert" sort="Lodato, Robert" uniqKey="Lodato R" first="Robert" last="Lodato">Robert Lodato</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas</wicri:regionArea></affiliation></author><author><name sortKey="Castriotta, Richard J" sort="Castriotta, Richard J" uniqKey="Castriotta R" first="Richard J." last="Castriotta">Richard J. Castriotta</name><affiliation wicri:level="1"><nlm:aff id="aff0001">Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0004">Division of Pulmonary, Critical and Sleep Medicine, University of South California Keck School of Medicine, Los Angeles, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Critical and Sleep Medicine, University of South California Keck School of Medicine, Los Angeles, California</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cardiovascular Pathology</title><idno type="ISSN">1054-8807</idno><idno type="eISSN">1879-1336</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0001">The pandemic of coronavirus disease 2019 (COVID-19) has emerged as a major health crisis, with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) having infected over a million people around the world within a few months of its identification as a human pathogen.</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0002">Initially, SARS-CoV-2 infects cells in the respiratory system and causes inflammation and cell death.</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0003">Subsequently, the virus spreads out and damages other vital organs and tissues, triggering a complicated spectrum of pathophysiological changes and symptoms, including cardiovascular complications.</p></list-item><list-item id="celistitem0004"><label>•</label><p id="para0004">Acting as the receptor for SARS-CoV entering mammalian cells, angiotensin converting enzyme-2 (ACE2) plays a pivotal role in the regulation of cardiovascular cell function.</p></list-item><list-item id="celistitem0005"><label>•</label><p id="para0005">Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment.</p></list-item><list-item id="celistitem0006"><label>•</label><p id="para0006">This review provides a summary of the rapidly appearing laboratory and clinical evidence for the pathophysiology and therapeutic approaches to COVID-19 pulmonary and cardiovascular complications.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Sun, P" uniqKey="Sun P">P. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Cardiovasc Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Cardiovasc. Pathol</journal-id><journal-title-group><journal-title>Cardiovascular Pathology</journal-title></journal-title-group><issn pub-type="ppub">1054-8807</issn><issn pub-type="epub">1879-1336</issn><publisher><publisher-name>Published by Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7162778</article-id><article-id pub-id-type="publisher-id">S1054-8807(20)30032-6</article-id><article-id pub-id-type="doi">10.1016/j.carpath.2020.107228</article-id><article-id pub-id-type="publisher-id">107228</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Pathophysiological Characteristics and Therapeutic Approaches for Pulmonary Injury and Cardiovascular Complications of Coronavirus Disease 2019</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0001"><name><surname>Geng</surname><given-names>Yong-Jian</given-names></name><email>yong-jian.geng@uth.tmc.edu</email><xref rid="aff0001" ref-type="aff">a</xref><xref rid="cor0001" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="au0002"><name><surname>Wei</surname><given-names>Zhi-Yao</given-names></name><xref rid="aff0002" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au0003"><name><surname>Qian</surname><given-names>Hai-Yan</given-names></name><xref rid="aff0002" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="au0004"><name><surname>Huang</surname><given-names>Ji</given-names></name><xref rid="aff0003" ref-type="aff">c</xref></contrib><contrib contrib-type="author" id="au0005"><name><surname>Lodato</surname><given-names>Robert</given-names></name><xref rid="aff0001" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au0006"><name><surname>Castriotta</surname><given-names>Richard J.</given-names></name><xref rid="aff0001" ref-type="aff">a</xref><xref rid="aff0004" ref-type="aff">d</xref></contrib></contrib-group><aff id="aff0001"><label>a</label>Department of Internal Medicine, McGovern School of Medicine, University of Texas Health Science Center at Houston, Texas, USA</aff><aff id="aff0002"><label>b</label>Center for Coronary Heart Disease, Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China</aff><aff id="aff0003"><label>c</label>Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China</aff><aff id="aff0004"><label>d</label>Division of Pulmonary, Critical and Sleep Medicine, University of South California Keck School of Medicine, Los Angeles, California, USA</aff><author-notes><corresp id="cor0001"><label>⁎</label>Corresponding author: Yong-Jian Geng, MD, PhD, Professor and Director, The Center for Cardiovascular Biology and Atherosclerosis Research, McGovern Medical School University of Texas Health Science at Houston (UTHealth), Houston, Texas, USA, Telephone: 713-500-6590. <email>yong-jian.geng@uth.tmc.edu</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>17</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>17</day><month>4</month><year>2020</year></pub-date><elocation-id>107228</elocation-id><permissions><copyright-statement>© 2020 Published by Elsevier Inc.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0001"><title>Highlights</title><p><list list-type="simple" id="celist0001"><list-item id="celistitem0001"><label>•</label><p id="para0001">The pandemic of coronavirus disease 2019 (COVID-19) has emerged as a major health crisis, with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) having infected over a million people around the world within a few months of its identification as a human pathogen.</p></list-item><list-item id="celistitem0002"><label>•</label><p id="para0002">Initially, SARS-CoV-2 infects cells in the respiratory system and causes inflammation and cell death.</p></list-item><list-item id="celistitem0003"><label>•</label><p id="para0003">Subsequently, the virus spreads out and damages other vital organs and tissues, triggering a complicated spectrum of pathophysiological changes and symptoms, including cardiovascular complications.</p></list-item><list-item id="celistitem0004"><label>•</label><p id="para0004">Acting as the receptor for SARS-CoV entering mammalian cells, angiotensin converting enzyme-2 (ACE2) plays a pivotal role in the regulation of cardiovascular cell function.</p></list-item><list-item id="celistitem0005"><label>•</label><p id="para0005">Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment.</p></list-item><list-item id="celistitem0006"><label>•</label><p id="para0006">This review provides a summary of the rapidly appearing laboratory and clinical evidence for the pathophysiology and therapeutic approaches to COVID-19 pulmonary and cardiovascular complications.</p></list-item></list></p></abstract><abstract id="abs0002"><p>The pandemic of coronavirus disease 2019 (COVID-19) has emerged as a major health crisis, with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) having infected over a million people around the world within a few months of its identification as a human pathogen. Initially, SARS-CoV-2 infects cells in the respiratory system and causes inflammation and cell death. Subsequently, the virus spreads out and damages other vital organs and tissues, triggering a complicated spectrum of pathophysiological changes and symptoms, including cardiovascular complications. Acting as the receptor for SARS-CoV entering mammalian cells, angiotensin converting enzyme-2 (ACE2) plays a pivotal role in the regulation of cardiovascular cell function. Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment. This review provides a summary of the rapidly appearing laboratory and clinical evidence for the pathophysiology and therapeutic approaches to COVID-19 pulmonary and cardiovascular complications.</p></abstract><abstract abstract-type="graphical" id="abs0003"><title>Graphical abstract</title><p><fig id="fig0003" position="anchor"><alt-text id="alttx001">Image, graphical abstract</alt-text><graphic xlink:href="fx1_lrg"></graphic></fig></p></abstract><kwd-group id="keys0001"><title>Keywords</title><kwd>Coronavirus</kwd><kwd>Lung</kwd><kwd>Heart</kwd><kwd>Blood vessels</kwd><kwd>Infection</kwd><kwd>Injury</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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