Pathology and Pathogenesis of Severe Acute Respiratory Syndrome
Identifieur interne : 001681 ( Pmc/Curation ); précédent : 001680; suivant : 001682Pathology and Pathogenesis of Severe Acute Respiratory Syndrome
Auteurs : Jiang Gu ; Christine KortewegSource :
- The American Journal of Pathology [ 0002-9440 ] ; 2007.
Abstract
Severe acute respiratory syndrome (SARS) is an emerging infectious viral disease characterized by severe clinical manifestations of the lower respiratory tract. The pathogenesis of SARS is highly complex, with multiple factors leading to severe injury in the lungs and dissemination of the virus to several other organs. The SARS coronavirus targets the epithelial cells of the respiratory tract, resulting in diffuse alveolar damage. Several organs/cell types may be infected in the course of the illness, including mucosal cells of the intestines, tubular epithelial cells of the kidneys, neurons of the brain, and several types of immune cells, and certain organs may suffer from indirect injury. Extensive studies have provided a basic understanding of the pathogenesis of this disease. In this review we describe the most significant pathological features of SARS, explore the etiological factors causing these pathological changes, and discuss the major pathogenetic mechanisms. The latter include dysregulation of cytokines/chemokines, deficiencies in the innate immune response, direct infection of immune cells, direct viral cytopathic effects, down-regulation of lung protective angiotensin converting enzyme 2, autoimmunity, and genetic factors. It seems that both abnormal immune responses and injury to immune cells may be key factors in the pathogenesis of this new disease.
Url:
DOI: 10.2353/ajpath.2007.061088
PubMed: 17392154
PubMed Central: 1829448
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathology and Pathogenesis of Severe Acute Respiratory Syndrome</title><author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name></author><author><name sortKey="Korteweg, Christine" sort="Korteweg, Christine" uniqKey="Korteweg C" first="Christine" last="Korteweg">Christine Korteweg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17392154</idno><idno type="pmc">1829448</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829448</idno><idno type="RBID">PMC:1829448</idno><idno type="doi">10.2353/ajpath.2007.061088</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">001681</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001681</idno><idno type="wicri:Area/Pmc/Curation">001681</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001681</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pathology and Pathogenesis of Severe Acute Respiratory Syndrome</title><author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name></author><author><name sortKey="Korteweg, Christine" sort="Korteweg, Christine" uniqKey="Korteweg C" first="Christine" last="Korteweg">Christine Korteweg</name></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS) is an emerging infectious viral disease characterized by severe clinical manifestations of the lower respiratory tract. The pathogenesis of SARS is highly complex, with multiple factors leading to severe injury in the lungs and dissemination of the virus to several other organs. The SARS coronavirus targets the epithelial cells of the respiratory tract, resulting in diffuse alveolar damage. Several organs/cell types may be infected in the course of the illness, including mucosal cells of the intestines, tubular epithelial cells of the kidneys, neurons of the brain, and several types of immune cells, and certain organs may suffer from indirect injury. Extensive studies have provided a basic understanding of the pathogenesis of this disease. In this review we describe the most significant pathological features of SARS, explore the etiological factors causing these pathological changes, and discuss the major pathogenetic mechanisms. The latter include dysregulation of cytokines/chemokines, deficiencies in the innate immune response, direct infection of immune cells, direct viral cytopathic effects, down-regulation of lung protective angiotensin converting enzyme 2, autoimmunity, and genetic factors. It seems that both abnormal immune responses and injury to immune cells may be key factors in the pathogenesis of this new disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author><author><name sortKey="Brodt, Hr" uniqKey="Brodt H">HR Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L Kolesnikova</name></author><author><name sortKey="Fouchier, Ra" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Pathol</journal-id><journal-title-group><journal-title>The American Journal of Pathology</journal-title></journal-title-group><issn pub-type="ppub">0002-9440</issn><issn pub-type="epub">1525-2191</issn><publisher><publisher-name>American Society for Investigative Pathology. Published by Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17392154</article-id><article-id pub-id-type="pmc">1829448</article-id><article-id pub-id-type="publisher-id">S0002-9440(10)61329-6</article-id><article-id pub-id-type="doi">10.2353/ajpath.2007.061088</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Pathology and Pathogenesis of Severe Acute Respiratory Syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gu</surname><given-names>Jiang</given-names></name><email>jianggu@bmcu.edu.cn</email><xref rid="cor1" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Korteweg</surname><given-names>Christine</given-names></name></contrib></contrib-group><aff>Department of Pathology and Infectious Disease Center, School of Basic Medical Sciences, Peking (Beijing) University, Beijing, China</aff><author-notes><corresp id="cor1"><label>*</label>Address reprint requests to Jiang Gu, M.D., Ph.D., Professor and Chairman, Department of Pathology, Dean, School of Medical Sciences, Director, Infectious Disease Center, Peking (Beijing) University, 38 Xueyuan Rd., 100083 Beijing, China <email>jianggu@bmcu.edu.cn</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>16</day><month>12</month><year>2010</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>4</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>16</day><month>12</month><year>2010</year></pub-date><volume>170</volume><issue>4</issue><fpage>1136</fpage><lpage>1147</lpage><history><date date-type="accepted"><day>9</day><month>1</month><year>2007</year></date></history><permissions><copyright-statement>Copyright © 2007 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2007</copyright-year><copyright-holder>American Society for Investigative Pathology</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><p>Severe acute respiratory syndrome (SARS) is an emerging infectious viral disease characterized by severe clinical manifestations of the lower respiratory tract. The pathogenesis of SARS is highly complex, with multiple factors leading to severe injury in the lungs and dissemination of the virus to several other organs. The SARS coronavirus targets the epithelial cells of the respiratory tract, resulting in diffuse alveolar damage. Several organs/cell types may be infected in the course of the illness, including mucosal cells of the intestines, tubular epithelial cells of the kidneys, neurons of the brain, and several types of immune cells, and certain organs may suffer from indirect injury. Extensive studies have provided a basic understanding of the pathogenesis of this disease. In this review we describe the most significant pathological features of SARS, explore the etiological factors causing these pathological changes, and discuss the major pathogenetic mechanisms. The latter include dysregulation of cytokines/chemokines, deficiencies in the innate immune response, direct infection of immune cells, direct viral cytopathic effects, down-regulation of lung protective angiotensin converting enzyme 2, autoimmunity, and genetic factors. It seems that both abnormal immune responses and injury to immune cells may be key factors in the pathogenesis of this new disease.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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