Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism
Identifieur interne : 001674 ( Pmc/Curation ); précédent : 001673; suivant : 001675Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism
Auteurs : Rebecca L. Wilson ; Dennis E. HrubySource :
- Advanced Drug Delivery Reviews [ 0169-409X ] ; 2005.
Abstract
Following the anthrax attacks of 2001 and the recent SARS outbreak, concerns about emerging and re-emerging infectious diseases have catalyzed a renewed interest in developing new vaccination strategies that provide rapid and flexible response options to future threats. Because the probability of encountering one of these exotic agents is unknown, it is essential that new vaccine formulations employ methods that provide effective protection and extremely good safety profiles if they are to be used by either military or civilian populations. One approach, which potentially satisfies these criteria, is the use of live recombinant Gram-positive commensal bacteria as expression vectors. This review provides an overview of the system, its advantages and limitations, and details an example of how Gram-positive commensal bacteria are being developed as a fifth generation vaccine against a Class A biowarfare pathogen, namely smallpox.
Url:
DOI: 10.1016/j.addr.2005.01.015
PubMed: 15935879
PubMed Central: 7125890
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism</title><author><name sortKey="Wilson, Rebecca L" sort="Wilson, Rebecca L" uniqKey="Wilson R" first="Rebecca L." last="Wilson">Rebecca L. Wilson</name></author><author><name sortKey="Hruby, Dennis E" sort="Hruby, Dennis E" uniqKey="Hruby D" first="Dennis E." last="Hruby">Dennis E. Hruby</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15935879</idno><idno type="pmc">7125890</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125890</idno><idno type="RBID">PMC:7125890</idno><idno type="doi">10.1016/j.addr.2005.01.015</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001674</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001674</idno><idno type="wicri:Area/Pmc/Curation">001674</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001674</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism</title><author><name sortKey="Wilson, Rebecca L" sort="Wilson, Rebecca L" uniqKey="Wilson R" first="Rebecca L." last="Wilson">Rebecca L. Wilson</name></author><author><name sortKey="Hruby, Dennis E" sort="Hruby, Dennis E" uniqKey="Hruby D" first="Dennis E." last="Hruby">Dennis E. Hruby</name></author></analytic><series><title level="j">Advanced Drug Delivery Reviews</title><idno type="ISSN">0169-409X</idno><idno type="eISSN">1872-8294</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Following the anthrax attacks of 2001 and the recent SARS outbreak, concerns about emerging and re-emerging infectious diseases have catalyzed a renewed interest in developing new vaccination strategies that provide rapid and flexible response options to future threats. Because the probability of encountering one of these exotic agents is unknown, it is essential that new vaccine formulations employ methods that provide effective protection and extremely good safety profiles if they are to be used by either military or civilian populations. One approach, which potentially satisfies these criteria, is the use of live recombinant Gram-positive commensal bacteria as expression vectors. This review provides an overview of the system, its advantages and limitations, and details an example of how Gram-positive commensal bacteria are being developed as a fifth generation vaccine against a Class A biowarfare pathogen, namely smallpox.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jackson, R J" uniqKey="Jackson R">R.J. Jackson</name></author><author><name sortKey="Ramsay, A J" uniqKey="Ramsay A">A.J. Ramsay</name></author><author><name sortKey="Christensen, C D" uniqKey="Christensen C">C.D. 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Shchelkunov</name></author><author><name sortKey="Totmenin, A V" uniqKey="Totmenin A">A.V. Totmenin</name></author><author><name sortKey="Babkin, I V" uniqKey="Babkin I">I.V. Babkin</name></author><author><name sortKey="Safronov, P F" uniqKey="Safronov P">P.F. Safronov</name></author><author><name sortKey="Ryazankina, O I" uniqKey="Ryazankina O">O.I. Ryazankina</name></author><author><name sortKey="Petroy, N A" uniqKey="Petroy N">N.A. Petroy</name></author><author><name sortKey="Gutorov, V V" uniqKey="Gutorov V">V.V. Gutorov</name></author><author><name sortKey="Uvarova, E A" uniqKey="Uvarova E">E.A. Uvarova</name></author><author><name sortKey="Mikheev, M V" uniqKey="Mikheev M">M.V. Mikheev</name></author><author><name sortKey="Sisler, J R" uniqKey="Sisler J">J.R. Sisler</name></author><author><name sortKey="Esposito, J J" uniqKey="Esposito J">J.J. Esposito</name></author><author><name sortKey="Jahrling, P B" uniqKey="Jahrling P">P.B. Jahrling</name></author><author><name sortKey="Moss, B" uniqKey="Moss B">B. Moss</name></author><author><name sortKey="Sandakhchiev, L S" uniqKey="Sandakhchiev L">L.S. Sandakhchiev</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Adv Drug Deliv Rev</journal-id><journal-id journal-id-type="iso-abbrev">Adv. Drug Deliv. Rev</journal-id><journal-title-group><journal-title>Advanced Drug Delivery Reviews</journal-title></journal-title-group><issn pub-type="ppub">0169-409X</issn><issn pub-type="epub">1872-8294</issn><publisher><publisher-name>Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15935879</article-id><article-id pub-id-type="pmc">7125890</article-id><article-id pub-id-type="publisher-id">S0169-409X(05)00050-5</article-id><article-id pub-id-type="doi">10.1016/j.addr.2005.01.015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>Rebecca L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hruby</surname><given-names>Dennis E.</given-names></name><email>dhruby@sgph.com</email><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff>SIGA Technologies, Inc., 4575 SW Research Way, Suite 230, Corvallis, OR 97333, United States</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. Tel.: +1 541 753 2000; fax: +1 541 753 9999. <email>dhruby@sgph.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>14</day><month>4</month><year>2005</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>17</day><month>6</month><year>2005</year></pub-date><pub-date pub-type="epub"><day>14</day><month>4</month><year>2005</year></pub-date><volume>57</volume><issue>9</issue><fpage>1392</fpage><lpage>1402</lpage><history><date date-type="received"><day>15</day><month>12</month><year>2003</year></date><date date-type="accepted"><day>25</day><month>1</month><year>2005</year></date></history><permissions><copyright-statement>Copyright © 2005 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2005</copyright-year><copyright-holder>Elsevier B.V.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><p>Following the anthrax attacks of 2001 and the recent SARS outbreak, concerns about emerging and re-emerging infectious diseases have catalyzed a renewed interest in developing new vaccination strategies that provide rapid and flexible response options to future threats. Because the probability of encountering one of these exotic agents is unknown, it is essential that new vaccine formulations employ methods that provide effective protection and extremely good safety profiles if they are to be used by either military or civilian populations. One approach, which potentially satisfies these criteria, is the use of live recombinant Gram-positive commensal bacteria as expression vectors. This review provides an overview of the system, its advantages and limitations, and details an example of how Gram-positive commensal bacteria are being developed as a fifth generation vaccine against a Class A biowarfare pathogen, namely smallpox.</p></abstract><kwd-group><title>Keywords</title><kwd>Mucosal immunity</kwd><kwd>Surface expression</kwd><kwd>Smallpox</kwd><kwd>Vaccinia antigens</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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