Coronaviruses and their therapy
Identifieur interne : 001685 ( Pmc/Curation ); précédent : 001684; suivant : 001686Coronaviruses and their therapy
Auteurs : Bart L. Haagmans ; Albert D. M. E. OsterhausSource :
- Antiviral Research [ 0166-3542 ] ; 2006.
Abstract
Coronaviruses may cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses hampered development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) has prompted the discovery of such drugs. Subsequent studies in animal models demonstrated the efficacy of SARS-CoV specific monoclonal antibodies, pegylated-interferon-α and siRNAs against SARS-CoV. Furthermore, several antivirals shown to be effective against other viruses were tested in vitro. Because of availability and shown efficacy, the use of interferons may be considered should SARS-CoV or a related coronavirus (re)-emerge. The more recent design of wide-spectrum inhibitors targeting the coronavirus main proteases may lead to the discovery of new antivirals against multiple coronavirus induced diseases.
Url:
DOI: 10.1016/j.antiviral.2006.05.019
PubMed: 16837072
PubMed Central: 7114240
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Coronaviruses and their therapy</title><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16837072</idno><idno type="pmc">7114240</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114240</idno><idno type="RBID">PMC:7114240</idno><idno type="doi">10.1016/j.antiviral.2006.05.019</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">001685</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001685</idno><idno type="wicri:Area/Pmc/Curation">001685</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001685</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Coronaviruses and their therapy</title><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Coronaviruses may cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses hampered development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) has prompted the discovery of such drugs. Subsequent studies in animal models demonstrated the efficacy of SARS-CoV specific monoclonal antibodies, pegylated-interferon-α and siRNAs against SARS-CoV. Furthermore, several antivirals shown to be effective against other viruses were tested in vitro. Because of availability and shown efficacy, the use of interferons may be considered should SARS-CoV or a related coronavirus (re)-emerge. The more recent design of wide-spectrum inhibitors targeting the coronavirus main proteases may lead to the discovery of new antivirals against multiple coronavirus induced diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K. Anand</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P. Wadhwani</name></author><author><name sortKey="Mesters, J R" uniqKey="Mesters J">J.R. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Antiviral Res</journal-id><journal-id journal-id-type="iso-abbrev">Antiviral Res</journal-id><journal-title-group><journal-title>Antiviral Research</journal-title></journal-title-group><issn pub-type="ppub">0166-3542</issn><issn pub-type="epub">1872-9096</issn><publisher><publisher-name>Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16837072</article-id><article-id pub-id-type="pmc">7114240</article-id><article-id pub-id-type="publisher-id">S0166-3542(06)00170-7</article-id><article-id pub-id-type="doi">10.1016/j.antiviral.2006.05.019</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Coronaviruses and their therapy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Haagmans</surname><given-names>Bart L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Osterhaus</surname><given-names>Albert D.M.E.</given-names></name><email>a.osterhaus@erasmusmc.nl</email><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff>Department of Virology, Erasmus Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. Tel.: +31 10 4088066; fax: +31 10 4089485. <email>a.osterhaus@erasmusmc.nl</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>19</day><month>6</month><year>2006</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>9</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>19</day><month>6</month><year>2006</year></pub-date><volume>71</volume><issue>2</issue><fpage>397</fpage><lpage>403</lpage><history><date date-type="received"><day>24</day><month>4</month><year>2006</year></date><date date-type="accepted"><day>31</day><month>5</month><year>2006</year></date></history><permissions><copyright-statement>Copyright © 2006 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2006</copyright-year><copyright-holder>Elsevier B.V.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><p>Coronaviruses may cause respiratory, enteric and central nervous system diseases in many species, including humans. Until recently, the relatively low burden of disease in humans caused by few of these viruses hampered development of coronavirus specific therapeutics. However, the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) has prompted the discovery of such drugs. Subsequent studies in animal models demonstrated the efficacy of SARS-CoV specific monoclonal antibodies, pegylated-interferon-α and siRNAs against SARS-CoV. Furthermore, several antivirals shown to be effective against other viruses were tested in vitro. Because of availability and shown efficacy, the use of interferons may be considered should SARS-CoV or a related coronavirus (re)-emerge. The more recent design of wide-spectrum inhibitors targeting the coronavirus main proteases may lead to the discovery of new antivirals against multiple coronavirus induced diseases.</p></abstract><kwd-group><title>Keywords</title><kwd>Coronaviruses</kwd><kwd>SARS</kwd><kwd>Antivirals</kwd><kwd>Therapy</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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